Anticonvulsant effect of (±) citronellal possibly through the GABAergic and voltage-gated sodium channel receptor interaction pathways: In vivo and in silico studies

Neurochemistry International, Journal Year: 2024, Volume and Issue: 175, P. 105704 - 105704

Published: Feb. 22, 2024

Language: Английский

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Antiemetic activity of abietic acid possibly through the 5HT3 and muscarinic receptors interaction pathways

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 19, 2024

Abstract The present study was designed to evaluate the antiemetic activity of abietic acid (AA) using in vivo and silico studies. To assess effect, doses 50 mg/kg b.w. copper sulfate (CuSO 4 ⋅5H 2 O) were given orally 2-day-old chicks. test compound at two 20 40 On other hand, aprepitant (16 mg/kg), domperidone (6 diphenhydramine (10 hyoscine (21 ondansetron (5 mg/kg) administered as positive controls (PCs). vehicle used a control group. Combination therapies with referral drugs also three separate groups animals see synergistic antagonizing compound. Molecular docking visualization ligand-receptor interaction performed different computational tools against various emesis-inducing receptors (D , D 3 5HT H 1 M –M 5 ). Furthermore, pharmacokinetics toxicity properties selected ligands predicted by SwissADME Protox-II online servers. Findings indicated that AA dose-dependently enhances latency emetic retching reduces number compared Among treatments, treated (40 exhibited highest (98 ± 2.44 s) reduced (11.66 2.52 times) groups. Additionally, molecular exhibits binding affinity (− 10.2 kcal/mol) toward an elevated 8.1 kcal/mol), 7.7 8.7 8.5 than ligands. Taken together, our suggests has potent effects interacting 5TH muscarinic receptor pathways. However, additional extensive pre-clinical clinical studies are required efficacy AA.

Language: Английский

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Pharmacological Activities of Plant‐Derived Fraxin with Molecular Mechanisms: A Comprehensive Review

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(5)

Published: March 20, 2024

Abstract Fruits and vegetables serve not only as sources of nutrition but also medicinal agents for the treatment diverse diseases maladies. These dietary components are significant resources phytochemicals that demonstrate therapeutic properties against many illnesses. Fraxin is a naturally occurring coumarin glycoside mainly present in various species Fraxinus genera, having multitude uses disorders. This study focuses to investigate pharmacological activities, botanical sources, biopharmaceutical profile phytochemical fraxin based on different preclinical non‐clinical studies show scientific evidence evaluate underlying molecular mechanisms effects ailments. For this, data was searched collected (as February 15, 2024) variety credible electronic databases, including PubMed/Medline, Scopus, Springer Link, ScienceDirect, Wiley Online, Web Science, Google Scholar. The findings demonstrated favorable outcomes relation range or medical conditions, inflammation, neurodegenerative disorders such cerebral ischemia‐reperfusion (I/R) depression, viral infection, well diabetic nephropathy. showed protective osteoprotective, renoprotective, pulmoprotective, hepatoprotective, gastroprotective due its antioxidant capacity. has great capability diminish oxidative stress‐related damage organs by stimulating enzymes, downregulating nuclear factor kappa B NLRP3, triggering Nrf2/ARE signaling pathways. exhibited poor oral bioavailability because reduced absorption wide distribution into tissues organs. However, extensive research required decipher profiles, clinical necessary establish efficacy natural compound reliable agent.

Language: Английский

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Assessment of Antidiarrheal Effect of Oleuropein Through µ‐Oopioid Receptor Interaction Pathway: In Vivo and in Silico Studies

Drug Development Research, Journal Year: 2025, Volume and Issue: 86(1)

Published: Feb. 1, 2025

Oleuropein (OLP), a compound predominantly found in olive leaves, has been known for its numerous biological activities, including antioxidant, anti-inflammatory, and antimicrobial properties. Despite established therapeutic potential, role treating diarrhea not extensively explored. This study aimed to evaluate the antidiarrheal effects of OLP an vivo model investigate molecular interactions using silico docking studies, pharmacokinetic predictions, toxicity analysis. In study, castor oil was used induce 3-day-old chicks, effect tested at doses 10 20 mg/kg. The standard drug, loperamide (LOP) 3 mg/kg, comparison. results showed that both significantly (p < 0.05) reduced diarrheal secretions increased latency, with mg/kg dose demonstrating most effective results. combination (20 mg/kg) LOP (3 further enhanced effect. revealed exhibited strong binding affinities (BAs) key receptor, μ-opioid receptor associated diarrhea, while higher BA (‒8.9 kcal/mol) compared (‒8.7 kcal/mol). Pharmacokinetic analysis favorable properties studies no acute toxicity, LD50 2000 conclusion, findings suggest possesses significant potential through interaction, positioning it as promising natural agent managing diarrhea. Further are warranted fully elucidate mechanisms action clinical applicability.

