Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(27)

Published: March 28, 2022

Abstract Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed prepared based on benzo[ c ]thiophene unit as building block; it can be used for simultaneous fluorescence imaging (FLI) in second near‐infrared (NIR‐II) window, photoacoustic (PAI), (PTI), thermal eradication of Further experiments validate that therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys primary tumor but also enhances immunogenicity further suppressing growth at distant sites. Furthermore, PTT combining programmed death‐ligand 1 (PD‐L1) antibody prevents metastasis recurrence cancer potentiating effect immunotherapy.

Language: Английский

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Donor/π‐Bridge Manipulation for Constructing a Stable NIR‐II Aggregation‐Induced Emission Luminogen with Balanced Phototheranostic Performance**

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(51), P. 26769 - 26776

Published: Oct. 9, 2021

Abstract Owing to their versatile functionality and tunable energy dissipation, aggregation‐induced emission luminogens (AIEgens) have emerged as a potential platform for multimodal theranostics. Nevertheless, the construction of AIE‐active phototheranostic agents in second near‐infrared window (NIR‐II, 1000–1700 nm), which allows superior resolution minimized photodamage, is still formidable challenge. Herein, benzo[ c ]thiophene serves an electron‐rich bulky donor (D)/π‐bridge, can enlarge conjugation length distort backbone AIEgen. By precise D/π‐bridge engineering, highly stable NIR‐II AIEgen DPBTA‐DPTQ nanoparticles are obtained with acceptable fluorescence quantum yield excellent photothermal conversion efficiency. In addition, spatial conformation determined first time by X‐ray single crystal diffraction theoretical simulations. NPs good biocompatibility show efficient therapeutic effects vitro tests. Furthermore, were used fluorescence‐photoacoustic‐photothermal trimodal imaging‐guided eradication tumors HepG2 B16‐F10 tumor‐xenografted mice.

Language: Английский

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Triphenylamine‐Functionalized Multiple‐Resonance TADF Emitters with Accelerated Reverse Intersystem Crossing and Aggregation‐Induced Emission Enhancement for Narrowband OLEDs

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(12)

Published: Jan. 8, 2023

Abstract Multiple‐resonance (MR) thermal activated delayed fluorescence (TADF) emitters have attracted increasing attention in organic electroluminescence devices, owing to their superior quantum efficiency and narrowband emission for high color purity. However, MR‐TADF materials often suffer from severe aggregation‐caused quenching (ACQ) roll‐off problems due rigid planar structures the lack of sufficient charge‐transfer (CT) characters with inefficient reverse intersystem crossing (RISC). Herein, by attaching electron‐rich triphenylamine (TPA) twisted spatial conformation MR framework, two efficient emitters, namely BNCz‐pTPA BNCz‐mTPA , are developed. The TPA substituent endows new aggregation‐induced enhancement (AIEE) ACQ suppression. unprecedented AIEE‐MR‐TADF exhibit CT character high‐lying triplet excited states faster RISC, while locally‐excited (LE) first singlet state is retained efficiency. An light‐emitting diode (OLED) based on exhibits a maximum external 27.3% slow roll‐off, demonstrating much higher performances than those BNCz ‐based OLED. This study may provide simple but effective approach constructing high‐performance wide‐color‐gamut OLED displays.

Language: Английский

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Aggregation caused quenching to aggregation induced emission transformation: a precise tuning based on BN-doped polycyclic aromatic hydrocarbons toward subcellular organelle specific imaging

Chemical Science, Journal Year: 2022, Volume and Issue: 13(11), P. 3129 - 3139

Published: Jan. 1, 2022

Polycyclic aromatic hydrocarbons (PAHs) with boron-nitrogen (BN) moieties have attracted tremendous interest due to their intriguing electronic and optoelectronic properties. However, most of the BN-fused π-systems reported date are difficult modify exhibit traditional aggregation-caused quenching (ACQ) characteristics. This phenomenon greatly limits scope application. Thus, continuing efforts seek novel, structurally distinct functionally diverse structures highly desirable. Herein, we proposed a one-stone-two-birds strategy including simultaneous exploration reactivity tuning optical properties for BN-containing π-skeletons through flexible regioselective functionalization engineering. In this way, three novel functionalized BN luminogens (DPA-BN-BFT, MeO-DPA-BN-BFT DMA-DPA-BN-BFT) similar were obtained. Intriguingly, DPA-BN-BFT, DMA-DPA-BN-BFT completely different emission behaviors. Fluorogens DPA-BN-BFT typical ACQ effect; in sharp contrast, possesses prominent aggregation induced (AIE) effect. To best our knowledge, is first report integrate AIE into one backbone subtle modified structures. Comprehensive analysis crystal structure theoretical calculations reveal that relatively large twisting angles, multiple intermolecular interactions tight packing modes endow strong behavior. More importantly, cell imaging demonstrated luminescent materials can selectively sensitively detect lipid droplets (LDs) living MCF-7 cells. Overall, work provides new viewpoint rational design synthesis advanced BN-polycyclic aromatics features triggers discovery functions azaborine chemistry.

