Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
7, P. 101304 - 101304
Published: Jan. 1, 2024
A
diverse
set
of
tetrahydrobenzofuran-4(2H)-one
derivative
4(a-o)
were
synthesized
using
a
one-pot
treatment
dimedone,
3-(1H-imidazol-1-yl)benzaldehyde,
and
different
phenacyl
bromide
by
utilizing
cesium
carbonate
as
cost-effective
catalyst
in
acetonitrile
under
mild
reaction
condition.
During
the
synthesis
compounds,
two
carbon–carbon
(C–C)
bonds
one
carbon–oxygen
(C–O)
bond
are
formed.
All
compounds
obtained
with
moderate
to
good
yield.
The
underwent
screening
assess
their
antimicrobial
antimalarial
properties.
Compounds
4
l
(117
µM)
4d
(145
exhibited
highest
potency
against
A.
baumannii
Car.
Resistant
P.
aeruginosa
comparison
standard
drug
chloramphenicol
(155
µM),
respectively.
Compound
(234
displayed
efficacy
C.
albicans
than
that
drug,
fluconazole
(327
while
4f
(1018
showed
greater
niger
griseofulvin
(1417
µM).
In
addition,
all
titled
activity.
Among
them,
(1.60
has
falciparum
quinine
(2.71
Since
compound
exhibits
strong
antibacterial
fungal
action
among
synthetics,
it
shows
remarkable
binding
affinities
−8.5
kcal
mol−1
−9.1
Exploration,
Journal Year:
2023,
Volume and Issue:
3(1)
Published: Feb. 1, 2023
Bacterial
infection
has
become
one
of
the
leading
causes
death
worldwide,
particularly
in
low-income
countries.
Despite
fact
that
antibiotics
have
provided
successful
management
bacterial
infections,
long-term
overconsumption
and
abuse
contributed
to
emergence
multidrug
resistant
bacteria.
To
address
this
challenge,
nanomaterials
with
intrinsic
antibacterial
properties
or
serve
as
drug
carriers
been
substantially
developed
an
alternative
fight
against
infection.
Systematically
deeply
understanding
mechanisms
is
extremely
important
for
designing
new
therapeutics.
Recently,
nanomaterials-mediated
targeted
bacteria
depletion
either
a
passive
active
manner
most
promising
approaches
treatment
by
increasing
local
concentration
around
cells
enhance
inhibitory
activity
reduce
side
effects.
Passive
targeting
approach
widely
explored
searching
nanomaterial-based
alternatives
antibiotics,
while
strategy
relies
on
biomimetic
biomolecular
surface
feature
can
selectively
recognize
In
review
article,
we
summarize
recent
developments
field
therapy
based
nanomaterials,
which
will
promote
more
innovative
thinking
focusing
multidrug-resistant
Exploration,
Journal Year:
2023,
Volume and Issue:
4(2)
Published: Oct. 17, 2023
Abstract
The
emergence
of
drug‐resistant
bacteria
poses
a
significant
threat
to
people's
lives
and
health
as
bacterial
infections
continue
persist.
Currently,
antibiotic
therapy
remains
the
primary
approach
for
tackling
infections.
However,
escalating
rates
drug
resistance
coupled
with
lag
in
development
novel
drugs
have
led
diminishing
effectiveness
conventional
treatments.
Therefore,
nonantibiotic‐dependent
therapeutic
strategies
has
become
imperative
impede
rise
resistance.
chemodynamic
(CDT)
opened
up
new
possibility
due
CDT
can
convert
H
2
O
into
•OH
via
Fenton/Fenton‐like
reaction
treatment.
efficacy
is
limited
by
variety
practical
factors.
To
overcome
this
limitation,
sterilization
efficiency
be
enhanced
introducing
therapeutics
inherent
antimicrobial
capability.
In
addition,
researchers
explored
CDT‐based
combined
therapies
augment
its
effects
mitigate
potential
toxic
side
toward
normal
tissues.
This
review
examines
research
progress
field,
explores
various
enhance
presents
synergistic
combination
other
modalities.
And
last,
current
challenges
faced
future
directions
are
discussed.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(24)
Published: June 13, 2023
Nanozymes,
featuring
intrinsic
biocatalytic
effects
and
broad-spectrum
antimicrobial
properties,
are
emerging
as
a
novel
antibiotic
class.
However,
prevailing
bactericidal
nanozymes
face
challenging
dilemma
between
biofilm
penetration
bacterial
capture
capacity,
significantly
impeding
their
antibacterial
efficacy.
Here,
this
work
introduces
photomodulable
nanozyme
(ICG@hMnO
Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(29), P. 6746 - 6761
Published: Jan. 1, 2023
The
slow
healing
of
diabetic
wounds
has
seriously
affected
human
health.
Meanwhile,
the
open
are
susceptible
to
bacterial
infection.
Clinical
therapeutic
methods
such
as
antibiotic
therapy,
insulin
treatment,
and
surgical
debridement
have
made
great
achievements
in
treatment
wounds.
