Quintuple Free‐Radical Therapy: An Ultralong‐Retention FAND for NIR‐Involved Multiple Site‐Acting Hypoxic Tumor Therapy DOI
Chuang Zhang, Dongxu Zhao, Fang Fang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Abstract The heavy dependence on intratumoral O 2 and H availability has greatly restricted ROS‐based therapy. Although /H ‐irrelevant free‐radical nanogenerator garnered tremendous attention as a promising anticancer candidate to overcome the above intrinsic limitations of treatment, practical therapeutic efficacy therapy is still hindered by limited type inferior tumor retention performance. Herein, inspired new concept full‐API nanodrug (FAND) with 100% active pharmaceutical ingredient (API) content repurposing clinical anti‐malaria drug artesunate (ARTE) an generator, AFeI FANDs composed ARTE, human essential Fe 3+ , FDA‐approved fluorescent agent ICG for hypoxic are rationally designed constructed. Attractively, completely pharmaceutically components can be responsively liberated in acidic microenvironment synergistically produce five types free radicals including •O − •C, •OH, LOO•, 1 leading robust mitochondrial injury, nuclear DNA damage, lipid peroxides. More importantly, displayed ultralong longer than 108 h favorable suppression outcomes under mild NIR irradiation. Collectively, presented first paradigm FAND‐based quintuple expands horizons development clinically transferable nanomedicine

Language: Английский

Doping Engineering to Modulate Lattice and Electronic Structure for Enhanced Piezocatalytic Therapy and Ferroptosis DOI Open Access
Boshi Tian, Ruixue Tian, Shaohua Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: July 12, 2023

Piezocatalytic therapy, which generates reactive oxygen species (ROS) under mechanical force, has garnered extensive attention for its use in cancer therapy owing to deep tissue penetration depth and less O2 -dependence. However, the piezocatalytic therapeutic efficiency is limited poor piezoresponse, low separation of electron-hole pairs, complicated tumor microenvironment (TME). Herein, a biodegradable, porous Mn-doped ZnO (Mn-ZnO) nanocluster with enhanced piezoelectric effect constructed via doping engineering. Mn-doping not only induces lattice distortion increase polarization but also creates rich vacancies (OV ) suppressing recombination leading high-efficiency generation ROS ultrasound irradiation. Moreover, shows TME-responsive multienzyme-mimicking activity glutathione (GSH) depletion ability mixed valence Mn (II/III), further aggravating oxidative stress. Density functional theory calculations show that can improve performance enzyme Mn-ZnO due presence OV . Benefiting from boosting GSH ability, significantly accelerate accumulation lipid peroxide inactivate peroxidase 4 (GPX4) induce ferroptosis. The work may provide new guidance exploring novel sonosensitizers therapy.

Language: Английский

Citations

94
Amplification of Lipid Peroxidation by Regulating Cell Membrane Unsaturation To Enhance Chemodynamic Therapy DOI
Yang Zhu,

Peng Gong,

Jun Wang

et al.

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(12)

Published: Jan. 28, 2023

Abstract Lipid peroxidation (LPO) is one of the most damaging processes in chemodynamic therapy (CDT). Although it well known that polyunsaturated fatty acids (PUFAs) are much more susceptible than saturated or monounsaturated ones to LPO, there no study exploring effect cell membrane unsaturation degree on CDT. Here, we report a self‐reinforcing CDT agent (denoted as OA@Fe‐SAC@EM NPs), consisting oleanolic acid (OA)‐loaded iron single‐atom catalyst (Fe‐SAC)‐embedded hollow carbon nanospheres encapsulated by an erythrocyte (EM), which promotes LPO improve efficacy via modulating unsaturation. Upon uptake NPs cancer cells, Fe‐SAC‐catalyzed conversion endogenous hydrogen peroxide into hydroxyl radicals, addition initiating therapeutic process, causes dissociation EM shell and ensuing release OA can enrich cellular membranes with PUFAs, enabling amplification‐enhanced

Language: Английский

Citations

89
Enhancing Catalytic Activity of a Nickel Single Atom Enzyme by Polynary Heteroatom Doping for Ferroptosis-Based Tumor Therapy DOI
Yang Zhu, Wenyu Wang,

Peng Gong

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(3), P. 3064 - 3076

Published: Jan. 16, 2023

As a rising generation of nanozymes, single atom enzymes show significant promise for cancer therapy, due to their maximum utilization efficiency and well-defined electronic structures. However, it remains tremendous challenge precisely produce heteroatom-doped enzyme with an expected coordination environment. Herein, we develop anion exchange strategy controlled production edge-rich sulfur (S)- nitrogen (N)-decorated nickel (S-N/Ni PSAE). In particular, sulfurized S-N/Ni PSAE exhibits stronger peroxidase-like glutathione oxidase-like activities than the nitrogen-monodoped enzyme, which is attributed vacancies defective sites atoms. Moreover, both in vitro vivo results demonstrate that, compared N/Ni PSAE, more effectively triggers ferroptosis tumor cells via inactivating peroxidase 4 inducing lipid peroxidation. This study highlights enhanced catalytic efficacy polynary ferroptosis-based therapy.

