Journal of Composites Science,
Journal Year:
2025,
Volume and Issue:
9(3), P. 133 - 133
Published: March 13, 2025
Severe
skin
injuries
such
as
burns
and
chronic
wounds
are
a
subject
of
interest
in
the
medical
field,
they
require
much
attention.
These
types
susceptible
to
serious
complications,
which
can
worsen
health
patients
reduce
their
quality
life.
Hydrogels
have
emerged
innovative
wound
dressings
for
treating
acute
wounds,
including
burns,
diabetic
foot
ulcers,
venous
leg
pressure
ulcers.
polymeric
networks
provide
moist
environment,
promote
cellular
migration,
offer
antimicrobial
properties,
being
recognized
superior
conventional
dressings.
This
review
aims
explore
recent
advancements
hydrogel-based
dressings,
emphasizing
state-of-the-art
technologies
used
this
purpose
trend
achieving
personalized
therapeutic
approaches.
Despite
promising
vitro
vivo
findings
described
review,
further
clinical
validation
large-scale
manufacturing
optimizations
required
widespread
adoption.
Clinical and Translational Medicine,
Journal Year:
2022,
Volume and Issue:
12(11)
Published: Nov. 1, 2022
Abstract
Hydrogels
are
promising
and
widely
utilized
in
the
biomedical
field.
In
recent
years,
anti‐inflammatory
function
of
hydrogel
dressings
has
been
significantly
improved,
addressing
many
clinical
challenges
presented
ongoing
endeavours
to
promote
wound
healing.
Wound
healing
is
a
cascaded
highly
complex
process,
especially
chronic
wounds,
such
as
diabetic
severe
burn
which
adverse
endogenous
or
exogenous
factors
can
interfere
with
inflammatory
regulation,
leading
disruption
process.
Although
insufficient
inflammation
uncommon,
excessive
infiltration
an
almost
universal
feature
impedes
histological
repair
predictable
biological
step
chronological
order.
Therefore,
resolving
essential.
past
5
extensive
research
conducted
on
address
healing,
specifically
by
efficiently
scavenging
free
radicals,
sequestering
chemokines
promoting
M
1
‐to‐M
2
polarization
macrophages,
thereby
regulating
this
study,
we
introduced
novel
demonstrated
innovative
methods
for
their
preparation
application
achieve
enhanced
addition,
summarize
most
important
properties
required
discuss
our
analysis
potential
yet
be
addressed.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(4), P. 787 - 787
Published: March 23, 2023
Natural-based
biomaterials
play
an
important
role
in
developing
new
products
for
medical
applications,
primarily
cutaneous
injuries.
A
large
panel
of
with
antioxidant
properties
has
revealed
advancement
supporting
and
expediting
tissue
regeneration.
However,
their
low
bioavailability
preventing
cellular
oxidative
stress
through
the
delivery
system
limits
therapeutic
activity
at
injury
site.
The
integration
compounds
implanted
biomaterial
should
be
able
to
maintain
while
facilitating
skin
recovery.
This
review
summarises
recent
literature
that
reported
natural
antioxidant-incorporated
promoting
wound
healing
regeneration,
which
is
supported
by
evidence
from
vitro,
vivo,
clinical
studies.
Antioxidant-based
therapies
have
shown
promising
numerous
animal
studies,
even
though
studies
remain
very
limited.
We
also
described
underlying
mechanism
reactive
oxygen
species
(ROS)
generation
provided
a
comprehensive
ROS-scavenging
found
last
six
years.
Materials,
Journal Year:
2023,
Volume and Issue:
16(15), P. 5459 - 5459
Published: Aug. 3, 2023
The
treatment
of
skin
wounds
caused
by
trauma
and
pathophysiological
disorders
has
been
a
growing
healthcare
challenge,
posing
great
economic
burden
worldwide.
use
appropriate
wound
dressings
can
help
to
facilitate
the
repair
healing
rate
defective
skin.
Natural
polymer
biomaterials
such
as
collagen
hyaluronic
acid
with
excellent
biocompatibility
have
shown
promote
restoration
However,
low
mechanical
properties
fast
degradation
limited
their
applications.
Skin
based
on
biodegradable
biocompatible
synthetic
polymers
not
only
overcome
shortcomings
natural
but
also
possess
favorable
for
applications
in
wounds.
Herein,
we
listed
several
used
dressing
materials,
PVA,
PCL,
PLA,
PLGA,
PU,
PEO/PEG,
focusing
composition,
fabrication
techniques,
functions
promoting
healing.
Additionally,
future
development
prospects
polymer-based
are
put
forward.
Our
review
aims
provide
new
insights
further
using
polymers.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(41)
Published: June 13, 2023
Abstract
Hydrogels
have
been
widely
explored
to
adapt
different
application
circumstances.
As
typical
wet‐soft
materials,
the
high‐water
content
of
hydrogels
is
beneficial
their
wide
biomedical
applications.
Moreover,
displaying
considerable
potential
in
some
high‐tech
areas,
like
brain‐computer
interface,
intelligent
actuator,
flexible
sensor,
etc.
However,
traditional
hydrogel
susceptive
freezing
below
zero,
dehydration,
performance
swelling‐induced
deformation,
and
suffers
from
mechanical
damage
extremely
environments,
which
result
loss
peculiarities
(e.g.,
flexibility,
structure
integrity,
transparency),
greatly
limiting
Therefore,
reducing
point,
improving
dehydration/solution
resistance,
designing
adaptability
are
effective
strategies
endow
with
extreme
environmental
adaptability,
thus
broadening
fields.
This
review
systematically
summarizes
research
advances
environmentally
adaptive
(EAHs),
comprising
anti‐freezing,
dehydration‐resistant,
acid/base/swelling
deformation‐resistant,
environment
(MEAHs).
