Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Abstract
The
heavy
dependence
on
intratumoral
O
2
and
H
availability
has
greatly
restricted
ROS‐based
therapy.
Although
/H
‐irrelevant
free‐radical
nanogenerator
garnered
tremendous
attention
as
a
promising
anticancer
candidate
to
overcome
the
above
intrinsic
limitations
of
treatment,
practical
therapeutic
efficacy
therapy
is
still
hindered
by
limited
type
inferior
tumor
retention
performance.
Herein,
inspired
new
concept
full‐API
nanodrug
(FAND)
with
100%
active
pharmaceutical
ingredient
(API)
content
repurposing
clinical
anti‐malaria
drug
artesunate
(ARTE)
an
generator,
AFeI
FANDs
composed
ARTE,
human
essential
Fe
3+
,
FDA‐approved
fluorescent
agent
ICG
for
hypoxic
are
rationally
designed
constructed.
Attractively,
completely
pharmaceutically
components
can
be
responsively
liberated
in
acidic
microenvironment
synergistically
produce
five
types
free
radicals
including
•O
−
•C,
•OH,
LOO•,
1
leading
robust
mitochondrial
injury,
nuclear
DNA
damage,
lipid
peroxides.
More
importantly,
displayed
ultralong
longer
than
108
h
favorable
suppression
outcomes
under
mild
NIR
irradiation.
Collectively,
presented
first
paradigm
FAND‐based
quintuple
expands
horizons
development
clinically
transferable
nanomedicine
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(38)
Published: July 12, 2023
Piezocatalytic
therapy,
which
generates
reactive
oxygen
species
(ROS)
under
mechanical
force,
has
garnered
extensive
attention
for
its
use
in
cancer
therapy
owing
to
deep
tissue
penetration
depth
and
less
O2
-dependence.
However,
the
piezocatalytic
therapeutic
efficiency
is
limited
poor
piezoresponse,
low
separation
of
electron-hole
pairs,
complicated
tumor
microenvironment
(TME).
Herein,
a
biodegradable,
porous
Mn-doped
ZnO
(Mn-ZnO)
nanocluster
with
enhanced
piezoelectric
effect
constructed
via
doping
engineering.
Mn-doping
not
only
induces
lattice
distortion
increase
polarization
but
also
creates
rich
vacancies
(OV
)
suppressing
recombination
leading
high-efficiency
generation
ROS
ultrasound
irradiation.
Moreover,
shows
TME-responsive
multienzyme-mimicking
activity
glutathione
(GSH)
depletion
ability
mixed
valence
Mn
(II/III),
further
aggravating
oxidative
stress.
Density
functional
theory
calculations
show
that
can
improve
performance
enzyme
Mn-ZnO
due
presence
OV
.
Benefiting
from
boosting
GSH
ability,
significantly
accelerate
accumulation
lipid
peroxide
inactivate
peroxidase
4
(GPX4)
induce
ferroptosis.
The
work
may
provide
new
guidance
exploring
novel
sonosensitizers
therapy.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(12)
Published: Jan. 28, 2023
Abstract
Lipid
peroxidation
(LPO)
is
one
of
the
most
damaging
processes
in
chemodynamic
therapy
(CDT).
Although
it
well
known
that
polyunsaturated
fatty
acids
(PUFAs)
are
much
more
susceptible
than
saturated
or
monounsaturated
ones
to
LPO,
there
no
study
exploring
effect
cell
membrane
unsaturation
degree
on
CDT.
Here,
we
report
a
self‐reinforcing
CDT
agent
(denoted
as
OA@Fe‐SAC@EM
NPs),
consisting
oleanolic
acid
(OA)‐loaded
iron
single‐atom
catalyst
(Fe‐SAC)‐embedded
hollow
carbon
nanospheres
encapsulated
by
an
erythrocyte
(EM),
which
promotes
LPO
improve
efficacy
via
modulating
unsaturation.
Upon
uptake
NPs
cancer
cells,
Fe‐SAC‐catalyzed
conversion
endogenous
hydrogen
peroxide
into
hydroxyl
radicals,
addition
initiating
therapeutic
process,
causes
dissociation
EM
shell
and
ensuing
release
OA
can
enrich
cellular
membranes
with
PUFAs,
enabling
amplification‐enhanced
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(3), P. 3064 - 3076
Published: Jan. 16, 2023
As
a
rising
generation
of
nanozymes,
single
atom
enzymes
show
significant
promise
for
cancer
therapy,
due
to
their
maximum
utilization
efficiency
and
well-defined
electronic
structures.
However,
it
remains
tremendous
challenge
precisely
produce
heteroatom-doped
enzyme
with
an
expected
coordination
environment.
Herein,
we
develop
anion
exchange
strategy
controlled
production
edge-rich
sulfur
(S)-
nitrogen
(N)-decorated
nickel
(S-N/Ni
PSAE).
