Published: Jan. 1, 2024
Language: Английский
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 19, 2024
Abstract The global crisis of bacterial infections is exacerbated by the escalating threat microbial antibiotic resistance. Nanozymes promise to provide ingenious solutions. Here, we reported a homogeneous catalytic structure Pt nanoclusters with finely tuned metal–organic framework (ZIF‐8) channel structures for treatment infected wounds. Catalytic site normalization showed that active aggregates fine‐tuned pore modifications had capacity 14.903×10 5 min −1 , which was 18.7 times higher than particles in monodisperse state ZIF‐8 (0.793×10 ). In situ tests revealed change from homocleavage heterocleavage hydrogen peroxide at interface nanozyme one key reasons improvement activity. Density‐functional theory and kinetic simulations reaction jointly determine role center substrate together. Metabolomics analysis developed nanozyme, working conjunction reactive oxygen species, could effectively block energy metabolic pathways within bacteria, leading spontaneous apoptosis rupture. This pioneering study elucidates new ideas regulation artificial enzyme activity provides perspectives development efficient substitutes.
Language: Английский
Citations
38
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)
Published: Aug. 22, 2024
Single-atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)-mediated cancer therapy. However, the high energy barriers of reaction intermediates on single-atom sites and overexpressed antioxidants tumor microenvironment restrict amplification oxidative stress, resulting unsatisfactory therapeutic efficacy. Herein, we report a multi-enzyme mimetic MoCu dual-atom nanozyme (MoCu DAzyme) various catalytic active sites, which exhibits peroxidase, oxidase, glutathione (GSH) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mimicking activities. Compared Mo SAzyme, introduction Cu atoms, formation synergetic effects among enhance substrate adsorption reduce barrier, thereby endowing DAzyme stronger Benefiting from above enzyme-like activities, can not only generate multiple ROS, but also deplete GSH block its regeneration to trigger cascade stress. Additionally, strong optical absorption near-infrared II bio-window endows remarkable photothermal conversion performance. Consequently, achieves high-efficiency synergistic treatment incorporating collaborative therapy This work will advance applications DAzymes provide valuable insights for nanocatalytic
Language: Английский
Citations
19
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
This review provides a comprehensive summary of the dysregulation redox metabolism in cancer cells and advantages latest advances nanomaterial-assisted metabolic regulation therapy.
Language: Английский
Citations
12
Theranostics, Journal Year: 2024, Volume and Issue: 14(15), P. 5826 - 5852
Published: Jan. 1, 2024
Ferroptosis, an iron-dependent form of regulated cell death, is emerging as a crucial regulator human physiology and pathology. Increasing evidence showcases reciprocal relationship between ferroptosis dysregulated metabolism, propagating pathogenic vicious cycle that exacerbates pathology diseases, particularly metabolic disorders. Consequently, there rapidly growing interest in developing ferroptosis-based therapeutics. Therefore, comprehensive understanding the intricate interplay metabolism could provide invaluable resource for mechanistic insight therapeutic development. In this review, we summarize important substances associated pathways initiation progression, outline cascade responses disease development, overview roles mechanisms introduce methods detection, discuss perspectives ferroptosis, which collectively aim to illustrate view basic, translational, clinical science.
Language: Английский
Citations
7
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
Nanozymes, nanomaterials with intrinsic enzyme activity, have garnered significant attention in recent years due to their catalytic abilities comparable natural enzymes, cost-effectiveness, high activities, and stability against environmental fluctuations. As functional analogs of nanozymes participate various critical metabolic processes, including glucose metabolism, lactate the maintenance redox homeostasis, all which are essential for normal cellular functions. However, disruptions these pathways frequently promote tumorigenesis progression, making them potential therapeutic targets. While several therapies targeting tumor metabolism currently clinical or preclinical stages, efficacy requires further enhancement. Consequently, that target regarded as a promising strategy. Despite extensive studies investigating application relevant reviews relatively scarce. This article first introduces physicochemical properties biological behaviors nanozymes. Subsequently, we analyze role explore applications therapy. In conclusion, this review aims foster innovative research related fields advance development nanozyme-based strategies cancer diagnostics therapeutics.
