Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 170, P. 261 - 280

Published: Jan. 2, 2021

Language: Английский

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Structure–activity relationship of cationic surfactants as antimicrobial agents

Current Opinion in Colloid & Interface Science, Journal Year: 2019, Volume and Issue: 45, P. 28 - 43

Published: Dec. 6, 2019

Language: Английский

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Synthetic antimicrobial peptides: Characteristics, design, and potential as alternative molecules to overcome microbial resistance

Life Sciences, Journal Year: 2021, Volume and Issue: 278, P. 119647 - 119647

Published: May 24, 2021

Language: Английский

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Antibiotic Adjuvants: A Versatile Approach to Combat Antibiotic Resistance

ACS Omega, Journal Year: 2023, Volume and Issue: 8(12), P. 10757 - 10783

Published: March 14, 2023

The problem of antibiotic resistance is on the rise, with multidrug-resistant strains emerging even to last resort antibiotics. drug discovery process often stalled by stringent cut-offs required for effective design. In such a scenario, it prudent delve into varying mechanisms existing antibiotics and target them improve efficacy. Nonantibiotic compounds called adjuvants which bacterial can be used in combination obsolete drugs an improved therapeutic regime. field "antibiotic adjuvants" has gained significant traction recent years where other than β-lactamase inhibition have been explored. This review discusses multitude acquired inherent employed bacteria resist action. major focus this how these use adjuvants. Different types direct acting indirect breakers are discussed including enzyme inhibitors, efflux pump inhibitors teichoic acid synthesis, cellular processes. multifaceted class membrane-targeting poly pharmacological effects potential host immune-modulating also reviewed. We conclude providing insights about challenges preventing clinical translation different classes adjuvants, especially membrane-perturbing compounds, framework possible directions pursued fill gap. Antibiotic–adjuvant combinatorial therapy indeed immense as upcoming orthogonal strategy conventional discovery.

Language: Английский

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Intrinsic antimicrobial resistance: Molecular biomaterials to combat microbial biofilms and bacterial persisters

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122690 - 122690

Published: June 28, 2024

Language: Английский

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6,7-Coumarin-heterocyclic hybrids: A comprehensive review of their natural sources, synthetic approaches, and bioactivity

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1303, P. 137601 - 137601

Published: Jan. 22, 2024

Language: Английский

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Molecular Mechanisms of Bacterial Resistance to Antimicrobial Peptides in the Modern Era: An Updated Review

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1259 - 1259

Published: June 21, 2024

Antimicrobial resistance (AMR) poses a serious global health concern, resulting in significant number of deaths annually due to infections that are resistant treatment. Amidst this crisis, antimicrobial peptides (AMPs) have emerged as promising alternatives conventional antibiotics (ATBs). These cationic peptides, naturally produced by all kingdoms life, play crucial role the innate immune system multicellular organisms and bacterial interspecies competition exhibiting broad-spectrum activity against bacteria, fungi, viruses, parasites. AMPs target pathogens through multiple mechanisms, most importantly disrupting their membranes, leading cell lysis. However, host has slow co-evolutionary process between microorganisms hosts. Alarmingly, development last-resort treatment MDR infections, such colistin, is attributed misuse peptide high rate horizontal genetic transfer corresponding genes. AMP-resistant bacteria employ diverse including but not limited proteolytic degradation, extracellular trapping inactivation, active efflux, well complex modifications wall membrane structures. This review comprehensively examines constitutive inducible molecular mechanisms supported experimental evidence described date pathogens. We also explore specificity these toward structurally broaden enhance potential developing applying them therapeutics for bacteria. Additionally, we provide insights into significance AMP within context host-pathogen interactions.

Language: Английский

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Antimicrobial Peptides and Their Mimetics: Promising Candidates of Next‐Generation Therapeutic Agents Combating Multidrug‐Resistant Bacteria

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Abstract The increasing morbidity and mortality caused by multidrug‐resistant bacteria alerts human beings to the fact that conventional antibiotics are no longer reliable effective alternatives imperatively needed. Owing wide range of sources, diverse structures, unique mode action, antimicrobial peptides have been highly anticipated extensively studied in recent years. Besides, integration artificial intelligence helps researchers gain access vast unexplored chemical space, which opens more opportunities for optimization design novel structures. Moreover, Due advances chemistry synthetic biology, also begun focus on potential mimetics peptides. In this review, a comprehensive discussion about natural synthesized as well their is made, so provide summary field inspire follow‐up research.

Language: Английский

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Design and Application of Antimicrobial Peptide Conjugates

International Journal of Molecular Sciences, Journal Year: 2016, Volume and Issue: 17(5), P. 701 - 701

Published: May 11, 2016

Antimicrobial peptides (AMPs) are an interesting class of antibiotics characterized by their unique antibiotic activity and lower propensity for developing resistance compared to common antibiotics. They belong the membrane-active usually act selectively against bacteria, fungi protozoans. AMPs, but also peptide conjugates containing have come more into focus research during last few years. Within this article, recent work on AMP is reviewed. Different aspects will be highlighted as a combination AMPs with or organometallic compounds aiming increase antibacterial target selectivity, conjugation photosensitizers improving photodynamic therapy (PDT) attachment particles, name only few. Owing enormous resonance antimicrobial in literature so far, topic seems very attractive different scientific fields, like medicine, biology, biochemistry chemistry.

Language: Английский

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More Than a Pore: A Current Perspective on the In Vivo Mode of Action of the Lipopeptide Antibiotic Daptomycin

Antibiotics, Journal Year: 2020, Volume and Issue: 9(1), P. 17 - 17

Published: Jan. 3, 2020

Daptomycin is a cyclic lipopeptide antibiotic, which was discovered in 1987 and entered the market 2003. To date, it serves as last resort antibiotic to treat complicated skin infections, bacteremia, right-sided endocarditis caused by Gram-positive pathogens, most prominently methicillin-resistant Staphylococcus aureus. representative of novel class that introduced clinic. It also one few membrane-active compounds can be applied systemically. While antibiotics have long been limited topical applications were generally excluded from systemic drug development, they promise slower resistance development than many classical drugs target single proteins. The success daptomycin together with emergence more multi-resistant superbugs attracted renewed interest this compound class. Studying pioneering might help pave way for future membrane-targeting antibiotics. However, 30 years after its discovery, exact mechanism action still debated. In particular, there prominent discrepancy between vivo vitro studies. review, we discuss current knowledge on against bacteria try offer explanations these conflicting observations.

Language: Английский

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