Organic Letters,
Journal Year:
2020,
Volume and Issue:
22(12), P. 4883 - 4887
Published: June 10, 2020
A
three-component
annulation
reaction
of
N-alkyl
anilines,
cyclic
1,3-dicarbonyl
compounds,
and
aryl
aldehydes
to
julolidines
lilolidines
is
reported.
The
6π-electrocyclization
enabled
the
proceed
with
reversed
regioselectivity
as
compared
that
occurs
in
Povarov
reaction.
Both
acyclic
anilines
participated
provide
a
wide
range
single
regio-
diastereoisomers
good
excellent
yields.
The Journal of Organic Chemistry,
Journal Year:
2017,
Volume and Issue:
83(1), P. 521 - 526
Published: Dec. 12, 2017
The
development
of
original
strategies
for
the
preparation
indole
derivatives
is
a
major
goal
in
drug
design.
Herein,
we
report
first
straight
access
to
indoles
from
anilines
and
ethylene
glycol
by
heterogeneous
catalysis,
based
on
an
acceptorless
dehydrogenative
condensation,
under
noninert
conditions.
In
order
achieve
high
selectivity,
combination
Pt/Al2O3
ZnO
have
been
found
slowly
dehydrogenate
generating,
after
condensation
with
amine
tautomeric
equilibrium,
corresponding
pyrrole-ring
unsubstituted
indoles.
Catalysts,
Journal Year:
2019,
Volume and Issue:
9(4), P. 317 - 317
Published: March 31, 2019
The
present
study
describes
the
production
of
value-added
chemical
1,3-propanediol
(1,3-PD)
from
crude
glycerol,
a
waste
by-product
formed
during
biodiesel
production.
efficiency,
robustness,
and
stability
process
were
improved
by
immobilization
anaerobic
bacterium
Clostridium
butyricum
into
polyvinyl
alcohol
(PVA)
hydrogel.
highest
average
productivity,
6.8
±
0.2
g/(L·h),
was
achieved
in
10
consecutive,
repeated
batch
fermentations,
with
an
initial
concentration
pure
glycerol
45.5
0.7
g/L,
after
2.5
h.
final
yield
1,3-PD,
28.3
0.6
0.42
0.01
g/g,
respectively,
eleven
increasing
to
70.4
1.9
g/L.
Two
different
types
produced
used
cooking
oil
(UCO)
rapeseed
(RO),
tested
productivity
2.3
0.1
3.5
0.3
respectively.
12.6
0.9
0.35
0.02
observed
fifteen
fermentations
RO
glycerol.
An
excellent
immobilized
bacteria
increase
fermentation
demonstrated.
ACS Sustainable Chemistry & Engineering,
Journal Year:
2016,
Volume and Issue:
4(10), P. 5730 - 5736
Published: Aug. 31, 2016
Hydrogen
borrowing
provides
an
efficient
and
atom
economical
method
for
carbon–nitrogen
carbon–carbon
bond
formation
from
alcohol
precursors.
Glycerol
is
a
renewable
nontoxic
polyol
potential
precursor
to
small
functional
organic
molecules.
We
here
report
the
direct
amination
of
solketal,
1,2-hydroxy-protected
derivative
glycerol,
via
ruthenium-catalyzed
hydrogen
borrowing,
affording
up
99%
conversion
92%
isolated
yield
using
[Ru(p-cymene)Cl2]2
as
catalyst
precursor.
The
synthesis
antitussive
agent
in
86%
overall
solketal
was
also
demonstrated
this
methodology.
Green Chemistry,
Journal Year:
2015,
Volume and Issue:
18(6), P. 1751 - 1761
Published: Nov. 9, 2015
The
hydrogen
transfer
initiated
dehydration
of
1,3-propanadiol
to
propionaldehyde,
catalysed
by
a
highly
recyclable,
air
and
water
stable,
soluble
Ir(iii)
complex,
in
an
ionic
liquid,
was
demonstrated.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(21), P. 8625 - 8632
Published: Jan. 1, 2023
A
novel
half-sandwich
Co(dppbsa)
([Co])
was
synthesized
and
employed
for
the
catalytic
N
,
-dimethylation
of
nitroaromatics
with
CO
2
hydrosilane.
The
same
catalyst
also
enabled
highly
efficient
reduction
to
aromatic
amines.
Organic & Biomolecular Chemistry,
Journal Year:
2020,
Volume and Issue:
19(3), P. 677 - 683
Published: Dec. 17, 2020
The
use
of
diols
and
anilines
as
reagents
for
the
preparation
indoles
represents
a
challenge
in
organic
synthesis.
By
means
acceptorless
dehydrogenative
condensation,
heterocycles,
such
indoles,
can
be
obtained.
Herein
we
present
an
experimental
theoretical
study
this
purpose
employing
heterogeneous
catalysts
Pt/Al2O3
ZnO
combination
with
acid
catalyst
(p-TSA)
NMP
solvent.
Under
our
optimized
conditions,
diol
excess
has
been
reduced
down
to
2
equivalents.
This
major
advance,
allows
other
diols.
2,3-Butanediol
or
1,2-cyclohexanediol
employed
affording
2,3-dimethyl
tetrahydrocarbazoles.
In
addition,
1,3-propanediol
prepare
quinolines
natural
synthetic
julolidines.
