Future Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 15
Published: Feb. 20, 2025
The
advancement
of
targeted
drug
delivery
systems
has
opened
up
a
wide
array
opportunities
in
cancer
therapy,
leading
to
the
exploration
various
strategies.
Among
these,
use
prodrugs
stands
out
as
particularly
promising
approach
treatment,
aimed
at
enhancing
selectivity
and
effectiveness
cytotoxic
agents.
In
last
few
years,
there
been
considerable
progress
area
dimeric-based
therapy.
advantages
presented
by
have
significantly
improved
efficiency
delivering
anticancer
drugs,
characterized
high
loading
capacity,
advantageous
pharmacokinetics,
release
that
responds
tumor
stimuli.
With
respect
importance
dimerization
field
prodrug
development,
herein
we
review
latest
reports
covering
research
dimeric
prodrugs.
We
categorized
article
according
reported
also
spent
great
deal
attention
on
different
types
used
linkers
methods
dissociation
into
free
monomeric
drugs.
Readers
will
easily
be
able
compare
between
using
same
drugs
with
or
well
cell
lines
studies.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: March 25, 2023
Abstract
Nanomedicine
holds
great
promise
to
enhance
cancer
therapy.
However,
low
active
pharmaceutical
ingredient
(API)
loading
content,
unpredictable
drug
release,
and
potential
toxicity
from
excipients
limit
their
translational
capability.
We
herein
report
a
full-API
nanodrug
composed
of
FDA-approved
5-aminolevulinic
acid
(ALA),
human
essential
element
Fe
3+
,
natural
bioactive
compound
curcumin
with
an
ideal
API
content
pH-responsive
release
profile
for
continuous
spatiotemporal
therapy
achieved
by
multi-step
tandem
endogenous
biosynthesis.
First,
ALA
enzymatically
converts
into
photosensitizer
protoporphyrin
IX
(PpIX).
Afterward,
multiple
downstream
products
including
carbon
monoxide
(CO),
2+
biliverdin
(BV),
bilirubin
(BR)
are
individually
biosynthesized
through
the
PpIX-heme-CO/Fe
/BV-BR
metabolic
pathway,
further
cooperating
released
curcumin,
ultimately
eliciting
mitochondria
damage,
membrane
disruption,
intracytoplasmic
injury.
This
work
not
only
provides
paradigm
exploiting
diversified
metabolites
tumor
suppression,
but
also
presents
safe
efficient
nanodrug,
facilitating
practical
translation
nanodrugs.
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Nov. 6, 2023
Pancreatic
cancer
is
a
highly
aggressive
malignancy
with
limited
treatment
options
and
poor
prognosis.
Trophoblast
cell
surface
antigen
2
(TROP2),
overexpressed
in
the
tumors
of
more
than
half
pancreatic
patients,
has
been
identified
as
potential
target
for
antibody-drug
conjugates
(ADCs).
Almost
all
reported
TROP2-targeted
ADCs
are
IgG
type
have
poorly
studied
cancer.
Here,
we
aimed
to
develop
novel
nanobody-drug
conjugate
(NDC)
targeting
TROP2
cancer.In
this
study,
developed
NDC,
HuNbTROP2-HSA-MMAE,
TROP2-positive
HuNbTROP2-HSA-MMAE
characterized
by
use
nanobodies
against
human
serum
albumin
(HSA)
drug-antibody
ratio
1.
exhibited
specific
binding
was
internalized
into
tumor
cells
high
endocytosis
efficiency
within
5
h,
followed
intracellular
translocation
lysosomes
release
MMAE
induce
apoptosis
through
caspase-3/9
pathway.
In
xenograft
model
cancer,
doses
0.2
mg/kg
1
demonstrated
significant
antitumor
effects,
dose
even
eradicated
tumor.HuNbTROP2-HSA-MMAE
desirable
affinity,
internalization
activity.
It
holds
promise
therapeutic
option
Exploration,
Journal Year:
2022,
Volume and Issue:
2(4)
Published: June 4, 2022
Self-assembled
prodrug
nanoparticles
with
tumor-responsive
capacity
have
great
potential
in
tumor
visualization
and
treatment.
However,
the
nanoparticle
formulas
usually
contain
multiple
components,
especially
polymeric
materials,
which
result
various
issues.
Herein,
we
report
an
indocyanine
green
(ICG)-driven
assembly
of
paclitaxel
prodrugs
integrating
near-infrared
fluorescence
imaging
tumor-specific
chemotherapy.
By
feat
hydrophilic
merit
ICG,
dimer
could
form
more
uniformly
monodispersed
nanoparticles.
