Single-value fMRI scores reflect both stage and risk across the Alzheimer’s disease continuum DOI Creative Commons
Joram Soch, Anni Richter, Jasmin M. Kizilirmak

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 12, 2023

Abstract Single-value scores reflecting the deviation from (FADE score) or similarity with (SAME prototypical novelty-related and memory-related functional magnetic resonance imaging (fMRI) activation patterns in young adults have been proposed as biomarkers of healthy neurocognitive aging. Here, we tested utility these potential diagnostic prognostic markers Alzheimer’s disease (AD) risk states like mild cognitive impairment (MCI) subjective decline (SCD). To this end, analyzed subsequent memory fMRI data individuals SCD, MCI, AD dementia well controls (HC) first-degree relatives patients (AD-rel) who participated multi-center DELCODE study (N = 468). Based on individual participants’ whole-brain novelty responses, calculated FADE SAME assessed their association stage, neuropsychological test scores, CSF amyloid positivity, ApoE genotype. Memory-based showed a considerably larger reference sample MCI groups compared to HC, SCD AD-rel. In addition, novelty-based significantly differed between groups. Across entire sample, single-value correlated performance. The score further Aβ-positive Aβ-negative AD-rel, ε4 carriers non-carriers Hence, are associated both performance factors for AD. Their warrants exploration, particularly patients.

Language: Английский

The power of many brains: Catalyzing neuropsychiatric discovery through open neuroimaging data and large-scale collaboration DOI Creative Commons
Bin Lü, Xiao Chen, F. Xavier Castellanos

et al.

Science Bulletin, Journal Year: 2024, Volume and Issue: 69(10), P. 1536 - 1555

Published: March 6, 2024

Recent advances in open neuroimaging data are enhancing our comprehension of neuropsychiatric disorders. By pooling images from various cohorts, statistical power has increased, enabling the detection subtle abnormalities and robust associations, fostering new research methods. Global collaborations imaging have furthered knowledge neurobiological foundations brain disorders aided imaging-based prediction for more targeted treatment. Large-scale magnetic resonance initiatives driving innovation analytics supporting generalizable psychiatric studies. We also emphasize significant role big understanding neural mechanisms early identification precise treatment However, challenges such as harmonization across different sites, privacy protection, effective sharing must be addressed. With proper governance science practices, we conclude with a projection how large-scale resources could revolutionize diagnosis, selection, outcome prediction, contributing to optimal health.

Language: Английский

Citations

11
Peripheral inflammation and neurocognitive impairment: correlations, underlying mechanisms, and therapeutic implications DOI Creative Commons
Siyou Tan, Wenyan Chen,

Gaoyin Kong

et al.

Frontiers in Aging Neuroscience, Journal Year: 2023, Volume and Issue: 15

Published: Nov. 29, 2023

Cognitive impairments, such as learning and memory deficits, may occur in susceptible populations including the elderly patients who are chronically ill or have experienced stressful events, surgery, infection, trauma. Accumulating lines of evidence suggested that peripheral inflammation featured by recruitment immune cells release pro-inflammatory cytokines be activated during aging these conditions, participating system-brain communication. Lots progress has been achieved deciphering core bridging mechanism connecting cognitive which helpful developing early diagnosis, prognosis evaluation, prevention methods based on blood circulation system sampling intervention. In this review, we summarized evolving prevalence inflammation-associated neurocognitive impairments discussed research advances underlying mechanisms. We also highlighted treatment strategies against dysfunction.

Language: Английский

Citations

13
Single-value brain activity scores reflect both severity and risk across the Alzheimer’s continuum DOI Creative Commons
Joram Soch, Anni Richter, Jasmin M. Kizilirmak

et al.

Brain, Journal Year: 2024, Volume and Issue: 147(11), P. 3789 - 3803

Published: May 14, 2024

Abstract Single-value scores reflecting the deviation from (FADE score) or similarity with (SAME prototypical novelty-related and memory-related functional MRI activation patterns in young adults have been proposed as imaging biomarkers of healthy neurocognitive ageing. Here, we tested utility these potential diagnostic prognostic markers Alzheimer’s disease (AD) risk states like mild cognitive impairment (MCI) subjective decline (SCD). To this end, analysed subsequent memory data individuals SCD, MCI AD dementia well controls first-degree relatives patients (AD-rel) who participated multi-centre DELCODE study (n = 468). Based on individual participants’ whole-brain novelty responses, calculated FADE SAME assessed their association stage, neuropsychological test scores, CSF amyloid positivity APOE genotype. Memory-based showed a considerably larger reference sample groups compared to controls, SCD AD-rel. In addition, novelty-based significantly differed between groups. Across entire sample, single-value correlated performance. The score further Aβ-positive Aβ-negative AD-rel, ApoE ɛ4 carriers non-carriers Hence, are associated both performance factors for AD. Their warrants exploration, particularly patients.

