Enhancing Early Detection of Blood Disorders through A Novel Hybrid Modeling Approach DOI Open Access
Pınar Karadayı Ataş

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, Journal Year: 2023, Volume and Issue: 12(4), P. 1261 - 1274

Published: Dec. 23, 2023

Blood disorders are such conditions that impact the blood’s ability to function correctly. There is a range of different symptoms depending on type. several types blood as Leukemia, chronic myelocytic leukemia, lymphoma, myelofibrosis, polycythemia, thrombocytopenia, anemia, and leukocytosis. Some resolve completely with therapy or do not cause affect overall lifespan. lifelong but how an individual lives. Other disorders, like sickle cell disease cancers, can be even fatal. needs capture hidden information in medical data for detecting diseases early stages. This paper presents novel hybrid modeling strategy makes use synergy between two methods histogram-based gradient boosting classifier tree random subspace. It should emphasized combination these models being employed this study first time. We present model built assessment diseases. The results show proposed predict tumor better than other classifiers.

Language: Английский

Contemporary evaluation of women and girls with abnormal uterine bleeding: FIGO Systems 1 and 2 DOI Creative Commons
Varsha Jain, Malcolm G. Munro, Hilary Critchley

et al.

International Journal of Gynecology & Obstetrics, Journal Year: 2023, Volume and Issue: 162(S2), P. 29 - 42

Published: Aug. 1, 2023

Abstract Abnormal uterine bleeding (AUB) is common, often debilitating, and may affect over 50% of reproductive‐aged women girls. Whereas AUB a collection symptoms that include intermenstrual abnormalities in period duration, cycle length, regularity, it heavy menstrual (HMB) most contributory to iron deficiency related anemia. It apparent AUB, general, HMB, particular, remain underrecognized underreported. FIGO created two systems for assessing classifying AUB. System 1 defines the pattern using four primary descriptors: frequency, flow volume. 2 provides structured classification system possible causes acronym PALM‐COEIN. “PALM” refers structural (Polyp, Adenomyosis, Leiomyoma, Malignancy), “COEI” nonstructural (Coagulopathy, Ovulatory dysfunction, Endometrial, Iatrogenic). The “N” reserved those entities are currently not otherwise classified. Using as gateway streamlines investigation girls with Understanding pathogenesis “PALM‐COEIN” helps interpret investigations onward management Numerous evidence gaps exist concerning AUB; however, if researchers trialists universally adopt Systems assessment diagnosis clear translatable research findings can be applied globally.

Language: Английский

Citations

29

Iron deficiency anemia among women: An issue of health equity DOI
Grace H. Tang, Michelle Sholzberg

Blood Reviews, Journal Year: 2023, Volume and Issue: 64, P. 101159 - 101159

Published: Nov. 29, 2023

Language: Английский

Citations

19

Longitudinal evaluation of iron status during pregnancy: a prospective cohort study in a high-resource setting DOI Creative Commons
Elaine K. McCarthy,

David Schneck,

Saonli Basu

et al.

American Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: 120(5), P. 1259 - 1268

Published: Sept. 26, 2024

Language: Английский

Citations

6

Tranexamic acid for management of heavy vaginal bleeding: barriers to access and myths surrounding its use DOI Creative Commons
Heather VanderMeulen, Grace H. Tang, Michelle Sholzberg

et al.

Research and Practice in Thrombosis and Haemostasis, Journal Year: 2024, Volume and Issue: 8(3), P. 102389 - 102389

Published: March 1, 2024

Tranexamic acid is safe and effective for the treatment of heavy vaginal bleeding during menstruation childbirth. It improves quality life, facilitates participation in school work, reduces risk death from postpartum hemorrhage. Despite its well-established benefits, individual- structural-level barriers preclude widespread utilization, hindering patient care perpetuating health inequities women's health. We first describe evidence use tranexamic treating menstrual Barriers to use, including structural sexism, period poverty, misinformation product monograph labeling, stigmatization blood loss, drug access, are then discussed. Finally, we summarize relevant data presented 2023 International Society on Thrombosis Haemostasis Congress.

Language: Английский

Citations

5

Therapeutic options for the management of abnormal uterine bleeding DOI Open Access
Becky MacGregor, Malcolm G. Munro, Mary Ann Lumsden

et al.

