Dual-crosslinked mussel-inspired smart hydrogels with enhanced antibacterial and angiogenic properties for chronic infected diabetic wound treatment via pH-responsive quick cargo release

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 411, P. 128564 - 128564

Published: Jan. 20, 2021

Language: Английский

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Recent Progress in Natural Biopolymers Conductive Hydrogels for Flexible Wearable Sensors and Energy Devices: Materials, Structures, and Performance

ACS Applied Bio Materials, Journal Year: 2020, Volume and Issue: 4(1), P. 85 - 121

Published: Aug. 17, 2020

Natural biopolymer-based conductive hydrogels, which combine inherent renewable, nontoxic features, biocompatibility and biodegradability of biopolymers, excellent flexibility conductivity exhibit great potential in applications wearable stretchable sensing devices. Compared to traditional flexible substrates deriving from petro-materials-derived polymers, hydrogels consisting continuous cross-linked polymer networks a large amount water more fantastic combination stretchability because their endow the with mechanical offers them consecutive ionic transport property. Different biopolymers that are extracted bioresource intrinsic commonly considered as appropriate candidates for constructing For example, such cellulose, chitosan, silk fibroin usually chosen promising construct endowing enhanced properties remarkable biocompatibility. This review summarizes recent progress natural utilized electrical devices series typical including fibroin, gelatin. The chemical structures physicochemical four demonstrated, diverse hydrogel sensors discussed detail. Finally, remaining challenges expectations discussed.

Language: Английский

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Stimuli-responsive metal–organic framework nanoparticles for controlled drug delivery and medical applications

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(7), P. 4541 - 4563

Published: Jan. 1, 2021

Different chemical, physical, and biomarker triggers to unlock the metal–organic framework nanoparticles release drugs loaded in particles will be addressed.

Language: Английский

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Phase-locked constructing dynamic supramolecular ionic conductive elastomers with superior toughness, autonomous self-healing and recyclability

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Aug. 18, 2022

Stretchable ionic conductors are considerable to be the most attractive candidate for next-generation flexible ionotronic devices. Nevertheless, high conductivity, excellent mechanical properties, good self-healing capacity and recyclability necessary but can rarely satisfied in one material. Herein, we propose an conductor design, dynamic supramolecular conductive elastomers (DSICE), via phase-locked strategy, wherein locking soft phase polyether backbone conducts lithium-ion (Li+) transport combination of disulfide metathesis stronger quadruple hydrogen bonds hard domains contributes versatility. The dual-phase design performs its own functions conflict among capability, compatibility thus defeated. well-designed DSICE exhibits conductivity (3.77 × 10-3 S m-1 at 30 °C), transparency (92.3%), superior stretchability (2615.17% elongation), strength (27.83 MPa) toughness (164.36 MJ m-3), capability (~99% room temperature) favorable recyclability. This work provides interesting strategy designing advanced offers promise devices or solid-state batteries.

Language: Английский

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Advances in Application of Azobenzene as a Trigger in Biomedicine: Molecular Design and Spontaneous Assembly

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(26)

Published: May 24, 2021

Abstract Azobenzene is a well‐known derivative of stimulus‐responsive molecular switches and has shown superior performance as functional material in biomedical applications. The results multiple studies have led to the development light/hypoxia‐responsive azobenzene for use. In recent years, long‐wavelength‐responsive been developed. Matching longer wavelength absorption hypoxia‐response characteristics switch unit bio‐optical window large effective stimulus response. addition, used hypoxia‐sensitive connector via biological cleavage under appropriate conditions. This resulted on/off state switching properties such pharmacology fluorescence activity. Herein, advances design fabrication trigger biomedicine are summarized.

Language: Английский

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Naturally sourced hydrogels: emerging fundamental materials for next-generation healthcare sensing

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(9), P. 2992 - 3034

Published: Jan. 1, 2023

The flourishing development of flexible healthcare sensing systems is inseparable from the fundamental materials with application-oriented mechanical and electrical properties. Thanks to continuous inspiration our Mother Nature, hydrogels originating natural biomass are attracting growing attention for their structural functional designs owing unique chemical, physical biological These highly efficient architectural enable them be most promising candidates electronic devices. This comprehensive review focuses on recent advances in naturally sourced constructing multi-functional sensors applications thereof. We first briefly introduce representative polymers, including polysaccharides, proteins, polypeptides, summarize physicochemical design principles fabrication strategies hydrogel based these polymers outlined after material properties required presented. then highlight various techniques devices, illustrate examples wearable or implantable bioelectronics pressure, strain, temperature, biomarker field systems. Finally, concluding remarks challenges prospects hydrogel-based provided. hope that this will provide valuable information next-generation build a bridge between as matter an applied target accelerate new near future.

