Dynamic Adjust of Non‐Radiative and Radiative Attenuation of AIE Molecules Reinforces NIR‐II Imaging Mediated Photothermal Therapy and Immunotherapy DOI Creative Commons
Zhenjie Wang, Ling Yu,

Yuehua Wang

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(8)

Published: Jan. 22, 2022

Due to the aggregation-caused quenching effect and near-infrared I poor penetration capabilities of common fluorescent molecules, their applications in visualized imaging photoactivated treatment are limited. Therefore, new II (NIR-II) molecule (named TST), which had abilities aggregation-induced emission (AIE) photothermal therapy synthesized. Moreover, order further improve its yield therapeutic effect, camptothecin prodrug (CPT-S-PEG) novel immune checkpoint inhibitor AZD4635 used co-assemble with TST into nanoparticles for drug delivery. On account strong interaction TST, intramolecular rotation is limited, thereby inhibiting non-radiation attenuation promoting fluorescence generation when intact. As uptake by cancer cells, redox sensitive CPT-S-PEG degraded disintegrate. The released enhances non-radiative expedites conversion because removal constraint camptothecin. Furthermore, induces immunogenic cell death cells releases abundant ATP tumor microenvironment recruit cells. However, superfluous converted immunosuppressive adenosine through CD39-CD73-A2AR pathway. disintegration just blocks this pathway timely, achieving favorable synergistic therapy, chemotherapy, immunotherapy.

Language: Английский

Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes DOI
Zhiqiang Mao, Jianhua Xiong, Pengzhan Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 454, P. 214356 - 214356

Published: Dec. 14, 2021

Language: Английский

Citations

126
Self-Assembled Metallacage with Second Near-Infrared Aggregation-Induced Emission for Enhanced Multimodal Theranostics DOI
Yi Qin, Xiaohong Chen,

Yixiong Gui

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(28), P. 12825 - 12833

Published: July 5, 2022

The construction of supramolecular coordination complexes (SCCs) featuring prominent cancer theranostic functions is an appealing yet significantly challenging task. In this study, we rationally designed and facilely constructed a prism-like metallacage C-DTTP with efficient fluorescence emission in the second near-infrared (NIR-II) region through assembly aggregation-induced emission-active four-arm ligand 90° Pt acceptors Pt(PEt3)2(OTf)2. held longest maximum wavelength (1005 nm) compared those previously reported SCCs up to now exhibited both high photothermal conversion efficiency (39.3%) superior reactive oxygen species generation behavior precursor ligand. vitro vivo assessments demonstrated that metallacage-loaded nanoparticles excellent biocompatibility stability were capable simultaneously affording precise tumor diagnosis complete elimination by means NIR-II fluorescence/photothermal dual imaging-guided photodynamic/photothermal synergistic therapy.

Language: Английский

Citations

125
Recent advances in activity-based probes (ABPs) and affinity-based probes (AfBPs) for profiling of enzymes DOI Creative Commons

Haixiao Fang,

Bo Peng, Sing Yee Ong

et al.

Chemical Science, Journal Year: 2021, Volume and Issue: 12(24), P. 8288 - 8310

Published: Jan. 1, 2021

This review highlights the recent advances in use of activity-based probes (ABPs) and affinity-based (AfBPs), summarizes their design strategies (based on inhibitors substrates) detection approaches.

Language: Английский

Citations

124
ROS/RNS and Base Dual Activatable Merocyanine‐Based NIR‐II Fluorescent Molecular Probe for in vivo Biosensing DOI
Xin Zhang, Ying Chen, Haisheng He

et al.

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(50), P. 26337 - 26341

Published: Oct. 4, 2021

Inflammation usually results in high-level reactive oxygen species (ROS) and nitrogen (RNS) not only acidic tissue but also alkaline tissue. However, noninvasively vivo monitoring specifically within remains a huge challenge. Here we introduce dual activatable fluorescent probe PN910 located the second near-infrared window (NIR-II, 900-1700 nm), which shows high selectivity toward H2 O2 OONO- at pH beyond 7.4. Then verified that could be used for real-time, specific accurate of cystitis colitis living animals. This report presents unique approach to development biosensing.

Language: Английский

Citations

124
Small Molecular NIR-II Fluorophores for Cancer Phototheranostics DOI Creative Commons

Hanming Dai,

Qing Shen, Jinjun Shao

et al.

The Innovation, Journal Year: 2021, Volume and Issue: 2(1), P. 100082 - 100082

Published: Jan. 19, 2021

Phototheranostics integrates deep-tissue imaging with phototherapy (containing photothermal therapy and photodynamic therapy), holding great promise in early diagnosis precision treatment of cancers. Recently, second near-infrared (NIR-II) fluorescence exhibits the merits high accuracy specificity, as well real-time detection. Among NIR-II fluorophores, organic small molecular fluorophores have shown superior properties biocompatibility, variable structure, tunable emission wavelength than inorganic materials. What's more, some also display excellent cytotoxicity when illuminated NIR laser. This review summarizes progress different central cores for cancer phototheranostics past few years, focusing on structures phototheranostic performances. Furthermore, challenges prospects future development toward clinical translation are discussed.

