Kagome-topology 2D covalent organic frameworks assembled from D2h-symmetric and non-centrosymmetric C2-symmetric blocks for photothermal imaging DOI
Jiahao Li, Guinan Chen, Chunhong Chen

et al.

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(88), P. 13191 - 13194

Published: Jan. 1, 2023

2D COFs with kagome-topology are synthesized using 4-connected D 2h -symmetric and 2-connected non-centrosymmetric C 2 building blocks, showcasing remarkable photothermal imaging performance.

Language: Английский

An H2S‐BMP6 Dual‐Loading System with Regulating Yap/Taz and Jun Pathway for Synergistic Critical Limb Ischemia Salvaging Therapy DOI

Jiateng Hu,

Zhijue Xu,

Donghui Liao

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(28)

Published: Aug. 2, 2023

Critical limb ischemia, the final course of peripheral artery disease, is characterized by an insufficient supply blood flow and excessive oxidative stress. H2 S molecular therapy possesses huge potential for accelerating revascularization scavenging intracellular reactive oxygen species (ROS). Moreover, it found that BMP6 most significantly up-expressed secreted protein-related gene in HUVECs treated with GYY4137, a donor, based on transcriptome analysis. Herein, UIO-66-NH2 @GYY4137@BMP6 co-delivery nanoplatform to strengthen therapeutic effects ischemia developed. The established exerts its proangiogenic anti-oxidation functions regulating key pathways. underlying mechanisms dual-loading system lie upregulation phosphorylated YAP/TAZ Jun promote proliferation downregulation p53/p21 scavenge ROS. Meanwhile, laser-doppler perfusion imaging (LDPI), injury severity evaluation, histological analysis confirm excellent vivo. This work may shed light treatment critical YAP, Jun, p53 signaling pathways gas-protein synergistic therapy.

Language: Английский

Citations

57
pH-sensitive ameliorated quercetin delivery using graphene oxide nanocarriers coated with potential anticancer gelatin-polyvinylpyrrolidone nanoemulsion with bitter almond oil DOI Creative Commons

Amin Pirali Najafabadi,

Mehrab Pourmadadi, Fatemeh Yazdian

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 82, P. 104339 - 104339

Published: March 10, 2023

The rapid rise of cancer worldwide demonstrates the importance treatment strategies. In addition to reduce side effects conventional treatments, targeted drug delivery systems increase performance and effectiveness. this research, nanocarriers comprising gelatin (G)-polyvinylpyrrolidone (PVP) coated graphene oxide (GO) were prepared for first time. nanocarries loaded with quercetin (QC) a dual nanoemulsion water/oil/water bitter almond oil was developed as membrane around nanocomposite control further release. XRD, FTIR, FESEM, DLS analysis confirmed success synthesis loading. resulting pH-sensitive system showed an 87.5% encapsulation efficiency 45% loading, which are among highest values reported up date. zeta potential nanocomposites about −40 mV, indicating good stability. release kinetics followed Higuchi model, presence resulted in better entrapping efficiency, controlled long-term MTT assay flow cytometry methods revealed rate cell death 53.14%, 36.51% apoptotic phase. Taking into account results obtained herein, PVP-G-GO-QC can be considered new promising treatment.

Language: Английский

Citations

44
Advances in covalent organic frameworks for cancer phototherapy DOI
Nem Singh, Miae Won, Jusung An

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215720 - 215720

Published: Feb. 16, 2024

Language: Английский

Citations

20
A review of covalent organic frameworks for metal ion fluorescence sensing DOI
Deshuai Zhen, Chunlin Liu,

Qiuhui Deng

et al.

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(8), P. 109249 - 109249

Published: Oct. 29, 2023

Language: Английский

Citations

38
Drug delivery using biocompatible covalent organic frameworks (COFs) towards a therapeutic approach DOI
Pritam Ghosh, Priyabrata Banerjee

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(84), P. 12527 - 12547

Published: Jan. 1, 2023

COFs are used for multiple drug encapsulation/decapsulation in the biological medium and would be potential contenders clinical applications.

Language: Английский

Citations

30
Self-stablized monodispersing nano-MOFs for controlled enzyme delivery DOI
Peiwei Gong,

Huiying Cui,

Cheng Li

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 489, P. 150941 - 150941

Published: April 16, 2024

Language: Английский

Citations

17
Understanding the Mechanisms and Applications of Luminescent Covalent Organic Frameworks (COFs) for Multi-Analyte Sensing DOI
R. Arvind Singh, Brij Mohan, Neera Raghav

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1321, P. 139945 - 139945

Published: Sept. 7, 2024

Language: Английский

Citations

14
Phospholipid-inspired alkoxylation induces crystallization and cellular uptake of luminescent COF nanocarriers DOI
Wei Zhang, Shuo Xiang, Yuxin Han

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 306, P. 122503 - 122503

Published: Feb. 7, 2024

Language: Английский

Citations

9
Extraction and quantitation of fentanyl in exhaled breath condensate using a magnetic dispersive solid phase based on graphene oxide and covalent organic framework composite and LC-MS/MS analysis DOI

Sedigeh Mohamadzadeh,

Ali Fathi, Abolghasem Jouyban

et al.

Journal of Chromatography B, Journal Year: 2025, Volume and Issue: 1252, P. 124447 - 124447

Published: Jan. 5, 2025

Language: Английский

Citations

1
Enzyme coordination conferring stable monodispersity of diverse metal–organic frameworks for photothermal/starvation therapy DOI
Peiwei Gong, Cheng Li, Dandan Wang

et al.

Journal of Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 642, P. 612 - 622

Published: March 31, 2023

Language: Английский

Citations

20