Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(4)

Published: Oct. 1, 2023

Abstract Precision medicine that takes individual variability into account is a new way to minimize the for precise diagnosis and establish certain strategies of efficient therapy. Due miniaturization sensing area, remoting detection, flexible operation light, fiber optics have been successfully used develop in vitro, wearable, implanted biosensors, exhibiting high potential precision from vitro therapy vivo. When modified with recognition element, optic‐based biosensor enables point care testing detection disease biomarkers. Meanwhile, packaged needle/catheter also monitor medical Internet things continuous assessment human health. Moreover, light cladding or leaky mode excites strong photothermal effect The addressed drawbacks plasmonic limited penetration depths non‐selectivity integrated agent, biosensors provide situ information as well specifically efficiently kill tumor cells deep tissues. In this review, we summarized advances challenges prospection application were explored depth.

Language: Английский

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Sodium Citrate Nanoparticles Induce Dual-Path Pyroptosis for Enhanced Antitumor Immunotherapy through Synergistic Ion Overload and Metabolic Disturbance

Nano Letters, Journal Year: 2023, Volume and Issue: 23(21), P. 10034 - 10043

Published: Oct. 30, 2023

Metabolic reprogramming, as one of the characteristics cancer, is associated with tumorigenesis, growth, or migration, and modulation metabolic pathways has emerged a novel approach for cancer therapy. However, conventional metabolism-mediated apoptosis process in tumor cells exhibits limited immunogenicity inadequate activation antitumor immunity. Herein, phospholipid-coated sodium citrate nanoparticles (PSCT NPs) are successfully prepared, which dissolve then release significant amounts ions Na+ ions. Massive quantities lead to increased intracellular osmotic pressure, activates caspase-1/gasdermin D (GSDMD) mediated pyroptosis pathway. Simultaneously, induces caspase-8/gasdermin C (GSDMC) The combined action these two synergistically causes intense pyroptosis, exhibiting remarkable immune responses growth inhibition. This discovery provides new insight into potential nanomaterials modulating metabolism altering cell death patterns enhance immunotherapy.

Language: Английский

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Engineered Enzyme-Loaded Erythrocyte Vesicles Precisely Deprive Tumoral Nutrients to Induce Synergistic Near-Infrared-II Photothermal Therapy and Immune Activation

ACS Nano, Journal Year: 2023, Volume and Issue: 17(14), P. 13211 - 13223

Published: July 13, 2023

Starvation therapy has been considered a promising strategy in cancer treatment for altering the tumor microenvironment (TME) and causing cascade of therapeutic effects. However, it is still highly challenging to establish precisely potently depriving tumoral nutrition. In this study, glucose oxidase (GOx) thrombin-incorporated erythrocyte vesicle (EV) with cyclic (Arg-Gly-Asp) (cRGD) peptide modification, denoted as EV@RGT, were synthesized nutrition sequentially inducing second near-infrared region (NIR-II) photothermal (PTT) immune activation. The EV@RGT could specifically accumulate at site release enzymes acidic TME. combination GOx thrombin exhausts blocks supply same time, resulting severe energy deficiency reactive oxygen species (ROS) enrichment within cells. Subsequently, abundant clotted erythrocytes vessels present outstanding localized NIR-II PTT eradication owing hemoglobin. Furthermore, ROS generated by enhanced starvation repolarizes resident macrophages into antitumor M1 phenotype via DNA damage-induced STING/NF-κB pathway, ultimately contributing elimination. Consequently, engineered demonstrates powerful efficiency based on precise deprivation, sequential PTT, activation effect. This work provides an effective application enzyme-based reinforced therapy.

Language: Английский

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Targeted delivery of nano-radiosensitizers for tumor radiotherapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216101 - 216101

Published: July 27, 2024

Language: Английский

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Ω-Shaped fiber optic LSPR coated with hybridized nanolayers for tumor cell sensing and photothermal treatment

Talanta, Journal Year: 2024, Volume and Issue: 278, P. 126381 - 126381

Published: June 17, 2024

Language: Английский

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Enhancing Magnetic Hyperthermia Efficacy through Targeted Heat Shock Protein 90 Inhibition: Unveiling Immune-Mediated Therapeutic Synergy in Glioma Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 17145 - 17161

Published: June 21, 2024

The induction of heat stress response (HSR) mediated by the generation shock proteins (HSPs) on exposure to magnetic hyperthermia-mediated cancer therapy (MHCT) decreases efficacy localized treatment at tumor site, and thus remains a significant challenge. Hence, present study examined differential HSR elicited in glioma cells post-MHCT under different microenvironment conditions (2D monolayers, 3D monoculture, coculture spheroids) recognize target genes that, when downregulated, could enhance therapeutic effect MHCT. Gene expression analysis following MHCT revealed that HSP90 was upregulated as compared HSP70. treatment, combinatorial strategy using 17-DMAG an inhibitor investigated. effects terms cell viability, HSP levels immunofluorescence gene analysis, oxidative generation, alterations cellular integrity were evaluated, where demonstrated enhanced outcome with maximum death. Further, murine model, rapid inhibition 65 53% observed within 8 days primary secondary sites, respectively, MCHT + group, abscopal effect-mediated complete both sites 20 extracellularly released from dying further suggested immune supported upregulation IFN-γ calreticulin group. Overall, our findings indicate activates host systems efficiently cooperates blockade inhibit growth distant metastatic tumors.