Firstly,
fabrication
methods
presented,
including
deep
eutectic
solvent/ionic
liquid
substituent,
addition
salts,
organogel,
polymer
network
modification,
double
(DN)
complex/nanocomposite
strategy,
Meanwhile,
features
approaches
overviewed.
The
mechanisms,
properties,
applications
wound
dressing,
sensor)
EAHs
demonstrated.
Finally,
issues
future
perspectives
for
EAHs’
researches
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(24)
Published: Feb. 16, 2024
Abstract
Diabetic
wounds
are
difficult
to
heal,
and
the
key
wound
healing
is
exudate
management
effective
disinfection.
Inspired
by
asymmetric
wettability
of
Janus‐structured
lotus
leaves,
herein
study
has
presented
design
a
biomimetic
Janus
membrane
that
integrates
unidirectional
biofluid
drainage
photothermal‐enhanced
evaporation/sterilization
capabilities
for
accelerating
diabetic
healing.
This
prepared
electrospinning
polyacrylonitrile
(PAN)
nanofiber
containing
polydopamine
(PDA)
on
surface
polypropylene
(PP)
nonwoven
membrane.
Such
PP/PAN
x%PDA
enables
antigravity
“pumping”
water
from
hydrophobic
PP
layer
hydrophilic
PAN
within
22
s
through
contact
points
interface.
The
incorporation
30
wt%
PDA
in
imparts
high
photoabsorption
photothermal
responsiveness,
facilitating
continuous
volatilization
exudate,
achieving
twice
displacement
water,
causing
irreversible
damage
bacteria.
As
result,
it
effectively
alleviates
inflammation
cellular
fibrosis
while
promoting
collagen
deposition
due
its
structure
antibacterial
properties.
Impressively,
such
achieves
an
impressive
closure
rate
96.7%
wounds,
better
than
(59.8%)
conventional
bandages.
Therefore,
this
offers
promising
alternative
chronic
wounds.
Gels,
Journal Year:
2023,
Volume and Issue:
9(7), P. 539 - 539
Published: July 3, 2023
Aloe
vera-based
hydrogels
have
emerged
as
promising
platforms
for
the
delivery
of
therapeutic
agents
in
wound
dressings
due
to
their
biocompatibility
and
unique
wound-healing
properties.
The
present
study
provides
a
comprehensive
overview
recent
advances
application
healing.
synthesis
methods,
structural
characteristics,
properties
are
discussed.
Mechanisms
released
from
hydrogels,
including
diffusion,
swelling,
degradation,
also
analyzed.
In
addition,
effects
on
healing,
well
reduction
inflammation,
antimicrobial
activity,
tissue
regeneration,
highlighted.
incorporation
various
agents,
such
anti-inflammatory
ones,
into
is
reviewed
detail.
Furthermore,
challenges
future
prospects
dressing
applications
considered.
This
review
valuable
information
current
status
highlights
potential
improve
healing
outcomes.
Materials Horizons,
Journal Year:
2023,
Volume and Issue:
11(1), P. 37 - 101
Published: Oct. 27, 2023
The
unique
network
characteristics
and
stimuli
responsiveness
of
supramolecular
hydrogels
have
rendered
them
highly
advantageous
in
the
field
wound
dressings,
showcasing
unprecedented
potential.
However,
there
are
few
reports
on
a
comprehensive
review
hydrogel
dressings
for
repair
hemostasis.
This
first
introduces
major
cross-linking
methods
hydrogels,
which
includes
hydrogen
bonding,
electrostatic
interactions,
hydrophobic
host-guest
metal
ligand
coordination
some
other
interactions.
Then,
we
advanced
materials
reported
recent
years
then
summarize
basic
principles
each
method.
Next,
classify
structures
before
outlining
their
forming
process
propose
potential
future
directions.
Furthermore,
also
discuss
raw
materials,
structural
design
principles,
material
used
to
achieve
functions
such
as
antibacterial
function,
tissue
adhesion,
substance
delivery,
anti-inflammatory
antioxidant
functions,
cell
behavior
regulation,
angiogenesis
promotion,
hemostasis
innovative
years.
Finally,
existing
problems
well
development
directions
strategy,
design,
discussed.
is
proposed
stimulate
further
exploration
by
researchers
future.
Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
11(9), P. 3051 - 3076
Published: Jan. 1, 2023
This
review
offers
systematic
considerations
of
material
design
principles
and
fabrication
techniques
for
biomimetic
skin
tissue
engineering
scaffolds.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: May 19, 2023
Chito-oligosaccharides
(COS),
derived
from
chitosan
(CH),
are
attracting
increasing
attention
as
drug
delivery
carriers
due
to
their
biocompatibility,
biodegradability,
and
mucoadhesive
properties.
Grafting,
the
process
of
chemically
modifying
CH/COS
by
adding
side
chains,
has
been
used
improve
performance
enhancing
stability,
targeted
delivery,
controlled
release.
In
this
review,
we
aim
provide
an
in-depth
study
on
recent
advances
in
grafting
for
multifarious
applications.
Moreover,
various
strategies
techniques
grafting,
including
chemical
modification,
enzymatic
physical
elaborated.
The
properties
grafted
CH/COS,
such
solubility,
were
reported.
Additionally,
review
detailed
applications
small
molecule,
proteins,
RNA
interference
therapeutics.
Furthermore,
effectiveness
improving
pharmacokinetics
pharmacodynamics
drugs
was
included.
Finally,
challenges
limitations
associated
with
use
outline
directions
future
research
addressed.
insights
provided
will
be
valuable
researchers
development
professionals
interested
application
