Ashwagandha Ethanol Extract Attenuates Sarcopenia-Related Muscle Atrophy in Aged Mice DOI Open Access

Jin-Sung Ko,

BoYoon Chang,

Youngju Choi

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(1), P. 157 - 157

Published: Jan. 3, 2024

The investigation focused on the impact of Withania somnifera (ashwagandha) extract (WSE) age-related mechanisms affecting skeletal muscle sarcopenia-related atrophy in aged mice. Beyond evaluating muscular aspects, study explored chronic low-grade inflammation, regeneration, and mitochondrial biogenesis. WSE administration, comparison to control group, demonstrated no significant differences body weight, diet, or water intake, affirming its safety profile. Notably, exhibited a propensity reduce epidermal abdominal fat while significantly increasing mass at dosage 200 mg/kg. muscle-to-fat ratio, adjusted for increased across all treatment groups. administration led reduction pro-inflammatory cytokines TNF-α IL-1β, mitigating inflammation-associated atrophy. In 12-month-old mouse model equivalent 50-year-old human, effectively preserved strength, stabilized grip tissue weight. Positive effects were observed running performance endurance. Mechanistically, balanced protein synthesis/degradation, promoted fiber differentiation, enhanced biogenesis through IGF-1/Akt/mTOR pathway. This provides compelling evidence anti-sarcopenic WSE, positioning it as promising candidate preventing sarcopenia pending further clinical validation.

Language: Английский

Gut microbes and muscle function: can probiotics make our muscles stronger? DOI
Muriel Giron, Muriel Thomas, Dominique Dardevet

et al.

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 13(3), P. 1460 - 1476

Published: March 12, 2022

Language: Английский

Citations

115
Sarcopenia, a condition shared by various diseases: can we alleviate or delay the progression? DOI Creative Commons
Giovanni Tarantino,

Gaia Sinatti,

Vincenzo Citro

et al.

Internal and Emergency Medicine, Journal Year: 2023, Volume and Issue: 18(7), P. 1887 - 1895

Published: July 25, 2023

Abstract Sarcopenia is a severe condition common to various chronic diseases and it reckoned as major health problem. It encompasses many different molecular mechanisms that have been for while discovered but not definitely clarified. Although sarcopenia disability status leads serious consequences, the scarcity of suitable animal models has curtailed research addressing this disorder. Another limitation in field clinical investigation sarcopenic patients lack generally accepted definition coupled with difficulty adopting diagnostic criteria. In fact, both do permit clarify exact prevalence rate consequently limit physicians establish any kind therapeutical approach or, when possible, adopt preventive measures. Unfortunately, there no standardized cure, apart from doing more physical activity embracing balanced diet, newly substances start being considered. review, authors try give an overview principal pathways offer critical features possible interventions.

Language: Английский

Citations

75
Gut microbiota–bile acid–skeletal muscle axis DOI Creative Commons
Laura Mancin,

Gary D. Wu,

Antonio Paoli

et al.

Trends in Microbiology, Journal Year: 2022, Volume and Issue: 31(3), P. 254 - 269

Published: Oct. 30, 2022

The gut microbiota represents a 'metabolic organ' that can regulate human metabolism. Intact contributes to host homeostasis, whereas compositional perturbations, termed dysbiosis, are associated with wide range of diseases. Recent evidence demonstrates and the accompanying loss microbiota-derived metabolites, results in substantial alteration skeletal muscle As an example, bile acids, produced liver further metabolized by intestinal microbiota, considerable interest since they several metabolic pathways activating nuclear receptors, including farnesoid X receptor (FXR). Indeed, may lead atrophy via acid-FXR pathway. This Review aims suggest new pathway connects different mechanisms, involving gut-muscle axis, often seen as unrelated, and, starting from preclinical studies, we hypothesize strategies aimed at optimizing functionality.

Language: Английский

Citations

71
Fiber-Type Shifting in Sarcopenia of Old Age: Proteomic Profiling of the Contractile Apparatus of Skeletal Muscles DOI Open Access
Paul Dowling, Stephen Gargan, Dieter Swandulla

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2415 - 2415

Published: Jan. 26, 2023

The progressive loss of skeletal muscle mass and concomitant reduction in contractile strength plays a central role frailty syndrome. Age-related neuronal impairments are closely associated with sarcopenia the elderly, which is characterized by severe muscular atrophy that can considerably lessen overall quality life at old age. Mass-spectrometry-based proteomic surveys senescent human muscles, as well animal models sarcopenia, have decisively improved our understanding molecular cellular consequences fiber-type shifting during aging. This review outlines spectrometric identification proteome-wide changes atrophying focus on proteins potential markers distribution patterns. observed trend fast-to-slow transitions individual muscles aging process most likely linked to preferential susceptibility fast-twitching fibers atrophy. Studies models, including mostly aged rodent confirmed shifting. analysis fast versus slow isoforms key proteins, such myosin heavy chains, light actins, troponins tropomyosins, suggests them suitable bioanalytical tools

Language: Английский

Citations

45
Research advances of microplastics and potential health risks of microplastics on terrestrial higher mammals: a bibliometric analysis and literature review DOI Open Access
Manman Liu,

Jinyan Liu,

Fei Xiong

et al.

