BODIPY as a Multifunctional Theranostic Reagent in Biomedicine: Self‐Assembly, Properties, and Applications

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(18)

Published: Nov. 18, 2022

Abstract The use of boron dipyrromethene (BODIPY) in biomedicine is reviewed. To open, its synthesis and regulatory strategies are summarized, inspiring cutting‐edge work post‐functionalization highlighted. A brief overview assembly model BODIPY then provided: introduced as a promising building block for the formation single‐ multicomponent self‐assembled systems, including nanostructures suitable aqueous environments, thereby showing great development potential supramolecular applications. frontier progress biomedical application thereafter described, supported by examples frontiers applications BODIPY‐containing smart materials: it mainly involves materials based on blocks their assemblies fluorescence bioimaging, photoacoustic imaging, disease treatment photodynamic therapy, photothermal immunotherapy. Lastly, not only current status family field but also challenges worth considering summarized. At same time, insights into future prospects biomedically applicable provided.

Language: Английский

---

NIR Plasmonic Nanozymes: Synergistic Enhancement Mechanism and Multi‐Modal Anti‐Infection Applications of MXene/MOFs

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(8)

Published: Oct. 9, 2023

Abstract Nanozymes are considered as the promising antimicrobial agents due to enzyme‐like activity for chemo‐dynamic therapy (CDT). However, it remains a challenge develop novel nanozyme systems achieving stimuli‐responsive, and efficient catalysis with multimodal synergistic enhancement. In this work, near‐infrared (NIR) plasmonic‐enhanced photothermal performance effective applications proposed. A Ti 3 C 2 MXene/Fe‐MOFs composite (MXM) NIR CDT combined properties is successfully developed by loading metal‐organic framework (MOF) nanozymes onto MXene. The mechanism of induced localized surface plasmon resonance (LSPR)‐enhanced (PTT) well explained through activation energy ( E ), electrochemical impedance spectroscopy (EIS), X‐ray photoelectron (XPS), fluorescence analysis experiments, finite element simulation. It reveals that MXene nanosheets exhibit exciters generate hot electrons can transfer Fe‐MOFs, promoting Fenton reaction enhances CDT. While heating produced LSPR also boost Fe‐MOFs under irradiation. Both in vitro vivo experimental results demonstrate LSPR‐induced MXM system has outstanding properties, promote angiogenesis collagen deposition, leading accelerated wound healing.

Language: Английский

---

Evolution of BODIPY as triplet photosensitizers from homogeneous to heterogeneous: The strategies of functionalization to various forms and their recent applications

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 482, P. 215074 - 215074

Published: Feb. 16, 2023

Language: Английский

---

Near-infrared boron–dipyrrin (BODIPY) nanomaterials: Molecular design and anti-tumor therapeutics

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215718 - 215718

Published: Feb. 18, 2024

Language: Английский

---

Tuning Shortwave‐Infrared J‐aggregates of Aromatic Ring‐Fused Aza‐BODIPYs by Peripheral Substituents for Combined Photothermal and Photodynamic Therapies at Ultralow Laser Power

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(11)

Published: Jan. 16, 2024

Abstract Achieving photothermal therapy (PTT) at ultralow laser power density is crucial for minimizing photo‐damage and allowing higher maximum permissible skin exposure. However, this requires agents to possess not just superior conversion efficiency (PCE), but also exceptional near‐infrared (NIR) absorptivity. J ‐aggregates, exhibit a significant redshift narrower absorption peak with extinction coefficient. Nevertheless, achieving predictable ‐aggregates through molecular design remains challenge. In study, we successfully induced desirable J‐ aggregation (λ abs max : 968 nm, ϵ: 2.96×10 5 M −1 cm , λ em 972 Φ FL 6.2 %) by tuning electrostatic interactions between π‐conjugated planes manipulating surface potential of aromatic ring‐fused aza‐BODIPY dyes. Notably, controlling the preparation method encapsulating dyes into F‐127 polymer, were able selectively generate H ‐/ respectively. Furthermore, exhibited two controllable morphologies: nanospheres nanowires. Importantly, shortwave‐infrared ‐aggregated nanoparticles impressive PCE 72.9 % effectively destroyed cancer cells mice‐tumors an 0.27 W −2 (915 nm). This phototherapeutic nano‐platform, which generates behavior, can controllably form / H‐ aggregates selectable aggregate morphology, valuable paradigm developing tumor‐treatment density.

Language: Английский

---

Chiral organic nanoparticles based photodynamic antibacterial films for food preservation

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 486, P. 150361 - 150361

Published: March 12, 2024

Language: Английский

---

Supramolecular H-Aggregates of Squaraines with Enhanced Type I Photosensitization for Combined Photodynamic and Photothermal Therapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(37), P. 25671 - 25684

Published: Sept. 3, 2024

Combined photodynamic and photothermal therapy (PDT PTT) can achieve more superior therapeutic effects than the sole mode by maximizing photon utilization, but there remains a significant challenge in development of related single-molecule photosensitizers (PSs), particularly those with type I photosensitization. In this study, self-assembly squaraine dyes (SQs) is shown to be promising strategy for designing PSs combined PDT PTT, supramolecular PS (TPE-SQ7) has been successfully developed through subtle molecular design an indolenine SQ, which self-assemble into highly ordered H-aggregates aqueous solution as well nanoparticles (NPs). contrast typical quenching effect on reactive oxygen species (ROS) generation, our results encouragingly manifest that enhance ROS (

Language: Английский

---

Recent advances in near-infrared-II organic J-aggregates for bio-applications

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 528, P. 216379 - 216379

Published: Jan. 4, 2025

Language: Английский

---

Synergistic photothermal antibacterial therapy enabled by multifunctional nanomaterials: progress and perspectives

Materials Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 7(3), P. 355 - 380

Published: Dec. 16, 2022

This review summarizes the applications of multifunctional nanomaterials for synergistic photothermal antibacterial therapy and discusses mechanism two treatment methods in therapy.

Language: Английский

---

Unique Double Intramolecular and Intermolecular Exciton Coupling in Ethene‐Bridged aza‐BODIPY Dimers for High‐Efficiency Near‐Infrared Photothermal Conversion and Therapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(44)

Published: Sept. 13, 2022

Spatial electronic communications of chromophores are both theoretically and practically fascinating. Despite intramolecular or intermolecular exciton coupling was observed in multichromophoric oligomers J-aggregates, respectively, it is unusual that they occur the same molecule. Herein, ethene-bridged aza-BODIPY dimers with splitting have been developed. By encapsulating dimer into F-127 polymer, J-type aggregated nanoparticles were produced, which showed obvious dramatically redshifted absorption emission peaks at 936 1003 nm, respectively. The fabricated nanoagents high photothermal conversion ability (η=60.3 %) ultra-photostable, leading to complete tumor ablation 915 nm laser irradiation. This phototherapeutic nanoplatform through modulating intra- couplings a valuable paradigm for developing agents treatment.

Language: Английский

---