Language: Английский

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Multifunctional AIE Nanosphere-Based “Nanobomb” for Trimodal Imaging-Guided Photothermal/Photodynamic/Pharmacological Therapy of Drug-Resistant Bacterial Infections

ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 4601 - 4618

Published: Feb. 24, 2023

Injudicious or inappropriate use of antibiotics has led to the prevalence drug-resistant bacteria, posing a huge menace global health. Here, self-assembled aggregation-induced emission (AIE) nanosphere (AIE-PEG1000 NPs) that simultaneously possesses near-infrared region II (NIR-II) fluorescence emissive, photothermal, and photodynamic properties is prepared using multifunctional AIE luminogen (AIE-4COOH). The AIE-PEG1000 NPs were encapsulated with teicoplanin (Tei) ammonium bicarbonate (AB) into lipid nanovesicles form laser-activated "nanobomb" (AIE-Tei@AB NVs) for multimodal theranostics bacterial infections. In vivo experiments validate enables high-performance NIR-II fluorescence, infrared thermal, ultrasound (AB decomposition during photothermal process produce numerous CO2/NH3 bubbles, which an efficient contrast agent) imaging multidrug-resistant bacteria-infected foci after intravenous administration AIE-Tei@AB NVs followed by 660 nm laser stimulation. highly features NVs, combined excellent pharmacological property rapidly released Tei bubble generation NV disintegration, collectively promote broad-spectrum eradication three clinically isolated bacteria strains rapid healing infected wounds. This imaging-guided synergistic therapeutic strategy can be extended superbugs.

Language: Английский

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On-Site Electrospinning Nanofiber Membranes Incorporating V-Shaped Organic Semiconductors for Multifunctional Diabetic Wound Dressing

Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(5), P. 1413 - 1427

Published: May 7, 2024

Language: Английский

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Amphiphilic AIEgen‐polymer aggregates: Design, self‐assembly and biomedical applications

Aggregate, Journal Year: 2021, Volume and Issue: 3(1)

Published: Oct. 21, 2021

Abstract Aggregation‐induced emission (AIE) is a phenomenon in which fluorescence enhanced rather than quenched upon molecular assembly. AIE fluorogens (AIEgens) are flexible, conjugated systems that limited their dynamics when assembled, improves fluorescent properties. This intriguing feature has been incorporated many different assemblies and extended to nanoparticles composed of amphiphilic polymer building blocks. The integration the fascinating design principle with versatile chemistry opens up new frontiers approach solve intrinsic obstacles conventional materials nanoscience, including aggregation‐caused quenching effect. Furthermore, this drawn significant attention from nanomedicine community, due additional advantages comprising AIEgenic molecules, such as brightness stability. In regard, range polymers have developed, displaying self‐assembly/aggregated state. regarded attractive nanomaterials inherent fluorescence, display promising features biomedical context, for instance biosensing, cell/tissue imaging tracking, well (photo) therapeutics. review, we describe recent strategies synthesis novel types via facile approaches direct conjugation natural/synthetic polymers, polymerization, post‐polymerization supramolecular host−guest interactions. Their self‐assembly behavior potential will be discussed.

Language: Английский

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Aggregation-induced emission luminogens for assisted cancer surgery

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 464, P. 214552 - 214552

Published: April 18, 2022

Language: Английский

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Ion−π interactions for constructing organic luminescent materials

Aggregate, Journal Year: 2022, Volume and Issue: 3(6)

Published: Oct. 24, 2022

Abstract Organic luminescent materials are one of the research hotspots worldwide. The efficiency these can be tuned by introducing noncovalent interactions. Ion−π interactions, mainly including anion−π interactions and cation−π relatively new but powerful with extensive applications in supramolecular chemistry. use ion−π to fabricate highly is initiated since they were introduced develop aggregation‐induced emission luminogens 2017. Then, this field undergoing through challenging very prospective developments. In minireview, we start a brief introduction then make summary reports on organic fluorescence based room temperature phosphorescence induced bioimaging, imaging‐guided anticancer antibacterial treatment also discussed. challenges prospects using for constructing presented final part. It expected that minireview will provide some guidelines fabricating novel further extend application potential

Language: Английский

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A Versatile 980 nm Absorbing Aggregation‐Induced Emission Luminogen for NIR‐II Imaging‐Guided Synergistic Photo‐Immunotherapy Against Advanced Pancreatic Cancer

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(36)

Published: June 24, 2022

Abstract To address urgent tasks in the treatment of advanced deep‐seated tumors, a 980 nm absorbing agent with aggregation‐induced emission tendency, namely TPE‐BT‐BBTD, which simultaneously possesses longest absorption wavelength among all reported AIE molecules is developed. The functionality deep near‐infrared‐II fluorescence imaging (NIR‐II FLI) and outstanding photothermal performance well‐tailored for pancreatic cancer treatment. With covalent attachment programmed death‐ligand 1 (αPD‐L1) antibody, αPD‐L1@TPE‐BT‐BBTD nanoparticles show precise tumor targeting excellent immunosuppression reversal ability. Following local therapy, immunogenic vaccination induced to trigger infiltration cytotoxic T lymphocytes (CTLs) tumors. decreased FoxP3 + Treg cells M2‐like macrophages that are reversed by αPD‐L1, CTLs activity further enhanced more production granzyme B (GrB), much accurately leads apoptosis effectively suppressed spontaneous metastases. Overall, based NIR‐II FLI‐mediated photo‐immunotherapy able significantly improve control primary metastasis

Language: Английский

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