Plasmonic nanobipyramids with photo-enhanced catalytic activity under near-infrared II window for effective treatment of breast cancer

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 170, P. 496 - 506

Published: Sept. 1, 2023

Language: Английский

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Cu9S5/coal gasification fine slag composites for electromagnetic wave absorption using compositional synergies and interface engineering strategies

Materials Research Bulletin, Journal Year: 2024, Volume and Issue: 174, P. 112720 - 112720

Published: Feb. 6, 2024

Language: Английский

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Fluorescent Microneedle‐Based Theranostic Patch for Naked‐Eye Monitoring and On‐Demand Photo‐Therapy of Bacterial Biofilm Infections

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Abstract The eradication of recalcitrant bacterial biofilm infections necessitates the development speedy diagnostics and prompt therapeutics. However, constructing a portable versatile platform that enables in situ monitoring accompanied by potent antibiofilm activity remains challenging. To address this conundrum, microneedle theranostic patch (Mn: C/G@MN) is devised incorporating an innovative biophotonic probe (manganese‐doped carbon dots, Mn: CDs) into methacrylated gelatin for visual infection on‐demand photo‐therapy. C/G@MN penetrates physical barrier biofilms to track their acidic microenvironment, exhibiting visualized fluorescence color change (from yellow turquoise) enable naked‐eye infection. Furthermore, can drastically eradicate through synergy local hyperthermia hydroxyl radical (•OH) storm under 808 nm near‐infrared light illumination, enabling damaging extracellular polymeric substances (EPS) matrix disperse subsequently kill detached bacteria. Both vitro vivo findings authenticate monitoring‐and‐treating be achieved. Moreover, conducive suppressing inflammatory responses, expediting collagen deposition, stimulating angiogenesis, accelerating biofilm‐infected wound healing. As envisaged, work highlights potential such application integrated theranostics

Language: Английский

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Highly Crystalline Copper Aluminum-Layered Double Hydroxides with Intrinsic Fenton-Like Catalytic Activity for Robust Oral Health Management

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(23), P. 10691 - 10704

Published: May 28, 2024

As the main challenge of dental healthcare, oral infectious diseases are highly associated with colonization pathogenic microbes. However, current antibacterial treatments in field stomatology still lack a facile, safe, and universal approach. Herein, we report controllable synthesis copper aluminum-layered double hydroxides (CuAl-LDHs) high Fenton-like catalytic activity, which can be utilized treatment negligible side effects. Our strategy efficiently avoid unwanted doping other divalent metal ions Cu-contained LDHs result formation binary CuAl-LDHs crystallinity purity. Evidenced by experimental theoretical results, exhibit excellent ability toward ·OH generation presence H2O2 hold strong affinity bacteria, endowing them great sterilization against both Gram-positive Gram-negative bacteria. expected, these provide outstanding for mucosal infection periodontitis promoting wound healing remodeling periodontal microenvironment. Moreover, toxicity investigation demonstrates overall safety. Accordingly, study not only provides convenient economic treating but also extends development novel LDH-based Fenton or reagents further biomedical applications.

Language: Английский

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Density Functional Theory Calculations to Increase the Efficiency of Oxygen Electrode Catalysts from Ytterbium Single Atom Catalysts Using Nitrogen Solid Supports

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(13), P. 15526 - 15534

Published: June 28, 2024

The research and design of oxygen electrode catalysts are great significance for achieving carbon peak neutrality goals. In this study, a comprehensive including detailed stability, adsorption properties, electronic characteristics, activity center configuration ytterbium single-atom (YbNx-gra) loaded on two-dimensional nanomaterials under acidic conditions, was conducted according to density functional theory calculations. results indicated that with the increase nitrogen content, efficiency using solid supports improved. There several good linear relationships between free energy intermediates, such as ΔGOH* ΔGOOH*, ΔGOH*, ΔGO*. This provides basis drawing volcano maps rapid prediction highly active catalysts. Due reaction selectivity catalysts, O* intermediates 2OH* accompany catalytic reaction. For activity, YbN4-II catalyst showed lowest overpotential ORR which ηORR = 0.42 V. particular, ηOER YbN3-IV were low 0.58 0.41 V, respectively. plots indicate feasibility some YbNx-gra making them promising candidates

Language: Английский

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Fluorescent Iron-Doped Polymer Dot Nanozyme-Based Cascade System for Dual-Mode Detection of Acetylcholinesterase Activity and Its Inhibitors

Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

The advancement of acetylcholinesterase (AChE) activity and its inhibitor assays is crucial for clinical diagnosis, drug screening, environmental monitoring. A nanozyme-mediated cascade reaction system could offer promising prospects a wide range applications in such biosensing; however, the creation nanozyme catalysts with diverse functionalities remains significant challenge. Herein, we have proposed multifunctional iron-doped polymer dots (Fe-PDs) possessing excellent fluorescence peroxidase (POD)-mimicking activity. Notably, Fe-PDs capable catalyzing H

