Defect Engineering in Nanocatalysts: From Design and Synthesis to Applications

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: Feb. 13, 2024

Abstract Defect engineering is an emerging technology for tailoring nanomaterials' characteristics and catalytic performance in various applications. Recently, defect‐engineered nanoparticles have emerged as highly researched materials applications because of their exceptional redox reaction capabilities physicochemical optical properties. The properties nanomaterials can be readily adjusted by controlling the nature concentration defects within nanoparticles, avoiding need intricate design strategies. This review investigates defect nanocatalysts, including design, fabrication, Initially, categories strategies nanomaterial impacts on nanocatalysts' electronic surface properties, activity, selectivity, stability are summarized. Then, processes uses, gas sensing, hydrogen (H 2 ) evolutions, water splitting, reductions carbon dioxide (CO nitrogen to value‐aided products, pollutant degradation, biomedical (oncotherapy, antibacterial wound healing, biomolecular sensing) discussed. Finally, limitations prospective paths allowing logical optimization nanocatalytic long‐term efficient also examined. comprehensive gives unique insights into current state nanocatalysts inspires future research exploiting shortcomings improve customize performance.

Language: Английский

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Nanocatalysts for modulating antitumor immunity: fabrication, mechanisms and applications

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(5), P. 2643 - 2692

Published: Jan. 1, 2024

This review discusses the structures and engineering strategies of nanocatalysts, highlighting their underlying mechanisms applications in cancer immunotherapy.

Language: Английский

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Oxygen vacancies in piezocatalysis: A critical review

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150480 - 150480

Published: March 16, 2024

Language: Английский

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Doping Engineering of Piezo‐Sonocatalytic Nanocoating Confer Dental Implants with Enhanced Antibacterial Performances and Osteogenic Activity

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)

Published: Jan. 30, 2024

Abstract Rescuing dental implants from plaque‐induced infection and implementing effective plaque control methods in a limited oral environment pose challenges for modern dentistry. To address this issue, Al ion doped strontium titanate/titanium dioxide nanotubes (Al‐SrTiO 3 /TiO 2 nanotubes, Al‐STNT) are designed as an ultrasound‐responsive nanocoating immobilized on the Ti implant surface. Introducing 3+ ions into inorganic sonosensitive SrTiO heterojunction induces oxygen vacancies disrupts lattice of . By overcoming bandgap barrier through ultrasonic stimulated piezoelectric effect, Al‐STNT produces more reactive species (ROS). In sonodynamic therapy (SDT) process, stimulus abundant ROS efficiently disrupting bacteria biofilm inhibiting metabolism. Moreover, specific nanoscale coating endows with osteogenic activity, facilitating formation rigid osseointegration between surface alveolar bone. mimicking human rats, demonstrates optimal postimplant while retaining its antibacterial ability sonosensitizer. Thanks to portability ultrasound instrument stability implant‐based sonosensitizer, strategy presents attractive option patients self‐treat secure long‐term success their implants.

Language: Английский

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Oxygen‐Vacancy‐Engineered W₁₈O_49−x Nanobrush with a Suitable Band Structure for Highly Efficient Sonodynamic Therapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(9)

Published: Jan. 12, 2024

With the rapid development of external minimally invasive or noninvasive therapeutic modalities, ultrasound-based sonodynamic therapy (SDT) is a new alternative for treating deep tumors. However, inadequate sonosensitizer efficiency and poor biosecurity limit clinical applications. In this study, we prepared an oxygen-vacancy-engineered W

Language: Английский

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Traditional Herb (Moxa) Modified Zinc Oxide Nanosheets for Quick, Efficient and High Tissue Penetration Therapy of Fungal Infection