Language: Английский

Citations

82
Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes DOI Creative Commons
Lu Yang, Shuming Dong, Shili Gai

et al.

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 21, 2023

Since the discovery of enzyme-like activity Fe

Language: Английский

Citations

74
Nanoprobe-based molecular imaging for tumor stratification DOI

Xianbin Ma,

Mingchuan Mao,

Jiaqi He

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(18), P. 6447 - 6496

Published: Jan. 1, 2023

This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.

Language: Английский

Citations

51
Delivering metal ions by nanomaterials: Turning metal ions into drug-like cancer theranostic agents DOI

Chenguang Liu,

Lingxiao Guo,

Yong Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 494, P. 215332 - 215332

Published: July 17, 2023

Language: Английский

Citations

49
A Strategy of Fenton Reaction Cycloacceleration for High‐Performance Ferroptosis Therapy Initiated by Tumor Microenvironment Remodeling DOI
Lin Huang, Jie Feng,

Jiaoyang Zhu

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(18)

Published: March 9, 2023

Abstract The emerging tumor ferroptosis therapy confronts impediments of the microenvironment (TME) with weak intrinsic acidity, inadequate endogenous H 2 O , and a powerful intracellular redox balance system that eliminates toxic reactive oxygen species (ROS). Herein, strategy Fenton reaction cycloacceleration initiated by remodeling TME for magnetic resonance imaging (MRI)‐guided high‐performance tumors is proposed. synthesized nanocomplex exhibits enhanced accumulation at carbonic anhydrase IX (CAIX)‐positive based on CAIX‐mediated active targeting, increased acidification via inhibition CAIX 4‐(2‐aminoethyl) benzene sulfonamide (ABS) (remodeling TME). This accumulated + abundant glutathione in synergistically trigger biodegradation to release loaded cuprous oxide nanodots (CON), β ‐lapachon (LAP), Fe 3+ gallic acid‐ferric ions coordination networks (GF). Fenton‐like reactions are cycloaccelerated catalytic loop Fe‐Cu, LAP‐triggered nicotinamide adenine dinucleotide phosphate quinone oxidoreductase1‐mediated cycle, generating robust ROS plenitudinous lipid peroxides cells. detached GF network has improved relaxivities response TME. Therefore, promising MRI‐guided tumors.

Language: Английский

Citations

48
Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy DOI Creative Commons
Hai Xu, Dahee Kim, Yuanyuan Zhao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(27)

Published: March 29, 2024

Cancer treatment requires precise tumor-specific targeting at specific sites that allows for high-resolution diagnostic imaging and long-term patient-tailorable cancer therapy; while, minimizing side effects largely arising from non-targetability. This can be realized by harnessing exogenous remote stimuli, such as tissue-penetrative ultrasound, magnetic field, light, radiation, enable local activation therapy in deep tumors. A myriad of nanomedicines efficiently activated when the energy stimuli transformed into another type energy. review discusses control transformation targetable, efficient, therapy. Such ultrasonic, magnetic, photonic, radiative, radioactive mechanical, thermal, chemical, radiative to a variety modalities. The current article describes multimodal where serial cascade or multiple types occur. includes not only hyperthermia, radiation but also emerging thermoelectric, pyroelectric, piezoelectric therapies treatment. It illustrates resonance, fluorescence, computed tomography, photoluminescence, photoacoustic imaging-guided therapies. highlights afterglow eliminate autofluorescence sustained signal emission after excitation.

Language: Английский

Citations

27
Rational Design of Magnetic Nanoparticles as T1–T2 Dual-Mode MRI Contrast Agents DOI Creative Commons
Carlos F. G. C. Geraldes

Molecules, Journal Year: 2024, Volume and Issue: 29(6), P. 1352 - 1352

Published: March 18, 2024

Magnetic nanoparticles (MNPs), either paramagnetic or superparamagnetic depending on their composition and size, have been thoroughly studied as magnetic resonance imaging (MRI) contrast agents using in vitro vivo biomedical preclinical studies, while some are clinically used. Their properties responsible cases for high magnetization values, together with large surface area-to-volume ratios the possibility of functionalization, used MRI-based diagnostic theranostics applications. MNPs usually positive (T1) negative (T2) MRI agents, causing brightening darkening selected regions images, respectively. This review focusses recent developments optimization containing Gd, Mn, Fe other lanthanide ions which may function dual-mode T1–T2 (DMCAs). They induce same scanner upon changing its operational mode between T1-weighted T2-weighted pulse sequences. The type they depends critically r2/r1 relaxivity ratio, DMCAs should be 2–10 range values. After briefly discussing basic principles relaxation MNPs, this review, strategies rational design presented typical examples discussed, including applications: (1) use NPs a single material, Gd- Mn-based appropriate size to provide T2 T1 contrast; (2) inclusion both types materials nanoplatform by relative positions.

Language: Английский

Citations

19
Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy DOI

Wei Xu,

Guoqiang Guan, Renye Yue

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

Citations

9