Language: Английский

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Dual enzyme-mimicking carbon dots for enhanced antibacterial activity

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(37), P. 8916 - 8925

Published: Jan. 1, 2023

Carbon dot (CD)-based nanozymes have great potential in antibacterial applications. In order to achieve enhanced broad-spectrum capacity, we synthesized Co-doped drug-based CDs (Co-Lvx-CDs) using levofloxacin and vitamin B12 as precursors by mimicking the catalysis of activity natural enzymes. The Co-Lvx-CDs retained not only effective functional groups traditional antibiotic but also achieved oxidase-like peroxidase-like activities generate reactive oxygen species (ROS) through Co doping. Additionally, had superb fluorescence properties could be applied information encryption. were validated a bactericidal effect against Gram-positive -negative bacteria, compensating for limitations while having sterilization ability. Importantly, proposed provide new idea design multifunctional CD-based with preconceived outcomes.

Language: Английский

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Single‐atom metal‐nitrogen‐carbon catalysts energize single molecule detection for biosensing

InfoMat, Journal Year: 2023, Volume and Issue: 5(6)

Published: April 24, 2023

Abstract Biosensors featuring single molecule detection present huge opportunities as well challenges in food safety inspection, disease diagnosis, and environmental monitoring. Single‐molecule is largely lacking of high enough activity, precision selectivity, understanding the exact operating mechanism. Single‐atom catalysts (SACs), especially those metals‐nitrogen‐carbon that mimic natural metalloenzyme structure, with well‐defined metal atom bond configurations, level molecular easy fabrication, endow detections practical‐use feasibilities. The recent advances single‐atom also new pathways key mechanism understandings. In this short review, we will first visit brief history advantages SACs have been explored only recently for molecule‐scale biosensors, where they are analogous differentiated from nanozymes metalloenzymes. Their applications electrochemical, photochemical, photoelectrochemical sensors then discussed comprehensively by focusing on different sensing modes achieving local coordination‐modulated signal amplifications. Finally, identify faced these SACs‐based further development biosensors. image

Language: Английский

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Precise Modulation of the Coordination Environment of Single Cu Site Catalysts to Regulate the Peroxymonosulfate Activation Pathway for Water Remediation

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: 63(20), P. 9307 - 9314

Published: May 8, 2024

Single atom site catalysts (SACs) with atomically dispersed active sites can be expected to potential ideal for accurately modulating the persulfate activation pathway during water remediation process because of their well-defined structure and maximum metallic utilization. In this paper, a series Cu SACs different coordination environments were synthesized elaborately regulate peroxymonosulfate in AOPs clarify species generation transformation remediation. The degradation rate constants (kobs) Cu-N2, Cu-N3, Cu-N4 0.028, 0.021, 0.015 min–1, respectively. Cu-N2 exhibited noticeable enhanced performance bisphenol A (BPA) removal from compared that Cu-Nx (x = 3, 4), accompanied by (PMS) variation. As shown experimental theoretical results, PMS was transformed ROS electron transfer nitrogen numbers decreasing 4 2, which ascribed uneven charge distribution as well upshifts d-band center, thereby optimized activation. Furthermore, increasing vacancies single also result more unoccupied 3d orbitals atoms SACs, improving intermediates' (PMS BPA) adsorption–desorption BPA performance. These findings provided beneficial approach number regulation

Language: Английский

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Elucidating Manganese Single‐Atom Doping: Strategies for Fluorescence Enhancement in Water‐Soluble Red‐Emitting Carbon Dots and Applications for FL/MR Dual Mode Imaging

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract The absence of the enhancement fluorescence in carbon dots (CDs) through doping with transition metal atoms (TMAs) hinders advancement multi‐modal bio‐imaging CDs high photoluminescence quantum yield (PLQY). Herein, Mn‐atomically‐doped R‐CDs (R‐Mn‐CDs) a PLQY 41.3% water is presented, enabling efficient vivo dual‐mode fluorescence/magnetic resonance (MR) imaging. comprehensive characterizations reveal that incorporation Mn leads to Mn‐N 2 O coordinating structure, resulting five significant effects: an increase sp conjugation domains, reduction band gap, decreased oxidation level, photo‐excited electron numbers, and suppression non‐radiative relaxation pathways. Collectively, these factors contribute remarkable R‐Mn‐CDs. Additionally, also endows R‐Mn‐CDs superior MR imaging capabilities due to, which highlights their promising prospect as dual‐modal platform for fluorescence/MR Furthermore, findings indicate introduction various TMAs, such Mn, Zn, Ni, Cu, can universally improve water‐soluble construction TMAs─O bonds. This research provides valuable theoretical insights into mechanisms underlying induced by TMAs offers guidance future design CDs.

Language: Английский

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