Clinical Features and Vaccine Efficacy Analysis of COVID-19 patients in a Chongqing Shelter hospital in 2022 DOI Creative Commons

yining luo,

Mei Zhao,

Xingyu Zhao

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 14, 2023

Abstract Background The long-term impact of coronavirus disease 2019 (COVID-19) on many aspects society emphasizes the necessity vaccination and nucleic acid conversion time as markers prevention diagnosis. However, little research has been conducted immunological effects vaccines influencing factors virus clearance. Epidemiological characteristics related to prognosis need be explored. Design participants: We reviewed published documentation create an initial draft. data were then statistically evaluated determine their link. Given that a Chongqing shelter hospital is typical in terms COVID-19 patients receiving management treatment effects, retrospective analysis was 4,557 cases infection December 2022, which comprised 2,291 males 2,266 females. variables included age, medical history, time, status, clinical symptoms. Results Univariate survival using Log-rank test (P < 0.05) showed such age significantly affected time. COX regression indicated significant association between history hypertension had hazard ratio 0.897 (95% CI: 0.811–0.992). A difference observed vaccinated unvaccinated infected individuals presence symptoms cough sensory system manifestations 0.05). Conclusion effect against coughing, nasal congestion, muscle aches, runny nose, determined. Typical symptoms, generally higher than ones; previous influential factor with infection.

Language: Английский

Causal associations between major depressive disorder and COVID-19 DOI Creative Commons
Ancha Baranova, Yi Zhao, Hongbao Cao

et al.

General Psychiatry, Journal Year: 2023, Volume and Issue: 36(2), P. e101006 - e101006

Published: April 1, 2023

We aimed to evaluate whether major depressive disorder (MDD) could aggravate the outcomes of coronavirus disease 2019 (COVID-19) or genetic liability COVID-19 trigger MDD.We assess bidirectional causal associations between MDD and COVID-19.We performed correlation Mendelian randomisation (MR) analyses potential three outcomes. Literature-based network analysis was conducted construct molecular pathways connecting found that has positive correlations with (rg: 0.10-0.15). Our MR indicated is associated increased risks infection (odds ratio (OR)=1.05, 95% confidence interval (CI): 1.00 1.10, p=0.039). However, did not confer any effects on MDD. Pathway identified a panel immunity-related genes may mediate links COVID-19.Our study suggests increase susceptibility COVID-19. findings emphasise need social support improve mental health intervention networks for people mood disorders during pandemic.

Language: Английский

Citations

26
COVID-19 is associated with changes in brain function and structure: a multimodal meta-analysis of neuroimaging studies DOI
Zixuan Guo, Shilin Sun,

Shu Xiao

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105792 - 105792

Published: July 3, 2024

Language: Английский

Citations

6
Causal associations and genetic overlap between COVID-19 and intelligence DOI Creative Commons
Hongbao Cao, Ancha Baranova, Yuqing Song

et al.

QJM, Journal Year: 2023, Volume and Issue: 116(9), P. 766 - 773

Published: June 7, 2023

COVID-19 might cause neuroinflammation in the brain, which could decrease neurocognitive function. We aimed to evaluate causal associations and genetic overlap between intelligence.We performed Mendelian randomization (MR) analyses assess potential three outcomes intelligence (N = 269 867). The COVID phenotypes included severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection 501 486), hospitalized 1 965 329) critical 743 167). Genome-wide risk genes were compared genome-wide association study (GWAS) datasets on intelligence. In addition, functional pathways constructed explore molecular connections intelligence.The MR indicated that liabilities SARS-CoV-2 (odds ratio [OR]: 0.965, 95% confidence interval [CI]: 0.939-0.993) (OR: 0.989, CI: 0.979-0.999) confer effects There was suggestive evidence supporting effect of 0.988, 0.972-1.003). Hospitalized share 10 within genomic loci, including MAPT WNT3. Enrichment analysis showed these are functionally connected distinct subnetworks 30 linked cognitive decline. pathway revealed COVID-19-driven pathological changes brain multiple peripheral systems may lead impairment.Our suggests exert a detrimental tau protein Wnt signaling mediate influence

Language: Английский

Citations

14
Causal Associations between Posttraumatic Stress Disorder and COVID-19 DOI Creative Commons
Ancha Baranova, Li Fu, Yuqing Song

et al.

Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(4), P. 68 - 68

Published: April 1, 2024

Objective: We aimed to evaluate bidirectional genetic relationships between posttraumatic stress disorder (PTSD) and COVID-19. Methods: investigated potential causal associations PTSD two COVID-19 conditions (COVID-19 hospitalization SARS-CoV-2 infection) via Mendelian randomization (MR) analyses. Three genome-wide association study (GWAS) summary datasets were used in the study, including (N = 174,659), infection 2,597,856), 2,095,324). performed a literature-based analysis uncover molecular pathways connecting Results: found that exerts effect on (odds ratio (OR): 1.10, 95% confidence interval (CI): 1.00–1.21, p 0.048) hospitalized (OR: 1.34, CI: 1.07–1.67, 0.001). However, both not associated with risk of PTSD. Pathway revealed several immunity-related genes may link Conclusions: Our suggests was increased risks for susceptibility severity. Early diagnosis effective treatment individuals infected coronavirus improve management outcomes

Language: Английский

Citations

5
Identifying shared genetic loci and common risk genes of rheumatoid arthritis associated with three autoimmune diseases based on large-scale cross-trait genome-wide association studies DOI Creative Commons
Yaping Wen, Zu‐Guo Yu

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 12, 2023

Introduction Substantial links between autoimmune diseases have been shown by an increasing number of studies, and one hypothesis for this comorbidity is that there a common genetic cause. Methods In paper, large-scale cross-trait Genome-wide Association Studies (GWAS) was conducted to investigate the overlap among rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease type 1 diabetes. Results discussion Through local correlation analysis, 2 regions with locally significant associations arthritis 4 diabetes were discovered. By meta-analysis, 58 independent loci associated 86 disease, 107 identified genome-wide significance. addition, 82 risk genes found through identification. Based on gene set enrichment it shared are enriched in exposed dermal system, calf, musculoskeletal, subcutaneous fat, thyroid other tissues, also significantly 35 biological pathways. To verify association diseases, Mendelian randomized analysis performed, which shows possible causal The structure explored these believed important discovery will lead new ideas clinical treatment.

Language: Английский

Citations

12
Exploring the causal effects of depression and antidepressants on COVID-19 DOI Creative Commons
Li Fu, Ancha Baranova, Hongbao Cao

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 359, P. 350 - 355

Published: May 25, 2024

Language: Английский

Citations

4
Causal effects of education, intelligence, and income on COVID-19: evidence from a Mendelian randomization study DOI Creative Commons
Yuqing Song, Ancha Baranova, Hongbao Cao

et al.

Human Genomics, Journal Year: 2025, Volume and Issue: 19(1)

Published: Feb. 25, 2025

Abstract Background The protective effects of higher educational attainment (EA) and intelligence on COVID-19 outcomes are not yet understood with regard to their dependency income. objective our study was examine the overall as well independent three psychosocial factors susceptibility severity COVID-19. To accomplish this, we utilized genetic correlation, Mendelian randomization (MR), multivariable MR (MVMR) analyses evaluate associations between EA, intelligence, household income, specific outcomes: SARS-CoV-2 infection, hospitalized COVID-19, critical Results correlation analysis revealed that were negatively correlated (r g : -0.19‒-0.36). indicated liability income exerted against infection (OR: 0.86‒0.92), 0.70‒0.80), 0.65‒0.85). MVMR elevated levels EA conferred 0.85), hospitalization due 0.79), 0.63). Furthermore, exhibited a negative association risk 0.91), whereas linked an 1.13). Conclusions Our findings could significantly reduce regardless However, impact or supported by research.

