Cancer therapy resistance mediated by cancer-associated fibroblast-derived extracellular vesicles: biological mechanisms to clinical significance and implications DOI Creative Commons
Zhengjun Lin, Guoqing Li, Ke Jiang

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 7, 2024

Cancer-associated fibroblasts (CAFs) are a diverse stromal cell population within the tumour microenvironment, where they play fundamental roles in cancer progression and patient prognosis. Multiple lines of evidence have identified that CAFs critically involved shaping structure function microenvironment with numerous functions regulating behaviours, such as metastasis, invasion, epithelial-mesenchymal transition (EMT). can interact extensively cells by producing extracellular vesicles (EVs), multiple secreted factors, metabolites. Notably, CAF-derived EVs been critical mediators therapy resistance, constitute novel targets biomarkers management. This review aimed to summarize biological detailed molecular mechanisms mediating resistance chemotherapy, targeted agents, radiotherapy, immunotherapy. We also discussed therapeutic potential clinical management, thereby providing strategy for enhancing efficacy improving

Language: Английский

From fatty liver to fibrosis: the impact of miRNAs on NAFLD and NASH DOI
Reda Mansour,

Sherif S Abdel Mageed,

Ahmed I. Abulsoud

et al.

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 31, 2025

Language: Английский

Citations

1
Therapeutic Targeting of Cancer-Associated Fibroblasts in the Non-Small Cell Lung Cancer Tumor Microenvironment DOI Open Access
Yasushi Shintani, Tōru Kimura, Soichiro Funaki

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(2), P. 335 - 335

Published: Jan. 4, 2023

Lung cancer is the most frequently diagnosed and leading cause of death worldwide. The common lung non-small cell (NSCLC), with an overall 5-year survival rate around 20% because NSCLC a metastatic disease. A better understanding mechanism underlying metastasis therefore urgently needed. tumor microenvironment involves different types stromal cells functions as key components in progression NSCLC. Through epithelial–mesenchymal transition (EMT), which epithelial lose their polarity acquire mesenchymal potential, abilities, well stem-cell-like potential. We previously reported that cancer-associated fibroblasts (CAFs) interact to allow for acquisition malignancy treatment resistance by paracrine loops via EMT signals microenvironment. Furthermore, CAFs regulate cytotoxic activity immune various cytokines chemokines, creating tolerance. Regulation can affect responses. Recent research has shown several roles tumorigenesis, owing heterogeneity, so molecular markers should be elucidated classify tumor-promoting subtypes facilitate establishment CAF-specific targeted therapies. CAF-targeted treatments may suppress niche stem immunosuppressive network thus prove useful through multiple mechanisms.

Language: Английский

Citations

20
Exosomes derived from cancer-associated fibroblasts mediate response to cancer therapy DOI
Nastaran Masoudi-Khoram, Mohammad Hasan Soheilifar,

Shima Ghorbanifar

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2023, Volume and Issue: 185, P. 103967 - 103967

Published: March 23, 2023

Language: Английский

Citations

20
Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via exosomes in gastrointestinal tumors DOI Creative Commons

Longyang Cao,

Hong Ouyang

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 23, 2024

Gastrointestinal (GI) tumors are a significant global health threat, with high rates of morbidity and mortality. Exosomes contain various biologically active molecules like nucleic acids, proteins, lipids can serve as messengers for intercellular communication. They play critical roles in the exchange information between tumor cells microenvironment (TME). The TME consists mesenchymal components extracellular matrix (ECM), fibroblasts being most abundant cell type mesenchyme. Cancer-associated (CAFs) derived from normal stem that activated TME. CAFs secrete exosomes to modulate proliferation, invasion, migration, drug resistance, other biological processes tumors. Additionally, manipulate function behavior through direct cell-cell interactions. This review provides summary crosstalk GI exosomes, along potential underlying mechanisms.

Language: Английский

Citations

8
Cancer therapy resistance mediated by cancer-associated fibroblast-derived extracellular vesicles: biological mechanisms to clinical significance and implications DOI Creative Commons
Zhengjun Lin, Guoqing Li, Ke Jiang

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 7, 2024

Cancer-associated fibroblasts (CAFs) are a diverse stromal cell population within the tumour microenvironment, where they play fundamental roles in cancer progression and patient prognosis. Multiple lines of evidence have identified that CAFs critically involved shaping structure function microenvironment with numerous functions regulating behaviours, such as metastasis, invasion, epithelial-mesenchymal transition (EMT). can interact extensively cells by producing extracellular vesicles (EVs), multiple secreted factors, metabolites. Notably, CAF-derived EVs been critical mediators therapy resistance, constitute novel targets biomarkers management. This review aimed to summarize biological detailed molecular mechanisms mediating resistance chemotherapy, targeted agents, radiotherapy, immunotherapy. We also discussed therapeutic potential clinical management, thereby providing strategy for enhancing efficacy improving

Language: Английский

Citations

8