Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(24), P. 3243 - 3247
Published: Aug. 24, 2024
Comprehensive
Summary
A
mechanistically
distinctive
visible‐light‐promoted
metal‐free
aerobic
oxidation
of
alkenyl
silanes
with
alcohols
was
disclosed
to
efficiently
construct
α
‐alkoxy
ketones
under
mild
conditions.
The
primary,
secondary,
and
tertiary
could
be
used
as
reactants.
protocol
carried
out
on
a
gram‐scale.
Various
derivatizations
products
conducted.
Mechanistic
studies
indicated
the
reaction
initiated
by
single‐electron
silanes,
rather
than
radical
addition
silanes.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(7)
Published: Jan. 2, 2024
Chromium-catalyzed
enantioselective
Nozaki-Hiyama-Kishi
(NHK)
reaction
represents
one
of
the
most
powerful
approaches
for
formation
chiral
carbon-heteroatom
bond.
However,
construction
sterically
encumbered
tetrasubstituted
stereocenter
through
NHK
still
posts
a
significant
challenge.
Herein,
we
disclose
cobalt-catalyzed
aza-NHK
ketimine
with
alkenyl
halide
to
provide
convenient
synthetic
approach
manufacture
enantioenriched
α-vinylic
amino
acid.
This
protocol
exhibits
excellent
functional
group
tolerance
99
%
ee
in
cases.
Additionally,
this
asymmetric
reductive
method
is
also
applicable
aldimine
access
trisubstituted
stereogenic
centers.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(25)
Published: Jan. 22, 2024
β-Tertiary
amino
acid
derivatives
constitute
one
of
the
most
frequently
occurring
units
in
natural
products
and
bioactive
molecules.
However,
efficient
asymmetric
synthesis
this
motif
still
remains
a
significant
challenge.
Herein,
we
disclose
cobalt-catalyzed
enantioselective
reductive
addition
reaction
ketimine
using
α-chloro
carbonyl
compound
as
radical
precursor,
providing
expedient
access
to
diverse
array
enantioenriched
β-quaternary
analogues.
This
protocol
exhibits
outstanding
enantioselectivity
broad
substrate
scope
with
excellent
functional
group
tolerance.
Preliminary
mechanism
studies
rule
out
possibility
Reformatsky-type
confirm
involvement
species
stereoselective
process.
The
synthetic
utility
has
been
demonstrated
through
rapid
assembly
iterative
oligopeptide,
showcasing
its
versatile
platform
for
late-stage
modification
drug
candidates.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(19), P. 3799 - 3842
Published: Jan. 1, 2024
Tetrabutylammonium
decatungstate
(TBADT)
has
recently
emerged
as
an
intriguing
photocatalyst
under
visible-light
or
near-visible-light
irradiation
in
a
wide
range
of
organic
reactions
that
were
previously
not
conceivable.
Given
its
ability
to
absorb
visible
light
and
excellent
effectiveness
activating
unactivated
chemical
bonds,
it
is
promising
addition
traditional
photocatalysts.
This
review
covers
some
the
contemporary
developments
photocatalysis
enabled
by
TBADT
catalyst
2023,
with
contents
organized
reaction
type.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(62)
Published: Aug. 10, 2024
The
difunctionalization
of
alkenes
represents
a
powerful
tool
to
incorporate
two
functional
groups
into
the
alkene
bones
for
increasing
molecular
complexity
and
has
been
widely
utilizations
in
chemical
synthesis.
Upon
catalysis
green,
sustainable,
mild
photo-/electrochemistry
technologies,
much
attentions
have
attracted
development
new
tactics
transformations
important
alkane
feedstocks
driven
by
C-H
radical
functionalization.
Herein,
we
summarize
recent
advances
photo-/electrocatalytic
enabled
We
detailedly
discuss
substrate
scope
mechanisms
reactions
selecting
impressive
synthetic
examples,
which
are
divided
four
sections
based
on
final
terminated
step,
including
oxidative
radical-polar
crossover
coupling,
reductive
radical-radical
transition-metal-catalyzed
coupling.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(11), P. 2297 - 2302
Published: March 11, 2024
We
report
a
deoxygenative
amidation
reaction
of
alcohols
with
carbamoyl
chlorides
to
afford
amides
through
nickel–photoredox
dual
catalysis.
Good
excellent
yields
can
be
obtained
even
for
diverse
complex
sugar
and
steroid
derivatives.