In
particular,
sulfurized
S-N/Ni
PSAE
exhibits
stronger
peroxidase-like
glutathione
oxidase-like
activities
than
the
nitrogen-monodoped
enzyme,
which
is
attributed
vacancies
defective
sites
atoms.
Moreover,
both
in
vitro
vivo
results
demonstrate
that,
compared
N/Ni
PSAE,
more
effectively
triggers
ferroptosis
tumor
cells
via
inactivating
peroxidase
4
inducing
lipid
peroxidation.
This
study
highlights
enhanced
catalytic
efficacy
polynary
ferroptosis-based
therapy.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(18), P. 6447 - 6496
Published: Jan. 1, 2023
This
review
highlights
the
use
of
nanoprobes
to
stratify
various
therapeutic
modalities
and
provides
an
outlook
on
challenges
future
directions
for
patient
stratification.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(27)
Published: March 29, 2024
Cancer
treatment
requires
precise
tumor-specific
targeting
at
specific
sites
that
allows
for
high-resolution
diagnostic
imaging
and
long-term
patient-tailorable
cancer
therapy;
while,
minimizing
side
effects
largely
arising
from
non-targetability.
This
can
be
realized
by
harnessing
exogenous
remote
stimuli,
such
as
tissue-penetrative
ultrasound,
magnetic
field,
light,
radiation,
enable
local
activation
therapy
in
deep
tumors.
A
myriad
of
nanomedicines
efficiently
activated
when
the
energy
stimuli
transformed
into
another
type
energy.
review
discusses
control
transformation
targetable,
efficient,
therapy.
Such
ultrasonic,
magnetic,
photonic,
radiative,
radioactive
mechanical,
thermal,
chemical,
radiative
to
a
variety
modalities.
The
current
article
describes
multimodal
where
serial
cascade
or
multiple
types
occur.
includes
not
only
hyperthermia,
radiation
but
also
emerging
thermoelectric,
pyroelectric,
piezoelectric
therapies
treatment.
It
illustrates
resonance,
fluorescence,
computed
tomography,
photoluminescence,
photoacoustic
imaging-guided
therapies.
highlights
afterglow
eliminate
autofluorescence
sustained
signal
emission
after
excitation.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(6), P. 1352 - 1352
Published: March 18, 2024
Magnetic
nanoparticles
(MNPs),
either
paramagnetic
or
superparamagnetic
depending
on
their
composition
and
size,
have
been
thoroughly
studied
as
magnetic
resonance
imaging
(MRI)
contrast
agents
using
in
vitro
vivo
biomedical
preclinical
studies,
while
some
are
clinically
used.
Their
properties
responsible
cases
for
high
magnetization
values,
together
with
large
surface
area-to-volume
ratios
the
possibility
of
functionalization,
used
MRI-based
diagnostic
theranostics
applications.
MNPs
usually
positive
(T1)
negative
(T2)
MRI
agents,
causing
brightening
darkening
selected
regions
images,
respectively.
This
review
focusses
recent
developments
optimization
containing
Gd,
Mn,
Fe
other
lanthanide
ions
which
may
function
dual-mode
T1–T2
(DMCAs).
They
induce
same
scanner
upon
changing
its
operational
mode
between
T1-weighted
T2-weighted
pulse
sequences.
The
type
they
depends
critically
r2/r1
relaxivity
ratio,
DMCAs
should
be
2–10
range
values.
After
briefly
discussing
basic
principles
relaxation
MNPs,
this
review,
strategies
rational
design
presented
typical
examples
discussed,
including
applications:
(1)
use
NPs
a
single
material,
Gd-
Mn-based
appropriate
size
to
provide
T2
T1
contrast;
(2)
inclusion
both
types
materials
nanoplatform
by
relative
positions.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Ferroptosis,
an
iron-dependent
form
of
regulatory
cell
death,
has
garnered
significant
interest
as
a
therapeutic
target
in
cancer
treatment
due
to
its
distinct
characteristics,
including
lipid
peroxide
generation
and
redox
imbalance.
However,
clinical
application
oncology
is
currently
limited
by
issues
such
suboptimal
efficacy
potential
off-target
effects.
The
advent
nanotechnology
provided
new
way
for
overcoming
these
challenges
through
the
development
activatable
magnetic
nanoparticles
(MNPs).
These
innovative
MNPs
are
designed
improve
specificity
ferroptosis
induction.
This
Review
delves
into
chemical
biological
principles
guiding
design
ferroptosis-based
therapies
imaging-guided
therapies.
It
discusses
mechanisms
attributes
ferroptosis,
composition
MNPs,
their
mechanism
action
inducers,
integration
with
advanced
imaging
techniques
monitoring.
Additionally,
we
examine
convergence
other
strategies,
chemodynamic
therapy,
photothermal
photodynamic
sonodynamic
immunotherapy,
within
context
nanomedicine
strategies
utilizing
MNPs.
highlights
multifunctional
surpass
limitations
conventional
treatments,
envisioning
future
drug-resistance-free,
precision
diagnostics
treating
recalcitrant
cancers.