Localized Surface Plasmon Resonance‐Enhanced Photocatalytic Antibacterial of In Situ Sprayed 0D/2D Heterojunction Composite Hydrogel for Treating Diabetic Wound DOI Creative Commons
Zhengao Wang, Wei Li,

Youzhun Fan

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(29)

Published: March 20, 2024

Abstract Chronic diabetic wounds pose significant challenges due to uncontrolled bacterial infections, prolonged inflammation, and impaired angiogenesis. The rapid advancement of photo‐responsive antibacterial therapy shows promise in addressing these complex issues, particularly utilizing 2D heterojunction materials, which offer unique properties. Herein, an situ sprayed Bi/BiOCl 0D/2D composite fibrin gel with the characteristics formation effective near‐infrared activation is designed for treatment non‐healing diabetes‐infected wounds. can provide protective shielding skin tissues promote endothelial cell proliferation, vascularization, heterojunction, its localized surface plasmon resonance (LSPR), overcome wide bandgap limitation BiOCl, enhancing generation local heat reactive oxygen species under irradiation. This facilitates elimination reduced supporting accelerated healing study underscores potential LSPR‐enhanced heterojunctions as advanced wound therapies chronic

Language: Английский

Photothermal antibacterial materials to promote wound healing DOI

Luning He,

Donghua Di,

Xinhui Chu

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 180 - 200

Published: Sept. 27, 2023

Language: Английский

Citations

143

Nanomaterials-based photothermal therapies for antibacterial applications DOI Creative Commons
Hao Liu, Fei Xing, Yuxi Zhou

et al.

Materials & Design, Journal Year: 2023, Volume and Issue: 233, P. 112231 - 112231

Published: Aug. 9, 2023

Bacterial infection continues to be one of the biggest threats human health. The therapeutic effect is significantly reduced as a result development super-bacteria-resistant bacteria due overuse antibiotics for conventional antimicrobial treatment. emergence drug-resistant makes it necessary develop new treatments. Following successful application photothermal therapy in field oncology treatment, more and researchers are applying treatments achieving important results, especially treatment bacterial infections. As non-invasive anti-infection method, has advantages broad-spectrum properties, short period, low systemic impact. In PTT, efficacy strongly depends on different laser properties choice agents (PTAs). purpose this review discuss most recent developments nanomaterials that antibacterial. We will delve into principles spectrum PTAs provide summary current synthesis, classification, structural features, physicochemical antibacterial performance research. challenges future prospects enhanced cytotoxicity investigated.

Language: Английский

Citations

84

Friends against the Foe: Synergistic Photothermal and Photodynamic Therapy against Bacterial Infections DOI Creative Commons
Atanu Naskar, Kwang-sun Kim

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1116 - 1116

Published: March 31, 2023

Multidrug-resistant (MDR) bacteria are rapidly emerging, coupled with the failure of current antibiotic therapy; thus, new alternatives for effectively treating infections caused by MDR required. Hyperthermia-mediated photothermal therapy (PTT) and reactive oxygen species (ROS)-mediated photodynamic (PDT) have attracted extensive attention as antibacterial therapies owing to advantages such low invasiveness, toxicity, likelihood causing bacterial resistance. However, both strategies notable drawbacks, including high temperature requirements PTT weak ability PDT-derived ROS penetrate target cells. To overcome these limitations, a combination PDT has been used against bacteria. In this review, we discuss unique benefits limitations The mechanisms underlying synergistic effects PTT–PDT also discussed. Furthermore, introduced advancements in methods using nano-based agents treat Finally, highlight existing challenges future perspectives We believe that review will encourage PTT- PDT-based research can be referenced clinical applications.

Language: Английский

Citations

49

A hyaluronic acid hydrogel as a mild photothermal antibacterial, antioxidant, and nitric oxide release platform for diabetic wound healing DOI
Changyuan He, Siwei Bi,

Rongya Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 543 - 555

Published: May 11, 2024

Language: Английский

Citations

34

Trends in Photothermal Nanostructures for Antimicrobial Applications DOI Open Access
Violeta Dediu, Jana Ghițman, Grațiela Grădișteanu Pîrcălăbioru

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9375 - 9375

Published: May 27, 2023

The rapid development of antimicrobial resistance due to broad antibiotic utilisation in the healthcare and food industries non-availability novel antibiotics represents one most critical public health issues worldwide. Current advances nanotechnology allow new materials address drug-resistant bacterial infections specific, focused, biologically safe ways. unique physicochemical properties, biocompatibility, wide range adaptability nanomaterials that exhibit photothermal capability can be employed develop next generation photothermally induced controllable hyperthermia as antibacterial nanoplatforms. Here, we review current state art different functional classes strategies optimise efficiency. recent achievements trends developing active nanostructures, including plasmonic metals, semiconductors, carbon-based organic polymers, mechanisms action, anti-multidrug-resistant bacteria biofilm removal, will discussed. Insights into effect various factors influencing performance, emphasising structure-performance relationship, are We examine agents' functionalisation for specific bacteria, effects near-infrared light irradiation spectrum, multimodal synergistic-based therapies minimise side maintain low costs. relevant applications presented, such antibiofilm formation, penetration or ablation, nanomaterial-based infected wound therapy. Practical employing agents, alone synergistic combination with other nanomaterials, considered. Existing challenges limitations therapy future perspectives presented from structural, functional, safety, clinical potential points view.

