Self-Immolative Photosensitizers for Self-Reported Cancer Phototheranostics

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(24), P. 13099 - 13113

Published: May 22, 2023

Photosensitizers to precise target and change fluorescence upon light illumination could accurately self-report where when the photosensitizers work, enabling us visualize therapeutic process precisely regulate treatment outcomes, which is unremitting pursuit of precision personalized medicine. Here, we report self-immolative by adopting a strategy light-manipulated oxidative cleavage C═C bonds that can generate burst reactive oxygen species, cleave release self-reported red-emitting products trigger nonapoptotic cell oncosis. Strong electron-withdrawing groups are found effectively suppress bond phototoxicity via studying structure-activity relationship, allowing elaborate NG1-NG5 temporarily inactivate photosensitizer quench different glutathione (GSH)-responsive groups. Thereinto, NG2 with 2-cyano-4-nitrobenzene-1-sulfonyl group displays excellent GSH responsiveness than other four. Surprisingly, shows better reactivity in weakly acidic condition, inspires application tumor microenvironment elevates. To this end, further synthesize NG-cRGD anchoring integrin αvβ3 binding cyclic pentapeptide (cRGD) for targeting. In A549 xenografted mice, successfully deprotects restore near-infrared because elevated site, subsequently cleaved irradiation releasing working, while ablating tumors triggered The advanced organic may accelerate development phototheranostics future oncology.

Language: Английский

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Mitochondria-Targeting Upconversion Nanoparticles@MOF for Multiple-Enhanced Photodynamic Therapy in Hypoxic Tumor

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(30), P. 35884 - 35894

Published: July 24, 2023

The effect of photodynamic therapy (PDT) is severely limited by tumor hypoxia and the short half-life reactive oxygen species (ROS). Herein, we constructed a near-infrared (NIR) light-regulated PDT nanoplatform (TPP-UCNPs@MOF-Pt) consisting an upconversion nanoparticle (UCNP) core porphyrin-based metal-organic framework (MOF) shell with platinum nanoparticles (PtNPs) mitochondria-targeting triphenylphosphine (TPP) group on surface. TPP-UCNPs@MOF-Pt could effectively relieve converting intracellular H2O2 to (O2) elevated ROS level enhance efficacy under NIR light irradiation. In addition, was localized mitochondria, leading severe depolarization mitochondrial membrane activation apoptotic pathway, further amplifying therapeutic efficacy. vitro in vivo experiments demonstrated that greatly enhanced achieved combining relief targeting activation. This study provides promising strategy for construction MOF-based multifunctional address current limitations treatment hypoxic tumors.

Language: Английский

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Phototherapy: progress, challenges, and opportunities

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

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DNA-Targeting Bioactive Photosensitizer for Chemo-Photodynamic Therapy of Malignant Tumor

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(3), P. 969 - 975

Published: Feb. 15, 2024

The design of a biologically active photosensitizer that effectively combines chemotherapy and photodynamic therapy remains significant challenge. This article introduces DNA targeted photosensitizer, CQA, which integrates the alkylating moiety chlormethine with photosensitizing moiety. Through damage experiments molecular docking, CQA has been demonstrated to act as an effective targeting damaging chemotherapeutic agent via chlormethine. Meanwhile, can substantially amplify under light irradiation. Such enhancement is attributed introduction anthraquinone group, possesses good redox properties acts electron acceptor promote transfer. Consequently, efficiently generates both type-I type-II reactive oxygen species (ROS), exerting excellent (PDT) effect. antitumor efficacy validated results from in vivo tumor growth experiments, H&E staining, IHC analyses. this study emphasizes enhanced ROS generation, underscoring crucial role efficient synergistic chemo- advancing cancer treatment strategies.

