Bicyclic 5-6 Systems: Three Heteroatoms 1:2 DOI
Xacobe C. Cambeiro

Elsevier eBooks, Journal Year: 2021, Volume and Issue: unknown, P. 188 - 211

Published: Sept. 17, 2021

Language: Английский

Synthesis Strategies and Medicinal Value of Pyrrole and its Fused Heterocyclic Compounds DOI

Samar S. Fatahala,

Mosaad S. Mohamed,

Jaqueline Youssef Sabry

et al.

Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 18(10), P. 1013 - 1043

Published: March 26, 2022

In the last several decades, interest in pyrrole and pyrrolopyrimidine derivatives has increased owing to their biological importance, such as anti-tumor, anti-microbial, anti-inflammatory, anti-diabetic, anti-histaminic, anti-malarial, anti-Parkinson, antioxidant anti-viral effects, specially recently against COVID-19. These tremendous features have motivated scientists discover more fused derivatives, great importance of nucleus a pharmacophore many drugs, us present this article, highlighting on different synthetic pathways its compounds, pyrrolopyrimidine, well medicinal value from 2017 till 2021.

Language: Английский

Citations

13
Synthesis of 4‐Hydroxy‐3‐(2‐arylimidazo[1,2‐a]pyridin‐3‐yl)quinolin‐2(1H)‐ones in the Presence of DABCO as an Efficient Organocatalyst DOI
Jabbar Khalafy, Nasser Etivand, Ahmad Poursattar Marjani

et al.

Journal of Heterocyclic Chemistry, Journal Year: 2019, Volume and Issue: 56(6), P. 1857 - 1865

Published: May 10, 2019

The one‐pot, three‐component, synthesis of a new series 4‐hydroxy‐3‐(2‐arylimidazo[1,2‐ ]pyridin‐3‐yl)quinolin‐2(1 H )‐ones in the presence DABCO as catalyst has been achieved using aryl glyoxal monohydrates, quinoline‐2,4(1 ,3 )‐dione, and 2‐aminopyridine 2 O/EtOH under reflux conditions. cheapness organocatalyst, simple workup, operational simplicity, regioselectivity, high yields are some advantages this protocol.

Language: Английский

Citations

12
Recent applications of aminouracil in multicomponent reactions DOI Creative Commons
Ramin Javahershenas

ARKIVOC, Journal Year: 2021, Volume and Issue: 2021(1), P. 236 - 272

Published: Feb. 14, 2021

6-Aminouracil and its derivatives are versatile heterocyclic compounds frequently employed to synthesize a wide array of fused uracils annulated with other rings which can serve address biological pharmacological targets.Multicomponent reactions (MCRs) important in the synthesis natural products pharmaceuticals by forming molecular frameworks generally high atom-economy single reaction step.This review embraces various modern synthetic strategies, summarizing recent research developments providing 6-aminouracil highlight progress based on MCRs between 2015 2020.

Language: Английский

Citations

10
Aminouracil and aminothiouracil as versatile precursors for a variety of heterocyclic systems DOI Creative Commons

Hadeer M. Diab,

Mostafa E. Salem, Ismail A. Abdelhamid

et al.

ARKIVOC, Journal Year: 2021, Volume and Issue: 2021(1), P. 329 - 377

Published: March 5, 2021

Heterocycles, particularly pyrimidine derivatives, which are present in many natural products and interesting synthetic compounds, the most diverse class of organic compounds have significant chemical, biomedical industrial applications.Uracil, a derivative, constitutes promising structure widespread its derivatives exhibited pharmacological properties.They been widely used as starting materials for synthesis huge number biologically important nitrogen-containing heterocycles.This review casts light on various methods construction different heterocyclic systems utilizing aminouracil aminothiouracil versatile precursors.The mentioned this categorized according to type systems.

Language: Английский

Citations

8
An efficient and novel protocol for the synthesis of spiro[1,3]oxazino[5,6-c]quinoline derivatives by one-pot, three-component reaction DOI

Maryam Aslanpanjeh,

Ahmad Poursattar Marjani, Jabbar Khalafy

et al.

