Polymers,
Journal Year:
2021,
Volume and Issue:
13(3), P. 341 - 341
Published: Jan. 21, 2021
Polymer
nanoparticles
and
nano/micromotors
are
novel
nanostructures
that
of
increased
interest
especially
in
the
diagnosis
therapy
cancer.
These
structures
modified
by
antibodies
or
nucleic
acid
aptamers
can
recognize
cancer
markers
at
membrane
cells
intracellular
side.
They
serve
as
a
cargo
for
targeted
transport
drugs
acids
chemo-
immuno-
gene
therapy.
The
various
mechanisms,
such
enzyme,
ultrasound,
magnetic,
electrical,
light,
served
driving
force
nano/micromotors,
allowing
their
into
cells.
This
review
is
focused
on
recent
achievements
development
polymer
aptamers.
methods
preparation
nanoparticles,
structure
properties
provided
together
with
those
synthesis
application
nano/micromotors.
mechanisms
chemical,
electric
magnetic
fields
explained.
targeting
drug
delivery
based
modification
receptors
antibodies.
Special
focus
therefore
method
selection
recognition
well
comparison
immobilization
provided.
Examples
applications
controlled
release
presented.
future
perspectives
biomimetic
personalized
nanomedicine
also
discussed.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Oct. 9, 2023
Abstract
The
use
of
nanotechnology
has
the
potential
to
revolutionize
detection
and
treatment
cancer.
Developments
in
protein
engineering
materials
science
have
led
emergence
new
nanoscale
targeting
techniques,
which
offer
renewed
hope
for
cancer
patients.
While
several
nanocarriers
medicinal
purposes
been
approved
human
trials,
only
a
few
authorized
clinical
cells.
In
this
review,
we
analyze
some
formulations
discuss
challenges
translating
findings
from
lab
clinic.
This
study
highlights
various
compounds
that
can
be
used
selective
tumor
inherent
difficulties
therapy.
Nanotechnology
provides
promising
platform
improving
future,
but
further
research
is
needed
overcome
current
limitations
translation.
Graphical
Advanced NanoBiomed Research,
Journal Year:
2021,
Volume and Issue:
2(2)
Published: Nov. 25, 2021
Lipid
nanoparticles
have
attracted
significant
interests
in
the
last
two
decades,
and
achieved
tremendous
clinical
success
since
first
approval
of
Doxil
1995.
At
same
time,
lipid
also
demonstrated
enormous
potential
delivering
nucleic
acid
drugs
as
evidenced
by
RNA
therapies
mRNA
COVID‐19
vaccines.
In
this
review,
an
overview
on
different
classes
nanoparticles,
including
liposomes,
solid
nanostructured
carriers,
is
provided,
followed
introduction
their
preparation
methods.
Then
characterizations
are
briefly
reviewed
applications
encapsulating
hydrophobic
drugs,
hydrophilic
RNAs
highlighted.
Finally,
various
for
overcoming
delivery
challenges,
crossing
blood–brain
barrier,
targeted
delivery,
routes
administration,
summarized.
drug
systems
offer
many
attractive
benefits
such
great
biocompatibility,
ease
preparation,
feasibility
scale‐up,
nontoxicity,
while
current
challenges
warrant
future
studies
about
structure–function
correlations,
large‐scale
production,
to
realize
full
wider
pharmaceutical
future.
ChemPlusChem,
Journal Year:
2020,
Volume and Issue:
85(9), P. 2143 - 2157
Published: Aug. 10, 2020
Abstract
Formulating
drugs
into
nanoparticles
offers
many
attractive
advantages
over
free
including
improved
bioavailability,
minimized
toxic
side
effects,
enhanced
drug
delivery,
feasibility
of
incorporating
other
functions
such
as
controlled
release,
imaging
agents
for
imaging,
targeting
and
loading
more
than
one
combination
therapies.
One
the
key
parameters
is
loading,
which
defined
mass
ratio
to
drug‐loaded
nanoparticles.
Currently,
most
nanoparticle
systems
have
relatively
low
(<10
wt%),
developing
methods
increase
remains
a
challenge.
This
Minireview
presents
an
overview
recent
research
on
with
high
(>10
wt%)
from
perspective
synthesis
strategies,
post‐loading,
co‐loading,
pre‐loading.
Based
these
three
different
various
materials
are
summarized
discussed
in
terms
their
methods,
loadings,
encapsulation
efficiencies,
release
profiles,
stabilities,
applications
delivery.
