Clinical Pharmacokinetics, Journal Year: 2020, Volume and Issue: 60(3), P. 271 - 281
Published: Dec. 14, 2020
Language: Английский
ACS Infectious Diseases, Journal Year: 2020, Volume and Issue: 6(6), P. 1346 - 1365
Published: March 10, 2020
Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for drug discovery keep pace. Often, against a even before it reaches the market. This continued crisis has demonstrated that antibiotics with single protein targets rapidly be sustainable. Most successful long-established target more than one molecule or possess targets, which are encoded by multiple genes. realization motivated change in antibiotic development toward candidates targets. Some mechanisms of action presuppose at least effects, such as targeting cytoplasmic membrane carrier bactoprenol phosphate and therefore particularly promising. Moreover, combination therapy approaches being developed break sensitize bacteria action. In this Review, we provide an overview multitarget behind them.
Language: Английский
Citations
144
Advanced Science, Journal Year: 2023, Volume and Issue: 10(11)
Published: Jan. 30, 2023
Abstract Osteomyelitis is a destructive disease of bone tissue caused by infection with pathogenic microorganisms. Because the complex and long‐term abnormal conditions, osteomyelitis one refractory diseases in orthopedics. Currently, anti‐infective therapy primary modality for addition to thorough surgical debridement. However, bacterial resistance has gradually reduced benefits traditional antibiotics, development advanced antibacterial agents received growing attention. This review introduces main targets treating osteomyelitis, including cell wall, membrane, intracellular macromolecules, energy metabolism, focuses on their mechanisms, predicts prospects clinical applications.
Language: Английский
Citations
64
ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(10), P. 3440 - 3474
Published: July 17, 2024
There is a lack of new antibiotics to combat drug-resistant bacterial infections that increasingly threaten global health. The current pipeline clinical-stage antimicrobials primarily populated by "new and improved" versions existing antibiotic classes, supplemented several novel chemical scaffolds act on traditional targets. fresh chemotypes acting previously unexploited targets (the "holy grail" for due their scarcity) particularly unfortunate as these offer the greatest opportunity innovative breakthroughs overcome resistance. In recognition potential, this review focuses subset high value antibiotics, providing structures where available. This candidates have progressed clinical trials, well selected examples promising pioneering approaches in advanced stages development, order stimulate additional research aimed at combating infections.
Language: Английский
Citations
20
Microorganisms, Journal Year: 2021, Volume and Issue: 9(4), P. 830 - 830
Published: April 14, 2021
Coagulase-negative staphylococci (CoNS) are among the most frequently recovered bacteria in routine clinical care. Their incidence has steadily increased over past decades parallel to advancement medicine, especially regard utilization of foreign body devices. Many new species have been described within years, while information those is still sparse. In addition, interspecies differences that render some more virulent than others be taken into account. The distinct populations which CoNS infections play a prominent role preterm neonates, patients with implanted medical devices, immunodeficient patients, and other relevant comorbidities. Due property colonize human skin, contamination blood cultures or samples occurs frequently. Hence, main diagnostic hurdle correctly identify cases causative agents rather contaminants. However, neither phenotypic nor genetic tools able provide satisfying solution this problem. Another dilemma practice pertains their extensive antimicrobial resistance profile, healthcare settings. Therefore, true caused by often necessitate use second-line drugs.
Language: Английский
Citations
100
Chemical Reviews, Journal Year: 2020, Volume and Issue: 121(6), P. 3412 - 3463
Published: Dec. 29, 2020
The biological diversity of the unicellular bacteria—whether assessed by shape, food, metabolism, or ecological niche—surely rivals (if not exceeds) that multicellular eukaryotes. relationship between bacteria whose niche is eukaryote, and often symbiosis stasis. Some bacteria, however, seek advantage in this relationship. One most successful—to disadvantage eukaryote—is small (less than 1 μm diameter) nearly spherical Staphylococcus aureus bacterium. For decades, successful clinical control its infection has been accomplished using β-lactam antibiotics such as penicillins cephalosporins. Over these same decades S. perfected resistance mechanisms against antibiotics, which are then countered new generations structure. This review addresses current breadth biochemical microbiological efforts to preserve future through a better understanding how protects enzyme targets β-lactams, penicillin-binding proteins. proteins essential catalysts for biosynthesis cell wall, wall integrated into protective envelope bacterium may identify antibacterials adjuvants efficacy β-lactams.