Research on Chemical Intermediates, Journal Year: 2019, Volume and Issue: 46(1), P. 165 - 177

Published: Aug. 2, 2019

Language: Английский

Citations

8
A Three-Component, One-Pot Synthesis of Novel Benzimidazo[2,1-b]Thiazoles from Thiobarbituric Acid under Thermal and Microwave-Assisted Conditions DOI

Sara Asadi,

Keyvan Hassanzadeh Sartakhti,

Hossein Mehrabi

et al.

Organic Preparations and Procedures International, Journal Year: 2023, Volume and Issue: 56(2), P. 140 - 150

Published: July 28, 2023

Click to increase image sizeClick decrease size AcknowledgmentWe are grateful the Office of Graduate Studies Vali-e-Asr University Rafsanjan for partial support this work.

Language: Английский

Citations

2
Synthesis of Heterocyclic Compounds through Multicomponent Reactions Using 6-Aminouracil as Starting Reagent DOI
Ghodsi Mohammadi Ziarani,

Marzieh Rad,

Fatemeh Mohajer

et al.

Current Organic Chemistry, Journal Year: 2021, Volume and Issue: 25(9), P. 1070 - 1095

Published: March 3, 2021

The analogs of 6-Amino uracil are essential components due to their biological activities. is used as an important component for the synthesis heterocyclic compounds like pyrrolo-, pyrido-, pyrimidine-pyrimido scaffolds. Herein, application this compound reviewed a precursor in many cores from 2016 2020.

Language: Английский

Citations

5
An efficient domino strategy for synthesis of 3-substituted 4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine derivatives in water DOI
Xiaopeng Yang, Chunmei Li, Furen Zhang

et al.

Molecular Diversity, Journal Year: 2021, Volume and Issue: 26(3), P. 1663 - 1674

Published: Aug. 19, 2021

Language: Английский

Citations

4
Para toluenesulfonic acid-catalyzed one-pot, three-component synthesis of benzo[5,6]chromeno[3,2-c]quinoline compounds in aqueous medium DOI Creative Commons

Naser Sadeghpour Orang,

Hadi Soltani,

Mehdi Ghiamirad

et al.

Heterocyclic Communications, Journal Year: 2021, Volume and Issue: 27(1), P. 90 - 99

Published: Jan. 1, 2021

Abstract A new series of benzo[5,6]chromeno[3,2- c ]quinoline derivatives were successfully synthesized using various arylglyoxal monohydrates, quinoline-2,4-dione, and β-naphthol in H 2 O:EtOH (2:1) as a green solvent the presence catalytic amounts p -toluenesulfonic acid mild catalyst under reflux conditions with high yields (83–92%). The reaction optimized different solvents at variable thermal conditions, condition for this synthesis has been reported. structures all products defined by 1 H-NMR, 13 C-NMR, FT-IR, mass spectral data, HRMS.

Language: Английский

Citations

4
New One-Pot Pathway for the Synthesis of 2H–Pyrrolo[2,3-d]Pyrimidine-2,4-(3H)-Diones and 1H-Benzo[f]Indole-4,9-Dione Derivatives Substituted 3-Hydroxy-1,4-Naphthoquinonyl DOI

Rayhaneh Alipoor,

Mohammad R. Mohammadizadeh,

Dariush Saberi

et al.

Polycyclic aromatic compounds, Journal Year: 2022, Volume and Issue: 43(2), P. 1602 - 1618

Published: Feb. 4, 2022

One-pot three components effective methods are reported for the synthesis of two important families organic compounds, 2H-pyrrolo[2,3-d]pyrimidine-2,4(3H)-diones substituted 5-(3-hydroxy-1,4-naphthoquinonyl) and 1H-benzo[f]indole-4,9-diones 3-(3-hydroxy-1,4-naphthoquinonyl), by employment new starting materials. The formers were prepared via one-pot condensation reaction between phenylglyoxal, 2-hydroxynaphtoquinone 2-amino-1,4-naphthoquinone derivatives later through 2-hydroxy naphthoquinone derivatives. medium both procedures was acetic acid/water (1:1; v/v) at 100 °C, various these compounds obtained with high-efficiency identified their IR, 1H- 13C-NMR spectra. In spite apparent planar structures, NMR spectra some products shown asymmetric properties CH2 protons or existence diastereomers due to restriction Chydroxyquinoline˗Cpyrrol bonds, together formation relatively stable nonplanar eight membered ring resulted from hydrogen bond hydroxynapthoquinone’s OH carbonyl groups uracil motifs.

Language: Английский

Citations

3