Language: Английский

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Ferrous Selenide Stabilized Black Phosphorus Heterojunction Sonosensitizer for MR Imaging-Guided Sonodynamic Therapy of Bladder Cancer

Biomaterials Research, Journal Year: 2024, Volume and Issue: 28

Published: Jan. 1, 2024

It is urgent to develop an alternative dynamic therapy-based method overcome the limited efficacy of traditional therapy methods for bladder cancer and damage caused patients. Sonodynamic (SDT) has advantages high tissue penetration, spatiotemporal selectivity, being non-invasive, representing emerging eradicating deep solid tumors. However, effectiveness SDT often hindered by inefficient production reactive oxygen species nondegradability sonosensitizer. To improve anti-tumor effect on cancer, herein, a BP-based heterojunction sonosensitizer (BFeSe 2 ) was synthesized anchoring FeSe onto BP via P–Se bonding enhance stability SDT. As result, BFeSe showed great cytotoxicity cells under ultrasound (US) irradiation. led notable inhibition tumor growth in subcutaneous models orthotopic US In addition, could also T2-weighted magnetic resonance imaging (MRI) achieve monitoring guide treatment cancer. general, integrates MRI functions precise treatment, promising clinical potential theranostics

Language: Английский

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Nanothermometry for cellular temperature monitoring and disease diagnostics

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(2)

Published: March 25, 2024

Abstract Body temperature variations, including the generation, transfer, and dissipation of heat, play an important role throughout life participate in all biological events. Cellular information is indispensable link comprehensive understanding science processes, but traditional testing strategies cannot provide sufficient due to their low precision inefficient cellular‐entrance. In recent years, with help luminescent nanomaterials, a variety new thermometers have been developed achieve real‐time measurement at micro/nano scale. this review, we summarized latest advances several nanoparticles for cellular detection related applications revealing cell metabolism disease diagnosis. Furthermore, review proposed few challenges nano‐thermometry, expecting spark novel thought push forward its preclinical translational uses.

Language: Английский

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Photosensitive and dual-targeted chromium nanoparticle delivering small interfering RNA YTHDF1 for molecular-targeted immunotherapy in liver cancer

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 19, 2024

Abstract Tumor-associated macrophages (TAMs) are a promising target for cancer immunotherapy, but delivering therapeutic agents to TAMs within the tumor microenvironment (TME) is challenging. In this study, photosensitive, dual-targeting nanoparticle system (M.RGD@Cr-CTS-siYTHDF1 NPs) was developed. The structure includes shell of DSPE-modified RGD peptides targeting integrin receptors on cells and carboxymethyl mannose CD206 macrophages, with core chitosan adsorbing m6A reading protein YTHDF1 siRNA chromium nanoparticles (Cr NPs). approach specifically designed TAM cells, utilizing photothermal effect Cr NPs disrupt TME deliver siYTHDF1 TAM. experiments tumor-bearing mice, M.RGD@Cr-CTS-siYTHDF1 NPs, when exposed laser irradiation, effectively killed disrupted TME, delivered TAMs, silenced gene, shifted STAT3-STAT1 equilibrium by reducing STAT3 enhancing STAT1 expression. This reprogramming towards an anti-tumor phenotype led pro-immunogenic state. strategy also suppressed immunosuppressive IL-10 production, increased expression immunostimulatory factors (IL-12 IFN-γ), boosted CD8 + T cell infiltration M1-type reduced Tregs M2-type TME. conclusion, integrating capabilities therapy (PTT) RNA interference, offer molecular targeted immunotherapy potential clinical application. Graphical

Language: Английский

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Nano-Assisted Radiotherapy Strategies: New Opportunities for Treatment of Non-Small Cell Lung Cancer

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Lung cancer is the second most commonly diagnosed and a leading cause of cancer-related death, with non-small cell lung (NSCLC) being prevalent type. Over 70% patients require radiotherapy (RT), which operates through direct indirect mechanisms to treat cancer. However, RT can damage healthy tissues encounter radiological resistance, making it crucial enhance its precision optimize treatment outcomes, minimize side effects, overcome radioresistance. Integrating nanotechnology into presents promising method increase efficacy. This review explores various nano-assisted strategies aimed at achieving treatment. These include using nanomaterials as radiosensitizers, applying modify tumor microenvironment, employing nano-based radioprotectors radiation-treated products for RT. We also explore recent advancements in NSCLC, such biomimetic targeting that alters mesenchymal stromal cells, magnetic strategies, nanosensitization high-atomic number nanomaterials. Finally, we address existing challenges future directions nanotechnology, highlighting potential clinical applications.

Language: Английский

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