Microneedle Patch Integrated with Porous Silicon Confined Dual Nanozymes for Synergistic and Hyperthermia‐Enhanced Nanocatalytic Ferroptosis Treatment of Melanoma DOI Open Access

Jingwen Zhao,

Wei Duan, Xingyue Liu

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(47)

Published: Sept. 3, 2023

Abstract Superficial melanoma is the deadliest form of skin cancer without desirable clinically therapeutic options. Nanozymes, artificial nanomaterials with physicochemical performance and enzyme catalytic properties, have attracted considerable attention for antitumor therapy. However, efficiency nanozymes vulnerable to tumor microenvironment (TME) delivery process. Herein, a microneedle (MN) patch that integrates porous silicon (PSi) loaded dual devised bidirectionally regulate TME accurately deliver nanocomplex initiate ferroptosis treatment. Benefitting from channel confinement effect PSi, copper‐doped graphene quantum dots palladium nanoparticles coloaded PSi (CuGQD/PdNPs@PSi) exhibit synergistic enhanced mimicking peroxidase glutathione oxidase activities, which are ≈2–3‐fold higher than those monoconfined nanozyme or nonconfined complexes. Additionally, CuGQD/PdNPs@PSi can be improved via photostimuli hyperthermia. The induce manifested by upregulation lipid peroxides inactivation 4. Furthermore, loading nanocomplexes into MNs administration resulted in satisfactory growth inhibition 98.8% within 14 days. Therefore, encapsulated provide potentially nanocatalytic strategy ferroptosis‐inducing treatment while also meeting medical needs eradicating superficial tumors.

Language: Английский

Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application DOI
Jingyi Sheng,

Yuehuang Wu,

He Ding

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 25, 2023

Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years hold huge potential to be applied diverse fields, especially for biosensing therapeutics. Compared single nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, environmentally responsive selectivity. Nevertheless, along these merits, the catalytic mechanism rational design of complicated elusive as compared single-enzymic nanozymes. In this review, classification scheme based on numbers/types activities, internal external factors regulating multienzymatic chemical, biomimetic, computer-aided strategies, progress applications attributed advantages multicatalytic activities systematically discussed. Finally, current challenges future perspectives regarding development application suggested. This review aims deepen understanding inspire research a greater extent.

Language: Английский

Citations

202
Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy DOI Creative Commons
Xiaodong Zhang, Xiaokai Chen,

Yanli Zhao

et al.

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: April 6, 2022

Abstract Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, low yield, making them difficult to be broadly applicable. As an emerging type artificial enzyme, nanozymes that combine the characteristics nanomaterials are promising alternatives. On one hand, have enzyme-like catalytic activities regulate biochemical reactions. other also inherit properties nanomaterials, which can ameliorate shortcomings natural serve as versatile platforms for diverse applications. In this review, various mimic activity different introduced. The achievements in cancer diagnosis treatment technologies summarized by highlighting advantages these Finally, future research directions rapidly developing field outlooked."Image missing"

Language: Английский

Citations

181
“Electron Transport Chain Interference” Strategy of Amplified Mild-Photothermal Therapy and Defect-Engineered Multi-Enzymatic Activities for Synergistic Tumor-Personalized Suppression DOI
Shuming Dong, Yushan Dong, Zhiyu Zhao

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(17), P. 9488 - 9507

Published: March 31, 2023

Arming activatable mild-photothermal therapy (PTT) with the property of relieving tumor thermotolerance holds great promise for overcoming traditional mild PTT limitations such as thermoresistance, insufficient therapeutic effect, and off-target heating. Herein, a mitochondria-targeting, defect-engineered AFCT nanozyme enhanced multi-enzymatic activity was elaborately designed microenvironment (TME)-activatable phototheranostic agent to achieve remarkable anti-tumor via "electron transport chain (ETC) interference synergistic adjuvant therapy". Density functional theory calculations revealed that effect among multi-enzyme active centers endows nanozymes excellent catalytic activity. In TME, open sources H2O2 can be achieved by superoxide dismutase-mimicking nanozymes. response dual stimuli acidity, peroxidase-mimicking not only catalyzes accumulation generate ·OH but also converts loaded 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) into its oxidized form strong near-infrared absorption, specifically unlocking photothermal photoacoustic imaging properties. Intriguingly, undesired thermoresistance cells greatly alleviated owing reduced expression heat shock proteins enabled NADH POD-mimicking AFCT-mediated depletion consequent restriction ATP supply. Meanwhile, accumulated facilitate both apoptosis ferroptosis in cells, resulting outcomes combination TME-activated PTT.

