Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 4996 - 5041

Published: Jan. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Language: Английский

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Layered double hydroxide-based nanomaterials for biomedical applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(14), P. 6126 - 6176

Published: Jan. 1, 2022

Against the backdrop of increased public health awareness, inorganic nanomaterials have been widely explored as promising nanoagents for various kinds biomedical applications. Layered double hydroxides (LDHs), with versatile physicochemical advantages including excellent biocompatibility, pH-sensitive biodegradability, highly tunable chemical composition and structure, ease composite formation other materials, shown great promise in In this review, we comprehensively summarize recent advances LDH-based Firstly, material categories are discussed. The preparation surface modification nanomaterials, pristine LDHs, nanocomposites LDH-derived then described. Thereafter, systematically describe potential LDHs applications drug/gene delivery, bioimaging diagnosis, cancer therapy, biosensing, tissue engineering, anti-bacteria. Finally, on basis current state art, conclude insights remaining challenges future prospects rapidly emerging field.

Language: Английский

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Nanoparticles in Drug Delivery: From History to Therapeutic Applications

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(24), P. 4494 - 4494

Published: Dec. 19, 2022

Current research into the role of engineered nanoparticles in drug delivery systems (DDSs) for medical purposes has developed numerous fascinating nanocarriers. This paper reviews various conventionally used and current carriage system to deliver drugs. Due drawbacks conventional DDSs, nanocarriers have gained immense interest. Nanocarriers like polymeric nanoparticles, mesoporous nanomaterials, carbon nanotubes, dendrimers, liposomes, metallic nanomedicine, nanomaterials are as targeted at specific sites affected areas body. Nanomedicine rapidly grown treat certain diseases brain cancer, lung breast cardiovascular diseases, many others. These nanomedicines can improve bioavailability absorption time, reduce release eliminate aggregation, enhance solubility blood. introduced a new era by refining therapeutic directories energetic pharmaceutical elements within nanoparticles. In this context, vital information on was reviewed conferred towards ailments. All these were tested vitro vivo. coming years, human health more effectively adding advanced techniques system.

Language: Английский

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Biomaterials and nanomedicine for bone regeneration: Progress and future prospects

Exploration, Journal Year: 2021, Volume and Issue: 1(2)

Published: Oct. 1, 2021

Bone defects pose a heavy burden on patients, orthopedic surgeons, and public health resources. Various pathological conditions cause bone including trauma, tumors, inflammation, osteoporosis, so forth. Auto- allograft transplantation have been developed as the most commonly used clinic treatment methods, among which autologous grafts are golden standard. Yet repair of defects, especially large-volume in geriatric population or those complicated with systemic disease, is still challenge for regenerative medicine from clinical perspective. The fast development biomaterials nanomedicine favors emergence promotion efficient regeneration therapies. In this review, we briefly summarize progress novel biomaterial nanomedical approaches to then discuss current challenges that hinder their applications treating defects.

Language: Английский

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A MgFe‐LDH Nanosheet‐Incorporated Smart Thermo‐Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(5)

Published: Nov. 25, 2022

Although growth factor (GF)-loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart with excellent gelation/mechanical properties well controllable GF releasing capability. Herein, the incorporation of morphogenetic protein 2 (BMP-2)-functionalized MgFe-layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) loaded platelet-derived factor-BB (PDGF-BB) a injectable thermo-responsive hydrogel (denoted CSP-LB), which can achieve burst release PDGF-BB and sustained BMP-2, for highly efficient regeneration is reported. The MgFe-LDH CS not only shortens gelation time decreases sol-gel transition temperature, but also enhances mechanical property hydrogel. Because sequential dual-GFs bioactive Mg2+ /Fe3+ ions, vitro experiments prove that CSP-LB exhibits angiogenic osteogenic compared In vivo further significantly enhance higher volume mineral density than This thermo-sensitive possesses capability properties, thus providing minimally invasive solution defect treatment.

Language: Английский

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Biomedical engineering of two-dimensional MXenes

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 184, P. 114178 - 114178

Published: Feb. 26, 2022

Language: Английский

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Cancer nanomedicine toward clinical translation: Obstacles, opportunities, and future prospects

Med, Journal Year: 2022, Volume and Issue: 4(3), P. 147 - 167

Published: Dec. 21, 2022

Language: Английский

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Microneedle system for tissue engineering and regenerative medicine

Exploration, Journal Year: 2023, Volume and Issue: 3(1)

Published: Jan. 21, 2023

Abstract Global increasing demand for high life quality and length facilitates the development of tissue engineering regenerative medicine, which apply multidisciplinary theories techniques to achieve structural reconstruction functional recovery disordered or damaged tissues organs. However, clinical performances adopted drugs, materials, powerful cells in laboratory are inescapably limited by currently available technologies. To tackle problems, versatile microneedles developed as new platform local delivery diverse cargos with minimal invasion. The efficient delivery, well painless convenient procedure endow good patient compliance clinic. In this review, we first categorize different microneedle systems models, then summarize their applications medicine mainly involving maintenance rehabilitation end, discuss advantages, challenges, prospects depth future translations.

Language: Английский

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Ceramic Materials for Biomedical Applications: An Overview on Properties and Fabrication Processes

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(3), P. 146 - 146

Published: March 4, 2023

A growing interest in creating advanced biomaterials with specific physical and chemical properties is currently being observed. These high-standard materials must be capable to integrate into biological environments such as the oral cavity or other anatomical regions human body. Given these requirements, ceramic offer a feasible solution terms of mechanical strength, functionality, biocompatibility. In this review, fundamental physical, chemical, main nanocomposites are drawn, along some primary related applications biomedical fields, orthopedics, dentistry, regenerative medicine. Furthermore, an in-depth focus on bone-tissue engineering biomimetic scaffold design fabrication presented.

Language: Английский

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Biomedical Applications of MXenes: From Nanomedicine to Biomaterials

Accounts of Materials Research, Journal Year: 2022, Volume and Issue: 3(8), P. 785 - 798

Published: July 18, 2022

ConspectusThe rise of two-dimensional (2D) materials has led to significant interest in their potential applications for nanomedicine and biomaterials the hope that they can overcome some intrinsic limitations conventional theranostic materials. MXenes, an emerging family 2D mainly made transition metal carbides/nitrides, have drawn substantial biomedical because unique physicochemical properties. The remarkable photothermal energy-converting capability MXenes allows photonic hyperthermia treatment second near-infrared biowindow with deep tissue penetration. diverse choice elements endows them aptitudes act as contrast agents computed tomography magnetic resonance imaging. As understanding pathological characteristics is improved, desirable properties performances become more comprehensive, which unlikely be accomplished formulation alone.In this Account, we highlight recent progress ranging from biomaterials. We will start by introducing major synthetic techniques fabricating ultrathin structures nanoscale sizes purposes. then elaborate how differ other materials, showing exclusive applications. surface compositions allow tuning bandgap plasmon effect, essential nanodynamic therapy. could render enzymatic activities nanocatalytic also possess favorable biodegradability biocompatibility, facilitating clinical translation.However, might insufficient fulfill specific requirements advanced For instance, therapeutic efficiency alone would impaired reasons such low tumor accumulation nanomedicine, inclined thermal resistance cancer cells, hypoxic microenvironment. In addition, are limited therapy or theranostics. been integrated functional components tackle these issues. Thus, further discuss strategies fabricate MXene-based different dimensional a broad range applications, localized regeneration. Several methods modify demonstrated increase stability MXene physiological media. Decorating 0D nanoparticles enables combination imaging modalities. Integrating layered improved efficiency, 3D implantable discussed.

Language: Английский

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