However,
drug-resistant
bacteria
will
develop
after
long-term
use
antibiotics,
resulting
decreased
efficacy.
To
improve
effect,
increasing
drug
concentration
is
a
common
strategy
clinical
practice,
but
it
also
brings
serious
side
effects.
In
addition,
hyperglycemia
control
or
can
easily
bring
negative
effects
patients,
hypoglycemia
damage
normal
tissue.
Therefore,
essential
novel
strategies
effectively
promote
wound
healing.
recent
years,
nanozyme-based
systems
received
extensive
attention
because
they
possess
advantages
nanomaterials
natural
enzymes.
For
example,
nanozymes
small
size
high
surface
area
volume
ratio,
which
enhance
tissue
penetration
increase
reactive
active
sites.
Moreover,
compared
with
enzymes,
more
stable
catalytic
activity,
lower
production
cost,
stronger
operability.
this
review,
we
first
reviewed
basic
characteristics
then
elaborated
on
mechanism
action
principle
different
types
from
three
aspects:
controlling
infection,
hyperglycemia,
relieving
inflammation.
Finally,
challenges,
prospects
future
implementation
for
outlined.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(38)
Published: April 23, 2024
Abstract
Currently,
microbial
infections
have
posed
an
arduous
challenge
to
global
public
health,
whereas
the
rise
of
antibiotic
resistance
is
rendering
traditional
therapies
futile,
prompting
development
new
antimicrobial
technologies.
Photoactive
nanomaterials
thus
garnered
a
thriving
interest
for
disinfection
owing
their
superior
antibacterial
efficaciousness,
favorable
biosafety,
and
rapidness
spatiotemporal
precision
in
excreting
bactericidal
actions.
The
review
summarizes
recent
advances
emerging
trends
design,
nanoengineering,
bioapplications
photoactive
antimicrobials.
It
commences
by
elaborating
fundamental
theories
on
bacterial
resistance,
mechanisms
phototherapy.
Subsequently,
regulation
effectiveness
comprehensively
discussed,
centering
criteria
strategies
tuning
photoabsorption
spectra,
photothermal
conversion,
photocatalytic
efficiency,
alongside
tactics
enabling
synergistic
therapies.
This
followed
comparative
analyses
techniques
modalities
synthesizing
engineering
with
diverse
structures,
forms,
functionalities.
Thereafter,
state‐of‐the‐art
applications
phototherapies
across
various
medical
sectors
are
portrayed,
key
challenges
opportunities
finally
discussed
spur
future
innovations
translation.
envisaged
provide
useful
guidance
devising
developing
nanomaterials‐based
photoresponsive
antimicrobials
application‐specific
materials
properties
biological
functions.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(6)
Published: April 19, 2024
Abstract
Infected
burn
wounds
are
characterized
by
persistent
drug‐resistant
bacterial
infection
coupled
with
an
inflammatory
response,
impeding
the
wound‐healing
process.
In
this
study,
intelligent
nanoparticle
system
(CCM+TTD@ZIF‐8
NPs)
was
prepared
using
curcumin
(CCM),
aggregation‐induced
emission
luminogens
(TTD),
and
ZIF‐8
for
infection‐induced
wound
healing.
The
CCM+TTD@ZIF‐8
NPs
showed
multiple
functions,
including
bacteria
targeting,
fluorescence
imaging
pH
response‐guided
photodynamic
therapy
(PDT),
anti‐inflammatory.
positive
charges
of
allowed
targeting
in
infected
wounds,
thereby
realizing
emitting
red
at
site
upon
blue
light
irradiation.
pH‐responsive
characteristics
also
enabled
controllable
CCM
release
onto
site,
promoting
specific
accumulation
ROS
outstanding
bactericidal
efficacy
against
Staphylococcus
aureus
(S.
aureus)
Pseudomonas
aeruginosa
(P.
aeruginosa)
strains
vitro/in
vivo.
Additionally,
due
to
excellent
effect
anti‐inflammatory
properties
combined
irradiation,
regeneration
epidermal
tissue,
angiogenesis,
collagen
deposition
achieved,
accelerating
healing
process
wounds.
Therefore,
multifunctional
provides
great
potential
Quantitative Imaging in Medicine and Surgery,
Journal Year:
2024,
Volume and Issue:
14(8), P. 5460 - 5472
Published: Feb. 23, 2024
Non-small
cell
lung
cancer
(NSCLC)
patients
with
epidermal
growth
factor
receptor-sensitizing
(EGFR-sensitizing)
mutations
exhibit
a
positive
response
to
tyrosine
kinase
inhibitors
(TKIs).
Given
the
limitations
of
current
clinical
predictive
methods,
it
is
critical
explore
radiomics-based
approaches.
In
this
study,
we
leveraged
deep-learning
technology
multimodal
radiomics
data
more
accurately
predict
EGFR-sensitizing
mutations.
