Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(26), P. 6285 - 6304
Published: Jan. 1, 2024
Phototherapy,
including
photothermal
therapy
(PTT)
and
photodynamic
(PDT),
has
the
advantages
of
spatiotemporal
selectivity,
non-invasiveness,
negligible
drug
resistance.
Phototherapy
been
approved
for
treating
superficial
epidermal
tumors.
However,
its
therapeutic
efficacy
is
limited
by
hypoxic
tumor
microenvironment
highly
expressed
heat
shock
protein.
Moreover,
poor
tissue
penetration
focused
irradiation
laser
region
in
phototherapy
make
deep
tissues
metastatic
tumors
challenging.
Combination
strategies,
which
integrate
each
treatment
overcome
their
disadvantages,
can
significantly
improve
efficacy.
Recently,
many
combination
strategies
have
reported.
Our
study
summarizes
used
combining
with
other
cancer
treatments
such
as
chemotherapy,
immunotherapy,
sonodynamic
therapy,
gas
starvation
chemodynamic
therapy.
Some
research
cases
were
selected
to
analyze
effect,
delivery
platform
feature,
synergetic
anticancer
mechanisms.
additional
are
summarized
tables.
This
review
provides
strong
evidence
that
phototherapy-based
enhance
effect
compared
alone.
Additionally,
challenges
future
perspectives
associated
these
combinational
therapies
discussed.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(14), P. 13746 - 13759
Published: July 12, 2023
Mitochondria-specific
photosensitizer
accumulation
is
highly
recommended
for
photodynamic
therapy
and
mitochondrial
DNA
(mtDNA)
oxidative
damage-based
innate
immunotherapy
but
remains
challenging.
5-Aminolevulinic
acid
(ALA),
precursor
of
protoporphyrin
IX
(PpIX),
can
induce
the
exclusive
biosynthesis
PpIX
in
mitochondria.
Nevertheless,
its
effect
limited
by
intracellular
biotransformation
ALA
tumors.
Here,
we
report
a
metabolism-regulating
strategy
using
ALA/DNAzyme-co-loaded
nanoparticles
(ALA&Dz@ZIF-PEG)
mitochondria-targeting
immunotherapy.
The
zeolitic
imidazolate
framework
(ZIF-8)
be
disassembled
release
large
amounts
zinc
ions
(Zn2+)
within
tumor
cells.
Notably,
Zn2+
relieve
hypoxia
promoting
conversion
to
PpIX.
Moreover,
acts
as
cofactor
rationally
designed
DNAzyme
silencing
excessive
ferrochelatase
(FECH;
which
catalyzes
into
photoinactive
Heme),
cooperatively
mitochondria
via
"open
source
reduced
expenditure"
manner.
Subsequently,
effects
derived
from
lead
damage
mtDNA
activate
immune
response.
In
addition,
released
further
enhances
mtDNA/cGAS-STING
pathway
mediated
immunity.
ALA&Dz@ZIF-PEG
system
induced
3
times
more
than
ALA-loaded
liposome,
significantly
enhancing
regression
xenograft
models.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(4), P. 3161 - 3172
Published: Jan. 16, 2024
Designing
and
constructing
supramolecular
photosensitizer
nanosystems
with
highly
efficient
photodynamic
therapy
(PDT)
is
vital
in
the
nanomedical
field.
Despite
recent
advances
forming
well-defined
superstructures,
relationship
between
molecular
arrangement
nanostructures
properties
has
rarely
been
involved,
which
crucial
for
developing
stable
photosensitizers
PDT.
In
this
work,
through
a
microemulsion-assisted
self-assembly
approach,
indium
porphyrin
(InTPP)
was
used
to
fabricate
series
of
morphology-controlled
self-assemblies,
including
nanorods,
nanospheres,
nanoplates,
nanoparticles.
They
possessed
structure-dependent
1O2
generation
efficiency.
Compared
other
three
nanostructures,
InTPP
nanorods
featuring
strong
π–π
stacking,
J-aggregation,
high
crystallinity
proved
be
much
more
at
singlet
oxygen
(1O2)
production.
Also,
theoretical
modeling
photophysical
experiments
verified
that
intermolecular
stacking
could
cause
decreased
singlet–triplet
energy
gap
(ΔEST)
compared
monomer.
This
played
key
role
enhancing
intersystem
crossing
facilitating
generation.
Both
vitro
vivo
demonstrated
trigger
cell
apoptosis
tumor
ablation
upon
laser
irradiation
(635
nm,
0.1
W/cm2)
exhibited
negligible
dark
toxicity
phototoxicity.
