Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(29)
Published: March 20, 2024
Abstract
Chronic
diabetic
wounds
pose
significant
challenges
due
to
uncontrolled
bacterial
infections,
prolonged
inflammation,
and
impaired
angiogenesis.
The
rapid
advancement
of
photo‐responsive
antibacterial
therapy
shows
promise
in
addressing
these
complex
issues,
particularly
utilizing
2D
heterojunction
materials,
which
offer
unique
properties.
Herein,
an
situ
sprayed
Bi/BiOCl
0D/2D
composite
fibrin
gel
with
the
characteristics
formation
effective
near‐infrared
activation
is
designed
for
treatment
non‐healing
diabetes‐infected
wounds.
can
provide
protective
shielding
skin
tissues
promote
endothelial
cell
proliferation,
vascularization,
heterojunction,
its
localized
surface
plasmon
resonance
(LSPR),
overcome
wide
bandgap
limitation
BiOCl,
enhancing
generation
local
heat
reactive
oxygen
species
under
irradiation.
This
facilitates
elimination
reduced
supporting
accelerated
healing
study
underscores
potential
LSPR‐enhanced
heterojunctions
as
advanced
wound
therapies
chronic
Materials & Design,
Journal Year:
2023,
Volume and Issue:
233, P. 112231 - 112231
Published: Aug. 9, 2023
Bacterial
infection
continues
to
be
one
of
the
biggest
threats
human
health.
The
therapeutic
effect
is
significantly
reduced
as
a
result
development
super-bacteria-resistant
bacteria
due
overuse
antibiotics
for
conventional
antimicrobial
treatment.
emergence
drug-resistant
makes
it
necessary
develop
new
treatments.
Following
successful
application
photothermal
therapy
in
field
oncology
treatment,
more
and
researchers
are
applying
treatments
achieving
important
results,
especially
treatment
bacterial
infections.
As
non-invasive
anti-infection
method,
has
advantages
broad-spectrum
properties,
short
period,
low
systemic
impact.
In
PTT,
efficacy
strongly
depends
on
different
laser
properties
choice
agents
(PTAs).
purpose
this
review
discuss
most
recent
developments
nanomaterials
that
antibacterial.
We
will
delve
into
principles
spectrum
PTAs
provide
summary
current
synthesis,
classification,
structural
features,
physicochemical
antibacterial
performance
research.
challenges
future
prospects
enhanced
cytotoxicity
investigated.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1116 - 1116
Published: March 31, 2023
Multidrug-resistant
(MDR)
bacteria
are
rapidly
emerging,
coupled
with
the
failure
of
current
antibiotic
therapy;
thus,
new
alternatives
for
effectively
treating
infections
caused
by
MDR
required.
Hyperthermia-mediated
photothermal
therapy
(PTT)
and
reactive
oxygen
species
(ROS)-mediated
photodynamic
(PDT)
have
attracted
extensive
attention
as
antibacterial
therapies
owing
to
advantages
such
low
invasiveness,
toxicity,
likelihood
causing
bacterial
resistance.
However,
both
strategies
notable
drawbacks,
including
high
temperature
requirements
PTT
weak
ability
PDT-derived
ROS
penetrate
target
cells.
To
overcome
these
limitations,
a
combination
PDT
has
been
used
against
bacteria.
In
this
review,
we
discuss
unique
benefits
limitations
The
mechanisms
underlying
synergistic
effects
PTT–PDT
also
discussed.
Furthermore,
introduced
advancements
in
methods
using
nano-based
agents
treat
Finally,
highlight
existing
challenges
future
perspectives
We
believe
that
review
will
encourage
PTT-
PDT-based
research
can
be
referenced
clinical
applications.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(11), P. 9375 - 9375
Published: May 27, 2023
The
rapid
development
of
antimicrobial
resistance
due
to
broad
antibiotic
utilisation
in
the
healthcare
and
food
industries
non-availability
novel
antibiotics
represents
one
most
critical
public
health
issues
worldwide.
Current
advances
nanotechnology
allow
new
materials
address
drug-resistant
bacterial
infections
specific,
focused,
biologically
safe
ways.
unique
physicochemical
properties,
biocompatibility,
wide
range
adaptability
nanomaterials
that
exhibit
photothermal
capability
can
be
employed
develop
next
generation
photothermally
induced
controllable
hyperthermia
as
antibacterial
nanoplatforms.
Here,
we
review
current
state
art
different
functional
classes
strategies
optimise
efficiency.
recent
achievements
trends
developing
active
nanostructures,
including
plasmonic
metals,
semiconductors,
carbon-based
organic
polymers,
mechanisms
action,
anti-multidrug-resistant
bacteria
biofilm
removal,
will
discussed.
Insights
into
effect
various
factors
influencing
performance,
emphasising
structure-performance
relationship,
are
We
examine
agents'
functionalisation
for
specific
bacteria,
effects
near-infrared
light
irradiation
spectrum,
multimodal
synergistic-based
therapies
minimise
side
maintain
low
costs.
relevant
applications
presented,
such
antibiofilm
formation,
penetration
or
ablation,
nanomaterial-based
infected
wound
therapy.
Practical
employing
agents,
alone
synergistic
combination
with
other
nanomaterials,
considered.
Existing
challenges
limitations
therapy
future
perspectives
presented
from
structural,
functional,
safety,
clinical
potential
points
view.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(2)
Published: Nov. 17, 2023
Abstract
Titanium
implants
are
widely
used
;
however,
implantation
occasionally
fails
due
to
infections
during
the
surgery
or
poor
osseointegration
after
surgery.
