Copper Single-Atom Jellyfish-like Nanomotors for Enhanced Tumor Penetration and Nanocatalytic Therapy DOI
Yi Xing, Jidong Xiu, Mengyun Zhou

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(7), P. 6789 - 6799

Published: March 29, 2023

Single-atom catalysts with extraordinary catalytic activity have been receiving great attention in tumor therapy. However, most single-atom lack self-propulsion properties, restricting them from actively approaching cancer cells or penetrating the interior of tumors. Herein, we design N-doped jellyfish-like mesoporous carbon nanomotors coordinated copper (Cu-JMCNs). It is a combination nanocatalytic medicine and nanomotor for The Cu single atom can catalyze H2O2 into toxic hydroxyl radical (•OH) chemodynamic therapy (CDT). Near-infrared light triggers Cu-JMCNs to achieve self-thermophoretic motion because asymmetric structure photothermal property carbon, which significantly improves cellular uptake penetration three-dimensional In vivo experiments indicate that CDT near-infrared propulsion over 85% inhibition rate. This work sheds on development advanced biomedical applications.

Language: Английский

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy DOI

Boyi Niu,

Kaixin Liao,

Yixian Zhou

et al.

Biomaterials, Journal Year: 2021, Volume and Issue: 277, P. 121110 - 121110

Published: Aug. 30, 2021

Language: Английский

Citations

748
Stimuli‐Responsive Manganese Single‐Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions DOI
Yang Zhu, Wenyu Wang, Junjie Cheng

et al.

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(17), P. 9480 - 9488

Published: Feb. 6, 2021

Abstract The single‐atom enzyme (SAE) is a novel type of nanozyme that exhibits extraordinary catalytic activity. Here, we constructed PEGylated manganese‐based SAE (Mn/PSAE) by coordination manganese to nitrogen atoms in hollow zeolitic imidazolate frameworks. Mn/PSAE catalyzes the conversion cellular H 2 O . OH through Fenton‐like reaction; it also promotes decomposition and continuously cytotoxic − via oxidase‐like activity more pronounced weak acidic tumor environment; therefore, these cascade reactions enable sufficient generation reactive oxygen species (ROS) effectively kill cells. prominent photothermal property amorphous carbon can be utilized for therapy. Hence, significant therapeutic efficacy microenvironment stimulated multiple ROS

Language: Английский

Citations

381
A Bioinspired Five‐Coordinated Single‐Atom Iron Nanozyme for Tumor Catalytic Therapy DOI
Bolong Xu, Shanshan Li, Lirong Zheng

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(15)

Published: Feb. 1, 2022

Single-atom nanozymes (SAzymes) represent a new research frontier in the biomedical fields. The rational design and controllable synthesis of SAzymes with well-defined electronic geometric structures are essential for maximizing their enzyme-like catalytic activity therapeutic efficacy but remain challenging. Here, melamine-mediated pyrolysis activation strategy is reported fabrication iron-based SAzyme containing five-coordinated structure (FeN5 ), identified by transmission electron microscopy imaging X-ray absorption fine analyses. FeN5 exhibits superior peroxidase-like owing to optimized coordination structure, corresponding efficiency Fe-species 7.64 3.45 × 105 times higher than those traditional FeN4 Fe3 O4 nanozyme, respectively, demonstrated steady-state kinetic assay. In addition, mechanism jointly disclosed experimental results density functional theory studies. as-synthesized demonstrates significantly enhanced antitumor effect vitro vivo due excellent under tumor microenvironment.

Language: Английский

Citations

253
Tumor‐Microenvironment‐Activated Reactive Oxygen Species Amplifier for Enzymatic Cascade Cancer Starvation/Chemodynamic /Immunotherapy DOI
Man Wang, Mengyu Chang, Chunxia Li

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(4)

Published: Oct. 26, 2021

At present, some progress has been made in the field of cancer theranostics based on nanocatalysts (NCs), but achieving precise response to specific tumor microenvironment (TME) remains a major challenge. Herein, TME-responsive upconversion nanoparticles (UCNPs)-based smart UCNPs@Cu-Cys-GOx (UCCG) nanosystem is engineered, which combines natural enzymes and nanozymes so as amplify reactive oxygen species (ROS) generation situ for starvation/chemodynamic/immunotherapy. One biggest merits this material that it can be preserved inert (off) normal tissues, only TME specifically activated (on) through series enzymatic cascades boost ROS production via strategy open source (H2 O2 self-supplying ability) reduce expenditure (glutathione (GSH) consuming ability). More importantly, enhanced oxidative stress by UCCG NCs reverses immunosuppressive TME, facilitates antitumor immune responses. Meanwhile, starvation/chemodynamic synergistic therapy triggered combined with PD-L1 antibody effectively inhibits growth primary tumors metastasis. In addition, UCNPs present luminescence enhancement, exploited visualize reinforced real time. Collectively, work provides an original method devising exploitation UCNPs-based catalytic immunotherapy.

Language: Английский

Citations

236
Nanozyme-involved biomimetic cascade catalysis for biomedical applications DOI
Xiaoli Cai, Lei Jiao, Hongye Yan

et al.