Language: Английский

Citations

5
Amyloid and SCD jointly predict cognitive decline across Chinese and German cohorts DOI Creative Commons
Kai Shao, Xiaochen Hu, Luca Kleineidam

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(9), P. 5926 - 5939

Published: July 27, 2024

Abstract INTRODUCTION Subjective cognitive decline (SCD) in amyloid‐positive (Aβ+) individuals was proposed as a clinical indicator of Stage 2 the Alzheimer's disease (AD) continuum, but this requires further validation across cultures, measures, and recruitment strategies. METHODS Eight hundred twenty‐one participants from SILCODE DELCODE cohorts, including normal controls (NC) with SCD recruited community or memory clinics, underwent neuropsychological assessments over up to 6 years. Amyloid positivity derived positron emission tomography plasma biomarkers. Global change analyzed using linear mixed‐effects models. RESULTS In combined stratified Aβ+ showed steeper diminished practice effects compared NC Aβ− SCD. These findings were confirmed different operationalizations amyloid positivity, settings. DISCUSSION German Chinese populations greater global could be targeted for interventional trials. Highlights predicts decline. This finding does not rely on specific operationalization. is patients clinics. valid both populations. older adults target population

Language: Английский

Citations

5
Dynamic proportional loss of functional connectivity revealed change of left superior frontal gyrus in subjective cognitive decline: an explanatory study based on Chinese and Western cohorts DOI
Luyao Wang, Wenjing Hu, Fan Dong

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

0
Research progress on brain network imaging biomarkers of subjective cognitive decline DOI Creative Commons

Han Yingmei,

Chaojie Wang, Yi Zhang

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 13, 2025

Purpose Subjective cognitive decline (SCD) is an early manifestation of the Alzheimer’s disease (AD) continuum, and accurately diagnosing SCD to differentiate it from neurotypical aging in older adults a common challenge for researchers. Methods This review examines summarizes relevant studies regarding neuroimaging AD comprehensively outlines clinical features characterizing along with corresponding changes involving structural, functional, metabolic networks. Results The characteristics include subjective self-perceived function, there are significant imaging changes, such as reductions gray matter volume certain brain regions, abnormalities integrity white tracts diffusion metrics, alterations functional connectivity between different sub-networks or within networks, well networks cerebral blood flow perfusion. Conclusion 147 referenced this paper indicate that exploring network related through aims enhance goals mission science development programs: “Understanding Brain,” “Protecting “Creating thereby strengthening researchers’ investigation into mechanisms function. Early diagnosis SCD, prompt intervention, can reduce incidence spectrum while improving patients’ quality life, even integrating numerous scientific research achievements unified established standards applying them practice by doctors, thus all encouraging researchers further investigate issues adults.

Language: Английский

Citations

0
Longitudinal excitation-inhibition balance altered by sex and APOE-ε4 DOI Creative Commons

Andrew P. Burns,

Igor Fortel, Liang Zhan

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: March 25, 2025

Neuronal hyperexcitation affects memory and neural processing across the Alzheimer's disease (AD) cognitive continuum. Levetiracetam, an antiepileptic, shows promise in improving impairment by restoring excitation/inhibition balance AD patients. We previously identified a hyper-excitable phenotype cognitively unimpaired female APOE-ε4 carriers relative to male counterparts cross-sectionally. This sex difference lacks longitudinal validation; however, clarifying vulnerability of ε4-carriers could better inform antiepileptic treatment efficacy. Here, we investigated this sex-by-ε4 interaction using design. used resting-state fMRI diffusion tensor imaging collected longitudinally from 106 participants who were for at least one scan event but may have been assessed clinical dementia ratings corresponding early mild over time. By including events where transitioned impairment, modeled trajectory whole-brain excitation-inhibition ratio throughout preclinical healthy continuum extended impairment. A linear mixed model revealed significant three-way among sex, ε4-status, time, with showing trajectory. These findings suggest possible pathway preventative therapy targeting ε4-carriers. Longitudinal connectome modeling individuals reveals hyperexcitable carriers. Findings anti-excitatory therapies mitigate risk.

Language: Английский

Citations

0
High prevalence of subjective cognitive decline in older Chinese adults: a systematic review and meta-analysis DOI Creative Commons
Chao Xue, Juan Li,

Mingqing Hao

et al.

