Systematic review of microplastics and nanoplastics in indoor and outdoor air: identifying a framework and data needs for quantifying human inhalation exposures

Journal of Exposure Science & Environmental Epidemiology, Journal Year: 2024, Volume and Issue: 34(2), P. 185 - 196

Published: Jan. 6, 2024

Humans are likely exposed to microplastics (MPs) in a variety of places including indoor and outdoor air. Research better understand how exposure MPs correlates health is growing. To fully the possible impacts on human health, it necessary quantify MP identify what critical data gaps exist.

Language: Английский

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Polyvinyl chloride (PVC), its additives, microplastic and human health: Unresolved and emerging issues

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 960, P. 178276 - 178276

Published: Jan. 1, 2025

Language: Английский

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Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3703 - 3703

Published: Nov. 1, 2024

Humans cannot avoid plastic exposure due to its ubiquitous presence in the natural environment. The waste generated is poorly biodegradable and exists form of MPs, which can enter human body primarily through digestive tract, respiratory or damaged skin accumulate various tissues by crossing biological membrane barriers. There an increasing amount research on health effects MPs. Most literature reports focus impact plastics respiratory, digestive, reproductive, hormonal, nervous, immune systems, as well metabolic MPs accumulation leading epidemics obesity, diabetes, hypertension, non-alcoholic fatty liver disease. xenobiotics, undergo ADMET processes body, i.e., absorption, distribution, metabolism, excretion, are not fully understood. Of particular concern carcinogenic chemicals added during manufacturing adsorbed from environment, such chlorinated paraffins, phthalates, phenols, bisphenols, be released when absorbed body. continuous increase NMP has accelerated SARS-CoV-2 pandemic there was a need use single-use products daily life. Therefore, urgent diagnose problems related MP detection.

Language: Английский

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The Impact of Microplastics in Food and Drugs on Human Health: A Review of the MENA Region

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(3), P. 380 - 380

Published: March 5, 2025

Microplastics (MPs), defined as plastic particles smaller than 5 mm, have emerged a global environmental and public health crisis, infiltrating air, water, soil, food systems worldwide. MPs originate from the breakdown of larger debris, single-use plastics, industrial processes, entering food. Emerging evidence underscores ability to cross biological barriers, including blood–brain barrier, triggering neuroinflammatory responses contributing neurodegenerative diseases such Alzheimer’s Parkinson’s. Polystyrene (PS), common type MP, activates microglial cells, releasing pro-inflammatory cytokines like tumor necrosis factor (TNF-α) interleukins, which increase neuronal damage. also been linked cardiovascular diseases, with studies detecting polyethylene (PE) polyvinyl chloride (PVC) in carotid artery plaques, increasing risk myocardial infarction stroke. Furthermore, disrupt endocrine function, alter lipid metabolism, induce gut microbiome imbalances, posing multifaceted risks. In MENA region, MP pollution is particularly severe, Mediterranean Sea receiving an estimated 570,000 tons annually, equivalent 33,800 bottles per minute. Studies Egypt, Lebanon, Tunisia document high concentrations marine ecosystems, herbivorous fish Siganus rivulatus containing over 1000 individual due ingestion contaminated seaweed. Despite these findings, awareness regulatory frameworks remain inadequate, only 24% Egyptians demonstrating sufficient knowledge safe use. This review emphasizes urgent need for region-specific research, policy interventions, campaigns address pollution. Recommendations include sustainable waste management practices, promotion biodegradable alternatives, enhanced monitoring mitigate impacts region.

Language: Английский

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Biogeochemical Characterization of Water Resources in the Indian Himalayan Regions

Published: March 24, 2025

Language: Английский

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Plastic compounds and liver diseases: Whether bisphenol A is the only culprit

Liver International, Journal Year: 2024, Volume and Issue: 44(5), P. 1093 - 1105

Published: Feb. 26, 2024

Abstract Plastics, while providing modern conveniences, have become an inescapable source of global concern due to their role in environmental pollution. Particularly, the focus on bisphenol A (BPA) reveals its biohazardous nature and association with liver issues, specifically steatosis. However, research indicates that BPA is just one facet problem, as other analogues, microplastics, nanoplastics additional plastic derivatives also pose potential risks. Notably, implicated every stage non‐alcoholic fatty disease (NAFLD) onset progression, surpassing hepatitis B virus a primary cause chronic worldwide. As contamination tops contaminants list, urgent action needed assess causative factors mitigate impact. This review delves into molecular disruptions linking pollutant exposure diseases, emphasizing broader connection between plastics rising prevalence NAFLD.