Language: Английский

Citations

122
A Fast-Responsive OFF–ON Near-Infrared-II Fluorescent Probe for In Vivo Detection of Hypochlorous Acid in Rheumatoid Arthritis DOI
Peng Wu, Yu Zhu, Lulu Chen

et al.

Analytical Chemistry, Journal Year: 2021, Volume and Issue: 93(38), P. 13014 - 13021

Published: Sept. 15, 2021

Rheumatoid arthritis (RA) is a common chronic autoimmune inflammatory disease, and its etiology closely related to the overproduction of hypochlorous acid (HClO). However, early detection RA using an activatable near-infrared-II (NIR-II, 1000-1700 nm) fluorescent probe remains challenging. Herein, we first report "OFF-ON" NIR-II named PTA (phenothiazine triphenylamine) for imaging HClO in deep-seated RA. Electron-rich phenothiazine core was utilized as both HClO-recognition moiety precursor electron acceptors, displaying typical donor-acceptor-donor structure with excellent emission at 936/1237 nm once reacted HClO. The exhibited good water solubility, high photostability, rapid response capability toward within 30 s. Moreover, it able sensitively specifically detect exogenous endogenous living cells visible windows. Notably, enabled sensitive visualization generation mouse model, showing 4.3-fold higher fluorescence intensity than that normal hindlimb joints. These results demonstrate holds great promise robust platform diagnosis HOCl-mediated disorders.

Language: Английский

Citations

112
Supramolecular assembly confined purely organic room temperature phosphorescence and its biological imaging DOI Creative Commons

Wei‐Lei Zhou,

Wenjing Lin, Yong Chen

et al.

Chemical Science, Journal Year: 2022, Volume and Issue: 13(27), P. 7976 - 7989

Published: Jan. 1, 2022

Purely organic room temperature phosphorescence, especially in aqueous solution, is attracting increasing attention owing to its large Stokes shift, long lifetime, low preparation cost, toxicity, good processing performance advantages, and broad application value. This review mainly focuses on macrocyclic (cyclodextrin cucurbituril) hosts, nanoassembly, macromolecule (polyether) confinement-driven RTP. As an optical probe, the assembly two-stage strategy can realize confined purely RTP achieve energy transfer light-harvesting from fluorescence delayed or phosphorescence. supramolecular widely applied for luminescent materials, cell imaging, other fields because it effectively avoids oxygen quenching. In addition, near-infrared excitation, emission,

Language: Английский

Citations

109
Polyatomic molecules with emission quantum yields >20% enable efficient organic light-emitting diodes in the NIR(II) window DOI
Shengfu Wang,

Bo‐Kang Su,

Xueqi Wang

et al.

Nature Photonics, Journal Year: 2022, Volume and Issue: 16(12), P. 843 - 850

Published: Oct. 10, 2022

Language: Английский

Citations

106
Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging DOI
Jin Li, Yan Dong,

Ruwei Wei

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(31), P. 14351 - 14362

Published: July 29, 2022

Near-infrared (NIR) fluorophores absorbing maximally in the region beyond 800 nm, i.e., deep-NIR spectral region, are actively sought for biomedical applications. Ideal dyes bright, nontoxic, photostable, biocompatible, and easily derivatized to introduce functionalities (e.g., bioconjugation or aqueous solubility). The rational design of such remains a major challenge. Silicon-substituted rhodamines have been successful bioimaging applications red region. longer-wavelength silicon-substituted congeners unknown date. We successfully prepared four bis-benzannulated rhodamine (ESi5a–ESi5d), with an efficient five-step cascade on gram-scale. Because extensive overlapping their HOMO–LUMO orbitals, ESi5a–ESi5d highly (λabs ≈ 865 nm ε > 105 cm–1 M–1). By restraining both rotational freedom via annulation vibrational silicon-imparted strain, fluorochromic scaffold ESi5 is rigid, resulting unusually long fluorescence lifetime (τ 700 ps CH2Cl2) high quantum yield (ϕ = 0.14 CH2Cl2). Their half-lives toward photobleaching 2 orders magnitude longer than current standard (ICG serum). They stable presence biorelevant concentration nucleophiles reactive oxygen species. minimally toxic readily metabolized. Upon tail vein injection ESi5a (as example), vasculature nude mouse was imaged signal-to-background ratio. broad potentials

Language: Английский

Citations

98
NIRII‐HDs: A Versatile Platform for Developing Activatable NIR‐II Fluorogenic Probes for Reliable In Vivo Analyte Sensing DOI

Zuojia Qin,

Tian‐Bing Ren, Huijie Zhou

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(19)

Published: Feb. 26, 2022

Small-molecule-based second near-infrared (NIR-II) activatable fluorescent probes can potentially provide a high target-to-background ratio and deep tissue penetration. However, most of the reported NIR-II small-molecule exhibit poor versatility owing to lack general stable optically tunable group. In this study, we designed NIRII-HDs, novel dye scaffold optimized for probe development. particular, NIRII-HD5 showed best optical properties such as proper pKa value, excellent stability, brightness, which be beneficial in vivo imaging with contrast. To demonstrate applicability dye, three target-activatable ROS, thiols, enzymes. Using these probes, not only realized reliable different diseases mouse models but also evaluated redox potential liver during injury fidelity.

Language: Английский

Citations

94