Language: Английский

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Anti-diarrheal effect of piperine possibly through the interaction with inflammation inducing enzymes: In vivo and in silico studies

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 965, P. 176289 - 176289

Published: Dec. 27, 2023

Language: Английский

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Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects

Plants, Journal Year: 2023, Volume and Issue: 12(24), P. 4189 - 4189

Published: Dec. 18, 2023

Quercetin (QUA), a flavonoid compound, is ubiquitously found in plants and has demonstrated diverse range of biological activities. The primary objective the current study to assess potential antiemetic properties QUA using an vivo silico approach. In this experiment, 4-day-old chicks were purchased induce emesis by orally administering copper sulfate pentahydrate (CuSO4·5H2O) at dose 50 mg/kg (orally). Domperidone (DOM) (6 mg/kg), Hyoscine (HYS) (21 Ondansetron (OND) (5 mg/kg) treated as positive controls (PCs), distilled water trace amount Tween 80 mixture was employed negative control (NC). given two distinct doses (25 mg/kg). Additionally, (50 PCs administered separately or combination their antagonistic synergistic effects on chicks. binding affinity referral ligands towards serotonin receptor (5HT3), dopamine receptors (D2 D3), muscarinic acetylcholine (M1-M5) estimated, ligand-receptor interactions visualized through various computational tools. findings indicate that significant effect reducing number retches (16.50 ± 4.65 10.00 4.19 times) increasing chick latency period (59.25 4.75 94.25 4.01 s), respectively. with exhibited superior effects, onset emesis-inducing time. Furthermore, it worth noting strongest against D2 value -9.7 kcal/mol formation hydrogen hydrophobic bonds. summary, activity chicks, potentially interacting pathway.

Language: Английский

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Therapeutic potentials of ononin with mechanistic insights: A comprehensive review

Food Bioscience, Journal Year: 2023, Volume and Issue: 56, P. 103302 - 103302

Published: Oct. 27, 2023

Language: Английский

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Polyphenol-Standardized Aphanamixis polystachya Leaf Extract Ameliorates Diabetes, Oxidative Stress, Inflammation, and Fibrosis in Streptozotocin-Induced Diabetic Rats

Journal of Food Biochemistry, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 18

Published: Jan. 2, 2024

Background. Diabetes is a rising disorder that affects millions of people annually. It also creates more complications, such as neuropathy, oxidative stress, and hepatic kidney impairment. Aphanamixis polystachya plant, which possesses multiple medicinal values, used in this study to explore its potential treating diabetes. Methods. A single dose (65 mg/kg) intraperitoneal streptozotocin injection was utilized mediate diabetes Sprague-Dawley rats. Diabetic animals were treated orally with 250 or 500 mg/kg standardized leaves’ extract A. (AP) for 28 days evaluate the antidiabetic organ-protective effects plant. Different biochemical histological markers are measured according established protocol. Results. Our results demonstrated significant decrease blood glucose ( p <0.001 ) HbA1c p <0.05 levels diabetic animal after administering AP (250 doses) compared control groups. can regularize lipids, glycogen, alanine aminotransferase, aspartate aminotransferase. Furthermore, serum urea nitrogen creatinine decreased treatment reduced stress showed substantial elevation antioxidant enzymes animals. Overall, at revealed comparable against standard drug glyburide. Besides, investigation AP’s efficacy attenuating tissue inflammation damage. HPLC data elucidated leaf contains polyphenols antioxidant, antidiabetic, organ protective agents: gallic acid, rutin hydrate, quercetin hydrate. Conclusion. Taken together, may be one sources agents.

Language: Английский

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Anti-inflammatory and Anti-diabetic Activity of N1-(4-substitutedbenzyl)/Butyl-2-methyl-4-nitro-3-imidazolium (E)-3-(4-hydroxy-3-methoxyphenyl)acrylates

Journal of Ionic Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 100148 - 100148

Published: March 1, 2025

Language: Английский

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Efficacy of Rotundic Acid and Its Derivatives as Promising Natural Anticancer Triterpenoids: A Literature‐Based Study

Chemistry & Biodiversity, Journal Year: 2023, Volume and Issue: 21(2)

Published: Dec. 27, 2023

Abstract Rotundic acid (RA) is a naturally occurring pentacyclic triterpene with multitude of pharmacological activities. The primary emphasis this study on summarizing the anticancer properties underlying mechanisms RA and its derivatives, as well pharmacokinetic features. Data was collected (up to date November 10, 2023) from various reliable authentic literatures by searching in different academic search engines, including PubMed, Springer Link, Scopus, Wiley Online, Web Science, ScienceDirect, Google Scholar. findings imply that synthetic derivatives possess promising anti‐cancer against breast, colorectal, liver, cervical cancers preclinical test systems. results also indicate demonstrated effects via number cellular mechanisms, apoptotic cell death, inhibition oxidative stress, anti‐inflammatory effect, cytotoxicity, cycle arrest, anti‐proliferative anti‐angiogenic cancer migration invasion. It has been proposed derived compounds have capability serve hopeful chemotherapeutic agent, so further extensive clinical research necessary.

Language: Английский

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