International Journal of Gynecology & Obstetrics, Journal Year: 2023, Volume and Issue: 162(S2), P. 43 - 57

Published: Aug. 1, 2023

Language: Английский

Citations

11

Understanding hepcidin for iron management in pregnancy DOI Creative Commons
Sarah Rosson, Sue Pavord

Transfusion Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Iron deficiency anaemia (IDA) poses a significant health challenge during pregnancy, affecting up to 30% of pregnant women in the UK. It has been linked poor outcomes for mother, foetus, and infant. Despite its prevalence impact, current diagnostic therapeutic approaches are limited. Ensuring an adequate iron status pregnancy requires prompt investigation treatment whilst avoiding excessive supplementation associated side effects. Hepcidin, key regulator trafficking body, emerged as promising candidate tailoring individual needs responsiveness. However, research on hepcidin‐based yields mixed findings, necessitating comprehensive review elucidate potential utility guiding therapy with IDA. This literature seeks synthesise existing evidence explore role hepcidin personalised IDA identify avenues future pave way improved management pregnancy.

Language: Английский

Citations

0

Serum ferritin levels and risk of gestational diabetes mellitus: A cohort study DOI Creative Commons

Yupei Xie,

Siyu Dai, Qian Chen

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 4, 2025

Gestational diabetes mellitus (GDM) is a glucose metabolism disorder with an unclear etiology that occurs specifically during pregnancy. While elevated serum ferritin levels have been reported to increase the risk of GDM, these findings lack validation in large-scale studies and yet inform clinical practice effectively. This study enrolled 12,434 controls 3599 GDM patients employed binary multifactorial logistic regression, restricted cubic spline, propensity score matching, random forest algorithm explore relationship between as well effect size on GDM. The results indicated higher compared second third trimesters. A weak correlation was found OGTT 1-hour 2-hour blood trimester. Logistic regression (LR) spline (RCS) analyses showed significant positive Propensity matching analysis association second-trimester remained nearly constant before after matching. suggested among all confounders, had minimal risk. In conclusion, our provides further compelling evidence for gestational mellitus. However, additional research still needed clarify specific mechanisms underlying this association.

Language: Английский

Citations

0

Evidence gaps for the global problem of iron deficiency and iron deficiency anemia in women and girls of reproductive age DOI Creative Commons
Jason Abbott, Malcolm G. Munro

International Journal of Gynecology & Obstetrics, Journal Year: 2023, Volume and Issue: 162(S2), P. 89 - 92

Published: Aug. 1, 2023

Abstract The symptom of heavy menstrual bleeding and the frequently associated condition iron deficiency (ID) individually collectively adversely impact lives women girls reproductive age in various ways. insidious but sometimes profound effects periconceptual ID on developing fetus may continue throughout individual's life with consequences that are also felt by families, friends, society at large. Unfortunately, most instances, current healthcare policies not designed to address plethora issues a fashion will result meaningful improvement health other outcomes affect both individuals society. Identification prioritization many evidence gaps be an essential component strategy for change. This article identifies describes provides direction investigators those involved policy.

Language: Английский

Citations

5

Our path from abnormal uterine bleeding and iron deficiency to impaired fetal development: A long and winding road DOI Open Access
Malcolm G. Munro, Hilary Critchley

International Journal of Gynecology & Obstetrics, Journal Year: 2023, Volume and Issue: 162(S2), P. 3 - 6

Published: Aug. 1, 2023

Language: Английский

Citations

2

Knowledge and practices of pregnant women regarding iron deficiency anemia in the Eastern Region of Ghana DOI Creative Commons

Ebenezer Quayson,

Helena S. Jancy,

Hannah Okyere-Boateng

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 14, 2024

Abstract The prevalence of iron deficiency anemia in Ghana persists despite the national health policy routine supplementation and education for pregnant women during antenatal care. This makes it worrying as such, studies should be conducted to uncover why there is an increase among women, after interventions prevent phenomenon. Thus, study aimed assess knowledge, practices, relationship between knowledge practices regarding anemia. A descriptive cross-sectional design with a quantitative approach convenient sampling method was used conducting study. Standard closed-ended questionnaire elicit responses from registered respondents. revealed that 69.5% respondents’ depicted good pregnancy 65% showed on pregnancy. There positive correlation (r = 0.68) level Pregnant who received care at Anum's Salvation Army Hospital demonstrated adequate behaviors preventing It recommended midwives intensify clinical manifestations

Language: Английский

Citations

0