ACS Nano, Journal Year: 2024, Volume and Issue: 18(6), P. 5180 - 5195

Published: Feb. 1, 2024

Fungal infection possesses the characteristics of high invasion depth and easy formation a biofilm under skin, which greatly hinders treatment process. Here, traditional Chinese medicine moxa is carbonized modified with zinc oxide (ZnO) nanosheets to synthesize moxa@ZnO (CMZ) dual response properties yellow light (YL) ultrasound (US) for synergistic antifungal therapy. CMZ narrow bandgap can respond long-wavelength YL that highly safe helpful skin repair. Simultaneously, piezoelectric effect further enhance photocatalytic efficiency stimulation US tissue penetration. Gene mechanism investigation indicates when exposed irradiation, CMZ-based therapy adjust expression genes associated fungal virulence, metabolic activity, mycelial growth development, thus efficaciously eradicating planktonic Candida albicans (C. albicans) mature biofilm. Importantly, despite 1.00 cm thick barrier, rapidly eliminate 99.9% C. within 4 min, showing satisfactory deep fungicidal efficacy. The in vivo therapeutic this strategy demonstrated both open wound cutaneous tests, speaking dramatically better efficacy than fungicide ketoconazole (KTZ).

Language: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

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Enhanced Photocatalytic Efficiency Through Oxygen Vacancy‐Driven Molecular Epitaxial Growth of Metal–Organic Frameworks on BiVO₄

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Efficient charge separation at the semiconductor/cocatalyst interface is crucial for high‐performance photoelectrodes, as it directly influences availability of surface charges solar water oxidation. However, establishing strong molecular‐level connections between these interfaces to achieve superior interfacial quality presents significant challenges. This study introduces an innovative electrochemical etching method that generates a high concentration oxygen vacancy sites on BiVO 4 surfaces (Ov‐BiVO ), enabling interactions with oxygen‐rich ligands MIL‐101. reduces formation energy and promotes conformal growth . The Ov‐BiVO /MIL‐101 composite exhibits ideal interface, achieving impressive photocurrent density 5.91 mA cm −2 1.23 V RHE , along excellent stability. high‐performing photoanode enables unbiased tandem device /MIL‐101‐Si cell system, solar‐to‐hydrogen efficiency 4.33%. integration mitigates states enhances internal electric field, facilitating migration photogenerated holes into MIL‐101 overlayer. process activates highly efficient Fe catalytic sites, which effectively adsorb molecules, lowering barrier oxidation improving kinetics. Further studies confirm broad applicability vacancy‐induced molecular epitaxial in various MOFs, offering valuable insights defect engineering optimizing enhancing photocatalytic activity.

Language: Английский

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Strategies to Reverse Hypoxic Tumor Microenvironment for Enhanced Sonodynamic Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 6, 2023

Sonodynamic therapy (SDT) has emerged as a highly effective modality for the treatment of malignant tumors owing to its powerful penetration ability, noninvasiveness, site-confined irradiation, and excellent therapeutic efficacy. However, traditional SDT, which relies on oxygen availability, often fails generate satisfactory level reactive species because widespread issue hypoxia in tumor microenvironment solid tumors. To address this challenge, various approaches are developed alleviate improve efficiency SDT. These strategies aim either increase supply or prevent exacerbation, thereby enhancing effectiveness In view this, current review provides an overview these their underlying principles, focusing circulation from consumption external supply. The detailed research examples conducted using combination with SDT also discussed. Additionally, highlights future prospects challenges hypoxia-alleviated along key considerations clinical applications. include development efficient delivery systems, accurate methods detection, exploration therapies optimize outcomes.

Language: Английский

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Defect Engineering in Biomedical Sciences

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: June 4, 2023

Abstract With the promotion of nanochemistry research, large numbers nanomaterials have been applied in vivo to produce desirable cytotoxic substances response endogenous or exogenous stimuli for achieving disease‐specific therapy. However, performance is a critical issue that difficult improve and optimize under biological conditions. Defect‐engineered nanoparticles become most researched hot materials biomedical applications recently due their excellent physicochemical properties, such as optical properties redox reaction capabilities. Importantly, can be easily adjusted by regulating type concentration defects without requiring other complex designs. Therefore, this tutorial review focuses on defect engineering briefly discusses classification, introduction strategies, characterization techniques. Several representative defective are especially discussed order reveal relationship between properties. A series disease treatment strategies based engineered summarized. By summarizing design application nanomaterials, simple but effective methodology provided researchers therapeutic effects nanomaterial‐based platforms from science perspective.

Language: Английский

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