Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives DOI Creative Commons
Chen Zong, Annelies Bronckaers,

Guy Willems

et al.

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(6), P. 290 - 290

Published: May 24, 2023

Bioactive nanomaterials are increasingly being applied in oral health research. Specifically, they have shown great potential for periodontal tissue regeneration and substantially improved translational clinical applications. However, their limitations side effects still need to be explored elucidated. This article aims review the recent advancements discuss future research directions this field, especially focusing on using improve health. The biomimetic physiochemical properties of such as metals polymer composites described detail, including alveolar bone, ligament, cementum gingiva. Finally, biomedical safety issues application regenerative materials updated, with a discussion about complications perspectives. Although applications bioactive cavity at an initial stage, pose numerous challenges, suggests that promising alternative regeneration.

Language: Английский

Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment DOI Creative Commons
Fei Qu, Rui Geng, Yijing Liu

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 12(7), P. 3372 - 3406

Published: Jan. 1, 2022

Skin diseases are the fourth leading cause of nonfatal and chronic skin diseases, acting as a global burden affecting world economy. severely impact patients' quality life have influenced their physical mental state. Treatment these disorders with conventional methods shows lack therapeutic efficacy, long treatment duration, recurrence condition, systemic side effects due to improper drug delivery. However, pitfalls can be overcome applications advanced nanocarrier- microneedle (MN)-based transdermal delivery strategies that provide efficient site-specific at target site. These more effective than other administration routes by avoiding first-pass metabolism, enhancing concentration in local lesions, reducing toxicity. Compared traditional methods, or MN-based systems painless, noninvasive, minimum-invasive require no expensive equipment. More importantly, they introduce functions, including increased penetration efficiency, controlled release rates, enhanced targeting abilities, theranostic functions. Here, emergence versatile for various drugs is reviewed, focusing on design principles, advantages, considerations treating diverse psoriasis, dermatitis, melanoma, diseases. Moreover, prospects challenges dermatological summarized.

Language: Английский

Citations

147
Nanocarriers for Skin Applications: Where Do We Stand? DOI
Neha Tiwari, Ernesto Rafael Osorio‐Blanco, Ana S. Sonzogni

et al.

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(3)

Published: Sept. 6, 2021

Skin penetration of active molecules for treatment diverse diseases is a major field research owing to the advantages associated with skin like easy accessibility, reduced systemic-derived side effects, and increased therapeutic efficacy. Despite these advantages, dermal drug delivery generally challenging due low permeability therapeutics. Although various methods have been developed improve permeation therapeutics, they are usually aggressive could lead irreversible damage stratum corneum. Nanosized carrier systems represent an alternative approach current technologies, minimal natural barrier function skin. In this Review, use nanoparticles deliver molecules, genetic material, vaccines into discussed. addition, nanotoxicology studies recent clinical development highlighted shed light on their potential undergo market translation.

Language: Английский

Citations

108
Nanoemulgel: A Novel Nano Carrier as a Tool for Topical Drug Delivery DOI Creative Commons
Mahipal Reddy Donthi, Siva Ram Munnangi,

Kowthavarapu Venkata Krishna

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 164 - 164

Published: Jan. 3, 2023

Nano-emulgel is an emerging drug delivery system intended to enhance the therapeutic profile of lipophilic drugs. Lipophilic formulations have a variety limitations, which includes poor solubility, unpredictable absorption, and low oral bioavailability. Nano-emulgel, amalgamated preparation different systems aims deal with these limitations. The novel prepared by incorporation nano-emulsion into gel improves stability enables for both immediate controlled release. focus on nano-emulgel has also increased due its ability achieve targeted delivery, ease application, absence gastrointestinal degradation or first pass metabolism, safety profile. This review focuses formulation components topical pharmacokinetics profiles.