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Dec. 1, 2023

Background Subjective cognitive decline (SCD) is considered a preclinical stage of Alzheimer’s disease. However, reliable prevalence estimates SCD in the Chinese population are lacking, underscoring importance such metrics for policymakers to formulate appropriate healthcare strategies. Objective To systematically evaluate among older adults. Methods PubMed, Web Science, The Cochrane Library, Embase, CNKI, Wanfang, VIP, CBM, and Airiti Library databases were searched studies on individuals published before May 2023. Two investigators independently screened literature, extracted information, assessed bias risk included studies. A meta-analysis was then conducted using Stata 16.0 software via random-effects model analyze Results total 17 (n = 31,782). adults 46.4% (95% CI, 40.6–52.2%). Further, subgroup analyzes indicated that 50.8% men 58.9% women. Additionally, aged 60–69, 70–79, ≥ 80 years 38.0, 45.2, 60.3%, respectively. Furthermore, with BMI <18.5, 18.5–24.0, > 24.0 59.3, 54.0, 52.9%, Geographically, 41.3% North China 50.0% South China. In terms residence, 47.1% urban residents rural residents. As retired individuals, 44.2% non-manual workers 49.2% manual workers. case education, an education level “elementary school below” had rate 62.8%; “middle school, “52.4%; “high “55.0%; “college above, “51.3%. Finally, lower married surviving spouses than single who divorced, widowed, or unmarried. Conclusion Our systematic review identified significant widespread Therefore, our findings highlight urgent requirement medical institutions across all levels prioritize rapidly develop implement comprehensive preventive therapeutic strategies SCD. Systematic registration : https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023406950 , identifier: CRD42023406950.

Language: Английский

Citations

8
Spatial and temporal patterns of cortical mean diffusivity in Alzheimer's disease and suspected non‐Alzheimer's disease pathophysiology DOI Creative Commons
Pan Sun,

Zhengbo He,

Anqi Li

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: 20(10), P. 7048 - 7061

Published: Aug. 12, 2024

Abstract INTRODUCTION The spatial and temporal patterns of cortical mean diffusivity (cMD), as well its association with Alzheimer's disease (AD) suspected non‐Alzheimer's pathophysiology (SNAP), are not yet fully understood. METHODS We compared baseline ( n = 617) longitudinal changes 421) cMD, thickness, gray matter volume their relations to vascular risk factors, amyloid beta (Aβ), tau positron emission tomography (PET), cognitive decline in Aβ PET negative positive older adults. RESULTS cMD increases were more sensitive detecting brain structural alterations than thinning atrophy. Tau‐related partially mediated Aβ‐related AD, whereas disease‐related increased levels substantially age‐related SNAP. DISCUSSION These findings revealed the dynamic microstructural macrostructural indicators associations AD SNAP, providing novel insights into understanding upstream downstream events neurodegenerative disease. Highlights Cortical (cMD) was factors. beta–related (AD). White hyperintensity–related higher mainly explained (SNAP). may assist tracking earlier signs

Language: Английский

Citations

3
Brain Topological Changes in Subjective Cognitive Decline and Associations with Amyloid Stages DOI Creative Commons
Xueyan Jiang, Mingkai Zhang, Chuyao Yan

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 11, 2024

Abstract Background Amyloid spreads throughout the cortex in Alzheimer's disease (AD), which is thought to cause disturbances brain networks. It not clear how structural and functional connectivity change as amyloid accumulates progressively across cortical stages individuals with subjective cognitive decline (SCD), a risk condition for AD. Methods Graph-theoretic analyses of networks were performed using resting-state magnetic resonance imaging diffusion tensor 100 SCD 86 normal controls (NC) derived from an ongoing large cohort study. Topological properties at node network levels characterized indicators information exchange efficiency robustness. burden was quantified subset 55 by positron emission tomography frequency-based staging method, yielding mean regional standardized uptake value ratios (SUVr) four anatomical divisions global SUVr entire cortex, further correlated topological property measures. Results Individuals showed increased nodal betweenness left anterior median cingulate gyri compared NC. No group differences network-level found. Frequency-based revealed divisions, including fusiform lateral temporal (> 50%), occipital areas (30%-50%), default mode network, midline frontotemporal (10%-30%), remaining (< 10%). Global positively associated node-level set hubs, posterior being congruently all stages. Conclusion cingulate, unchanged effectiveness or robustness complex network. In this at-risk population, progressive accumulation continuously influences adaptation via irrespective local physical proximity pathology. The positive associations between suggest increasing processing hubs during early deposition population disease.

Language: Английский

Citations

0