Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(88), P. 13191 - 13194
Published: Jan. 1, 2023
2D
COFs
with
kagome-topology
are
synthesized
using
4-connected
D
2h
-symmetric
and
2-connected
non-centrosymmetric
C
2
building
blocks,
showcasing
remarkable
photothermal
imaging
performance.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(28)
Published: Aug. 2, 2023
Critical
limb
ischemia,
the
final
course
of
peripheral
artery
disease,
is
characterized
by
an
insufficient
supply
blood
flow
and
excessive
oxidative
stress.
H2
S
molecular
therapy
possesses
huge
potential
for
accelerating
revascularization
scavenging
intracellular
reactive
oxygen
species
(ROS).
Moreover,
it
found
that
BMP6
most
significantly
up-expressed
secreted
protein-related
gene
in
HUVECs
treated
with
GYY4137,
a
donor,
based
on
transcriptome
analysis.
Herein,
UIO-66-NH2
@GYY4137@BMP6
co-delivery
nanoplatform
to
strengthen
therapeutic
effects
ischemia
developed.
The
established
exerts
its
proangiogenic
anti-oxidation
functions
regulating
key
pathways.
underlying
mechanisms
dual-loading
system
lie
upregulation
phosphorylated
YAP/TAZ
Jun
promote
proliferation
downregulation
p53/p21
scavenge
ROS.
Meanwhile,
laser-doppler
perfusion
imaging
(LDPI),
injury
severity
evaluation,
histological
analysis
confirm
excellent
vivo.
This
work
may
shed
light
treatment
critical
YAP,
Jun,
p53
signaling
pathways
gas-protein
synergistic
therapy.
Journal of Drug Delivery Science and Technology,
Journal Year:
2023,
Volume and Issue:
82, P. 104339 - 104339
Published: March 10, 2023
The
rapid
rise
of
cancer
worldwide
demonstrates
the
importance
treatment
strategies.
In
addition
to
reduce
side
effects
conventional
treatments,
targeted
drug
delivery
systems
increase
performance
and
effectiveness.
this
research,
nanocarriers
comprising
gelatin
(G)-polyvinylpyrrolidone
(PVP)
coated
graphene
oxide
(GO)
were
prepared
for
first
time.
nanocarries
loaded
with
quercetin
(QC)
a
dual
nanoemulsion
water/oil/water
bitter
almond
oil
was
developed
as
membrane
around
nanocomposite
control
further
release.
XRD,
FTIR,
FESEM,
DLS
analysis
confirmed
success
synthesis
loading.
resulting
pH-sensitive
system
showed
an
87.5%
encapsulation
efficiency
45%
loading,
which
are
among
highest
values
reported
up
date.
zeta
potential
nanocomposites
about
−40
mV,
indicating
good
stability.
release
kinetics
followed
Higuchi
model,
presence
resulted
in
better
entrapping
efficiency,
controlled
long-term
MTT
assay
flow
cytometry
methods
revealed
rate
cell
death
53.14%,
36.51%
apoptotic
phase.
Taking
into
account
results
obtained
herein,
PVP-G-GO-QC
can
be
considered
new
promising
treatment.