Assessment of Antihyperglycemic and Modulatory Effects of trans‐Ferulic Acid on Glibenclamide and Metformin: In Vivo and Molecular Docking Studies DOI
Md. Sakib Al Hasan, Md. Shimul Bhuia, Salehin Sheikh

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(14)

Published: April 1, 2025

Abstract Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin secretion, resistance, or both. trans ‐Ferulic acid (TFA) has several biological activities, including sedative, anxiolytic, anti‐inflammatory, and so on. However, there no in vivo silico study on the antihyperglycemic activity of TFA. This assessed antidiabetic potential TFA its modulatory effect glibenclamide (GLI) metformin (MET) through hypoglycemic tests mice molecular docking targeting glucose metabolism proteins. (25, 50, 75 mg/kg, p.o.) was tested glucose‐induced hyperglycemic alongside GLI (10 MET (100 p.o.), with blood levels (BGLs) monitored. significantly ( p < 0.05) reduced BGLs dose‐dependent manner, mg/kg dose achieving 30.99% reduction at 180 min, compared 52.04% 55.27% (MET). Combination therapy (TFA‐50+GLI‐10 TFA‐50+MET‐100) further enhanced glucose‐lowering effects, TFA‐50+GLI‐10 showing highest (58.90%). In analysis revealed that exhibited elevated binding affinities complex I (−6.4 kcal/mol) mitochondrial glycerol‐3‐phosphate dehydrogenase (−6.8 kcal/mol). These findings suggest significant potential, supporting role regulation.

Language: Английский

Assessment of Antidiarrheal Effect of Oleuropein Through µ‐Oopioid Receptor Interaction Pathway: In Vivo and in Silico Studies DOI Open Access
Nishat Jahan,

Manoj Mandal,

Imam Hossen Rakib

et al.

Drug Development Research, Journal Year: 2025, Volume and Issue: 86(1)

Published: Feb. 1, 2025

Oleuropein (OLP), a compound predominantly found in olive leaves, has been known for its numerous biological activities, including antioxidant, anti-inflammatory, and antimicrobial properties. Despite established therapeutic potential, role treating diarrhea not extensively explored. This study aimed to evaluate the antidiarrheal effects of OLP an vivo model investigate molecular interactions using silico docking studies, pharmacokinetic predictions, toxicity analysis. In study, castor oil was used induce 3-day-old chicks, effect tested at doses 10 20 mg/kg. The standard drug, loperamide (LOP) 3 mg/kg, comparison. results showed that both significantly (p < 0.05) reduced diarrheal secretions increased latency, with mg/kg dose demonstrating most effective results. combination (20 mg/kg) LOP (3 further enhanced effect. revealed exhibited strong binding affinities (BAs) key receptor, μ-opioid receptor associated diarrhea, while higher BA (‒8.9 kcal/mol) compared (‒8.7 kcal/mol). Pharmacokinetic analysis favorable properties studies no acute toxicity, LD50 2000 conclusion, findings suggest possesses significant potential through interaction, positioning it as promising natural agent managing diarrhea. Further are warranted fully elucidate mechanisms action clinical applicability.

Language: Английский

Citations

2
Tangeretin enhances sedative activity of diazepam in Swiss mice through GABAA receptor interaction: In vivo and in silico approaches DOI
Md. Sakib Al Hasan, Md. Shimul Bhuia, Raihan Chowdhury

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 572, P. 1 - 10

Published: March 5, 2025

Language: Английский

Citations

2
Possible hemoglobin enhancing effect of phytol in methotrexate-induced folate deficient Swiss albino mice: In vivo and in silico studies DOI Creative Commons
Muhammad Torequl Islam, Raihan Chowdhury, Md. Sakib Al Hasan

et al.

Pharmaceutical Science Advances, Journal Year: 2024, Volume and Issue: 2, P. 100043 - 100043

Published: June 14, 2024

The diterpenoid phytol is evidently acting against anemia in experimental animals. However, the molecular mechanisms behind this issue are yet to be discovered. This study aimed evaluate phytol's effect on methotrexate-induced folate-deficient animals through vivo and silico studies. For this, a total of thirty adult male Swiss albino mice were randomly divided into six different groups, namely normal control (vehicle), negative (folate deficiency inducer, methotrexate 3 ​mg/kg), standard (folic acid 1.5 two test groups comprising 25 50 ​mg/kg, combined group composed highest doses phytol. Except for vehicle, all treated with first days (once/day) induce folate deficiency. Then followed by respective treatment once day days. Hemoglobin (Hb) level was measured from peripheral blood (by tail cutting) 1st (before treatment), 4th (after 7th treatment). On other hand, computational studies performed PyMol, PyRex, Discovery Studio, complementary tools. Findings suggest that significantly (p ​< ​0.05) augmented Hb levels altered reduction dose-dependently. combination also animals; however, its slightly lower than individual (standard test). In study, showed good binding capacity (binding energy: −7.0 ​kcal/mol) dihydrofolate reductase (DHFR). conclusion, may act altering methotrexate's impacts animals, possibly interacting DHFR. Further validated research necessary develop as an anti-anemia drug near future.

Language: Английский

Citations

13
Gigantol, a promising natural drug for inflammation: a literature review and computational based study DOI
Raihan Chowdhury, Md. Shimul Bhuia, Asraful Islam Rakib

et al.