Language: Английский

Citations

42

Photoelectrons Sequentially Regulate Antibacterial Activity and Osseointegration of Titanium Implants DOI
Yufei Tang, Kai Wang,

Bingfeng Wu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Nov. 17, 2023

Abstract Titanium implants are widely used ; however, implantation occasionally fails due to infections during the surgery or poor osseointegration after surgery. To solve problem, an intelligent functional surface on titanium implant that can sequentially eradicate bacteria biofilm at initial period and promote late of post‐surgery time is designed. Such surfaces be excited by near infrared light (NIR), with rare earth nanoparticles upconvert NIR visible range adsorb Au nanoparticles, supported oxide porous film implants. Under irradiation, converts energy phonon hot electrons lattice vibrations, while former flows directly contact substance partially reacts surrounding generate reactive oxygen species, latter leads local temperature increase. The microbes eradicated treatment in vitro vivo. Additionally, exhibits superior biocompatibility for cell survival, adhesion, proliferation, osteogenic differentiation, which provides foundation osseointegration. In vivo experiments demonstrate also promoted. This work thus demonstrates NIR‐generated biofilms regulate process, providing new solutions fabricate efficient surfaces.

Language: Английский

Citations

26

Recent Progress of Photothermal Therapy Based on Conjugated Nanomaterials in Combating Microbial Infections DOI Creative Commons
Yue Zhao, Yi Wang, Xiaoyu Wang

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(15), P. 2269 - 2269

Published: Aug. 7, 2023

Photothermal therapy has the advantages of non-invasiveness, low toxicity, simple operation, a broad spectrum antibacterial ability, and non-proneness to developing drug resistance, which provide it with irreplaceable superiority in fighting against microbial infection. The effect photothermal is closely related choice agent. Conjugated nanomaterials are potential candidates for agents because their easy modification, excellent conversion efficiency, good photostability, biodegradability. In this paper, application based on conjugated antimicrobial treatment reviewed, including small molecules, oligomers, polymers, pseudo-conjugated polymers. At same time, combination (PTT) photodynamic (PDT) briefly introduced. Finally, research status, limitations, prospects using as discussed.

Language: Английский

Citations

25

Recent Updates on Multifunctional Nanomaterials as Antipathogens in Humans and Livestock: Classification, Application, Mode of Action, and Challenges DOI Creative Commons
Samreen Sadiq, Iltaf Khan,

Zhenyu Shen

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(22), P. 7674 - 7674

Published: Nov. 20, 2023

Pathogens cause infections and millions of deaths globally, while antipathogens are drugs or treatments designed to combat them. To date, multifunctional nanomaterials (NMs), such as organic, inorganic, nanocomposites, have attracted significant attention by transforming antipathogen livelihoods. They very small in size so can quickly pass through the walls bacterial, fungal, parasitic cells viral particles perform their antipathogenic activity. more reactive a high band gap, making them effective than traditional medications. Moreover, due some pathogen’s resistance currently available medications, performance NMs is becoming crucial. Additionally, prospective properties administration methods, eventually chosen for cutting-edge applications therapies, including drug diagnostic tools antipathogens. Herein, characteristics that facilitate identifying eliminating pathogens real-time. This mini-review analyzes antimicrobial investigates mode action. We also discussed challenges need be solved utilization

Language: Английский

Citations

24

Chondroitin sulfate/silk fibroin hydrogel incorporating graphene oxide quantum dots with photothermal-effect promotes type H vessel-related wound healing DOI

Tanjun Deng,

Wenli Lu,

Xiaoxian Zhao

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 121972 - 121972

Published: Feb. 23, 2024

Language: Английский

Citations

16

Designing of a Multifunctional 3D-Printed Biomimetic Theragenerative Aerogel Scaffold via Mussel-Inspired Chemistry: Bioactive Glass Nanofiber-Incorporated Self-Assembled Silk Fibroin with Antibacterial, Antiosteosarcoma, and Osteoinductive Properties DOI

Nahal Abie,

Ceyda Ünlü,

Ana Rita Pinho

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Biomaterial-mediated bone tissue engineering (BTE) offers an alternative, interesting approach for the restoration of damaged tissues in postsurgery osteosarcoma treatment. This study focused on synthesizing innovative composite inks, integrating self-assembled silk fibroin (SF), tannic acids (TA), and electrospun bioactive glass nanofibers 70SiO2-25CaO-5P2O5 (BGNF). By synergistically combining unique characteristics these three components through self-assembly microextrusion-based three-dimensional (3D) printing, our goal was to produce durable versatile aerogel-based 3D scaffolds. These scaffolds were designed exhibit hierarchical porosity along with antibacterial, antiosteosarcoma, regeneration properties. Taking inspiration from mussel foot protein attachment chemistry involving coordination dihydroxyphenylalanine (DOPA) amino ferric ions (Fe3+), we synthesized a tris-complex catecholate-iron gel. gel formation occurred oxidized SF (SFO) TA polydopamine-modified BGNF (BGNF-PDA). The dynamic nature ligand–metal bonds within SFO matrix provided excellent shear-thinning properties, allowing SFO-TA-BGNF complex be extruded nozzle, facilitating printing into outstanding shape fidelity. Moreover, developed aerogels exhibited multifaceted features, including NIR-triggered photothermal antibacterial vitro antiosteosarcoma In studies showcased their biocompatibility osteogenic features as seeded cells successfully differentiated osteoblasts, promoting 21 days. Through comprehensive characterizations biological validations, scaffold demonstrated promise exceptional platform concurrent cancer therapy, setting stage potential clinical application.

Language: Английский

Citations

12