Phosphorescence resonance energy transfer from purely organic supramolecular assembly

Nature Reviews Chemistry, Journal Year: 2023, Volume and Issue: 7(12), P. 854 - 874

Published: Nov. 22, 2023

Language: Английский

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Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(21)

Published: July 21, 2023

Abstract Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability eliminate cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, challenges in tracking treatment efficacy. These limitations greatly hinder widespread clinical application. In contrast, supramolecular chemotherapy, which relies on host–guest interactions, presents a promising alternative by offering highly efficient minimally toxic anticancer delivery. this review, overview recent advancements based interactions provided. The significant role it plays guiding therapy emphasized. Drawing wealth cutting‐edge research, herein, timely valuable resource individuals interested the field or therapy, presented. Furthermore, review contributes progression toward

Language: Английский

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Macrocyclic Supramolecular Assemblies Based on Hyaluronic Acid and Their Biological Applications

Accounts of Chemical Research, Journal Year: 2022, Volume and Issue: 55(23), P. 3417 - 3429

Published: Nov. 16, 2022

ConspectusHyaluronic acid (HA), which contains multiple carboxyl, hydroxyl, and acetylamino groups is an agent that targets tumors, has drawn great attention in supramolecular diagnosis treatment research. It can not only assemble directly with macrocyclic host–guest complexes through hydrogen bonding electrostatic interactions but also be modified compounds or functional guest molecules by amidation reaction used for further assembly. Macrocycles play a main role the construction of drug carriers, targeted imaging agents, hydrogels, such as cyclodextrins cucurbit[n]urils, encapsulate photosensitizers, drugs, other via interactions. Therefore, formed assemblies respond to various stimuli, enzymes, light, electricity, magnetism controlled delivery, enhance luminescence intensity assembly, improve loading capacity. In addition, nanosupramolecular assembly HA biocompatibility reduce toxicity side effects, cell permeability; thus, extensive application value biomedical This Account mainly focuses on based HA, especially their biological applications progress field, these include (i) guest-modified pyridinium-, adamantane-, peptide-, functional-group-modified along cyclodextrin cucurbit[n]uril assemblies; (ii) macrocycle-modified derivatives guests; (iii) direct between unmodified cyclodextrin- cucurbit[n]uril-based complexes. Particularly, we discussed important HA-based roles included improving water solubility efficacy hydrophobic enhancing luminescent assemblies, inducing room temperature phosphorescence providing energy transfer systems, constructing multi-stimulus-responsive situ formation hydrogels. Additionally, believe obtaining in-depth knowledge encompasses many challenges regarding wound healing, soft materials would certainly contribute rapid development treatment.

Language: Английский

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Erasable, Rewritable, and Reprogrammable Dual Information Encryption Based on Photoluminescent Supramolecular Host–Guest Recognition and Hydrogel Shape Memory

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(40)

Published: June 26, 2023

Information encryption technologies are very important for security, health, commodity, and communications, etc. Novel information mechanisms materials desired to achieve multimode reprogrammable encryption. Here, a supramolecular strategy is demonstrated multimodal, erasable, reprogrammable, reusable by reversibly modulating fluorescence. A butyl-naphthalimide with flexible ethylenediamine functionalized β-cyclodextrin (N-CD) utilized as fluorescent responsive ink printing or patterning on polymer brushes dangling adamantane group grafted hydrogels. The photoluminescent naphthalimide moiety bonded β-CD entrapped in the cavity. Its fluorescence highly weakened cavity recovers after being expelled from competing guest molecule emit bright green photoluminescence under UV. Experiments theoretical calculations suggest π-π stacking ICT primary mechanism naphthalimides assembly fluorescence, which can be quenched through insertion of conjugated molecules recover removing insert. Such reversible quenching recovering used repeated writing, erasing, re-writing information. Supramolecular recognition hydrogel shape memory further combined dual-encryption. This study provides novel develop smart improved security broad applications.

Language: Английский

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Enhancing Purely Organic Room Temperature Phosphorescence via Supramolecular Self‐Assembly

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)

Published: Jan. 25, 2024

Abstract Long‐lived and highly efficient room temperature phosphorescence (RTP) materials are in high demand for practical applications lighting display, security signboards, anti‐counterfeiting. Achieving RTP aqueous solutions, near‐infrared (NIR) emission, NIR‐excited crucial bio‐imaging, but these goals pose significant challenges. Supramolecular self‐assembly provides an effective strategy to address the above problems. This review focuses on recent advances enhancement of via supramolecular self‐assembly, covering four key aspects: small molecular cocrystals, macrocyclic hosts guests, multi‐stage self‐assembly. not only highlights progress areas also underscores prominent challenges associated with developing materials. The resulting strategies development high‐performance discussed, aiming satisfy biomedical science.

Language: Английский

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Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(24), P. 13966 - 14037

Published: Nov. 22, 2023

Phosphorescence, characterized by luminescent lifetimes significantly longer than that of biological autofluorescence under ambient environment, is great value for biomedical applications. Academic evidence fluorescence imaging indicates virtually all metrics (sensitivity, resolution, and penetration depths) are improved when progressing into wavelength regions, especially the recently reported second near-infrared (NIR-II, 1000–1700 nm) window. Although emission probes does matter, it not clear whether guideline "the wavelength, better effect" still suitable developing phosphorescent probes. For tissue-specific bioimaging, long-lived probes, even if they emit visible phosphorescence, enable accurate visualization large deep tissues. studies dealing with bioimaging tiny architectures or dynamic physiopathological activities, prerequisite rigorous planning long-wavelength being aware cooperative contribution long wavelengths improving spatiotemporal depth, sensitivity bioimaging. In this Review, emerging molecular engineering methods room-temperature phosphorescence discussed through lens photophysical mechanisms. We highlight roles from to NIR-II windows toward bioapplications. To appreciate such advances, challenges prospects in rapidly growing described.

Language: Английский

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Supramolecular systems for bioapplications: recent research progress in China

Science China Chemistry, Journal Year: 2024, Volume and Issue: 67(5), P. 1397 - 1441

Published: March 22, 2024

Language: Английский

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Emerging trends in the application of hydrogel-based biomaterials for enhanced wound healing: A literature review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129300 - 129300

Published: Jan. 11, 2024

Language: Английский

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Macrocycle-embedded metal-covalent organic frameworks for catalysis: A bridge between covalent and non-covalent functional frameworks

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 512, P. 215894 - 215894

Published: April 26, 2024

Language: Английский

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Supramolecular Lipid Nanoparticles Based on Host–Guest Recognition: A New Generation Delivery System of mRNA Vaccines For Cancer Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(23)

Published: March 4, 2024

Abstract Dendritic cell (DC) maturation is a crucial process for antigen presentation and the initiation of T cell‐mediated immune responses. Toll‐like receptors play pivotal roles in stimulating DC promoting presentation. Here, novel message RNA (mRNA) cancer vaccine reported that boosts antitumor efficacy by codelivering an mRNA encoding tumor TLR7/8 agonist (R848) to using supramolecular lipid nanoparticles (SMLNP) as delivery platform, which new ionizable (N2‐3L) remarkably enhances translation efficiency β‐cyclodextrin (β‐CD)‐modified (Lip‐CD) encapsulates R848. The incorporation R848 adjuvant into through noncovalent host–guest complexation significantly promotes after vaccination, thus resulting superior vivo. Moreover, further boosted synergized with checkpoint blockade potentiating anticancer capability cytotoxic lymphocytes infiltrated sites. This work indicates SMLNP shows brilliant potential next‐generation system development vaccines high efficacy.

Language: Английский

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