Is There a Link between the Microbiome and Autoimmune Aspects of Long COVID-19? DOI Open Access
Altijana Hromić‐Jahjefendić, Lejla Mahmutović, Abas Sezer

et al.

Published: June 11, 2024

Long COVID-19 affects a significant percentage of survivors and is characterized by wide range symptoms, including weariness mental fog as well emotional symptoms like worry sadness. closely linked to the autoimmune disorders that are becoming more prevalent worldwide immune system hyperactivation, neutrophil extracellular trap (NET) development, molecular mimicry pathways. Long-term COVID-related responses include watchful system, altered innate adaptive cells, autoantigens secreted living or dead neutrophils, high concentrations autoantibodies directed against different proteins. The microbiome, which consists billions bacteria in human body, essential for controlling supporting overall health. microbiome can affect course long-term COVID-associated autoimmunity, degree illness, rate recovery, onset reactions. Although precise role long COVID autoimmunity still being investigated, new studies indicate probiotics, prebiotics, dietary changes—interventions target microbiome—may be able reduce reactions enhance outcomes survivors. It clear research required precisely understand how COVID-19-related create tailored treatment plans.

Language: Английский

Interplay between Comorbidities and Long COVID: Challenges and Multidisciplinary Approaches DOI Creative Commons
Rasha Ashmawy, Esraa Abdellatif Hammouda, Yousra A. El‐Maradny

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(7), P. 835 - 835

Published: July 11, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID’s burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Language: Английский

Citations

11
Translating insights into therapies for Long Covid DOI Open Access
Annukka A.R. Antar, Andrea L. Cox

Science Translational Medicine, Journal Year: 2024, Volume and Issue: 16(773)

Published: Nov. 13, 2024

Long Covid is defined by a wide range of symptoms that persist after the acute phase severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported include fatigue, weakness, postexertional malaise, and cognitive dysfunction, with many other reported. Symptom range, duration, severity are highly variable partially overlap myalgic encephalomyelitis/chronic fatigue post-acute infectious syndromes, highlighting opportunities to define shared mechanisms pathogenesis. Potential diverse, including persistence viral reservoirs, dysregulated immune responses, direct damage tissues targeted SARS-CoV-2, inflammation driven reactivation latent infections, vascular endothelium activation or subsequent thromboinflammation, autoimmunity, metabolic derangements, microglial activation, microbiota dysbiosis. The heterogeneity baseline characteristics people Covid, as well varying states immunity therapies given at time infection, have made etiologies difficult determine. Here, we examine progress on preclinical models for review being in clinical trials, need large human studies further development better understand Covid. Such will inform trials treatments benefit those living this condition.

Language: Английский

Citations

4
Reduced Presence of SARS-CoV-2 microRNA-like Small RNA in the Serum of Patients with Post-Acute Sequelae SARS-CoV-2 Infection DOI Creative Commons
Maria Alfreda Stincarelli, Isabella Abbate, Giulia Matusali

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 126 - 126

Published: Jan. 9, 2025

The mechanisms underlying post-acute sequelae of SARS-CoV-2 infection (PASC) are a topic debate. This study examined the presence microRNA (miRNA)-like small RNAs in extracellular fluids and their potential link to PASC by using quantitative stem-loop RT-PCR MiRNA assay. Initially, it was demonstrated that three previously identified miRNA-like RNAs, specifically svRNA 1 2 miR-07a, were significantly expressed infected cells vitro released into supernatant following different variants. Then, expression studied both nasopharyngeal swabs (NPS) sera from 24 patients at initial COVID-19 diagnosis (T0) collected 91 193 days post-diagnosis (T1). Notably, 11 out (46%) reported consequences. All NPS samples showed RNA with an altered cytokine network during acute infection, but did not correlate outcomes. Serum had similar statuses, though patients, notably T1, T0, displayed reduced overall positivity compared those without PASC. host target between groups. suggests need for further research its role viral behavior

Language: Английский

Citations

0
Viral persistence in long COVID: Research advances and treatment strategies DOI Creative Commons
Shiyang Liu, Yuming Guo, Fu‐Sheng Wang

et al.