Language: Английский
Citations
83
Microbiology and Molecular Biology Reviews, Journal Year: 2023, Volume and Issue: 87(2)
Published: April 27, 2023
Clinical management of Staphylococcus aureus infections presents a challenge due to the high incidence, considerable virulence, and emergence drug resistance mechanisms.
Language: Английский
Citations
36
ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(5), P. 1483 - 1519
Published: May 1, 2024
The development of effective antibacterial solutions has become paramount in maintaining global health this era increasing bacterial threats and rampant antibiotic resistance. Traditional antibiotics have played a significant role combating infections throughout history. However, the emergence novel resistant strains necessitates constant innovation research. We analyzed data on antibacterials from CAS Content Collection, largest human-curated collection published scientific knowledge, which proven valuable for quantitative analysis knowledge. Our focuses mining Collection recent publications (since 2012). This article aims to explore intricate landscape research while reviewing advancement traditional emerging strategies. By delving into resistance mechanisms, paper highlights need find alternate strategies address growing concern.
Language: Английский
Citations
16
Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 77, P. 101147 - 101147
Published: Aug. 31, 2024
Staphylococcus aureus, a notorious pathogen with versatile virulence, poses significant challenge to current antibiotic treatments due its ability develop resistance mechanisms against variety of clinically relevant antibiotics. In this comprehensive review, we carefully dissect the employed by S. aureus various antibiotics commonly used in clinical settings. The article navigates through intricate molecular pathways, elucidating which evades therapeutic efficacy antibiotics, such as β-lactams, vancomycin, daptomycin, linezolid, etc. Each is scrutinised for mechanism action, impact on bacterial physiology, and corresponding strategies adopted aureus. By synthesising knowledge surrounding these mechanisms, review aims serve resource that provides foundation development innovative alternative infections. Understanding evolving landscape imperative devising effective countermeasures battle formidable pathogen.
Language: Английский
Citations
16
ACS Infectious Diseases, Journal Year: 2024, Volume and Issue: 10(4), P. 1034 - 1055
Published: March 1, 2024
Pathogenic bacteria cause the deaths of millions people every year. With development antibiotics, hundreds and thousands people's lives have been saved. Nevertheless, can develop resistance to rendering them insensitive antibiotics over time. Peptides containing specific amino acids be used as antibacterial agents; however, they easily degraded by proteases in vivo. To address these issues, branched peptide dendrimers are now being considered good agents due their high efficacy, protease degradation, low cytotoxicity. The ease with which synthesized modified makes accessible for use various biological nonbiological fields. That is, hold a promising future prolonged efficacy without bacterial development. Their vivo stability multivalence allow effectively target multi-drug-resistant strains prevent biofilm formation. Thus, it is interesting an overview applications research, including possibility employing machine learning approaches design AMPs dendrimers. This review summarizes synthesis agents. challenges perspectives using also discussed.
Language: Английский
Citations
11
Frontiers in Cellular and Infection Microbiology, Journal Year: 2020, Volume and Issue: 10
Published: Oct. 19, 2020
Antimicrobial peptides (AMPs) are a promising alternative to classical antibiotics in the fight against multi-resistant bacteria. They produced by organisms from all domains of life and constitute nearly universal defense mechanism infectious agents. No drug can be approved without information about its action. In order use them clinical setting, it is pivotal understand how AMPs work. While many pore-forming well-characterized model membrane systems, non-pore-forming often poorly understood. Moreover, there evidence that pore formation may not happen or play role vivo. It therefore imperative study interact with their targets vivo consequently kill microorganisms. This has been difficult past, since established methods did provide much mechanistic details. Especially, membrane-active compounds have scarce. Recent advances, particular microscopy technology cell biological labelling techniques, now allow studying mechanisms unprecedented detail. review gives an overview available investigate antibacterial AMPs. addition mode action classification assays, we discuss advanced global profiling such as genomic proteomic approaches, well bacterial cytological other assays. We cover approaches determine effects on morphology, outer membrane, wall, inner properties, cellular macromolecules, protein targets. particularly expand examine cytoplasmic parameters, composition, thickness, organization, fluidity, potential, functionality membrane-associated processes. The advantages limitations these techniques feasibility suitability for different research questions discussed. aims guide researchers, who seek broad methodology living
Language: Английский
Citations
56