The
disadvantages
strategies
presented
objective
providing
useful
design
rules
future
development
high‐drug‐loading
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(9), P. 5505 - 5616
Published: April 16, 2024
The
recent
emergence
of
nanomedicine
has
revolutionized
the
therapeutic
landscape
and
necessitated
creation
more
sophisticated
drug
delivery
systems.
Polymeric
nanoparticles
sit
at
forefront
numerous
promising
designs,
due
to
their
unmatched
control
over
physiochemical
properties
such
as
size,
shape,
architecture,
charge,
surface
functionality.
Furthermore,
polymeric
have
ability
navigate
various
biological
barriers
precisely
target
specific
sites
within
body,
encapsulate
a
diverse
range
cargo
efficiently
release
this
in
response
internal
external
stimuli.
However,
despite
these
remarkable
advantages,
presence
wider
clinical
application
is
minimal.
This
review
will
provide
comprehensive
understanding
vehicles.
affecting
be
outlined
first,
followed
by
description
nanoparticle
designs
preparation
methods,
beginning
with
polymers
on
which
they
are
based.
meticulously
explore
current
performance
against
myriad
diseases
including
cancer,
viral
bacterial
infections,
before
finally
evaluating
advantages
crucial
challenges
that
determine
potential
decades
come.
Journal of Materials Chemistry B,
Journal Year:
2021,
Volume and Issue:
9(35), P. 7030 - 7062
Published: Jan. 1, 2021
Polysaccharides
have
attracted
considerable
attention
in
a
broad
range
of
applications
recent
years,
which
is
due
to
their
remarkable
features
such
as
biocompatibility,
biodegradability,
renewable
origin,
and
facile
modification.
Considerable
research
efforts
been
focused
on
developing
polysaccharide
nanoparticles
promote
various
areas
biomedicine
particular.
The
present
review
highlights
the
properties
common
polysaccharides
used
nanoparticle
formation
well
strategies
fabricate
nanoparticles.
Furthermore,
combination
polymers
presented
brought
into
context
applications.
Finally,
nano-delivery
system,
Pickering
emulsion
stabilisers,
material
reinforcing
agent
fields
nanomedicine,
cosmetics,
food
system
are
highlighted.
Moreover,
this
describes
critically
discusses
limitations
drawbacks
preparation
use
nanoparticles,
revealing
directions
develop
for
further
utilisation
future.
Small,
Journal Year:
2022,
Volume and Issue:
18(36)
Published: April 9, 2022
Abstract
Nanoparticles
(NPs)
have
attracted
tremendous
interest
in
drug
delivery
the
past
decades.
Microfluidics
offers
a
promising
strategy
for
making
NPs
due
to
its
capability
precisely
controlling
NP
properties.
The
recent
success
of
mRNA
vaccines
using
microfluidics
represents
big
milestone
microfluidic
pharmaceutical
applications,
and
rapid
scaling
up
demonstrates
feasibility
industrial‐scale
manufacturing.
This
article
provides
critical
review
progress
delivery.
First,
synthesis
organic
focusing
on
typical
methods
their
applications
popular
clinically
relevant
NPs,
such
as
liposomes,
lipid
polymer
well
mechanisms
are
summarized.
Then,
several
representative
inorganic
(e.g.,
silica,
metal,
metal
oxide,
quantum
dots),
hybrid
is
discussed.
Lastly,
various
presented.
Lab on a Chip,
Journal Year:
2023,
Volume and Issue:
23(5), P. 1389 - 1409
Published: Jan. 1, 2023
Nanoparticle
systems
are
functional
carriers
that
can
be
used
in
the
cancer
therapy
field
for
delivery
of
a
variety
hydrophobic
and/or
hydrophilic
drugs.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(23)
Published: Feb. 23, 2024
Polysaccharides
constitute
over
90%
of
the
carbohydrate
mass
in
nature,
which
makes
them
a
promising
feedstock
for
manufacturing
sustainable
materials.
Polysaccharide
particles
(PSPs)
are
used
as
effective
scavengers,
carriers
chemical
and
biological
cargos,
building
blocks
fabrication
macroscopic
The
biocompatibility
degradability
PSPs
advantageous
their
uses
biomaterials
with
more
environmental
friendliness.
This
review
highlights
progresses
PSP
applications
advanced
functional
materials,
by
describing
extraction,
preparation,
surface
functionalization
variety
groups,
polymers,
nanoparticles,
biologically
active
species.
also
outlines
PSP-derived
well
soft
robotics,
sensing,
scavenging,
water
harvesting,
drug
delivery,
bioengineering.
paper
is
concluded
an
outlook
providing
perspectives
development