Infectious Diseases & Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Although the coronavirus disease 2019 (COVID-19) pandemic has ended, enduring health impacts of severe acute respiratory syndrome 2 (SARS-CoV-2) infection continue to garner global attention, as approximately 10% patients develop long COVID (post COVID-19 condition). The epidemiological characteristics and symptoms have been reported, various pathogenic hypotheses proposed. Recent evidence suggests that SARS-CoV-2 nucleic acids or fragments persist in some post-infection these are correlated with symptoms. This review focuses on clinical studies linking persistence symptoms, explores relationship between viral other etiological hypotheses, such immune dysregulation, vascular issues, coagulation dysfunction, microbiome dysbiosis, brainstem/vagus nerve signaling latent virus reactivation. Futhermore, treatment strategies for proposed based current trials antiviral modulation therapies. Understanding role pathogenesis is critical developing targeted therapies improving management this debilitating condition.

Language: Английский

Citations

0
Are the Comorbidities Constitute an Intrinsic Factor for Long COVID? DOI Open Access
Rasha Ashmawy, Esraa Abdellatif Hammouda, Yousra A. El‐Maradny

et al.

Published: May 2, 2024

Long COVID, a name often given to the persistent symptoms following acute SARS-CoV-2 infection, poses multifaceted challenge for health. This review explores intrinsic relationship between comorbidities and autoimmune responses in shaping trajectory of long COVID. Autoantibodies have emerged as significant players COVID-19 pathophysiology, with implications disease severity progression. Studies show immune dysregulation persisting months after marked by activated innate cells high cytokine levels. The presence autoantibodies against various autoantigens suggests their potential comorbid factors Additionally, formation complexes may lead severe progression, highlighting urgency early detection intervention. Furthermore, COVID is highly linked cardiovascular complications neurological symptoms, posing challenges diagnosis management. Multidisciplinary approaches, including vaccination, tailored rehabilitation, pharmacological interventions, are used mitigating COVID's burden. However, numerous persist, from evolving diagnostic criteria addressing psychosocial impact predicting outcomes. Leveraging AI-based applications holds promise enhancing patient management improving our understanding As research continues unfold, unravelling complexities remains paramount effective intervention care.

Language: Английский

Citations

3
Humoral anti-SARS-CoV-2 response in patients with different long COVID phenotypes DOI Creative Commons
Piotr Rzymski, Jacek Niedziela,

Barbara Poniedziałek

et al.

Virology, Journal Year: 2024, Volume and Issue: 596, P. 110118 - 110118

Published: May 23, 2024

Long COVID (LC) is characterized by persistent symptoms following SARS-CoV-2 infection, with various mechanisms offered to explain its pathogenesis. This study explored whether adaptive humoral anti-SARS-CoV-2 responses differ in LC. Unvaccinated COVID-19 convalescents (n = 200) were enrolled, 21.5% 43) presenting LC three months post-infection. diagnosis was based on symptom(s) and alterations biochemical/clinical markers; phenotypes distinguished: cardiological, pulmonary, psychiatric All significantly decreased seroprevalence of IgG antibodies against nucleocapsid (anti-NP). associated odds testing positive for anti-NP (OR 0.35, 95%CI: 0.16-0.78, p 0.001). Seropositive patients had lower anti-S1 anti-S2 levels than individuals without LC, those pulmonary psychological also revealed anti-RBD concentrations. The results indicate that can be diminished response SARS-CoV-2. potential implication this phenomenon post-acute viral sequelae discussed.

Language: Английский

Citations

3
The intersection of microbiome and autoimmunity in long COVID-19: Current insights and future directions DOI
Altijana Hromić‐Jahjefendić, Lejla Mahmutović, Abas Sezer

et al.

Cytokine & Growth Factor Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

Citations

3
Is There a Link between the Microbiome and Autoimmune Aspects of Long COVID-19? DOI Open Access
Altijana Hromić‐Jahjefendić, Lejla Mahmutović, Abas Sezer

et al.

Published: June 11, 2024

Long COVID-19 affects a significant percentage of survivors and is characterized by wide range symptoms, including weariness mental fog as well emotional symptoms like worry sadness. closely linked to the autoimmune disorders that are becoming more prevalent worldwide immune system hyperactivation, neutrophil extracellular trap (NET) development, molecular mimicry pathways. Long-term COVID-related responses include watchful system, altered innate adaptive cells, autoantigens secreted living or dead neutrophils, high concentrations autoantibodies directed against different proteins. The microbiome, which consists billions bacteria in human body, essential for controlling supporting overall health. microbiome can affect course long-term COVID-associated autoimmunity, degree illness, rate recovery, onset reactions. Although precise role long COVID autoimmunity still being investigated, new studies indicate probiotics, prebiotics, dietary changes—interventions target microbiome—may be able reduce reactions enhance outcomes survivors. It clear research required precisely understand how COVID-19-related create tailored treatment plans.

Language: Английский

Citations

1