Language: Английский

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Dual‐Encryption in a Shape‐Memory Hydrogel with Tunable Fluorescence and Reconfigurable Architecture

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(29)

Published: June 3, 2021

Abstract Materials capable of shape‐morphing and/or fluorescence imaging have practical significances in the fields anti‐counterfeiting, information display, and protection. However, it's challenging to realize these functions hydrogels due poor mechanical properties lack tunable fluorescence. A tough hydrogel with good shape‐memory ability phototunable is reported here, which affords reprogrammable shape designing encoding for dual‐encryption. This prepared by incorporating donor–acceptor chromophore units into a poly(1‐vinylimidazole‐ co ‐methacrylic acid) network, dense intra‐ interchain hydrogen bonds lead desirable features including high stiffness, toughness, temperature‐mediated property. Additionally, shows photomediated through unimer‐to‐dimer transformation chromophores. By combining photolithography origami/kirigami designs, sheets encoded fluorescent patterns can deform specific 3D configurations. The geometrically encrypted architected readable only after sequential recovery UV light irradiation. As demonstrated proof‐of‐concept experiments, both pattern configuration are reprogrammable, facilitating repeated protection display. design rewritable reconfigurable shapes should guide future development smart materials improved security wider applications aqueous environments.

Language: Английский

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Recent advances in polysaccharide‐based hydrogels for synthesis and applications

Aggregate, Journal Year: 2021, Volume and Issue: 2(2)

Published: Jan. 19, 2021

Abstract Hydrogels are three‐dimensional (3D) crosslinked hydrophilic polymer networks that have garnered tremendous interests in many fields, including water treatment, energy storage, and regenerative medicine. However, conventional synthetic hydrogels poor biocompatibility. In this context, polysaccharides, a class of renewable natural materials with biocompatible biodegradable properties, been utilized as building blocks to yield polysaccharide‐based through physical and/or chemical crosslinking polysaccharides via variety monomers or ions. These polysaccharide‐derived exhibit peculiar physicochemical properties excellent mechanical due their unique structures abundant functional groups. This review focuses on recent advances synthesis applications by capitalizing set (i.e., cellulose, alginate, chitosan, cyclodextrins [CDs]). First, we introduce the design principles for crafting hydrogels. Second, interconnected various strategies (e.g., crosslinking, double networking) summarized. particular, introduction noncovalent dynamic covalent interactions imparts myriad intriguing performances stimuli–response self‐recovery). Third, diverse self‐healing, sensory, supercapacitor, battery, drug delivery, wound healing, tissues engineering, bioimaging fields discussed. Finally, perspectives promote future enable new functions outlined.

Language: Английский

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Hydrogels for RNA delivery

Nature Materials, Journal Year: 2023, Volume and Issue: 22(7), P. 818 - 831

Published: March 20, 2023

Language: Английский

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Stimuli‐responsive hydrogels: Fabrication and biomedical applications

View, Journal Year: 2021, Volume and Issue: 3(2)

Published: Aug. 27, 2021

Abstract Due to their similarity some bio‐architectures, for example, extracellular matrix, hydrogels are considered as bio‐inspired networks with bio‐mimetic and bio‐functional properties. With natural cytocompatibility biocompatibility, nowadays more involved in various bio‐applications including shape morphing, artificial muscles, soft robotics, regenerative medicine, so on. As an important subclass, stimuli‐responsive have been attracting interest within decades. In response single or multi‐triggers biological microenvironment, can undergo phase transition, stiffness change, biochemical properties activation, which make them intriguing biomaterials broad applications sensing, drug delivery, tissue engineering, wound healing. This review presents typical synthetic gelators comprising small molecules polymers building blocks of functional architectures. The fabrication strategies varied from supramolecular assembly dynamic covalent binding detailed. Various exogenous endogenous, physical chemical, stimuli together mechanism, design principle demonstrated. Through recent examples different perspectives, such bionic devices, dressing, cargo carrier, the benefits opportunities highlighted. Finally, current challenges future prospects view translation fundamental researches clinical application briefly discussed.

Language: Английский

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