Recent progress of chemodynamic therapy-induced combination cancer therapy

Nano Today, Journal Year: 2020, Volume and Issue: 35, P. 100946 - 100946

Published: Aug. 13, 2020

Language: Английский

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Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(47)

Published: Oct. 16, 2020

Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such deeper penetration depth, absence of phototoxicity, fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks the facile engineering nature nanotechnology, numerous novel nanoplatforms being applied this emerging field tackle these barriers achieve continuous innovations. In particular, combination other treatment strategies superior efficacy improving anticancer activity relative that monotherapies alone. Therefore, it is necessary summarize nanomaterial-assisted combinational cancer applications. Herein, design principles achieving synergistic effects based on nanomaterial methods highlighted. The ultimate goals stimulate better-quality combined schemes provide innovative ideas perspectives promoting future transformation clinical application.

Language: Английский

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Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Small, Journal Year: 2021, Volume and Issue: 18(6)

Published: Nov. 2, 2021

Abstract Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in tumor region, was first proposed by Bu, Shi, and co‐workers 2016. Recently, with rapid development of nanomaterials, CDT has attracted tremendous attention because its unique advantages: 1) It is tumor‐selective low side effects; 2) process does not depend on external field stimulation; 3) it can modulate hypoxic immunosuppressive microenvironment; 4) cost low. In addition Fe‐involved strategies, reaction‐mediated strategies have also been proposed, which are based many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, zinc. Moreover, combined therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy for achieving enhanced anticancer effects. Besides, there studies that extend application antibacterial field. This review introduces latest advancements nanomaterials‐involved from 2018 present proposes current limitations well future research directions related

Language: Английский

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Multifunctional Gold Nanoparticles: A Novel Nanomaterial for Various Medical Applications and Biological Activities

Frontiers in Bioengineering and Biotechnology, Journal Year: 2020, Volume and Issue: 8

Published: Aug. 13, 2020

Nanotechnology has become a trending area in science and made great advances with the development of functional, engineered nanoparticles. Various metal nanoparticles have been widely exploited for wide range medical applications. Among them, gold (AuNPs) are reported to guide an impressive resurgence highly remarkable. AuNPs, their multiple, unique functional properties, easy synthesis, attracted extensive attention. Their intrinsic features (optics, electronics, physicochemical characteristics) can be altered by changing characterization nanoparticles, such as shape, size aspect ratio. They applied applications, including drug gene delivery, photothermal therapy (PTT), photodynamic (PDT) radiation (RT), diagnosis, X-ray imaging, computed tomography (CT) other biological activities. However, best our knowledge, there is no comprehensive review that summarized applications AuNPs field. Therefore, this article we systematically methods modification techniques some activities provide reference future studies.

Language: Английский

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Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(22)

Published: April 19, 2021

Abstract Polyphenols, the phenolic hydroxyl group‐containing organic molecules, are widely found in natural plants and have shown beneficial effects on human health. Recently, polyphenol‐containing nanoparticles attracted extensive research attention due to their antioxidation property, anticancer activity, universal adherent affinity, thus great promise preparation, stabilization, modification of multifunctional nanoassemblies for bioimaging, therapeutic delivery, other biomedical applications. Additionally, metal−polyphenol networks, formed by coordination interactions between polyphenols metal ions, been used prepare an important class surface modification, drug disease treatments. By focusing different materials (e.g., inorganic materials, polymers, proteins, nucleic acids), a comprehensive review synthesis properties is provided. Moreover, remarkable versatility applications, including biodetection, multimodal protein gene bone repair, antibiosis, cancer theranostics also demonstrated. Finally, challenges faced future regarding discussed.

Language: Английский

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Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(48)

Published: Sept. 27, 2021

Chemodynamic therapy (CDT) uses the tumor microenvironment-assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective treatment. However, limited efficiency restricts therapeutic efficacy of CDT. Recent years have witnessed impressive development various strategies increase reaction. The introduction these reinforcement can dramatically improve treatment CDT and further promote enhanced (ECDT)-based multimodal anticancer treatments. In this review, authors systematically introduce strategies, from their basic working principles, mechanisms representative clinical applications. Then, ECDT-based is discussed, including how integrate emerging accelerating therapy, as well synergistic ECDT other methods. Eventually, future direction challenges therapies are elaborated, highlighting key scientific problems unsolved technical bottlenecks facilitate translation.