Environmental Geochemistry and Health, Journal Year: 2023, Volume and Issue: 45(6), P. 2803 - 2838

Published: Jan. 4, 2023

Language: Английский

Citations

42
Cellular Senescence in Sarcopenia: Possible Mechanisms and Therapeutic Potential DOI Creative Commons

Yongyu He,

Wenqing Xie, Hengzhen Li

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 9

Published: Jan. 10, 2022

Aging promotes most degenerative pathologies in mammals, which are characterized by progressive decline of function at molecular, cellular, tissue, and organismal levels account for a host health care expenditures both developing developed nations. Sarcopenia is prominent age-related disorder musculoskeletal system. Defined as gradual generalized chronic skeletal muscle disorder, sarcopenia involves accelerated loss mass, strength function, associated with increased adverse functional outcomes evolutionally refers to wasting accompanied other geriatric syndromes. More efforts have been made clarify mechanisms underlying new findings suggest that it may be feasible delay modulating fundamental such cellular senescence. Cellular senescence the essentially irreversible growth arrest mainly regulated p53/p21 CIP1 p16 INK4a /pRB pathways organism ages, possibly detrimentally contributing via stem cells (MuSCs) dysfunction senescence-associated secretory phenotype (SASP) while beneficial functions counteracting cancer progression, tissue regeneration wound healing. By now diverse studies mice humans established targeting powerful strategy alleviating sarcopenia. However, through senescent contribute progression need further researched. We review possible involved SASP resulting from senescence, their associations sarcopenia, current emerging therapeutic opportunities based on relevant potential paths clinical interventions genetically or pharmacologically.

Language: Английский

Citations

45
Induction of Accelerated Aging in a Mouse Model DOI Creative Commons

Nanshuo Cai,

Yifan Wu, Yan Huang

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(9), P. 1418 - 1418

Published: April 22, 2022

With the global increase of elderly population, improvement treatment for various aging-related diseases and extension a healthy lifespan have become some most important current medical issues. In order to understand developmental mechanisms aging disorders, animal models are essential conduct relevant studies. Among them, mice one prevalently used model animals studies due their high similarity humans in terms genetic background physiological structure, as well short ease reproduction. This review will discuss common emerging mouse accelerated related chronic recent years, with aim serving reference future application fundamental translational research.

Language: Английский

Citations

42
Hallmarks of ageing in human skeletal muscle and implications for understanding the pathophysiology of sarcopenia in women and men DOI Creative Commons
Antoneta Granic, Karen Suetterlin,

Tea Shavlakadze

et al.

Clinical Science, Journal Year: 2023, Volume and Issue: 137(22), P. 1721 - 1751

Published: Nov. 1, 2023

Abstract Ageing is a complex biological process associated with increased morbidity and mortality. Nine classic, interdependent hallmarks of ageing have been proposed involving genetic biochemical pathways that collectively influence trajectories susceptibility to pathology in humans. skeletal muscle undergoes profound morphological physiological changes loss strength, mass, function, condition known as sarcopenia. The aetiology sarcopenia whilst research this area growing rapidly, there relative paucity human studies, particularly older women. Here, we evaluate how the nine classic ageing: genomic instability, telomere attrition, epigenetic alterations, proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication contribute pathophysiology We also highlight five novel particular significance inflammation, neural extracellular matrix reduced vascular perfusion, ionic dyshomeostasis, discuss are interconnected. Their clinical relevance translational potential considered.

Language: Английский

Citations

32
CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP‐43 and Encoding A Novel TMEFF1‐339aa Protein DOI Creative Commons
Rui Chen, Tingting Yang,

Bing Jin

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(17)

Published: April 23, 2023

Skeletal muscle atrophy is a common clinical feature of many acute and chronic conditions. Circular RNAs (circRNAs) are covalently closed RNA transcripts that involved in various physiological pathological processes, but their role remains unknown. Global circRNA expression profiling indicated circRNAs the pathophysiological processes atrophy. circTmeff1 identified as potential candidate influences It further highly expressed multiple types vivo vitro. Moreover, overexpression triggers vitro vivo, while knockdown rescues vivo. In particular, partially mass mice during established atrophic settings. Mechanistically, directly interacts with TAR DNA-binding protein 43 (TDP-43) promotes aggregation TDP-43 mitochondria, which release mitochondrial DNA (mtDNA) into cytosol activation cyclic GMP-AMP synthase (cGAS)/ stimulator interferon genes (STING) pathway. Unexpectedly, TMEFF1-339aa novel encoded by mediates its pro-atrophic effects. Collectively, inhibition represents therapeutic approach for skeletal

Language: Английский

Citations

25
Sarcopenia: Molecular regulatory network for loss of muscle mass and function DOI Creative Commons

Jiaxiang Wu,

Pingan Ding, Haotian Wu

et al.

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: Feb. 2, 2023

Skeletal muscle is the foundation of human function and plays a key role in producing exercise, bone protection, energy metabolism. Sarcopenia systemic disease, which characterized by degenerative changes skeletal mass, strength, function. Therefore, sarcopenia often causes weakness, prolonged hospitalization, falls other adverse consequences that reduce quality life, even lead to death. In recent years, has become focus in-depth research. Researchers have suggested some molecular mechanisms for according different physiology. These cover neuromuscular junction lesion, imbalance protein synthesis breakdown, satellite cells dysfunction, etc. We summarize latest research progress on mechanism this review order provide new ideas future researchers find valuable therapeutic targets develop relevant prevention strategies.

Language: Английский

Citations

23