Photo‐facilitated chemodynamic therapeutic agents: Synthesis, mechanisms, and biomedical applications

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 16, 2023

Abstract Chemodynamic therapy (CDT) utilizes Fenton and/or Fenton‐like reactions in the tumor microenvironment (TME) to produce cytotoxic reactive oxygen species (ROS, mainly hydroxyl radicals, •OH) for inducing cancer cell death. Since CDT exhibits minimal invasiveness and high specificity by responding TME (overexpressed hydrogen peroxide (H 2 O ) glutathione (GSH) generation), a lot of related research has been conducted recently. Photo‐facilitated can further enhance catalytic activity controllability treatment. In addition, other photo‐induced therapies, including photodynamic photothermal (PDT, PTT), may synergize with obtain boosting treatment efficacy avoid multidrug resistance. this minireview, we summarize recent advances photo‐assisted CDT, PTT‐facilitated PDT‐facilitated CDT. More importantly, challenges encountered process are discussed potential development directions suggested facilitate clinical translation future.

Language: Английский

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Multienzyme‐Mimicking LaCoO₃ Nanotrigger for Programming Cancer‐Cell Pyroptosis

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(35)

Published: May 25, 2023

Pyroptosis, a distinct paradigm of programmed cell death, is an efficient strategy against cancer by overcoming resistance to apoptosis. In this study, LaCoO3 (LCO) lanthanide-based nanocrystals with multienzyme characteristics are rationally designed and engineered trigger the generation cytotoxic reactive oxygen species (ROS) release lanthanum ions, ultimately inducing lung pyroptosis. The peroxidase- oxidase-mimicking activities LCO endow ROS production capacity in tumor tissues acidic pH high hydrogen peroxide content. Concurrently, nanoenzyme exhibits catalase- glutathione peroxidase-like activities, reversing hypoxic microenvironment, destroying activated antioxidant system cells, amplifying sensitivity cells ROS. use ultrasound further accelerates enzymatic kinetic rate. Most importantly, La3+ ions released robustly destroy lysosomal membrane, finally canonical pyroptotic together LCO-nanocrystal-triggered pyroptosis amplifies therapeutic effects both vitro vivo, effectively restraining growth metastasis. This study paves new avenue for treatment metastasis through US-enhanced lanthanum-based platforms death.

Language: Английский

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In situ hydrogel based on Cu–Fe3O4 nanoclusters exploits oxidative stress and the ferroptosis/cuproptosis pathway for chemodynamic therapy

Biomaterials, Journal Year: 2024, Volume and Issue: 311, P. 122675 - 122675

Published: June 26, 2024

Language: Английский

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Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

Advanced Science, Journal Year: 2024, Volume and Issue: 11(20)

Published: March 19, 2024

Abstract Layered double hydroxides (LDHs) have been widely studied for biomedical applications due to their excellent properties, such as good biocompatibility, degradability, interlayer ion exchangeability, high loading capacity, pH‐responsive release, and large specific surface area. Furthermore, the flexibility in structural composition ease of modification LDHs makes it possible develop specifically functionalized meet needs different applications. In this review, recent advances applications, which include LDH‐based drug delivery systems, cancer diagnosis therapy, tissue engineering, coatings, functional membranes, biosensors, are comprehensively discussed. From these various research fields, can be seen that there is great potential possibility use However, at same time, must recognized actual clinical translation still very limited. Therefore, current limitations related on discussed by combining limited examples with requirements biomaterials. Finally, an outlook future provided.

Language: Английский

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Engineered Probiotic Bio‐heterojunction with Robust Antibiofilm Modality via “Eating” Extracellular Polymeric Substances for Wound Regeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 25, 2024

The compact three-dimensional (3D) structure of extracellular polymeric substances (EPS) within biofilms significantly hinders the penetration antimicrobial agents, making biofilm eradication challenging and resulting in persistent biofilm-associated infections. To address this challenge, a solution is proposed: probiotic bio-heterojunction (P-bioHJ) combining Lactobacillus rhamnosus with MXene (Ti

Language: Английский

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Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180

Published: Aug. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Language: Английский

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Language: Английский

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Characterizing tumor biology and immune microenvironment in high-grade serous ovarian cancer via single-cell RNA sequencing: insights for targeted and personalized immunotherapy strategies

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 17, 2025

High-grade serous ovarian cancer (HGSOC), the predominant subtype of epithelial cancer, is frequently diagnosed at an advanced stage due to its nonspecific early symptoms. Despite standard treatments, including cytoreductive surgery and platinum-based chemotherapy, significant improvements in survival have been limited. Understanding molecular mechanisms, immune landscape, drug sensitivity HGSOC crucial for developing more effective personalized therapies. This study integrates insights from immunology, profiling, analysis identify novel therapeutic targets improve treatment outcomes. Utilizing single-cell RNA sequencing (scRNA-seq), systematically examines tumor heterogeneity microenvironment, focusing on biomarkers influencing response activity, aiming enhance patient outcomes quality life. scRNA-seq data was obtained GEO database this study. Differential gene expression analyzed using ontology set enrichment methods. InferCNV identified malignant cells, while Monocle, Cytotrace, Slingshot software inferred differentiation trajectories. The CellChat package predicted cellular communication between cell subtypes other pySCENIC utilized transcription factor regulatory networks within subtypes. Finally, results were validated through functional experiments, a prognostic model developed assess prognosis, infiltration, across various risk groups. investigated scRNA-seq, their interactions microenvironment. We confirmed key role C2 IGF2+ HGSOC, which significantly associated with poor prognosis high levels chromosomal copy number variations. located terminal tumor, displaying higher degree malignancy close association IIIC tissue types. also metabolic pathways, such as glycolysis riboflavin metabolism, well programmed death processes. highlighted complex fibroblasts MK signaling pathway, may be closely related tumor-associated progression. Elevated PRRX1 connected impact disease progression by modulating transcription. A based demonstrated adverse outcomes, emphasizing importance infiltration clinical intervention strategies. oncology, immunotherapy, reveal mechanisms driving resistance. subtype, linked offers promising target future Emphasizing sensitivity, research highlights strategies life patients.

Language: Английский

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Smart hydrogel: A new platform for cancer therapy

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 340, P. 103470 - 103470

Published: March 7, 2025

Language: Английский

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A Sonication‐Activated Valence‐Variable Sono‐Sensitizer/Catalyst for Autography Inhibition/Ferroptosis‐Induced Tumor Nanotherapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(48)

Published: Oct. 6, 2022

Abstract The effective deployment of reactive oxygen species (ROS)‐mediated oncotherapy in practice remains challenging, mired by uncontrollable catalytic processes, stern reaction conditions and safety concerns. Herein, we develop a copper nanodot integrating sonodynamic effects within one active center, which responds to exogenous ultrasound (US) endogenous H 2 O stimuli. US irradiation induces the valence conversion from Cu II I catalyzing into ⋅OH for chemodynamic therapy. Meanwhile, transformation results electron‐hole pairs separation, promoting ROS generation Notably, nanodots not only block lysosome fusion degradation leading autophagy flux blockage, but also interfere with glutathione peroxidase 4 cystine‐glutamate antiporter SLC7A11 function achieving ferroptosis. Furthermore, reversible changes, inherent hydrophilicity renal clearance ultrasmall size guarantee biosafety.

Language: Английский

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