Progress in Retinal and Eye Research,
Journal Year:
2024,
Volume and Issue:
99, P. 101234 - 101234
Published: Jan. 2, 2024
The
cornea,
as
a
dynamic
and
responsive
tissue,
constantly
interacts
with
mechanical
forces
in
order
to
maintain
its
structural
integrity,
barrier
function,
transparency
refractive
power.
Cells
within
the
cornea
sense
respond
various
that
fundamentally
regulate
their
morphology
fate
development,
homeostasis
pathophysiology.
Corneal
cells
also
dynamically
extracellular
matrix
(ECM)
ensuing
cell-ECM
crosstalk
serves
signaling
reservoir
providing
biophysical
biochemical
cues
corneal
cells.
Here
we
provide
an
overview
of
mechanotransduction
pathways
then
delve
into
recent
advances
mechanobiology,
focusing
on
interplay
between
responses
epithelial,
stromal,
endothelial
We
identify
species-specific
differences
biomechanics
facilitate
identification
optimal
animal
models
study
wound
healing,
disease,
novel
therapeutic
interventions.
Finally,
key
knowledge
gaps
opportunities
mechanobiology
are
pressing
for
research
community
address
especially
pertinent
domains
limbal
stem
cell
deficiency,
keratoconus
Fuchs'
dystrophy.
By
furthering
our
understanding
can
contextualize
discoveries
regarding
diseases
well
innovative
treatments
them.
Mechanisms of Ageing and Development,
Journal Year:
2024,
Volume and Issue:
220, P. 111959 - 111959
Published: June 29, 2024
Oligodendrocyte
precursor
cells
(OPCs)
comprise
5-8
%
of
the
adult
glial
cell
population
and
stand
out
as
most
proliferative
type
in
central
nervous
system
(CNS).
OPCs
are
responsible
for
generating
oligodendrocytes
(OLs),
myelinating
CNS.
However,
OPC
functions
decline
we
age,
resulting
impaired
differentiation
inadequate
remyelination.
This
review
explores
cellular
molecular
changes
associated
with
aging,
their
impact
on
functionality.
Furthermore,
it
examines
aging
within
context
multiple
sclerosis
Alzheimer's
disease,
both
neurodegenerative
conditions
wherein
aged
exacerbate
disease
progression
by
impeding
Moreover,
various
pharmacological
interventions
targeting
pathways
related
to
senescence
discussed
potential
strategies
rejuvenate
OPCs.
Enhancing
our
understanding
mechanisms
holds
promise
developing
new
therapies
improve
remyelination
repair
age-related
disorders.
Brain and Behavior,
Journal Year:
2023,
Volume and Issue:
13(9)
Published: June 27, 2023
Abstract
Background
The
brain
is
a
highly
mechanosensitive
organ,
and
changes
in
the
mechanical
properties
of
tissue
influence
many
physiological
pathological
processes.
Piezo
type
ion
channel
component
1
(Piezo1),
protein
found
metazoans,
expressed
involved
sensing
microenvironment.
Numerous
studies
have
shown
that
Piezo1‐mediated
mechanotransduction
closely
related
to
glial
cell
activation
neuronal
function.
However,
precise
role
Piezo1
requires
further
elucidation.
Objective
This
review
first
discusses
roles
regulating
functions
variety
cells,
then
briefly
assesses
impact
on
progression
dysfunctional
disorders.
Conclusions
Mechanical
signaling
contributes
significantly
regulates
processes
such
as
differentiation,
migration,
axon
guidance,
neural
regeneration,
oligodendrocyte
myelination.
Additionally,
plays
significant
normal
aging
injury,
well
development
various
diseases,
including
demyelinating
Alzheimer's
disease,
tumors.
Investigating
pathophysiological
mechanisms
through
which
affects
function
will
give
us
novel
entry
point
for
diagnosis
treatment
numerous
diseases.
Mechanobiology in Medicine,
Journal Year:
2023,
Volume and Issue:
1(2), P. 100022 - 100022
Published: Aug. 24, 2023
The
use
of
mechanical
biology
and
biomechanical
signal
transduction
is
a
novel
approach
to
attenuate
biological
tissue
degeneration,
whereas
the
understanding
specific
cellular
responses
critical
delineate
underlying
mechanism.
Dynamic
signals
with
optimized
loading
signals,
i.e.,
intensity
frequency,
have
been
shown
potential
regulate
adaptation
regeneration.
Mechanotransduction
pathways
are
great
interest
in
elucidating
how
produce
such
observed
effects,
including
reduced
mass
loss,
increased
healing
formation,
cell
differentiation.
While
mechanobiology
cells
tissues
recorded
literature,
its
application
disease
mechanism
treatment
under
development.
We
would
congratulate
opening
Mechanobiology
Medicine
journal,
which
provides
an
effective
platform
for
advanced
research
basic
mechanotransduction
translation
diagnosis,
therapeutics,
beyond.
This
review
aims
develop
molecular
processes
regeneration,
may
provide
new
insights
into
mechanisms
promotion
healing.