Language: Английский

Citations

170
Insights on catalytic mechanism of CeO2 as multiple nanozymes DOI Open Access
Yuanyuan Ma, Zhimin Tian, Wenfang Zhai

et al.

Nano Research, Journal Year: 2022, Volume and Issue: 15(12), P. 10328 - 10342

Published: July 11, 2022

Language: Английский

Citations

128
Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy DOI

Zhaoyou Chu,

Juan Yang, Zheng Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 481, P. 215049 - 215049

Published: Feb. 9, 2023

Language: Английский

Citations

125
Antioxidant Therapy in Cancer: Rationale and Progress DOI Creative Commons

Maochao Luo,

Li Zhou, Zhao Huang

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(6), P. 1128 - 1128

Published: June 8, 2022

Cancer is characterized by increased oxidative stress, an imbalance between reactive oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of metabolic disturbances signaling aberrations, can promote carcinogenesis malignant progression inducing gene mutations activating pro-oncogenic signaling, providing possible rationale for targeting stress in cancer treatment. While numerous antioxidants have demonstrated therapeutic potential, their clinical efficacy remains unproven. Here, we review the for, recent advances in, pre-clinical research on antioxidant therapy cancer, including with nonenzymatic antioxidants, such NRF2 activators, vitamins, N-acetylcysteine GSH esters, or enzymatic NOX inhibitors SOD mimics. In addition, will offer insights into prospective options improving effectiveness therapy, which may expand its applications

Language: Английский

Citations

112
Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions DOI
Miaomiao Yan,

Sha Wu,

Yuhao Wang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(21)

Published: July 21, 2023

Abstract Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability eliminate cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, challenges in tracking treatment efficacy. These limitations greatly hinder widespread clinical application. In contrast, supramolecular chemotherapy, which relies on host–guest interactions, presents a promising alternative by offering highly efficient minimally toxic anticancer delivery. this review, overview recent advancements based interactions provided. The significant role it plays guiding therapy emphasized. Drawing wealth cutting‐edge research, herein, timely valuable resource individuals interested the field or therapy, presented. Furthermore, review contributes progression toward

Language: Английский

Citations

95
Multi-enzyme activity nanozymes for biosensing and disease treatment DOI
Su Li,

Sainan Qin,

Zhongjian Xie

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 473, P. 214784 - 214784

Published: Sept. 13, 2022

Language: Английский

Citations

94
Recent advances in multi-configurable nanomaterials for improved chemodynamic therapy DOI

Junya Lu,

Yuanqi Yang,

Qingqing Xu

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 474, P. 214861 - 214861

Published: Oct. 1, 2022

Language: Английский

Citations

85
Doping Engineering to Modulate Lattice and Electronic Structure for Enhanced Piezocatalytic Therapy and Ferroptosis DOI Open Access
Boshi Tian, Ruixue Tian, Shaohua Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: July 12, 2023

Piezocatalytic therapy, which generates reactive oxygen species (ROS) under mechanical force, has garnered extensive attention for its use in cancer therapy owing to deep tissue penetration depth and less O2 -dependence. However, the piezocatalytic therapeutic efficiency is limited poor piezoresponse, low separation of electron-hole pairs, complicated tumor microenvironment (TME). Herein, a biodegradable, porous Mn-doped ZnO (Mn-ZnO) nanocluster with enhanced piezoelectric effect constructed via doping engineering. Mn-doping not only induces lattice distortion increase polarization but also creates rich vacancies (OV ) suppressing recombination leading high-efficiency generation ROS ultrasound irradiation. Moreover, shows TME-responsive multienzyme-mimicking activity glutathione (GSH) depletion ability mixed valence Mn (II/III), further aggravating oxidative stress. Density functional theory calculations show that can improve performance enzyme Mn-ZnO due presence OV . Benefiting from boosting GSH ability, significantly accelerate accumulation lipid peroxide inactivate peroxidase 4 (GPX4) induce ferroptosis. The work may provide new guidance exploring novel sonosensitizers therapy.

Language: Английский

Citations

83