Optimized strategies of ROS-based nanodynamic therapies for tumor theranostics

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122391 - 122391

Published: Nov. 15, 2023

Language: Английский

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Regulating Photosensitizer Metabolism with DNAzyme-Loaded Nanoparticles for Amplified Mitochondria-Targeting Photodynamic Immunotherapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(14), P. 13746 - 13759

Published: July 12, 2023

Mitochondria-specific photosensitizer accumulation is highly recommended for photodynamic therapy and mitochondrial DNA (mtDNA) oxidative damage-based innate immunotherapy but remains challenging. 5-Aminolevulinic acid (ALA), precursor of protoporphyrin IX (PpIX), can induce the exclusive biosynthesis PpIX in mitochondria. Nevertheless, its effect limited by intracellular biotransformation ALA tumors. Here, we report a metabolism-regulating strategy using ALA/DNAzyme-co-loaded nanoparticles (ALA&Dz@ZIF-PEG) mitochondria-targeting immunotherapy. The zeolitic imidazolate framework (ZIF-8) be disassembled release large amounts zinc ions (Zn2+) within tumor cells. Notably, Zn2+ relieve hypoxia promoting conversion to PpIX. Moreover, acts as cofactor rationally designed DNAzyme silencing excessive ferrochelatase (FECH; which catalyzes into photoinactive Heme), cooperatively mitochondria via "open source reduced expenditure" manner. Subsequently, effects derived from lead damage mtDNA activate immune response. In addition, released further enhances mtDNA/cGAS-STING pathway mediated immunity. ALA&Dz@ZIF-PEG system induced 3 times more than ALA-loaded liposome, significantly enhancing regression xenograft models.

Language: Английский

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Recent progress in metal-organic cages for biomedical application: Highlighted research during 2018–2023

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215570 - 215570

Published: Nov. 24, 2023

Language: Английский

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Microemulsion-Assisted Self-Assembly of Indium Porphyrin Photosensitizers with Enhanced Photodynamic Therapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3161 - 3172

Published: Jan. 16, 2024

Designing and constructing supramolecular photosensitizer nanosystems with highly efficient photodynamic therapy (PDT) is vital in the nanomedical field. Despite recent advances forming well-defined superstructures, relationship between molecular arrangement nanostructures properties has rarely been involved, which crucial for developing stable photosensitizers PDT. In this work, through a microemulsion-assisted self-assembly approach, indium porphyrin (InTPP) was used to fabricate series of morphology-controlled self-assemblies, including nanorods, nanospheres, nanoplates, nanoparticles. They possessed structure-dependent 1O2 generation efficiency. Compared other three nanostructures, InTPP nanorods featuring strong π–π stacking, J-aggregation, high crystallinity proved be much more at singlet oxygen (1O2) production. Also, theoretical modeling photophysical experiments verified that intermolecular stacking could cause decreased singlet–triplet energy gap (ΔEST) compared monomer. This played key role enhancing intersystem crossing facilitating generation. Both vitro vivo demonstrated trigger cell apoptosis tumor ablation upon laser irradiation (635 nm, 0.1 W/cm2) exhibited negligible dark toxicity phototoxicity. Thus, strategy provides an avenue designing high-performance beyond.

Language: Английский

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A NIR‐Light‐Activated and Lysosomal‐Targeted Pt(II) Metallacycle for Highly Potent Evoking of Immunogenic Cell Death that Potentiates Cancer Immunotherapy of Deep‐Seated Tumors

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(37)

Published: May 22, 2024

Though platinum (Pt)-based complexes have been recently exploited as immunogenic cell death (ICD) inducers for activating immunotherapy, the effective activation of sufficient immune responses with minimal side effects in deep-seated tumors remains a formidable challenge. Herein, we propose first example near-infrared (NIR) light-activated and lysosomal targeted Pt(II) metallacycle (1) supramolecular ICD inducer. 1 synergistically potentiates immunomodulatory response via multiple-regulated approaches, involving NIR light excitation, boosted reactive oxygen species (ROS) generation, good selectivity between normal tumor cells, enhanced penetration/retention capabilities. Specifically, has excellent depth-activated ROS production (~7 mm), accompanied by strong anti-diffusion anti-ROS quenching ability. In vitro experiments demonstrate that exhibits significant cellular uptake generation cells well respective multicellular spheroids. Based on these advantages, induces more efficient an ultralow dose (i.e., 5 μM) compared clinical inducer-oxaliplatin (300 μM). vivo, vaccination further serves potent inducer through eliciting CD8

Language: Английский

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Hypoxia-accelerating pyroptosis nanoinducers for promoting image-guided cancer immunotherapy

Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122610 - 122610

Published: May 11, 2024

Language: Английский

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Protein nanoparticles as drug delivery systems for cancer theranostics

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 429 - 444

Published: June 8, 2024

Language: Английский

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Enhancing the Photosensitivity of Hypocrellin A by Perylene Diimide Metallacage-Based Host–Guest Complexation for Photodynamic Therapy

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 25, 2024

The development of supramolecular hosts which can efficiently encapsulate photosensitizers to improve the photodynamic efficacy holds great promise for cancer therapy. Here, we report two perylene diimide-based metallacages that form stable host-guest complexes with planar conjugated molecules including polycyclic aromatic hydrocarbons and (hypocrellin A). Such complexation not only prevents aggregation in aqueous environments, but also offers fluorescence resonance energy transfer (FRET) from metallacage further singlet oxygen generation (Φ

Language: Английский

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Carboxylesterase Activatable Molecular Probe for Personalized Treatment Guidance by Analyte‐Induced Molecular Transformation

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(31)

Published: May 10, 2024

Abstract Accurate visualization of tumor microenvironment is great significance for personalized medicine. Here, we develop a near‐infrared (NIR) fluorescence/photoacoustic (FL/PA) dual‐mode molecular probe (denoted as NIR−CE) distinguishing tumors based on carboxylesterase (CE) level by an analyte‐induced transformation (AIMT) strategy. The recognition moiety CE activity the acetyl unit NIR−CE, generating pre‐product, NIR−CE−OH, which undergoes spontaneous hydrogen atom exchange between nitrogen atoms in indole group and phenol hydroxyl group, eventually transforming into NIR−CE−H. In cellular experiments vivo blind studies, human hepatoma cells with high were successfully distinguished both NIR FL PA imaging. Our findings provide new imaging strategy treatment guidance.

Language: Английский

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Development of a hybrid rhodamine-hydrazine NIR fluorescent probe for sensitive detection and imaging of peroxynitrite in necrotizing enterocolitis model

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 152, P. 107729 - 107729

Published: Aug. 22, 2024

Language: Английский

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