Particular
attention
allotted
loading,
pathways,
as
associated
(e.g.,
Piezo
ion
channels
Wnt
signaling),
immune-response,
neuron
development,
repair,
stem
Altogether,
these
discussed
data
highlight
complex
yet
highly
coordinated
process
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
The
recent
identification
of
Piezo
ion
channels
demonstrating
a
mechano-sensitive
impact
on
neurons
revealed
distinct
Piezo-1
and
2
types.
While
predominates
in
linked
to
non-sensory
stimulation,
such
as
pressure
blood
vessels,
Piezo-2
sensory
touch.
have
major
bidirectional
transient
receptor
potential
(TRP)
channels,
TRPs
also
neurotransmitter
release.
Particularly
existent
dorsal
root
ganglion
(DRG)
neurons,
which
are
located
nerve
endings,
is
key
DRG
activator.
Subsequent
findings
been
vital
medical
haptic
technology
developments,
tandem
with
breakthroughs
the
emerging
neurology
subfield
connectomics
plus
AI
developments.
Included
this
review
historical
overview,
interrelationship
TRPs,
inclusive
TRPV1/TRPV8,
rehab
technology,
focus
use
stroke
survivor
pain
mitigation,
development
patch
aimed
at
alleviating
and/or
anxiety.
Neurogenic
resulting
from
hyperalgesia/allodynia
survivors
target
for
drugs
haptics
reduction;
patients
experiencing
neuropathic
or
psychosomatic
other
prime
targets.
Increased
knowledge
may
promote
more
precisely
targeted
therapeutic
Channels,
Journal Year:
2025,
Volume and Issue:
19(1)
Published: April 13, 2025
Microglia,
the
central
nervous
system
(CNS)
resident
immune
cells,
are
pivotal
in
regulating
neurodevelopment,
maintaining
neural
homeostasis,
and
mediating
neuroinflammatory
responses.
Recent
research
has
highlighted
importance
of
mechanotransduction,
process
by
which
cells
convert
mechanical
stimuli
into
biochemical
signals,
microglial
activity.
Among
various
mechanosensitive
channels,
Piezo1
emerged
as
a
key
player
microglia,
influencing
their
behavior
under
both
physiological
pathological
conditions.
This
review
focuses
on
expression
role
particularly
context
neuroinflammation
tumorigenesis.
We
explore
how
mediates
responses
to
changes
within
CNS,
such
alterations
tissue
stiffness
fluid
shear
stress,
common
conditions
like
multiple
sclerosis,
Alzheimer's
disease,
cerebral
ischemia,
gliomas.
The
also
discusses
potential
targeting
for
therapeutic
intervention,
given
its
involvement
modulation
activity
impact
disease
progression.
integrates
findings
from
recent
studies
provide
comprehensive
overview
Piezo1's
mechanistic
pathways
function.
These
insights
illuminate
new
possibilities
developing
targeted
therapies
addressing
CNS
disorders
with
mechanics.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
176, P. 116837 - 116837
Published: May 29, 2024
Hyperglycemic
stress
can
directly
lead
to
neuronal
damage.
The
mechanosensitive
ion
channel
PIEZO1
be
activated
in
response
hyperglycemia,
but
its
role
hyperglycemic
neurotoxicity
is
unclear.
of
was
explored
by
constructing
a
mouse
model
and
high-glucose
HT22
cell
model.
results
showed
that
significantly
upregulated
high
glucose
stress.
In
vitro
experiments
have
shown
induces
changes
morphology
membrane
tension,
key
mechanism
for
activation.
addition,
upregulates
serum/glucocorticoid-regulated
kinase-1
(SGK1)
activates
through
the
Ca
Abstract
Background
As
physical
signals,
mechanical
cues
regulate
the
neural
cells
in
brain.
The
mechanosensitive
channels
(MSCs)
perceive
and
transduce
them
by
permeating
specific
ions
or
molecules
across
plasma
membrane,
finally
trigger
a
series
of
intracellular
bioelectrical
biochemical
signals.
Emerging
evidence
supports
that
wide‐distributed,
high‐expressed
MSCs
like
Piezo1
play
important
roles
several
neurophysiological
processes
neurological
disorders.
Aim
s
To
systematically
conclude
functions
brain
provide
novel
mechanobiological
perspective
for
diseases.
Method
We
summarized
detected
research
progress
on
functional
physiological
conditions.
then
concluded
pathological
activation
downstream
pathways
triggered
two
categories
diseases,
neurodegenerative
diseases
place‐occupying
damages.
Finally,
we
outlined
methods
manipulating
discussed
their
medical
potential
with
some
crucial
outstanding
issues.
Results
present
underlying
common
mechanisms
different
acting
as
“transportation
hubs”
to
distinct
signal
patterns:
upstream
pathways.
Manipulating
is
feasible
alter
complicated
processes,
providing
promising
targets
clinical
treatment.
Conclusions
Recent
provides
insight
into
mediated
inspire
wide
range
therapeutic
potentials
targeted