Language: Английский

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Organic dye-based photosensitizers for fluorescence imaging-guided cancer phototheranostics

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 513, P. 215866 - 215866

Published: May 2, 2024

Language: Английский

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A mitochondria-targeted supramolecular nanoplatform for peroxynitrite-potentiated oxidative therapy of orthotopic hepatoma

Biomaterials, Journal Year: 2022, Volume and Issue: 290, P. 121854 - 121854

Published: Oct. 12, 2022

Language: Английский

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Structure and Photosensitaizer Ability of Polymethine Dyes in Photodynamic Therapy: A Review

Theoretical and Experimental Chemistry, Journal Year: 2023, Volume and Issue: 58(6), P. 373 - 401

Published: Jan. 1, 2023

Language: Английский

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Simultaneous In Vivo Imaging of Neutrophil Elastase and Oxidative Stress in Atherosclerotic Plaques Using a Unimolecular Photoacoustic Probe

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(46)

Published: Aug. 8, 2024

Abstract Atherosclerosis, a major global health concern with high morbidity and mortality rates, involves complex interactions of chronic inflammation, oxidative stress, proteolytic enzymes. Conventional imaging methods struggle to capture the dynamic biochemical processes in atherosclerotic plaques. Here, we introduce novel unimolecular photoacoustic probe (UMAPP) designed specific binding sites for neutrophil elastase (NE) redox pair O 2 ⋅ − /GSH, enabling real‐time monitoring stress activated neutrophils UMAPP, comprising boron‐dipyrromethene (BODIPY) core linked hydrophilic NE‐cleavable tetrapeptide dual stress‐responsive catechol moieties, facilitates NE‐mediated modulation photoinduced electron transfer impacting intensity at 685 nm (PA ). Furthermore, oxidation reduction groups by GSH induce reversible, ratiometric changes spectrum 745 /PA ratio). Initial UMAPP applications successfully distinguished healthy mice, evaluated pneumonia‘s effect on plaque composition verified probe‘s effectiveness drug‐treatment studies detecting molecular alterations before visible histopathological changes. The integrated capabilities offer promising advancements atherosclerosis diagnosis management, early accurate identification vulnerable

Language: Английский

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Activatable theranostic prodrug scaffold with tunable drug release rate for sequential photodynamic and chemotherapy

Smart Molecules, Journal Year: 2024, Volume and Issue: 2(1)

Published: Feb. 20, 2024

Abstract Glutathione (GSH)‐activated prodrugs are promising for overcoming the limitations of conventional anti‐tumor drugs. However, current GSH‐responsive disulfide groups exhibit unregulated reactivity, making it impossible to precisely control drug release rate. We herein report a series with “three‐in‐one” molecular design by integrating fluorescence unit, stimuli‐responsive unit and chemodrug into one scaffold tunable aromatic nucleophilic substitution (S N Ar) reactivity. The rate these is tailored modification substituent different electron‐withdrawing or ‐donating abilities on BODIPY core. Furthermore, self‐assemble in water form nanoparticles that serve as photosensitizers produce reactive oxygen species upon irradiation photodynamic therapy (PDT). PDT process also increases concentration GSH cells, further promoting drugs chemotherapy. This strategy provides powerful platform sequential chemotherapy rates synergistic therapeutic effects.

Language: Английский

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Novel Photocatalyst Based on Through‐Space Charge Transfer Induced Intersystem Crossing Enables Rapid and Efficient Polymerization Under Low‐Power Excitation Light

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(29)

Published: April 8, 2024

Abstract Currently, most photoredox catalysis polymerization systems are limited by high excitation power, long time, or the requirement of electron donors due to precise design efficient photocatalysts still poses a great challenge. Herein, we propose new approach: creation having low ground state oxidation potentials and excited energy levels, along with through‐space charge transfer (TSCT) induced intersystem crossing (ISC) properties. A cabazole‐naphthalimide (NI) dyad (NI‐1) characterized triplet lifetime (τ T =62 μs), satisfactory ISC efficiency (Φ Δ =54.3 %) powerful reduction capacity [Singlet: E 1/2 (PC +1 /*PC)=−1.93 eV, Triplet: /*PC)=−0.84 eV] was obtained. An rapid (83 % conversion 1 mM monomer in 30 s) observed under conditions without donor, power (10 mW cm −2 ) catalyst loading (<50 μM). In contrast, rate lower at 29 when reference (NI‐4) used for photopolymerization same conditions, demonstrating advantage TSCT photocatalyst. Finally, material as photocatalyst practical lithography first achieving pattern resolutions up 10 μm.

Language: Английский

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