Thus,
strategy
provides
an
avenue
designing
high-performance
beyond.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(37)
Published: May 22, 2024
Though
platinum
(Pt)-based
complexes
have
been
recently
exploited
as
immunogenic
cell
death
(ICD)
inducers
for
activating
immunotherapy,
the
effective
activation
of
sufficient
immune
responses
with
minimal
side
effects
in
deep-seated
tumors
remains
a
formidable
challenge.
Herein,
we
propose
first
example
near-infrared
(NIR)
light-activated
and
lysosomal
targeted
Pt(II)
metallacycle
(1)
supramolecular
ICD
inducer.
1
synergistically
potentiates
immunomodulatory
response
via
multiple-regulated
approaches,
involving
NIR
light
excitation,
boosted
reactive
oxygen
species
(ROS)
generation,
good
selectivity
between
normal
tumor
cells,
enhanced
penetration/retention
capabilities.
Specifically,
has
excellent
depth-activated
ROS
production
(~7
mm),
accompanied
by
strong
anti-diffusion
anti-ROS
quenching
ability.
In
vitro
experiments
demonstrate
that
exhibits
significant
cellular
uptake
generation
cells
well
respective
multicellular
spheroids.
Based
on
these
advantages,
induces
more
efficient
an
ultralow
dose
(i.e.,
5
μM)
compared
clinical
inducer-oxaliplatin
(300
μM).
vivo,
vaccination
further
serves
potent
inducer
through
eliciting
CD8
Nano-Micro Letters,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: June 25, 2024
The
development
of
supramolecular
hosts
which
can
efficiently
encapsulate
photosensitizers
to
improve
the
photodynamic
efficacy
holds
great
promise
for
cancer
therapy.
Here,
we
report
two
perylene
diimide-based
metallacages
that
form
stable
host-guest
complexes
with
planar
conjugated
molecules
including
polycyclic
aromatic
hydrocarbons
and
(hypocrellin
A).
Such
complexation
not
only
prevents
aggregation
in
aqueous
environments,
but
also
offers
fluorescence
resonance
energy
transfer
(FRET)
from
metallacage
further
singlet
oxygen
generation
(Φ
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(31)
Published: May 10, 2024
Abstract
Accurate
visualization
of
tumor
microenvironment
is
great
significance
for
personalized
medicine.
Here,
we
develop
a
near‐infrared
(NIR)
fluorescence/photoacoustic
(FL/PA)
dual‐mode
molecular
probe
(denoted
as
NIR−CE)
distinguishing
tumors
based
on
carboxylesterase
(CE)
level
by
an
analyte‐induced
transformation
(AIMT)
strategy.
The
recognition
moiety
CE
activity
the
acetyl
unit
NIR−CE,
generating
pre‐product,
NIR−CE−OH,
which
undergoes
spontaneous
hydrogen
atom
exchange
between
nitrogen
atoms
in
indole
group
and
phenol
hydroxyl
group,
eventually
transforming
into
NIR−CE−H.
In
cellular
experiments
vivo
blind
studies,
human
hepatoma
cells
with
high
were
successfully
distinguished
both
NIR
FL
PA
imaging.
Our
findings
provide
new
imaging
strategy
treatment
guidance.
Small,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Oct. 23, 2024
Abstract
Over
the
past
decade,
precision
medicine
has
garnered
increasing
attention,
making
significant
strides
in
discovering
new
therapeutic
drugs
and
mechanisms,
resulting
notable
achievements
symptom
alleviation,
pain
reduction,
extended
survival
rates.
However,
limited
target
specificity
of
primary
inter‐individual
differences
have
often
necessitated
high‐dosage
strategies,
leading
to
challenges
such
as
restricted
deep
tissue
penetration
rates
systemic
side
effects.
Material
science
advancements
present
a
promising
avenue
for
these
issues.
By
leveraging
distinct
internal
features
diseased
regions
application
specific
external
stimuli,
responsive
materials
can
be
tailored
achieve
targeted
delivery,
controllable
release,
biochemical
reactions.
This
review
aims
highlight
latest
stimuli‐responsive
their
potential
medicine.
Initially,
we
introduce
disease‐related
stimuli
capable
elucidating
reaction
principles
functional
groups.
Subsequently,
provide
detailed
analysis
representative
pre‐clinical
across
various
clinical
applications,
including
enhancements
treatment
cancers,
injury
diseases,
inflammatory
infection
high‐throughput
microfluidic
biosensors.
Finally,
discuss
some
challenges,
off‐target
effects,
long‐term
impacts
nano‐materials,
ethical
concerns,
offer
insights
into
future
perspectives
materials.