This
two-in-one
strategy
reinforces
complementary
advantages,
resulting
superior
behavior,
robust
colloidal
stability,
enhanced
accumulation
as
well
desirable
vivo
feedback
The
experiments
validated
activation
at
sites
evidenced
by
intensity,
potent
growth
suppression,
reduced
systemic
toxicity
compared
commercial
Taxol.
universality
ICG
potentiated
toward
photosensitizers
dyes
was
confirmed.
presentation
provides
deep
insight
into
feasibility
constructing
clinical-close
alternatives
for
improving
antitumor
efficacy.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(4)
Published: Feb. 9, 2024
Abstract
Prodrug‐based
self‐assembled
nanoparticles
(PSNs)
with
tailored
responses
to
tumor
microenvironments
show
a
significant
promise
for
chemodynamic
therapy
(CDT)
by
generating
highly
toxic
reactive
oxygen
species
(ROS).
However,
the
insufficient
level
of
intracellular
ROS
and
limited
drug
accumulation
remain
major
challenges
further
clinical
transformation.
In
this
study,
PSNs
delivery
artesunate
(ARS)
are
demonstrated
designing
pH‐responsive
ARS‐4‐hydroxybenzoyl
hydrazide
(HBZ)‐5‐amino
levulinic
acid
(ALA)
(AHA
NPs)
self‐supplied
excellent
chemotherapy
CDT.
The
greatly
improved
loading
capacity
generation
from
endoperoxide
bridge
using
electron
withdrawing
group
attached
directly
C10
site
artesunate.
ALA
ARS‐HBZ
could
be
released
AHA
NPs
under
cleavage
hydrazone
bonds
triggered
acidic
surroundings.
Besides,
increased
heme
in
mitochondria,
promoting
lipid
peroxidation
anti‐tumor
effects.
Our
study
ARS
through
chemical
modification,
pointing
out
potential
applications
fields.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 1867 - 1886
Published: Feb. 1, 2024
Abstract:
Although
the
frequency
of
bone
metastases
from
breast
cancer
has
increased,
effective
treatment
is
lacking,
prompting
development
nanomedicine,
which
involves
use
nanotechnology
for
disease
diagnosis
and
treatment.
Nanocarrier
drug
delivery
systems
offer
several
advantages
over
traditional
methods,
such
as
higher
reliability
biological
activity,
improved
penetration
retention,
precise
targeting
delivery.
Various
nanoparticles
that
can
selectively
target
tumor
cells
without
causing
harm
to
healthy
or
organs
have
been
synthesized.
Recent
advances
in
enabled
prevention
metastatic
diseases
well
ability
deliver
complex
molecular
"cargo"
particles
regions.
Nanoparticles
modulate
systemic
biodistribution
enable
targeted
accumulation
therapeutic
agents.
Several
strategies
are
used
treat
metastases,
including
untargeted
delivery,
bone-targeted
cell-targeted
Combining
agents
with
enhances
selective
payloads
lesions,
providing
multiple
In
this
review,
we
describe
recent
nanoparticle
treating
metastases.
Keywords:
cancer,
metastasis,
nanoparticle,
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(30)
Published: March 21, 2024
Abstract
The
combination
of
chemotherapy
and
immunotherapy
holds
great
potential
in
clinical
treatment
advanced
cancers.
Whereas,
the
therapeutic
outcome
chemotherapeutic
immune
regulator
is
suboptimal
due
to
their
poor
tumor
availability
severe
off‐target
toxicity.
Herein,
self‐carrier
nanoparticles
(PSMT
NPs)
integrating
a
paclitaxel
(PTX)
prodrug
indoleamine
2,3‐dioxygenase
1
(IDO)
inhibitor
(1‐methyl‐tryptophan,
1MT)
for
tumor‐specific
chemo‐immunotherapy
constructed.
After
internalization
by
cancer
cells,
PSMT
NPs
can
respond
endogenous
redox
stimulus,
release
PTX
1MT.
released
not
only
promote
cell
apoptosis
via
intervention
mitosis
but
also
initiate
immunogenic
death
facilitate
recruitment
activation
tumor‐infiltrating
cytotoxic
T
lymphocytes.
concomitant
1MT
inhibit
IDO
activity
exhaust
regulatory
thereby
synergistically
activating
exhibit
potentiated
antitumor
output
toward
triple‐negative
breast
negligible
systemic
This
facile
versatile
nanoplatform
provides
promising
strategy
cooperatively
activate
immunity
chemo‐immunotherapy.
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(8), P. 5121 - 5135
Published: July 23, 2024
Indocyanine
green
J-aggregates
(ICG-Jagg)
have
emerged
as
a
significant
subject
of
interest
in
biomedical
applications
due
to
their
unique
optical
properties,
tunable
size,
and
excellent
biocompatibility.
This
comprehensive
review
aims
provide
an
in-depth
exploration
ICG-Jagg,
with
focus
on
elucidating
the
diverse
facets
preparation
factors
that
influence
process.
Additionally,
discusses
diagnostics,
such
imaging
contrast
agents,
well
utilization
drug
delivery
various
phototherapeutic
interventions.
