Enhanced Peroxidase-Like Activity of Au@Pt-TiO2 Nanocomposite under Ultrasound Stimulus for Efficient ROS Generation in Medical Applications

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

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Advancements in the application of ablative therapy and its combination with immunotherapy in anti-cancer therapy

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(2), P. 189285 - 189285

Published: Feb. 10, 2025

Language: Английский

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Novel hormone therapies for advanced prostate cancer: understanding and countering drug resistance

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101232 - 101232

Published: Feb. 1, 2025

Language: Английский

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Tumor microenvironment-activated and near-infrared light-driven free radicals amplifier for tetra-modal cancer imaging and synergistic treatment

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 689, P. 137208 - 137208

Published: March 1, 2025

Language: Английский

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Versatile Copper-Chalcogenide-Based Nanoparticles for the Treatment of Brain Diseases

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Intelligent nanoreactor coupling tumor microenvironment manipulation and H2O2-dependent photothermal-chemodynamic therapy for accurate treatment of primary and metastatic tumors

Bioactive Materials, Journal Year: 2024, Volume and Issue: 34, P. 354 - 365

Published: Jan. 6, 2024

Tumor microenvironment (TME), as the "soil" of tumor growth and metastasis, exhibits significant differences from normal physiological conditions. However, how to manipulate distinctions achieve accurate therapy primary metastatic tumors is still a challenge. Herein, an innovative nanoreactor (AH@MBTF) developed utilize apparent (copper concentration H2O2 level) between cells eliminate based on H2O2-dependent photothermal-chemodynamic suppress through copper complexation. This constructed using functionalized MSN incorporating benzoyl thiourea (BTU), triphenylphosphine (TPP), folic acid (FA), while being co-loaded with horseradish peroxidase (HRP) its substrate ABTS. During therapy, BTU moieties AH@MBTF could capture excessive (highly correlated metastasis), presenting exceptional anti-metastasis activity. Simultaneously, complexation triggers formation cuprous ions, which further react generate cytotoxic hydroxyl radical (•OH), inhibiting via chemodynamic therapy. Additionally, stepwise targeting FA TPP guides accurately accumulate in mitochondria, containing abnormally high levels H2O2. As catalyst, HRP mediates oxidation reaction ABTS yield activated ABTS•+. Upon 808 nm laser irradiation, ABTS•+ performs tumor-specific photothermal achieving ablation by raising tissue temperature. Collectively, this intelligent possesses profound potential progression metastasis.

Language: Английский

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Extracellular Vesicle‐Inspired Therapeutic Strategies for the COVID‐19

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(29)

Published: June 25, 2024

Emerging infectious diseases like coronavirus pneumonia (COVID-19) present significant challenges to global health, extensively affecting both human society and the economy. Extracellular vesicles (EVs) have demonstrated remarkable potential as crucial biomedical tools for COVID-19 diagnosis treatment. However, due limitations in performance titer of natural vesicles, their clinical use remains limited. Nonetheless, EV-inspired strategies are gaining increasing attention. Notably, biomimetic inspired by EVs, possess specific receptors that can act "Trojan horses," preventing virus from infecting host cells. Genetic engineering enhance these enabling them carry more receptors, significantly specificity absorbing novel coronavirus. Additionally, inherit numerous cytokine parent cells, allowing effectively mitigate "cytokine storm" adsorbing pro-inflammatory cytokines. Overall, this strategy offers new avenues treatment emerging diseases. Herein, review systematically summarizes current applications COVID-19. The status associated with implementation also discussed. goal is provide insights into design expand application combating

Language: Английский

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Bioimaging and prospects of night pearls‐based persistence phosphors in cancer diagnostics

Exploration, Journal Year: 2024, Volume and Issue: 4(4)

Published: Jan. 23, 2024

Abstract Inorganic persistent phosphors feature great potential for cancer diagnosis due to the long luminescence lifetime, low background scattering, and minimal autofluorescence. With prominent advantages of near‐infrared light, such as deep penetration, high resolution, autofluorescence, tissue absorption, can be used bioimaging. We focus on highlighting inorganic phosphors, emphasizing synthesis methods applications in diagnostics. Typical synthetic high‐temperature solid state, thermal decomposition, hydrothermal/solvothermal, template are proposed obtain small‐size biological organisms. The mechanisms with different excitation discussed effective matrixes including galliumate, germanium, aluminate, fluoride explored. Finally, current directions where continue optimized how further overcome challenges summarized.

Language: Английский

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Oxygen‐Independent Synchronized ROS Generation and Hypoxia Prodrug Activation with Z‐Scheme Heterostructure Sonosensitizer

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Oct. 19, 2023

Abstract Combination therapy has emerged as a promising approach for effective tumor treatment. However, the combination of sonodynamic (SDT) and hypoxia‐activated prodrugs (HAPs) not been explored due to contradictory requirement oxygen (O 2 ) reactive species (ROS) generation necessity avoid O activation HAPs. In this study, challenge is addressed by developing BiOCl‐Au‐Ag S Z‐scheme heterostructure nanoparticles loaded with tirapazamine (TPZ) achieve ‐independent therapy. These demonstrate efficient electron–hole separation under ultrasound irradiation while maintaining high redox potential. The generated holes react water efficiently produce hydroxyl radicals, electrons autonomously activate TPZ, negating need . vitro in vivo assessments validate elimination these without disrupting hypoxic environment. This innovative design overcomes limitations associated SDT introduces novel strategy HAP synergistic between ROS HAPs‐based

Language: Английский

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High-temperature PTT/CDT coordination nanoplatform realizing exacerbated hypoxia for enhancing hypoxia-activated chemotherapy to overcome tumor drug resistance

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 26, 2024

Abstract Background Hypoxia-activated prodrugs present new opportunities for safe and effective tumor drug resistance therapy due to their high selectivity hypoxic cells. However, the uneven distribution of oxygen in solid insufficient hypoxia microenvironment greatly limit its therapeutic efficacy. Results In this paper, a novel AQ4N-Mn(II)@PDA coordination nanoplatform was designed functionalized with GMBP1 target drug-resistant Its excellent photothermal conversion efficiency could achieve local high-temperature tumors, which not only effectively exacerbate thus improve efficacy hypoxia-activated chemotherapy AQ4N but also significantly accelerate Mn 2+ -mediated Fenton-like activity enhance chemodynamic therapy. Moreover, real-time monitoring blood saturation through photoacoustic imaging reflect status tumors during treatment. Furthermore, synergistic treatment inhibited growth improved survival rate mice bearing orthotopic tumors. Conclusions This study provided idea PTT combined CDT explored vital theory

Language: Английский

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