Pathology - Research and Practice, Journal Year: 2021, Volume and Issue: 219, P. 153373 - 153373
Published: Feb. 9, 2021
Language: Английский
Gene, Journal Year: 2020, Volume and Issue: 742, P. 144577 - 144577
Published: March 18, 2020
Language: Английский
Citations
76
Cancer Gene Therapy, Journal Year: 2022, Volume and Issue: 29(12), P. 1866 - 1877
Published: July 4, 2022
Abstract Breast cancer affects millions of women each year. Despite recent advances in targeted treatments breast remains a significant threat to women’s health. In years the development high-throughput sequencing technologies has advanced field transcriptomics shedding light on role non-coding RNAs (ncRNAs), including long ncRNAs (lncRNAs), human cellular function and disease. LncRNAs are classified as transcripts longer than 200nt with no coding potential. These constitute diverse group regulatory molecules essential modulation crucial processes, which dysregulation leads exert their functions through sequences by forming complex secondary tertiary structures that interact other transcripts, chromatin and/or proteins. Numerous studies have provided evidence involvement tumor disease progression. They possess multiple characteristics make them novel therapeutic diagnostic targets. Indeed, discovery mechanism lncRNAs associated proteins can induce formation phase-separated droplets broadens our understanding spatiotemporal control processes opens up developing new treatment. Nevertheless, molecular mechanisms many regulation still remain elusive. This is due absence thorough characterization loci functional impact aberrations biology. Here, we present some latest concerning cancer.
Language: Английский
Citations
51
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: March 11, 2024
Abstract Breast cancer is significantly influenced by endoplasmic reticulum (ER) stress, impacting both its initiation and progression. When cells experience an accumulation of misfolded or unfolded proteins, they activate the protein response (UPR) to restore cellular balance. In breast cancer, UPR frequently triggered due challenging conditions within tumors. The has a dual impact on cancer. On one hand, it can contribute tumor growth enhancing cell survival resistance programmed death in unfavorable environments. other prolonged severe ER stress trigger mechanisms, limiting Furthermore, been linked regulation non-coding RNAs (ncRNAs) cells. These ncRNAs, including microRNAs (miRNAs) long (lncRNAs), play essential roles development influencing gene expression processes. An improved understanding how ncRNAs interact potentially lead new treatment approaches. Modifying specific involved might interfere with induce death. Additionally, focusing UPR-associated proteins that could offer novel therapeutic possibilities. Therefore, this review provides concise overview interconnection between elucidating nuanced effects fate emphasizing regulatory
Language: Английский
Citations
9
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155374 - 155374
Published: May 29, 2024
Language: Английский
Citations
9
Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 518 - 518
Published: March 17, 2025
Gene mutations in PIK3CA, the catalytic subunit of phosphoinositide 3-kinases, are significantly associated with prognosis breast cancer. This association suggests that cancer patients PIK3CA should receive mutant-specific treatment. review aimed to investigate novel treatments for PIK3CA-mutant study investigated effects respect gene ontology and PI3K/AKT/mTOR pathway. Subsequently, we comprehensively examined all clinical trials targeted mutations. Finally, this explored potential a new treatment noncoding RNA.
Language: Английский
Citations
1
Biomolecules, Journal Year: 2020, Volume and Issue: 10(7), P. 1040 - 1040
Published: July 12, 2020
Molecular signaling pathways involved in cancer have been intensively studied due to their crucial role cell growth and dissemination. Among them, zinc finger E-box binding homeobox-1 (ZEB1) -2 (ZEB2) are molecules that play vital roles ensure the survival of tumor cells, particularly through enhancing proliferation, promoting migration invasion, triggering drug resistance. Importantly, ZEB proteins regulated by microRNAs (miRs). In this review, we demonstrate impact miRs on therapy, targeting proteins. MiRs able act as onco-suppressor factors inhibit malignancy cells ZEB1/2 down-regulation. This can lead an inhibition epithelial-mesenchymal transition (EMT) mechanism, therefore reducing metastasis. Additionally, ZEB1/2-mediated resistance immunosuppression. explore upstream modulators such long non-coding RNAs (lncRNAs) circular (circRNAs), these regulators influence inhibitory effect progression.
Language: Английский
Citations
71
European Journal of Pharmacology, Journal Year: 2020, Volume and Issue: 892, P. 173660 - 173660
Published: Oct. 24, 2020
Language: Английский
Citations
69
Life Sciences, Journal Year: 2020, Volume and Issue: 256, P. 117899 - 117899
Published: June 3, 2020
Language: Английский
Citations
65
IUBMB Life, Journal Year: 2024, Volume and Issue: 76(11), P. 883 - 921
Published: Aug. 1, 2024
Cancer drug resistance poses a significant obstacle to successful chemotherapy, primarily driven by the activity of ATP-binding cassette (ABC) transporters, which actively efflux chemotherapeutic agents from cancer cells, reducing their intracellular concentrations and therapeutic efficacy. Recent studies have highlighted pivotal role long noncoding RNAs (lncRNAs) in regulating this resistance, positioning them as crucial modulators ABC transporter function. lncRNAs, once considered transcriptional noise, are now recognized for complex regulatory capabilities at various cellular levels, including chromatin modification, transcription, post-transcriptional processing. This review synthesizes current research demonstrating how lncRNAs influence modulating expression transporters. can act molecular sponges, sequestering microRNAs that would otherwise downregulate genes. Additionally, they alter epigenetic landscape these genes, affecting activity. Mechanistic insights reveal contribute thereby altering drugs promoting resistance. Understanding interactions provides new perspective on basis chemoresistance, emphasizing network knowledge not only deepens our understanding biological mechanisms underlying but also suggests novel strategies. In conclusion, intricate interplay between transporters is developing innovative solutions combat underscoring importance continued field.
Language: Английский
Citations
7
Experimental and Molecular Pathology, Journal Year: 2021, Volume and Issue: 123, P. 104602 - 104602
Published: Jan. 10, 2021
Language: Английский
Citations
39