A tumor-targeting porphyrin-micelle with enhanced STING agonist delivery and synergistic photo-/immuno- therapy for cancer treatment DOI
Yuqing Pan,

Haijing Qu,

Han Chen

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Macrophage membrane-camouflaged pure-drug nanomedicine for synergistic chemo- and interstitial photodynamic therapy against glioblastoma DOI
Wei Cheng,

Zhiran Duan,

Han Chen

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy DOI Creative Commons
Yuwei Liu, Shuting Xu,

Qingyang Lyu

et al.

Aggregate, Journal Year: 2023, Volume and Issue: 5(1)

Published: Oct. 12, 2023

Abstract Nowadays, cancer has become the leading cause of death worldwide, driving need for effective therapeutics to improve patient prognosis. Photodynamic therapy (PDT) been widely applied as an antitumor modality, owing its minimal invasiveness, localized tumor damage, and high safety profile. However, efficacy is limited by poor stability photosensitizers, inadequate accumulation, a complex microenvironment. To overcome these challenges, extensive endeavors have made explore co‐assembly used photosensitizer chlorin e6 (Ce6) with various functional small molecules enhance pharmacodynamic activity. This review provides comprehensive overview current studies on Ce6‐based nanoparticles PDT precise delivery molecules. The self‐assembly mechanism will be discussed in detail, focus potential strategies combinational PDT.

Language: Английский

Citations

24
Biomimetic Lung-Targeting Nanoparticles with Antioxidative and Nrf2 Activating Properties for Treating Ischemia/Reperfusion-Induced Acute Lung Injury DOI
Yanjun Wang, Hui Dong,

Haijing Qu

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(7), P. 2131 - 2141

Published: Jan. 16, 2024

Ischemia/reperfusion (IR)-induced acute lung injury (ALI) has a high mortality rate. Reactive oxygen species (ROS) play crucial role in causing cellular damage and death IR-induced ALI. In this work, we developed biomimetic lung-targeting nanoparticle (PC@MB) as an antioxidative protector for treating PC@MBs showed excellent ROS scavenging Nrf2 activation properties, along with function through autologous cell membrane coating. The exhibited impressive pulmonary protective via redox homeostasis recovery heme oxygenase-1 activation. could maintain viability by effectively the intracellular restoring equilibrium lesion. IR mouse model, preferentially accumulated distinctly repaired pneumonic damage. Our strategy potential to offer promising therapeutic paradigm ALI incorporation of different mechanisms.

Language: Английский

Citations

12
Manganese-coordinated nanoparticle with high drug-loading capacity and synergistic photo-/immuno-therapy for cancer treatments DOI
Han Chen,

Haijing Qu,

Yuqing Pan

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 312, P. 122745 - 122745

Published: Aug. 3, 2024

Language: Английский

Citations

9
Drug-drug conjugates self-assembled nanomedicines triggered photo−/immuno- therapy for synergistic cancer treatments DOI

Haijing Qu,

Longmeng Li,

Han Chen

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 361 - 375

Published: Sept. 29, 2023

Language: Английский

Citations

18
Nanotechnology‐Empowered Combination Cancer Immunotherapies: Mechanisms, Synergies, and Perspectives DOI Creative Commons
Yuqing Pan, Xiangdong Xue, Xing‐Jie Liang

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(4)

Published: Jan. 26, 2024

This review is aiming to systematically elucidate the unique role of nanotechnology in optimizing therapeutic modalities for combinatorial cancer immunotherapy, which enables synergistic integration multiple treatment strategies. In particular, has enabled combination immunotherapy with physical therapies, chemotherapy, metal therapy, and nucleic acid therapy. each regimen, nanocarriers play multifaceted roles by achieving targeted codelivery different therapeutics individual modality. offers new paradigms guide precision medicine treatment. Immunotherapy alone unlikely achieve personalized cancer, are needed future. To overcome technical bottlenecks realize precise regulation tumor microenvironment treatment, it crucial develop novel nanosystems integrated sensing, targeting, functionalities.

Language: Английский

Citations

6
Charge-reversible crosslinked nanoparticle for pro-apoptotic peptide delivery and synergistic photodynamic cancer therapy DOI

Haijing Qu,

Han Chen, Wei Cheng

et al.

Nano Research, Journal Year: 2023, Volume and Issue: 16(12), P. 13267 - 13282

Published: Oct. 13, 2023

Language: Английский

Citations

15
Bifunctional drug delivery system with carbonic anhydrase IX targeting and glutathione-responsivity driven by host-guest amphiphiles for effective tumor therapy DOI
Jiawei Zhou, Ya‐Min Li,

Lutao Wang

et al.

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 326, P. 121577 - 121577

Published: Nov. 14, 2023

Language: Английский

Citations

14
Hierarchically Engineered Self-Adaptive Nanoplatform Guided Intuitive and Precision Interventions for Deep-Seated Glioblastoma DOI
Wei Cheng,

Haijing Qu,

Jiaojiao Yang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Glioblastoma multiforme (GBM), particularly the deep-seated tumor where surgical removal is not feasible, poses great challenges for clinical treatments due to complicated biological barriers and risk of damaging healthy brain tissue. Here, we hierarchically engineer a self-adaptive nanoplatform (SAN) that overcomes delivery by dynamically adjusting its structure, surface charge, particle size, targeting moieties precisely distinguish between parenchyma cells. We further devise

Language: Английский

Citations

0
Leveraging supramolecular systems in biomedical breakthroughs DOI

Shreya Maity,

Vishal Kumar Deb,

Samim Ali Mondal

et al.

BioFactors, Journal Year: 2025, Volume and Issue: 51(1)

Published: Jan. 1, 2025

Abstract Supramolecular systems, intricate assemblies of molecular subunits organized through various intermolecular interactions, offer versatile platforms for diverse applications, including gene therapy, antimicrobial and cellular engineering. These systems are cost‐effective environmentally friendly, contributing to their attractiveness in biomaterial design. Furthermore, supramolecular biomaterials based on acyclic, macrocyclic compounds lipid‐based assembly potential applications distinct types biomedical approaches. In this context, they can transport several therapeutic agents very effectively the target site. hydrogels exhibit potent activity by disrupting microbial membranes, offering promising solutions combat drug‐resistant pathogens. Additionally, luminescent nanoparticles enable targeted cell imaging, facilitating disease diagnosis treatment with high specificity sensitivity. engineering, small molecules demonstrate biological activities, overcoming challenges cancer inhibiting signaling pathways inducing apoptosis cells. This review emphasizes from therapy tissue showcasing drive innovation address pressing healthcare challenges.

Language: Английский

Citations

0