Published: Jan. 1, 2024
Language: Английский
Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)
Published: June 12, 2024
Abstract In addition to its recognized role in providing structural support, bone plays a crucial maintaining the functionality and balance of various organs by secreting specific cytokines (also known as osteokines). This reciprocal influence extends these modulating homeostasis development, although this aspect has yet be systematically reviewed. review aims elucidate bidirectional crosstalk, with particular focus on osteokines. Additionally, it presents unique compilation evidence highlighting critical function extracellular vesicles (EVs) within bone-organ axes for first time. Moreover, explores implications crosstalk designing implementing bone-on-chips assembloids, underscoring importance comprehending interactions advancing physiologically relevant vitro models. Consequently, establishes robust theoretical foundation preventing, diagnosing, treating diseases related axis from perspective cytokines, EVs, hormones, metabolites.
Language: Английский
Citations
14
Bone Research, Journal Year: 2025, Volume and Issue: 13(1)
Published: March 17, 2025
Abstract Following the discovery of bone as an endocrine organ with systemic influence, bone-brain interaction has emerged a research hotspot, unveiling complex bidirectional communication between and brain. Studies indicate that brain can influence each other’s homeostasis via multiple pathways, yet there is dearth systematic reviews in this area. This review comprehensively examines interactions across three key areas: bone-derived factors on function, effects brain-related diseases or injuries (BRDI) health, concept skeletal interoception. Additionally, discusses innovative approaches biomaterial design inspired by mechanisms, aiming to facilitate through materiobiological aid treatment neurodegenerative bone-related diseases. Notably, integration artificial intelligence (AI) highlighted, showcasing AI’s role expediting formulation effective targeted strategies. In conclusion, offers vital insights into mechanisms suggests advanced harness these clinical practice. These offer promising avenues for preventing treating impacting skeleton brain, underscoring potential interdisciplinary enhancing human health.
Language: Английский
Citations
1
Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)
Published: Oct. 21, 2024
Abstract Severe tissue defects present formidable challenges to human health, persisting as major contributors mortality rates. The complex pathological microenvironment, particularly the disrupted immune landscape within these defects, poses substantial hurdles existing regeneration strategies. However, emergence of nanobiotechnology has opened a new direction in immunomodulatory nanomedicine, providing encouraging prospects for and restoration. This review aims gather recent advances nanomedicine foster regeneration. We begin by elucidating distinctive features local microenvironment defective tissues its crucial role Subsequently, we explore design functional properties nanosystems. Finally, address clinical translation development, aiming propose potent approach enhance through synergistic modulation integration.
Language: Английский
Citations
8
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133622 - 133622
Published: Aug. 1, 2024
Language: Английский
Citations
7
Biomaterials, Journal Year: 2024, Volume and Issue: 309, P. 122585 - 122585
Published: April 27, 2024
Language: Английский
Citations
6
Tissue Engineering Part B Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
Language: Английский
Citations
0
Acta Neurologica Belgica, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
Language: Английский
Citations
0
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116699 - 116699
Published: May 4, 2024
Osteoporosis (OP) constitutes a significant health concern that profoundly affects individuals' quality of life. Bisphosphonates, conventional pharmaceuticals widely employed in OP treatment, encounter limitations related to inadequate drug targeting and short effective duration, thereby compromising their clinical efficacy. The burgeoning field nanotechnology has witnessed the development application diverse functional nanosystems designed for treatment. Owing bone tissue affinity bisphosphonates, these are modified address shortcomings associated with traditional delivery. In this review, we explore potential bisphosphonate-modified as promising strategy addressing osteoporotic conditions. With modification, exhibit targeted reversible effect on remodeling, presenting solution enhance precision synthesis methods, physicochemical properties, vitro/in vivo performance comprehensively examined review. Through thorough analysis recent advances accomplishments field, aim provide insights into applications future directions remodeling.
Language: Английский
Citations
2
Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1399 - 1399
Published: June 24, 2024
Traumatic brain injury (TBI) and long bone fractures are a common pattern in polytrauma patients modulate each other’s healing process. As only limited number of studies have investigated both traumatic sites, we tested the hypothesis that brain–bone mutually impacts neuro- osteopathological outcomes. Adult female C57BL/6N mice were subjected to controlled cortical impact (CCI), and/or osteosynthetic stabilized femoral fracture (FF), or sham surgery. Neuromotor behavioral impairments assessed by neurological severity score, open field test, rotarod elevated plus maze test. Brain tissues processed 42 days after trauma. CCI+FF had increased formation as compared FF mRNA expression sialoprotein (BSP). Bone did not aggravate neuropathology neuroinflammation cerebral lesion size, hippocampal integrity, astrocyte microglia activation, gene expression. Behavioral assessments demonstrated an overall impaired recovery neuromotor function persistent abnormalities anxiety-related behavior mice. This study shows enhanced healing, anxiety-like model. However, TBI-evoked neuropathology, suggesting existence outcome-relevant mechanisms independent extent structural damage neuroinflammation.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0