International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 403 - 444
Published: Jan. 1, 2025
Abstract:
Nanotechnology
has
emerged
as
a
revolutionary
domain
with
diverse
applications
in
medicine,
and
one
of
the
noteworthy
developments
is
exploration
bacterial
magnetosomes
acquired
from
magnetotactic
bacteria
(MTB)
for
therapeutic
purposes.
The
demand
natural
nanomaterials
biomedical
field
continuously
increasing
due
to
their
biocompatibility
eco-friendly
nature.
MTB
produces
uniform,
well-ordered
magnetic
nanoparticles
inside
magnetosomes,
drawing
attention
unique
remarkable
features.
have
gained
popularity
cancer
treatment
diagnosis,
especially
resonance
imaging.
Distinctive
features
highlighted
include
advancements
extraction,
characterization,
functionalization
techniques,
alongside
breakthroughs
utilizing
MTB-based
contrast
agents
imaging,
biocompatible
drug
carriers,
tools
minimally
invasive
therapies.
nature,
functionalizing
surface
response
external
make
them
potential
candidate
theragnostic
purpose
magnetosomes.
In
present
review,
emphasis
been
given
foundation
at
genetic
level,
mass
production
etc.
Further
authors
reviewed
various
methods
treatment.
Finally,
recent
magnetosome-based
detection,
Challenges
such
scalability,
long-term
safety,
clinical
translation
are
also
discussed,
presenting
roadmap
future
research
exploiting
MTBs
magnetosomes'
properties.
Keywords:
bacteria,
hyperthermia,
gene
therapy,
nanomedicine
Biosensors,
Journal Year:
2022,
Volume and Issue:
12(7), P. 550 - 550
Published: July 21, 2022
Aggregation-induced
emission
(AIE)
is
a
unique
research
topic
and
property
that
can
lead
to
wide
range
of
applications,
including
cellular
imaging,
theranostics,
analyte
quantitation
the
specific
detection
biologically
important
species.
Towards
development
AIE-active
materials,
many
aromatic
moieties
composed
tetraphenylethylene,
anthracene,
pyrene,
etc.,
have
been
developed.
Among
these
moieties,
pyrene
an
hydrocarbon
with
polycyclic
flat
structure
containing
four
fused
benzene
rings
provide
unusual
electron
delocalization
feature
in
AIE
property.
Numerous
pyrene-based
materials
reported
towards
sensing,
imaging
theranostics
applications.
Most
importantly,
exist
as
small
molecules,
Schiff
bases,
polymers,
supramolecules,
metal-organic
frameworks,
etc.
This
comprehensive
review
outlines
utilizations
on
studies.
Moreover,
design
synthesis
molecules
are
delivered
discussions
their
future
scopes.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(49), P. 27095 - 27102
Published: Nov. 28, 2023
Stable
luminescent
radicals
are
open-shell
emitters
with
unique
doublet
emission
characteristics.
This
feature
makes
stable
exhibit
widespread
application
prospects
in
constructing
optical,
electrical,
and
magnetic
materials.
In
this
work,
a
radical-based
X-ray
scintillator
of
AuPP-1.0
was
prepared,
which
exhibited
high
excited
luminescence
(XEL)
efficiency
as
well
excellent
stability.
A
mechanism
study
showed
that
the
heavy
atom
Au
endowed
it
effective
absorption
X-rays,
characteristics
significantly
increased
its
exciton
utilization
rate
radioluminescence
process.
Moreover,
has
good
processability
to
fabricate
flexible
screen
for
high-quality
imaging,
whose
resolution
can
reach
20
LP
mm-1.
work
demonstrates
is
beneficial
improving
radioluminescence,
providing
brand-new
strategy
construction
high-performance
scintillators.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: April 2, 2024
Atherosclerotic
plaque
formation
is
considered
the
primary
pathological
mechanism
underlying
atherosclerotic
cardiovascular
diseases,
leading
to
severe
events
such
as
stroke,
acute
coronary
syndromes,
and
even
sudden
cardiac
death.
Early
detection
timely
intervention
of
plaques
are
challenging
due
lack
typical
symptoms
in
initial
stages.
Therefore,
precise
early
play
a
crucial
role
risk
stratification
achieving
favorable
post-interventional
outcomes.
The
continuously
advancing
nanoplatforms
have
demonstrated
numerous
advantages
including
high
signal-to-noise
ratio,
enhanced
bioavailability,
specific
targeting
capabilities
for
imaging
agents
therapeutic
drugs,
enabling
effective
visualization
management
plaques.
Motivated
by
these
superior
properties,
various
noninvasive
modalities
recognition
preliminary
stage
atherosclerosis
comprehensively
summarized.
Additionally,
several
strategies
proposed
enhance
efficacy
treating
Finally,
existing
challenges
promising
prospects
accelerating
clinical
translation
nanoplatform-based
molecular
therapy
discussed.
In
conclusion,
this
review
provides
an
insightful
perspective
on
diagnosis
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(8)
Published: Feb. 21, 2024
Abstract
This
research
work
is
based
on
synthesis
of
eleven
novel
thiazole
derivatives
(3
a‐k)
thiophene
carbaldehyde.
All
the
synthesized
compounds
were
successfully
synthesized,
characterized
by
1
H‐NMR
and
EI‐MS
spectroscopic
techniques
finally
subjected
for
their
in
vitro
α‐glucosidase
inhibitory
activity.
Seven
3
i
(IC
50
=10.21±1.84
μM)
,
b
=11.14±0.99
f
=13.21±2.76
h
=14.21±0.31
k
=15.21±1.02
e
=16.21±1.32
μM),
c
=18.21±1.89
series
displayed
excellent
potential
better
than
standard
acarbose.
However,
two
g
=33.21±1.99
d
=42.31±2.12
showed
significant
activity
while
j
a
found
less
active
with
IC
values
82.31±0.31
88.36±1.21
μM
respectively.
Additional
revealed
that
are
not
exhibiting
any
cytotoxic
effects.
The
molecular
docking
study
these
good
binding
site
interactions
scores.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(31)
Published: May 25, 2022
Abstract
Reported
here
is
the
first
catalytic
atroposelective
electrophilic
amination
of
indoles,
which
delivers
functionalized
atropochiral
N
‐sulfonyl‐3‐arylaminoindoles
with
excellent
optical
purity.
This
reaction
was
furnished
by
1,6‐nucleophilic
addition
to
p
‐quinone
diimines.
Control
experiments
suggest
an
ionic
mechanism
that
differs
from
radical
pathway
commonly
proposed
for
1,6‐addition
quinones.
The
origin
selectivity
investigated
through
computational
studies.
Preliminary
studies
show
obtained
3‐aminoindoles
atropisomers
exhibit
anticancer
activities.
method
valuable
respect
enlarging
toolbox
amine
derivatives.
