Non-linear development of brain morphometry in child and adolescent offspring of individuals with bipolar disorder or schizophrenia DOI Creative Commons
Simon R. Poortman, Nikita Setiaman, Marjolein E.A. Barendse

et al.

European Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 87, P. 56 - 66

Published: July 30, 2024

Offspring of parents with severe mental illness (e.g., bipolar disorder or schizophrenia) are at increased risk developing psychopathology. Structural brain alterations have been found in child and adolescent offspring patients schizophrenia, but the developmental trajectories anatomy this high-familial-risk population still unclear. 300 T1-weighted scans were obtained 187 least one parent diagnosed (n=80) schizophrenia (n=53) without (n=54). The age range was 8 to 23 years old; 113 underwent two scans. Global measures regional cortical thickness surface area computed. A generalized additive mixed model used capture non-linear trajectories. had smaller total volume than (d=-0.20, p=0.004) control (d=-0.22, p=0.005) lower mean (d=-0.23, p<0.001). showed differential cerebral white matter compared (both p's=0.003). Regionally, a significantly different trajectory middle temporal gyrus versus (p<0.001) (p=0.001), which no longer significant after correcting for thickness. These findings suggest that particularly familial high is related reductions deviating global structure measures, not driven by specific regions.

Language: Английский

Age Trajectories of the Structural Connectome in Child and Adolescent Offspring of Individuals With Bipolar Disorder or Schizophrenia DOI Creative Commons
Simon R. Poortman, Marjolein E.A. Barendse, Nikita Setiaman

et al.

Biological Psychiatry Global Open Science, Journal Year: 2024, Volume and Issue: 4(5), P. 100336 - 100336

Published: May 28, 2024

Offspring of parents with severe mental illness (e.g., bipolar disorder or schizophrenia) are at elevated risk developing psychiatric illness, owing to both genetic predisposition and increased burden environmental stress. Emerging evidence indicates a disruption brain network connectivity in young offspring patients schizophrenia, but the age trajectories these networks this high-familial-risk population remain be elucidated. 271 T1-weighted diffusion-weighted scans were obtained from 174 least one parent diagnosed (n=74) schizophrenia (n=51) without (n=49). The range was 8 23 years old; 97 underwent two scans. Anatomical reconstructed into structural matrices. Network analysis performed investigate anatomical connectivity. had differential strength clustering compared global efficiency local disorder. findings study suggest that particularly familial high is related deviations connectome properties strength.

Language: Английский

Citations

2
Sex differences in brain homotopic co-activations: a meta-analytic study DOI Creative Commons
Chiara Bonelli, Lorenzo Mancuso, Jordi Manuello

et al.

Brain Structure and Function, Journal Year: 2022, Volume and Issue: 227(8), P. 2839 - 2855

Published: Oct. 21, 2022

An element of great interest in functional connectivity is 'homotopic connectivity' (HC), namely the between two mirrored areas hemispheres, mainly mediated by fibers corpus callosum. Despite a long tradition studying sexual dimorphism human brain, to our knowledge only one study has addressed influence sex on HC.We investigated issue homotopic co-activations women and men using coordinate-based meta-analytic method data from BrainMap database. A first unexpected observation was that database affected bias: women-only groups are less often than men-only ones, they more studied certain domains such as emotion compared men, cognition. Implementing series sampling procedures equalize size proportion datasets, results indicated females exhibit stronger interhemispheric co-activation males, suggesting female brain lateralized integrated males. In addition, males appear show intense but extensive females. Some local differences also appeared. particular, it appears primary motor perceptual co-activated contrast opposite trend rest brain. This argues for multidimensional view suggests should be approached with complex models previously thought.

Language: Английский

Citations

8
Sex-related variability of white matter tracts in the whole HCP cohort DOI Creative Commons

B Herlin,

I. Uszynski,

Maëlig Chauvel

et al.

Brain Structure and Function, Journal Year: 2024, Volume and Issue: 229(7), P. 1713 - 1735

Published: July 16, 2024

Abstract Behavioral differences between men and women have been studied extensively, as in brain anatomy. However, most studies focused on gray matter, while white matter has much less studied. We conducted a comprehensive study of 77 deep tracts to analyze their volumetric microstructural variability the full Human Connectome Project (HCP) cohort 1065 healthy individuals aged 22–35 years. found significant difference total volume (+ 12.6% men), consistent with literature. 16 showed women, one which stood out due larger effect size: corpus callosum genu, was 7.3% p = 5.76 × 10 –19 ). In addition, we several parameters both using standard Diffusion Tensor Imaging (DTI) more complex from Neurite Orientation Dispersion Density (NODDI) model, showing greatest belonging motor (cortico-spinal tracts, cortico-cerebellar tracts) or limbic (cingulum, fornix, thalamo-temporal radiations) systems. These may be related known behavioral sexes timed performance, aggressiveness/impulsivity, social cognition.

Language: Английский

Citations

1
Effects of Congenital Adrenal Hyperplasia (CAH) and Biological Sex on Brain Size DOI Creative Commons

Eileen Lüders,

Christian Gaser, Debra Spencer

et al.

Anatomia, Journal Year: 2024, Volume and Issue: 3(3), P. 155 - 162

Published: July 18, 2024

Congenital Adrenal Hyperplasia (CAH) has been reported to involve structural alterations in some brain regions. However, it remains be established whether there is also an impact on the size of as a whole. Here, we compiled largest CAH sample date (n = 53), matched pair-wise control group 53) sex, age, and verbal intelligence. Using T1-weighted scans, calculated intracranial volume (ICV) well total (TBV), which are both common estimates for size. The statistical analysis was performed using general linear model assessing effects (CAH vs. controls), sex (women men), any CAH-by-sex interaction. outcomes were comparable ICV TBV, i.e., no significant main effect with larger ICVs TBVs men than women. Our findings contribute understudied field research exploring anatomy CAH. In contrast existing studies suggesting smaller CAH, did not observe such effect. other words, TBV women differ significantly from those controls. Notwithstanding, observed well-known difference (12.69% 12.50% TBV), volumes women, agreement literature.

Language: Английский

Citations

1
Non-linear development of brain morphometry in child and adolescent offspring of individuals with bipolar disorder or schizophrenia DOI Creative Commons
Simon R. Poortman, Nikita Setiaman, Marjolein E.A. Barendse

et al.

European Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 87, P. 56 - 66

Published: July 30, 2024

Offspring of parents with severe mental illness (e.g., bipolar disorder or schizophrenia) are at increased risk developing psychopathology. Structural brain alterations have been found in child and adolescent offspring patients schizophrenia, but the developmental trajectories anatomy this high-familial-risk population still unclear. 300 T1-weighted scans were obtained 187 least one parent diagnosed (n=80) schizophrenia (n=53) without (n=54). The age range was 8 to 23 years old; 113 underwent two scans. Global measures regional cortical thickness surface area computed. A generalized additive mixed model used capture non-linear trajectories. had smaller total volume than (d=-0.20, p=0.004) control (d=-0.22, p=0.005) lower mean (d=-0.23, p<0.001). showed differential cerebral white matter compared (both p's=0.003). Regionally, a significantly different trajectory middle temporal gyrus versus (p<0.001) (p=0.001), which no longer significant after correcting for thickness. These findings suggest that particularly familial high is related reductions deviating global structure measures, not driven by specific regions.

Language: Английский

Citations

1