To
solve
problem,
an
intelligent
functional
surface
on
titanium
implant
that
can
sequentially
eradicate
bacteria
biofilm
at
initial
period
and
promote
late
of
post‐surgery
time
is
designed.
Such
surfaces
be
excited
by
near
infrared
light
(NIR),
with
rare
earth
nanoparticles
upconvert
NIR
visible
range
adsorb
Au
nanoparticles,
supported
oxide
porous
film
implants.
Under
irradiation,
converts
energy
phonon
hot
electrons
lattice
vibrations,
while
former
flows
directly
contact
substance
partially
reacts
surrounding
generate
reactive
oxygen
species,
latter
leads
local
temperature
increase.
The
microbes
eradicated
treatment
in
vitro
vivo.
Additionally,
exhibits
superior
biocompatibility
for
cell
survival,
adhesion,
proliferation,
osteogenic
differentiation,
which
provides
foundation
osseointegration.
In
vivo
experiments
demonstrate
also
promoted.
This
work
thus
demonstrates
NIR‐generated
biofilms
regulate
process,
providing
new
solutions
fabricate
efficient
surfaces.
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(15), P. 2269 - 2269
Published: Aug. 7, 2023
Photothermal
therapy
has
the
advantages
of
non-invasiveness,
low
toxicity,
simple
operation,
a
broad
spectrum
antibacterial
ability,
and
non-proneness
to
developing
drug
resistance,
which
provide
it
with
irreplaceable
superiority
in
fighting
against
microbial
infection.
The
effect
photothermal
is
closely
related
choice
agent.
Conjugated
nanomaterials
are
potential
candidates
for
agents
because
their
easy
modification,
excellent
conversion
efficiency,
good
photostability,
biodegradability.
In
this
paper,
application
based
on
conjugated
antimicrobial
treatment
reviewed,
including
small
molecules,
oligomers,
polymers,
pseudo-conjugated
polymers.
At
same
time,
combination
(PTT)
photodynamic
(PDT)
briefly
introduced.
Finally,
research
status,
limitations,
prospects
using
as
discussed.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(22), P. 7674 - 7674
Published: Nov. 20, 2023
Pathogens
cause
infections
and
millions
of
deaths
globally,
while
antipathogens
are
drugs
or
treatments
designed
to
combat
them.
To
date,
multifunctional
nanomaterials
(NMs),
such
as
organic,
inorganic,
nanocomposites,
have
attracted
significant
attention
by
transforming
antipathogen
livelihoods.
They
very
small
in
size
so
can
quickly
pass
through
the
walls
bacterial,
fungal,
parasitic
cells
viral
particles
perform
their
antipathogenic
activity.
more
reactive
a
high
band
gap,
making
them
effective
than
traditional
medications.
Moreover,
due
some
pathogen’s
resistance
currently
available
medications,
performance
NMs
is
becoming
crucial.
Additionally,
prospective
properties
administration
methods,
eventually
chosen
for
cutting-edge
applications
therapies,
including
drug
diagnostic
tools
antipathogens.
Herein,
characteristics
that
facilitate
identifying
eliminating
pathogens
real-time.
This
mini-review
analyzes
antimicrobial
investigates
mode
action.
We
also
discussed
challenges
need
be
solved
utilization
Biomaterial-mediated
bone
tissue
engineering
(BTE)
offers
an
alternative,
interesting
approach
for
the
restoration
of
damaged
tissues
in
postsurgery
osteosarcoma
treatment.
This
study
focused
on
synthesizing
innovative
composite
inks,
integrating
self-assembled
silk
fibroin
(SF),
tannic
acids
(TA),
and
electrospun
bioactive
glass
nanofibers
70SiO2-25CaO-5P2O5
(BGNF).
By
synergistically
combining
unique
characteristics
these
three
components
through
self-assembly
microextrusion-based
three-dimensional
(3D)
printing,
our
goal
was
to
produce
durable
versatile
aerogel-based
3D
scaffolds.
These
scaffolds
were
designed
exhibit
hierarchical
porosity
along
with
antibacterial,
antiosteosarcoma,
regeneration
properties.
Taking
inspiration
from
mussel
foot
protein
attachment
chemistry
involving
coordination
dihydroxyphenylalanine
(DOPA)
amino
ferric
ions
(Fe3+),
we
synthesized
a
tris-complex
catecholate-iron
gel.
gel
formation
occurred
oxidized
SF
(SFO)
TA
polydopamine-modified
BGNF
(BGNF-PDA).
The
dynamic
nature
ligand–metal
bonds
within
SFO
matrix
provided
excellent
shear-thinning
properties,
allowing
SFO-TA-BGNF
complex
be
extruded
nozzle,
facilitating
printing
into
outstanding
shape
fidelity.
Moreover,
developed
aerogels
exhibited
multifaceted
features,
including
NIR-triggered
photothermal
antibacterial
vitro
antiosteosarcoma
In
studies
showcased
their
biocompatibility
osteogenic
features
as
seeded
cells
successfully
differentiated
osteoblasts,
promoting
21
days.
Through
comprehensive
characterizations
biological
validations,
scaffold
demonstrated
promise
exceptional
platform
concurrent
cancer
therapy,
setting
stage
potential
clinical
application.