The
is
scalable,
the
synthetic
utility
was
demonstrated
by
homologation
deliver
several
important
γ-amino
synthetically
challenging
bioactive
compound
intermediate.
ACS Catalysis,
Journal Year:
2024,
Volume and Issue:
14(16), P. 12181 - 12191
Published: July 30, 2024
The
advancement
of
sophisticated
synthetic
methodologies
that
streamline
reaction
processes
while
enhancing
molecular
complexity
is
a
perpetual
necessity
in
the
realm
chemistry.
Catalytic
one-pot
cascade
play
crucial
role
efficient
construction
intricate
molecules
with
exceptional
chemoselectivity.
Herein,
we
present
approach
for
synthesis
polycyclic
fused
δ-lactams
via
sequential
phosgenation,
Pd/NBE-catalyzed
ortho-carbamoylation/ipso-Heck-type
cyclization,
and
C–H
activation
from
readily
available
aryl
halides,
amines,
triphosgenes.
This
stands
out
as
first
example
situ
carbamoyl
chloride
formation
amine
precursors,
presenting
an
alternative
to
existing
transformations
involving
chlorides.
practical
significance
these
showcased
by
81
rapid
economically
favorable
manner,
without
need
intermediate
purification.
Moreover,
were
scalable
compatible
various
natural
products
pharmaceuticals,
further
underscoring
effectiveness
this
strategy.
relatively
rigid
coplanar
structure
displayed
our
synthesized
exhibits
distinct
room-temperature
phosphorescence
characteristics,
which
have
been
utilized
anticounterfeiting
high-security-level
data
encryption.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 12, 2024
Enantioenriched
unnatural
amino
acids
represent
a
prevalent
motif
in
organic
chemistry,
with
profound
applications
biochemistry,
medicinal
and
materials
science.
Herein,
we
report
cobalt-catalyzed
aza-Barbier
reaction
of
dehydroglycines
unactivated
alkyl
halides
to
afford
α-amino
esters
high
enantioselectivity.
This
catalytic
reductive
alkylative
addition
protocol
circumvents
the
use
moisture-,
air-sensitive
organometallic
reagents,
stoichiometric
chiral
auxiliaries,
enabling
conversion
variety
primary,
secondary,
even
tertiary
α-alkyl-amino
under
mild
conditions,
thus
leading
broad
functional
group
tolerance.
The
expedient
access
biologically
active
motifs
demonstrates
practicality
this
by
reducing
number
synthetic
steps
enhancing
efficiency.
Chinese Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
42(6), P. 599 - 604
Published: Nov. 2, 2023
Comprehensive
Summary
Transition
metal‐catalyzed
carbometallation
of
unsaturated
hydrocarbons
constitutes
one
the
most
efficient
synthetic
methodologies
for
construction
C—C
bond.
Recently,
incorporation
organometallic
reagent
with
CO
gas
as
a
nucleophilic
acyl
synthon
could
enable
acylmetallation
reaction,
which
greatly
increases
horizon
chemistry.
Herein,
we
report
nickel‐catalyzed
regiodivergent
acylzincation
o
‐cyano
cinnamate
ester
and
styrene,
in
cyano
moiety
intramolecularly
captures
zinc
intermediates
to
trigger
tandem
cyclization
process.
This
protocol
features
mild
conditions,
broad
substrate
scope
excellent
functional
group
tolerance,
thus
affording
diverse
array
highly
functionalized
carbocyclic
compounds.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(7)
Published: Jan. 2, 2024
Abstract
Chromium‐catalyzed
enantioselective
Nozaki–Hiyama–Kishi
(NHK)
reaction
represents
one
of
the
most
powerful
approaches
for
formation
chiral
carbon‐heteroatom
bond.
However,
construction
sterically
encumbered
tetrasubstituted
stereocenter
through
NHK
still
posts
a
significant
challenge.
Herein,
we
disclose
cobalt‐catalyzed
aza‐NHK
ketimine
with
alkenyl
halide
to
provide
convenient
synthetic
approach
manufacture
enantioenriched
α‐vinylic
amino
acid.
This
protocol
exhibits
excellent
functional
group
tolerance
99
%
ee
in
cases.
Additionally,
this
asymmetric
reductive
method
is
also
applicable
aldimine
access
trisubstituted
stereogenic
centers.