Language: Английский

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Recent Advances in Nanomaterial‐Based Nanoplatforms for Chemodynamic Cancer Therapy

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(22)

Published: March 8, 2021

Abstract Triggered by the endogenous chemical energy in tumor microenvironment (TME), chemodynamic therapy (CDT) as an emerging non‐exogenous stimulant therapeutic modality has received increasing attention recent years. The agents can convert internal hydrogen peroxide (H 2 O ) into lethal reactive oxygen species (ROS) hydroxyl radicals ( • OH) for oncotherapy. Compared with other modalities, CDT possesses many notable advantages, such tumor‐specific, highly selective, fewer systemic side effects, and no need external stimulation. Nevertheless, mild acid pH, low H content, overexpressed reducing substance TME severely suppressed efficiency. With rapid development of nanotechnology, some kinds nanomaterials have been utilized improved In particular, excellent photo‐, ultrasound‐, magnetic‐, stimuli‐response properties make it possible combination cancer shown superior anti‐cancer activity than monotherapies. Therefore, is necessary to summarize application nanomaterial‐based therapy. this review, various nanomaterials‐based nanoplatforms its combinational therapies are summarized discussed, aiming provide inspiration design better‐quality promote lay foundation future conversion clinical applications.

Language: Английский

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Conferring Ti‐Based MOFs with Defects for Enhanced Sonodynamic Cancer Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(18)

Published: April 1, 2021

Abstract The development of highly efficient, multifunctional, and biocompatible sonosensitizer is still a priority for current sonodynamic therapy (SDT). Herein, defect‐rich Ti‐based metal–organic framework (MOF) (D‐MOF(Ti)) with greatly improved sonosensitizing effect simply constructed used enhanced SDT. Compared the commonly TiO 2 , D‐MOF(Ti) results in superior reactive oxygen species (ROS) yield under ultrasound (US) irradiation due to its narrow bandgap, which principally improves US‐triggered electron–hole separation. Meanwhile, existence Ti 3+ ions, also exhibits high level Fenton‐like activity enable chemodynamic therapy. Particularly, US as excitation source SDT can simultaneously enhance reaction achieve remarkably synergistic outcomes oncotherapy. More importantly, be degraded metabolized out body after completion therapeutic functions without off‐target toxicity. Overall, this work identifies novel Ti‐familial harboring great potential cancer

Language: Английский

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Recent advances in enhanced chemodynamic therapy strategies

Nano Today, Journal Year: 2021, Volume and Issue: 39, P. 101162 - 101162

Published: May 18, 2021

Language: Английский

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Guiding Transition Metal‐Doped Hollow Cerium Tandem Nanozymes with Elaborately Regulated Multi‐Enzymatic Activities for Intensive Chemodynamic Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(7)

Published: Dec. 5, 2021

Clinical applications of nanozyme-initiated chemodynamic therapy (NCDT) have been severely limited by the poor catalytic efficiency nanozymes, insufficient endogenous hydrogen peroxide (H2 O2 ) content, and its off-target consumption. Herein, authors developed a hollow mesoporous Mn/Zr-co-doped CeO2 tandem nanozyme (PHMZCO-AT) with regulated multi-enzymatic activities, that is, enhancement superoxide dismutase (SOD)-like peroxidase (POD)-like activities inhibition catalase (CAT)-like activity. PHMZCO-AT as H2 homeostasis disruptor promotes evolution restrains elimination to achieve intensive NCDT. SOD-like activity catalyzes anion (O2•- into in tumor region. The suppression CAT depletion glutathione largely weaken decomposition O. Elevated is then catalyzed downstream POD-like generate toxic hydroxyl radicals, further inducing apoptosis death. T1 -weighted magnetic resonance imaging X-ray computed tomography are also achieved using due existence paramagnetic Mn2+ high attenuation ability elemental Zr, permitting vivo tracking therapeutic process. This work presents typical paradigm NCDT efficacy regulating nanozymes perturb homeostasis.

Language: Английский

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