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 17

Published: April 16, 2024

Gigantol, a bibenzyl compound extracted from various medicinal plants, has shown number of biological activities, making it an attractive candidate for potential medical applications. This systematic review aims to shed light on gigantol's promising role in inflammation treatment and its underlying mechanisms. Gigantol exhibits anti-inflammatory properties pre-clinical pharmacological test systems. It effectively reduced the levels pro-inflammatory markers arachidonic acid metabolites through pathways, such as NF-κB, AKT, PI3K, JNK/cPLA2/12-LOX. The in-silico investigations demonstrated that MMP-13 enzyme served most target gigantol with highest binding affinity (docking score = −8.8 kcal/mol). Encouragingly, absorption, distribution, metabolism, excretion, toxicity (ADMET) analysis confirmed compatibility necessary physiochemical, pharmacokinetic, properties, bolstering drug candidate. well-documented could be agent treating near future.

Language: Английский

Citations

11
A mechanistic insight into the anticancer potentials of resveratrol: Current perspectives DOI
Md. Shimul Bhuia, Raihan Chowdhury,

Mst. Asma Akter

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 3877 - 3898

Published: May 20, 2024

Abstract Resveratrol is a widely recognized polyphenolic phytochemical found in various plants and their fruits, such as peanuts, grapes, berry fruits. It renowned for its several health advantages. The well known anticancer properties, substantial amount of clinical evidence has also established promise chemotherapeutic agent. This study focuses on assessing the properties resveratrol gaining insight into underlying molecular mechanisms. evaluates biopharmaceutical, toxicological characteristics, utilization to determine suitability further development reliable Therefore, information about preclinical studies was collected from different electronic databases up‐to‐date (2018–2023). Findings this revealed that potent therapeutic benefits against cancers involving mechanisms, induction oxidative stress, cytotoxicity, inhibition cell migration invasion, autophagy, arresting S phase cycle, apoptotic, anti‐angiogenic, antiproliferative effects by regulating pathways including PI3K/AKT, p38/MAPK/ERK, NGFR‐AMPK‐mTOR, so on. However, compound poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation resveratrol). Clinical application showed types cancer with no serious adverse effects. We suggest additional extensive check efficacy, safety, long‐term hazards. could involve larger number samples establish drug treatment cancer.

Language: Английский

Citations

10
Sedative Effects of Daidzin, Possibly Through the GABAA Receptor Interaction Pathway: In Vivo Approach with Molecular Dynamic Simulations DOI
Muhammad Torequl Islam, Md. Shimul Bhuia, Salehin Sheikh

et al.

Journal of Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 74(3)

Published: Sept. 4, 2024

Language: Английский

Citations

10
Allium cepa bioactive phytochemicals as potent ALK (Anaplastic lymphoma kinase) inhibitors and therapeutic agents against non-small cell lung cancer (NSCLC): a computational Study DOI
Md. Sakib Al Hasan, Emon Mia,

Noshin Tasnim Yana

et al.

Pharmacological Research - Natural Products, Journal Year: 2024, Volume and Issue: unknown, P. 100124 - 100124

Published: Nov. 1, 2024

Language: Английский

Citations

9
GabaAergic sedative prospection of sclareol-linalool co-treatment: An antagonistic intervention through in vivo and in silico studies DOI
Muhammad Torequl Islam, Md. Sakib Al Hasan, Jannatul Ferdous

et al.

Neuroscience Letters, Journal Year: 2024, Volume and Issue: unknown, P. 138060 - 138060

Published: Nov. 1, 2024

Language: Английский

Citations

7
Anti-inflammatory effects of thymol: an emphasis on the molecular interactions through in vivo approach and molecular dynamic simulations DOI Creative Commons
Muhammad Torequl Islam, Mehedi Hasan Bappi, Md. Shimul Bhuia

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: June 25, 2024

Thymol (THY), as the natural monoterpene phenol, acts against oxidative stress and inflammatory processes. This study aimed to evaluate anti-inflammatory effects possible molecular mechanisms of THY via formalin-induced mouse egg albumin-induced chick models alongside docking dynamic (MD) simulations. (7.5, 15, 30 mg/kg) was investigated, compared celecoxib ketoprofen (42 mg/kg), standards. dose-dependently significantly ( p &lt; 0.05) decreased paw-licking edema diameter parameters in formalin (phases I II) models. Moreover, (15 exerted better combination with standard drug than alone celecoxib. In silico studies demonstrated elevated binding affinities cyclooxygenase-2 (COX-2) COX-1 enzyme, ligand binds at a similar location where interact. The results MD simulations confirmed stability test ligand. on Swiss mice young chicks, possibly by interacting COX-2. As conclusion, might be hopeful candidate for management disorders.

Language: Английский

Citations

5
Therapeutic Promises of Ferulic Acid and its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms DOI
Md. Shimul Bhuia, Raihan Chowdhury, Manik Chandra Shill

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(7)

Published: May 17, 2024

Ferulic acid (FA) is a naturally occurring phenolic compound commonly found in the plant Ferula communis. This study aims to investigate hepatoprotective effect of FA and its derivatives (methyl ferulic trans-ferulic acid) against oxidative stress inflammation-related hepatotoxicity due toxicants based on results different non-clinical preclinical tests. For this, data was collected from reliable electronic databases such as PubMed, Google Scholar, ScienceDirect, etc. The this investigation demonstrated that have potent effects damage. findings also revealed these protective are antioxidant anti-inflammatory chemical compound. analogues significantly inhibit free radical generation hinder proinflammatory markers inflammatory enzymes, resulting diminished cytotoxic apoptotic hepatocyte death. compounds prevent intracellular lipid accumulation provide effects.

Language: Английский

Citations

4