Nanoprobe-based molecular imaging for tumor stratification

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(18), P. 6447 - 6496

Published: Jan. 1, 2023

This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.

Language: Английский

---

Tumor-microenvironment-activatable organic phototheranostic agents for cancer therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 509, P. 215786 - 215786

Published: March 20, 2024

Language: Английский

---

Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies

Chemical Science, Journal Year: 2024, Volume and Issue: 15(31), P. 12234 - 12257

Published: Jan. 1, 2024

Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently, great efforts have made improve the PDT effect in terms of safety efficiency. In this review, we highlight recent advances innovative strategies for enhanced PDT, including (1) development novel radicals, (2) design activatable photosensitizers based on TME light, (3) photocatalytic NADH oxidation damage mitochondrial electron transport chain. Additionally, new mechanisms are also presented an inspiration PSs. Finally, discuss current challenges future prospects clinical practice these strategies. It is hoped that review will provide angle understanding relationship between intratumoural redox environment mechanisms, ideas smart systems.

Language: Английский

---

Cell death: The underlying mechanisms of photodynamic therapy for skin diseases

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Photodynamic therapy (PDT) has significant potential in the treatment of dermatological, oncological, and nonneoplastic conditions through induction cell death, immune regulation, antimicrobial effects, etc. However, response some patients is unsatisfactory, there a lack an ideal protocol for multiple specific diseases (subtypes) to choose proper photosensitizer (PS), light source, dose. A thorough understanding underlying mechanism integral solving these problems, death gained much attention. In addition apoptosis, autophagy, necrosis, several novel pathways, such as necroptosis, mitotic catastrophe, paraptosis pyroptosis, have been reported PDT treatment. The type induced depends on dose PDT, subcellular location PSs, regulation signaling pathways. addition, different types by same apoptosis may interact with each other. Some can also trigger immunogenic (ICD), which ignite against antigens derived from dying/dead cells present improved antitumor effects. On basis mechanisms, strategies, targeted combined immunotherapy ICD‐based vaccines, proposed improve therapeutic efficacy. Future studies are needed elucidate relationship between effects shed new exploration precise patients.

Language: Английский

---

Phototherapy: progress, challenges, and opportunities

Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Language: Английский

---

Tissue Ablation: Applications and Perspectives

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: May 21, 2024

Tissue ablation techniques have emerged as a critical component of modern medical practice and biomedical research, offering versatile solutions for treating various diseases disorders. Percutaneous is minimally invasive offers numerous advantages over traditional surgery, such shorter recovery times, reduced hospital stays, decreased healthcare costs. Intra-procedural imaging during also allows precise visualization the treated tissue while minimizing injury to surrounding normal tissues, reducing risk complications. Here, mechanisms innovative energy delivery systems are explored, highlighting recent advancements that reshaped landscape clinical practice. Current challenges related discussed, underlining unmet needs more advanced material-based approaches improve pharmacology-based therapeutics.

Language: Английский

---

Optimizing Surface Maleimide/cRGD Ratios Enhances Targeting Efficiency of cRGD-Functionalized Nanomedicines

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Thiol-maleimide (MI) chemistry is a cornerstone of bioconjugation strategies, particularly in the development drug delivery systems. The cyclic arginine-glycine-aspartic acid (cRGD) peptide, recognized for its ability to target integrin α

Language: Английский

---

Minimized background tumor imaging through self-assembled disulfide dicyanine nanoparticles

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 334, P. 125908 - 125908

Published: Feb. 16, 2025

Language: Английский

---

Hydrogen sulfide-responsive and depleting NIR-II nanoplatform synergistic photodynamic therapy for colorectal cancer

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161711 - 161711

Published: March 1, 2025

Language: Английский

---

Rationally designed NIR-II excitable and endoplasmic reticulum-targeted molecular phototheranostics for imaging-guided enhanced photoimmunotherapy of triple-negative breast cancer

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 22, 2025

Triple-negative breast cancer (TNBC) is a highly aggressive subtype of characterized by an extremely poor prognosis. Photoimmunotherapy has emerged as promising strategy for the treatment TNBC. This approach works selectively destroying tumor cells, releasing tumor-associated antigens, activating immune system, and effectively inhibiting proliferation metastasis. However, majority current phototheranostic approaches are hindered limited tissue penetration in first near-infrared (NIR-I) ultraviolet–visible (UV–Vis) regions. Additionally, due to lack specific subcellular targets, it may be difficult treat deep-seated lesions with ambiguous extensive boundaries caused TNBC metastases. Consequently, development effective, deep-penetrating, organelle-targeted phototheranostics essential enhancing outcomes work proposes novel molecular design NIR-II realize planar rigid conjugation alkyl chain functionalization. The di-hexaalkyl chains vertical configuration on donor (4H-cyclopenta[2,1-b:3,4-b'] dithiophene) shielding units (fluorene) introduced construct S-D-A-D-S type (IR-FCD). structure IR-FCD exhibits robust intramolecular charge transfer capability, lower band gap, enhanced photon absorption properties, significant steric hindrance from vertically arranged minimize non-radiative energy loss. By incorporating N-(but-3-yn-1-yl)-4-methylbenzenesulfonamide at terminus elongated chain, followed self-assembly into DSPE-S-S-PEG2000, excitable (IR-FCD-Ts NPs) endoplasmic reticulum (ER) targeting capability were successfully synthesized imaging-guided photoimmunotherapy IR-FCD-Ts NPs demonstrate exceptional optical characteristics, maximum 1068 nm (extending 1300 nm) emission 1273 1700 nm), along high molar coefficient 2.76*104 L/mol·c 1064 aqueous solution. Under exposure laser irradiation, exhibit superior photothermal properties have potential photodynamic therapy. ER, thereby inducing ER stress significantly immunogenic cell death (ICD) triggers strong antitumor response inhibits metastasis

Language: Английский

---