Multi-enzyme activity nanozymes for biosensing and disease treatment

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 473, P. 214784 - 214784

Published: Sept. 13, 2022

Language: Английский

---

Biomedicine meets nanozyme catalytic chemistry

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 491, P. 215245 - 215245

Published: May 22, 2023

Language: Английский

---

Cerium oxide nanozyme attenuates periodontal bone destruction by inhibiting the ROS–NFκB pathway

Nanoscale, Journal Year: 2022, Volume and Issue: 14(7), P. 2628 - 2637

Published: Jan. 1, 2022

Periodontitis, an inflammatory disease of oxidative stress, occurs due to excess reactive oxygen species (ROS) contributing cell and tissue damage which in turn leads alveolar bone resorption as well the destruction other periodontal support tissues. With significant recent advances nanomaterials, we considered a unique type nanomaterials possessing enzyme-like characteristics (called nanozymes) for potential future clinical applications, especially light increasing number studies evaluating nanozymes setting diseases. Here, introduced therapeutic approach management periodontitis utilizing injection cerium oxide nanoparticles (CeO2 NPs) situ. In this study, our synthesized CeO2 NPs could act ROS scavengers microenvironment with ideal outcomes. vitro vivo experiments provide strong evidence on roles scavenging multiple suppressing ROS-induced inflammation reactions stimulated by lipopolysaccharides. Moreover, inhibit MAPK-NFκB signalling pathway suppress factors. addition, results from rat model demonstrate that exhibit remarkable capacity attenuate resorption, decrease osteoclast activity inflammation, consequently improve restoration destroyed Collectively, present study underscores application treatment periodontitis, provides valuable insights into

Language: Английский

---

Versatile carbon dots with superoxide dismutase-like nanozyme activity and red fluorescence for inflammatory bowel disease therapeutics

Carbon, Journal Year: 2023, Volume and Issue: 204, P. 526 - 537

Published: Jan. 6, 2023

Language: Английский

---

Fibrous Zr‐MOF Nanozyme Aerogels with Macro‐Nanoporous Structure for Enhanced Catalytic Hydrolysis of Organophosphate Toxins

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: June 13, 2023

Abstract Metal–organic frameworks (MOFs) with Lewis acid catalytic sites, such as zirconium‐based MOFs (Zr‐MOFs), comprise a growing class of phosphatase‐like nanozymes that can degrade toxic organophosphate pesticides and nerve agents. Rationally engineering shaping from as‐synthesized powders into hierarchically porous monoliths is essential for their use in emerging applications, filters air water purification personal protection gear. However, several challenges still limit the production practical MOF composites, including need sophisticated reaction conditions, low catalyst loadings resulting poor accessibility to MOF‐based active sites. To overcome these limitations, rapid synthesis method developed introduce Zr‐MOF nanozyme coating cellulose nanofibers, formation processable monolithic aerogel composites high loadings. These contain embedded structure, hierarchical macro‐micro porosity enables excellent This multifaceted rational design strategy, selection many fine‐tuning morphology, fabrication structured aerogel, renders synergistic effects toward efficient continuous hydrolytic detoxification organophosphorus‐based agent simulants contaminated water.

Language: Английский

---

Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 21, 2023

Since the discovery of enzyme-like activity Fe

Language: Английский

---

Designing nanozymes for in vivo applications

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 2(10), P. 849 - 868

Published: July 18, 2024

Language: Английский

---

A Rational Design of Metal–Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 30, 2023

Metal-organic frameworks (MOFs) have attracted significant research interest in biomimetic catalysis. However, the modulation of activity MOFs by precisely tuning coordination metal nodes is still a challenge. Inspired metalloenzymes with well-defined structures, series containing halogen-coordinated copper (Cu-X MOFs, X = Cl, Br, I) are employed to elucidate their structure-activity relationship. Intriguingly, experimental and theoretical results strongly support that halogen atoms directly regulates enzyme-like activities Cu-X influencing spatial configuration electronic structure Cu active center. The optimal Cu-Cl MOF exhibits excellent superoxide dismutase-like specific one order magnitude higher than reported Cu-based nanozymes. More importantly, performing enzyme-mimicking catalysis, nanozyme can significantly scavenge reactive oxygen species alleviate oxidative stress, thus effectively relieving ocular chemical burns. Mechanistically, antioxidant antiapoptotic properties achieved regulating NRF2 JNK or P38 MAPK pathways. Our work provides novel way refine nanozymes engineering microenvironment and, more significantly, demonstrating potential therapeutic effect ophthalmic disease.

Language: Английский

---

Biomedical Metal–Organic Framework Materials: Perspectives and Challenges

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(43)

Published: Nov. 21, 2023

Abstract Metal–organic framework (MOF) materials are gaining significant interest in biomedical research, owing to their high porosity, crystallinity, and structural compositional diversity. Their versatile hybrid organic/inorganic chemistry endows MOFs with the capacity retain organic (drug) molecules, metals, gases, effectively channel electrons photons, survive harsh physiological conditions such as low pH, even protect sensitive biomolecules. Extensive preclinical research has been carried out treat several pathologies and, recently, integration other stents implants demonstrated promising performance regenerative medicine. However, there remains a gap between MOF translation into clinically societally relevant medicinal products. Here, intrinsic features of outlined suitability specific applications detoxification, drug gas delivery, or (combination) therapy platforms is discussed. Furthermore, examples how have engineered evaluated different medical indications, including cancer, microbial, inflammatory diseases described. Finally, challenges facing clinic critically examined, goal establishing directions more realistic approaches that can bridge translational MOF‐containing (nano)materials.

Language: Английский

---

Catalyzing Generation and Stabilization of Oxygen Vacancies on CeO_2−x Nanorods by Pt Nanoclusters as Nanozymes for Catalytic Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(31)

Published: Sept. 14, 2023

Abstract Although CeO 2 nanomaterials have been widely explored as nanozymes for catalytic therapy, they still suffer from relatively low activities. Herein, the catalyzing generation and stabilization of oxygen vacancies on nanorods by Pt nanoclusters via H gas reduction under mild temperature (350 °C) to obtain Pt/CeO 2− x , which can serve a highly efficient nanozyme cancer is reported. The deposited atomic layer deposition technique not only catalyst generate through hydrogen spillover effect, but also stabilize generated vacancies. Meanwhile, provide anchoring sites forming strong metal‐support interactions thus preventing their agglomerations. Importantly, reduced at 350 °C (Pt/CeO ‐350R) exhibits excellent enzyme‐mimicking activity reactive species (e.g., ·OH) compared other control samples, including temperatures, achieving performance tumor‐specific therapy efficiently eliminate cells in vitro ablate tumors vivo. ‐350R originates good activities vacancy‐rich nanoclusters.

Language: Английский

---