Language: Английский
Citations
1
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
Dual-atom nanozymes (DAzymes) have garnered considerable attention as catalysts for reactive oxygen species (ROS)-based therapies, effectively leveraging ROS generation within the tumor microenvironment (TME). Herein, we introduce FeMn-NCe DAzymes, which are meticulously engineered enhanced peroxidase (POD)-mimetic activity and potent radiosensitization to advance radioimmunotherapy. Density functional theory (DFT) calculations reveal that DAzymes lower energy barrier increase substrate affinity, enabling highly efficient catalytic performance. Within TME, these efficiently convert overexpressed hydrogen peroxide (H2O2) into hydroxyl radicals (•OH), potentially activating cGAS-STING immune pathway. This POD-mimetic catalysis is further accelerated under X-ray irradiation, significantly enhancing radiosensitization. Additionally, a uniform coating of ultrasmall gold nanoparticles on enhances absorption cancer cells. The incorporation STING agonist diABZI onto induces long-term antitumor immunity, reprograms immunosuppressive suppresses growth metastasis following single low-dose treatment. work highlights valuable strategy designing radiodynamic immunotherapy.
Language: Английский
Citations
1
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 242, P. 114094 - 114094
Published: July 14, 2024
Language: Английский
Citations
4
Progress in Materials Science, Journal Year: 2024, Volume and Issue: unknown, P. 101375 - 101375
Published: Sept. 1, 2024
Language: Английский
Citations
3
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 7, 2025
Uricase replacement therapy is a promising approach for managing hyperuricemia and gout but hindered by challenges such as short blood circulation time, reduced catalytic activity, excessive hydrogen peroxide (H2O2) production. These limitations necessitate innovative strategies to enhance therapeutic efficacy safety. We designed synthesized RBC@SeMSN@Uri, red cell-coated biomimetic self-cascade bioreactor, which encapsulates uricase (Uri) selenium-based nano-scavenger (SeMSN) within RBC membranes. This design aims reduce immunogenicity, extend systemic circulation, maintain enzymatic activity. In vitro assays were conducted evaluate biocompatibility, anti-inflammatory effects, oxidative stress protection. vivo experiments in models assessed efficacy, biodistribution, biosafety. RBC@SeMSN@Uri effectively degraded uric acid (UA) into allantoin converted H2O2 water, preventing damage inflammation. demonstrated excellent biocompatibility H2O2-induced inflammatory responses compared free uricase. vivo, the bioreactor prolonged significantly levels, alleviated kidney damage, mitigated symptoms of gout. It also targeted inflamed joints, reducing swelling inflammation gouty arthritis models. study presents novel strategy enzyme By integrating membranes, addresses key traditional therapies, offering enhanced stability, superior efficacy. platform holds potential broader applications protein or antibody delivery therapies other diseases.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 19, 2025
Abstract Transition metals especially Fe‐based catalysts representing an emerging type of enzyme‐mimicking materials are great interest in biosensing and therapy fields. However, the poor affinity toward H 2 O limits their catalytic activity while high‐precise controllable regulation engineering nanozymes remains a challenge. Herein, facile approach is presented to fabricate FeCu/hemin aerogel with self‐supported, hierarchically porous network structures through second metal center surface ligand engineering, achieving sequential ‐affinity amplification. Excitingly, for exhibits 14.03‐fold enhancement than that Fe particle, accompanied 5.88‐fold efficiency ( K cat / m ) increase FeCu. Mechanism studies suggest Cu hemin modifications upshift d ‐band from −0.49 −0.17 eV promote electron transfer process, thus facilitating dissociation . Importantly, allow highly sensitive detection norfloxacin low limit 72 n Notably, it shows remarkable inhibition on bacterial growth vitro vivo no apparent side effects. Therefore, this work not only sheds light rational design active stable properties, but also offers new prospects tuning boost enzyme‐mimic activity.
Language: Английский
Citations
0