Language: Английский

Citations

85
New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective DOI Creative Commons
Neha Raina, Radha Rani, Vijay Kumar Thakur

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(22), P. 19145 - 19167

Published: May 19, 2023

Skin, the largest organ in humans, is an efficient route for delivery of drugs as it circumvents several disadvantages oral and parenteral routes. These advantages skin have fascinated researchers recent decades. Drug via a topical includes moving drug from product to locally targeted region with dermal circulation throughout body deeper tissues. Still, due skin's barrier function, through can be difficult. using conventional formulations micronized active components, instance, lotions, gels, ointments, creams, results poor penetration. The use nanoparticulate carriers one promising strategies, provides overcomes disadvantage traditional formulations. Nanoformulations smaller particle sizes contribute improved permeability therapeutic agents, targeting, stability, retention, making nanoformulations ideal route. Achieving sustained release preserving localized effect utilizing nanocarriers result effective treatment numerous infections or disorders. This article aims evaluate discuss most developments agent vehicles conditions patent technology market overview that will give future directions research. As systems shown great preclinical problems, research directions, we anticipate including in-depth studies nanocarrier behavior various customized treatments take into account phenotypic variability disease.

Language: Английский

Citations

81
Functional nano-systems for transdermal drug delivery and skin therapy DOI Creative Commons
Lijun Liu,

Zhao Wenbin,

Qingming Ma

et al.

Nanoscale Advances, Journal Year: 2023, Volume and Issue: 5(6), P. 1527 - 1558

Published: Jan. 1, 2023

Functional nano-systems have been applied as a promising strategy for transdermal drug delivery and skin therapy.

Language: Английский

Citations

80
Strategies to develop polymeric microneedles for controlled drug release DOI
Bo Zhi Chen,

Yu Ting He,

Ze Qiang Zhao

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 203, P. 115109 - 115109

Published: Oct. 30, 2023

Language: Английский

Citations

60
Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery DOI
Yisi Tang,

Bao Liu,

Yuting Zhang

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 209, P. 115304 - 115304

Published: April 9, 2024

Language: Английский

Citations

21
Transforming Medicine: Cutting-Edge Applications of Nanoscale Materials in Drug Delivery DOI Creative Commons
Rumiana Koynova, Kevin J. Hughes,

Magesh Ganesan

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Since their inception in the early 1960s, development and use of nanoscale materials have progressed tremendously, roles diverse fields ranging from human health to energy electronics are undeniable. The application nanotechnology inventions has revolutionized many aspects everyday life including various medical applications specifically drug delivery systems, maximizing therapeutic efficacy contained drugs by means bioavailability enhancement or minimization adverse effects. In this review, we utilize CAS Content Collection, a vast repository scientific information extracted journal patent publications, analyze trends nanoscience research relevant an effort provide comprehensive detailed picture field. We examine publication landscape area insights into current knowledge advances developments. review major classes nanosized routes, targeted diseases. outline most discussed concepts assess advantages nanocarriers. objective is broad overview evolving regarding challenges, evaluate growth opportunities. merit stems extensive, wide-ranging coverage up-to-date information, allowing unmatched breadth analysis in-depth insights.

Language: Английский

Citations

5
Advances in medical devices using nanomaterials and nanotechnology: Innovation and regulatory science DOI

Chubing Lin,

Xin Huang, Yueguang Xue

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 353 - 369

Published: Feb. 20, 2025

Language: Английский

Citations

4
Liposomal Amphotericin B for Treatment of Leishmaniasis: From the Identification of Critical Physicochemical Attributes to the Design of Effective Topical and Oral Formulations DOI Creative Commons
Frédéric Frézard, Marta Gontijo Aguiar, Lucas Antônio Miranda Ferreira

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 15(1), P. 99 - 99

Published: Dec. 28, 2022

The liposomal amphotericin B (AmB) formulation, AmBisome®, still represents the best therapeutic option for cutaneous and visceral leishmaniasis. However, its clinical efficacy depends on patient’s immunological status, manifestation endemic region. Moreover, need parenteral administration, side effects high cost significantly limit use in developing countries. This review reports progress achieved thus far toward understanding of mechanism responsible reduced toxicity AmB formulations factors that influence their against It also presents recent advances development more effective formulations, including topical oral liposome formulations. critical role aggregation state release rate reduction drug by non-invasive routes is emphasized. paper expected to guide future research innovative AmB.

Language: Английский

Citations

55