Language: Английский

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Co-exposure of polyvinyl chloride microplastics with cadmium promotes nonalcoholic fatty liver disease in female ducks through oxidative stress and glycolipid accumulation

Poultry Science, Journal Year: 2024, Volume and Issue: 103(11), P. 104152 - 104152

Published: Aug. 5, 2024

A recently discovered environmental contaminant, microplastics (MPs) are capable of amassing within the body and pose a grave threat to health both humans animals. It is widely acknowledged that combination cadmium (Cd), hazardous heavy metal, produces synergistic deleterious effects. Nevertheless, mechanism by which co-exposure polyvinyl chloride (PVC-MPs) Cd damages liver avian females unknown. Globally prevalent subject extensive research in mammals, non-alcoholic fatty disease (NAFLD) chronic condition. However, mechanisms underlying injury digestive system caused NAFLD remain Two months PVC-MPs, pure water, solitary exposure, single water were administered female Muscovy ducks this study. The objective was examine whether duck PVC-MPs Cd-induced oxidative stress resulted subsequent apoptosis hepatic cells. study's findings showed hepatocyte shape functional activity negatively impacted PVC-MP buildup tissues. Reduced organ coefficients, increased alanine aminotransferase (ALT) content, ultrastructural damage nuclei mitochondria indicators this. These results point possible impairment function. phosphoenolpyruvate carboxykinase 1 (PCK1) deficiency activates protein kinase B/phosphatidylinositol 3-kinase (PI3K/AKT) pathway livers reproductive have been damaged stress. This stimulation induces lipid deposition, fibrosis, glycogen accumulation, ultimately apoptosis. In summary, our provides evidence cause harm liver, subsequently fibrosis tissue, glucolipid metabolism,

Language: Английский

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Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(9), P. 1011 - 1017

Published: March 5, 2024

With continuous population and economic growth in the 21

Language: Английский

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Occupational Risks of Microplastics in Textile Manufacturing: Health Impacts and Mitigation Strategies

Advances in Research, Journal Year: 2025, Volume and Issue: 26(1), P. 134 - 139

Published: Jan. 7, 2025

Background: In the textile sector, atmospheric release of MPs during manufacturing, drying and use synthetic fabrics has also been observed, in addition to sewing process, where small structural changes fabric network favor polyester polypropylene fibrils this context, present study aimed discuss, through a literature review, occupational exposure manufacturing sector. Methodology: This was characterized as descriptive bibliographic focusing on search for theoretical references scientific journals, theses dissertations. Results Conclusions: To reduce employee exposure, it is important properly personal protective equipment, including face masks, which microfibers oral nasal mucosa, reducing possibility ingestion inhalation these. Furthermore, an adequate ventilation exhaust system makes possible remove suspended particles from work atmosphere, must be combined with filters prevent into factory's external environment.ential, they mitigate upper respiratory tract mouth microplastics released environment.

Language: Английский

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Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases

Molecular & Cellular Toxicology, Journal Year: 2025, Volume and Issue: 21(2), P. 387 - 397

Published: Feb. 27, 2025

Given the global increase in obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) is a major health concern. Because primary organ for xenobiotic metabolism, impact of environmental stressors on homeostasis and MASLD has garnered significant interest over past few decades. The concept metabolism-disrupting chemicals (MDCs) been introduced to underscore importance factors homeostasis. Recent epidemiological biological studies suggest causal link between exposure MDCs prevalence progression MASLD. This review aims introduce emerging their representative toxic mechanisms. In particular, this focuses broadening understanding impacts or steatohepatitis (MASH) progression. research highlighted contaminants, such as heavy metals, microplastics, pesticides, have potential influence hepatic metabolism aggravate MASLD/MASH These not only directly affect lipid hepatocytes but also other cell types, immune cells stellate cells, well gut-liver axis. Collectively, these findings contribute establishing well-defined adverse outcome pathway identify novel therapeutic options diseases associated with pollutants.

Language: Английский

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