Materials Today, Journal Year: 2021, Volume and Issue: 44, P. 211 - 228

Published: Jan. 14, 2021

Language: Английский

Citations

200
Strategies for enhancing cancer chemodynamic therapy performance DOI
Deblin Jana,

Yanli Zhao

Exploration, Journal Year: 2022, Volume and Issue: 2(2)

Published: March 7, 2022

Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species-based cancer treatment modalities. CDT utilizes endogenous H

Language: Английский

Citations

199
Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy DOI Creative Commons
Xiaodong Zhang, Xiaokai Chen,

Yanli Zhao

et al.

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: April 6, 2022

Abstract Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, low yield, making them difficult to be broadly applicable. As an emerging type artificial enzyme, nanozymes that combine the characteristics nanomaterials are promising alternatives. On one hand, have enzyme-like catalytic activities regulate biochemical reactions. other also inherit properties nanomaterials, which can ameliorate shortcomings natural serve as versatile platforms for diverse applications. In this review, various mimic activity different introduced. The achievements in cancer diagnosis treatment technologies summarized by highlighting advantages these Finally, future research directions rapidly developing field outlooked."Image missing"

Language: Английский

Citations

186
One-Step Integration of Tumor Microenvironment-Responsive Calcium and Copper Peroxides Nanocomposite for Enhanced Chemodynamic/Ion-Interference Therapy DOI
Bin Liu,

Yulong Bian,

Shuang Liang

et al.

ACS Nano, Journal Year: 2021, Volume and Issue: 16(1), P. 617 - 630

Published: Dec. 27, 2021

Recently, various metal peroxide nanomaterials have drawn increasing attention as an efficient hydrogen (H2O2) self-supplying agent for enhanced tumor therapy. However, a single kind of is insufficient to achieve more effective antitumor performance. Here, hyaluronic acid modified calcium and copper peroxides nanocomposite has been synthesized by simple one-step strategy. After accumulation at the site due permeability retention (EPR) effect specific recognition hyaluronate with CD44 protein on surface cells, plenty Ca2+, Cu2+, H2O2 can be simultaneously released in hyaluronidase overexpressed microenvironment (TME), generating abundant hydroxyl radical through Fenton-type reaction between Cu2+ assistance glutathione depletion. Overloaded Ca2+ lead mitochondria injury thus enhance oxidative stress cells. Moreover, unbalanced transport channel caused further promote calcification necrosis, which generally defined ion-interference As result, synergistic Fenton-like dysfunction ROS generation performed. Therefore, TME-responsive based integration successfully established exhibits satisfactory efficiency than any peroxide.

Language: Английский

Citations

179
Coordination-Driven Self-Assembly Strategy-Activated Cu Single-Atom Nanozymes for Catalytic Tumor-Specific Therapy DOI
Jie Zhou, Deting Xu, Gan Tian

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 4279 - 4293

Published: Feb. 6, 2023

How to optimize the enzyme-like catalytic activity of nanozymes improve their applicability has become a great challenge. Herein, we present an l-cysteine (l-Cys) coordination-driven self-assembly strategy activate polyvinylpyrrolidone (PVP)-modified Cu single-atom MoOx-Cu-Cys (denoted as MCCP SAzymes) aiming at tumor-specific therapy. The single atom content can be rationally modulated 10.10 wt %, which activates catalase (CAT)-like MoOx nanoparticles catalyze decomposition H2O2 in acidic microenvironments increase O2 production. Excitingly, maximized CAT-like efficiency is 138-fold higher than that typical MnO2 and exhibits 14.3-fold affinity natural catalase, demonstrated by steady-state kinetics. We verify well-defined l-Cys-Cu···O active sites match through l-Cys bridge-accelerated electron transfer from Cys-Cu disclosed density functional theory calculations. Simultaneously, high loading atoms also enable generation •OH via Fenton-like reaction. Moreover, under X-ray irradiation, converts 1O2 for cascading radiodynamic therapy, thereby facilitating multiple reactive oxygen species (ROS) radiosensitization achieve substantial antitumor.

Language: Английский

Citations

165
Ultrasmall Alloy Nanozyme for Ultrasound- and Near-Infrared Light-Promoted Tumor Ablation DOI
Deblin Jana, Dongdong Wang, Anivind Kaur Bindra

et al.

ACS Nano, Journal Year: 2021, Volume and Issue: 15(4), P. 7774 - 7782

Published: April 12, 2021

The therapeutic effect of chemodynamic therapy (CDT) is significantly restricted by the stern reaction conditions and slow rate Fenton (pH 3–4). Herein, we report an ultrasmall trimetallic (Pd, Cu, Fe) alloy nanozyme (PCF-a NEs) possessing dynamic active-site synergism, thus exhibiting a cascade glutathione peroxidase (POD) mimicking activities in circumneutral pH. PCF-a NEs exhibit photothermally augmented POD property high photothermal conversion efficiency (62%) for synergistic tumor cell apoptosis. In addition, ultrasound can also enhance mass transfer at active catalytic sites NEs, turn accelerating Fenton-like tumor-specific CDT. This work provides strategy engineering nanozymes bioinspired way amplification intratumor reactive oxygen species response to external stimuli, demonstrating enhanced inhibition growth vitro vivo.

Language: Английский

Citations

156