Language: Английский

Citations

0
Metabolic predictors of COVID-19 mortality and severity: a survival analysis DOI Creative Commons

Abdallah Abdallah,

Asmma Doudin,

Theeb Osama Sulaiman

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 10, 2024

Introduction The global healthcare burden of COVID-19 pandemic has been unprecedented with a high mortality. Metabolomics, powerful technique, increasingly utilized to study the host response infections and understand progression multi-system disorders such as COVID-19. Analysis metabolites in SARS-CoV-2 infection can provide snapshot endogenous metabolic landscape its role shaping interaction SARS-CoV-2. Disease severity consequently clinical outcomes may be associated imbalance related amino acids, lipids, energy-generating pathways. Hence, metabolome help predict potential risks outcomes. Methods In this prospective study, using targeted metabolomics approach, we studied signature 154 patients (males=138, age range 48-69 yrs) it disease Blood plasma concentrations were quantified through LC-MS MxP Quant 500 kit, which coverage 630 from 26 biochemical classes including distinct lipids small organic molecules. We then employed Kaplan-Meier survival analysis investigate correlation between various markers, patient Results A comparison individuals levels (amino tryptophan, kynurenine, serotonin, creatine, SDMA, ADMA, 1-MH carnitine palmitoyltransferase 1 2 enzymes) those low revealed statistically significant differences further used four key markers (tryptophan, asymmetric dimethylarginine, 1-Methylhistidine) develop mortality risk model application multiple machine-learning methods. Conclusions Metabolomics signatures among different groups, reflecting discernible alterations acid perturbations tryptophan metabolism. Notably, critical exhibited higher short chain acylcarnitines, concomitant severe cases non-survivors. Conversely, 3-methylhistidine lower context.

Language: Английский

Citations

3
Exploring genetic associations between allergic diseases and indicators of COVID-19 using mendelian randomization DOI Creative Commons
Yujie Wang, Xiaoyu Gu, X Wang

et al.

iScience, Journal Year: 2023, Volume and Issue: 26(6), P. 106936 - 106936

Published: May 22, 2023

We carried out a bidirectional Mendelian randomization (MR) including cases of eczema (N = 218,792), asthma 462,933), and allergic rhinitis 112,583). COVID-19 susceptibility 1,683,768), hospitalization 1,887,658), severe respiratory symptom 1,388,342) were sampled from GWAS database. The MR analysis was primarily based on inverse variance weighted (IVW), supplemented by several other algorithms. In the analysis, negatively associated with (odds ratio (OR) IVW 0.92; p 0.031) (ORIVW 0.81, 0.010); 0.65, 0.005) 0.20, 0.001). No significant association found between 0.80, 0.174), 0.71, 0.207), or 0.56; 0.167). reverse showed no potential causal association. Our findings provided new evidence that diseases might be different risks susceptibility, hospitalization, symptom.

Language: Английский

Citations

8
Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study DOI Creative Commons
Yuxin Zou,

Manyi Pan,

Tianyu Zhou

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(5), P. e0301998 - e0301998

Published: May 3, 2024

Celiac disease exhibits a higher prevalence among patients with coronavirus 2019. However, the potential influence of COVID-19 on celiac remains uncertain. Considering significant association between gut microbiota alterations, and disease, two-step Mendelian randomization method was employed to investigate genetic causality as mediators. We genome-wide study select instrumental variables associated exposure. Subsequently, these were utilized evaluate impact risk its microbiota. Employing approach enabled examination causal relationships, encompassing: 1) effects infection, hospitalized critical disease; 2) 3) mediating disease. Our findings revealed an elevated (inverse variance weighted [IVW]: P = 0.035). Furthermore, we observed inverse correlation abundance Victivallaceae (IVW: 0.045). Notably, increased protective effect against 0.016). In conclusion, our analysis provides evidence supporting connection lower abundance, thereby increasing

Language: Английский

Citations

2