General Psychiatry, Journal Year: 2023, Volume and Issue: 36(6), P. e101088 - e101088
Published: Dec. 1, 2023
Language: Английский
BMJ Mental Health, Journal Year: 2024, Volume and Issue: 27(1), P. e300975 - e300975
Published: Jan. 1, 2024
Background Mental disorders have a high comorbidity with cardiovascular disease (CVD), but the causality between them has not been fully appreciated. Objective This study aimed to systematically explore bidirectional two broad categories of diseases. Methods We conducted Mendelian randomisation (MR) and multivariable MR (MVMR) analyses evaluate potential causal links 10 mental disorders, use antidepressants 7 CVDs. Findings discovered that major depressive disorder (MDD), attention-deficit/hyperactivity (ADHD) insomnia exhibit connections elevated risks or more Moreover, is linked heightened each CVD. Each distinct CVD correlated greater probability taking antidepressants. Our MVMR analysis demonstrated elevation respective across all conditions. includes arrhythmias (OR: 1.28), atrial fibrillation 1.44), coronary artery 1.16), hypertension heart failure stroke 1.44) entire group 1.35). However, MDD itself was risk any Conclusions The findings our indicate MDD, ADHD may increase highlight utilisation as an independent factor for CVD, thus explaining influence on through mediating effects Clinical implications When treating patients antidepressants, it necessary take into consideration beneficial detrimental
Language: Английский
Citations
24
Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)
Published: Feb. 23, 2024
Abstract Previous studies have observed a significant comorbidity between Alzheimer’s disease (AD) and some other neuropsychiatric disorders. However, the mechanistic connections disorders AD are not well understood. We conducted Mendelian randomization analysis to appraise potential influences of 18 neurodegenerative on AD. found that four causally associated with increased risk for AD, including bipolar disorder (BD) (OR: 1.09), migraine schizophrenia 1.05), Parkinson’s (PD) 1.07), while attention-deficit/hyperactivity (ADHD) was decreased 0.80). In case amyotrophic lateral sclerosis 1.04) Tourette’s syndrome there suggestive evidence their causal effects Our study shows genetic components predisposing BD, migraine, schizophrenia, PD may promote development ADHD be reduced The treatments aimed at alleviating diseases earlier onset also influence AD-related cognitive decline, which is typically later in life.
Language: Английский
Citations
16
General Psychiatry, Journal Year: 2024, Volume and Issue: 37(1), P. e101080 - e101080
Published: Feb. 1, 2024
Background Previous studies have shown that educational attainment (EA), intelligence and income are key factors associated with mental disorders. However, the direct effects of each factor on major disorders unclear. Aims We aimed to evaluate overall independent causal three psychosocial common Methods Using genome-wide association study summary datasets, we performed Mendelian randomisation (MR) multivariable MR (MVMR) analyses assess potential associations between 3 (EA, N=766 345; household income, N=392 422; intelligence, N=146 808) 13 disorders, sample sizes ranging from 9907 807 553. Inverse-variance weighting was employed as main method in analysis. Results Our analysis showed (1) higher EA a protective for eight but contributed anorexia nervosa, obsessive-compulsive disorder (OCD), bipolar (BD) autism spectrum (ASD); (2) five risk OCD ASD; (3) protected against 10 confers nervosa. MVMR attention-deficit/hyperactivity (ADHD) insomnia schizophrenia, BD schizophrenia depressive (MDD) seven including BD, MDD, ASD, post-traumatic stress disorder, ADHD anxiety disorder. Conclusions reveals education, intertwine other. For factor, its present more complex picture than effects.
Language: Английский
Citations
15
QJM, Journal Year: 2023, Volume and Issue: 116(9), P. 766 - 773
Published: June 7, 2023
COVID-19 might cause neuroinflammation in the brain, which could decrease neurocognitive function. We aimed to evaluate causal associations and genetic overlap between intelligence.We performed Mendelian randomization (MR) analyses assess potential three outcomes intelligence (N = 269 867). The COVID phenotypes included severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection 501 486), hospitalized 1 965 329) critical 743 167). Genome-wide risk genes were compared genome-wide association study (GWAS) datasets on intelligence. In addition, functional pathways constructed explore molecular connections intelligence.The MR indicated that liabilities SARS-CoV-2 (odds ratio [OR]: 0.965, 95% confidence interval [CI]: 0.939-0.993) (OR: 0.989, CI: 0.979-0.999) confer effects There was suggestive evidence supporting effect of 0.988, 0.972-1.003). Hospitalized share 10 within genomic loci, including MAPT WNT3. Enrichment analysis showed these are functionally connected distinct subnetworks 30 linked cognitive decline. pathway revealed COVID-19-driven pathological changes brain multiple peripheral systems may lead impairment.Our suggests exert a detrimental tau protein Wnt signaling mediate influence
Language: Английский
Citations
14
Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(4), P. 68 - 68
Published: April 1, 2024
Objective: We aimed to evaluate bidirectional genetic relationships between posttraumatic stress disorder (PTSD) and COVID-19. Methods: investigated potential causal associations PTSD two COVID-19 conditions (COVID-19 hospitalization SARS-CoV-2 infection) via Mendelian randomization (MR) analyses. Three genome-wide association study (GWAS) summary datasets were used in the study, including (N = 174,659), infection 2,597,856), 2,095,324). performed a literature-based analysis uncover molecular pathways connecting Results: found that exerts effect on (odds ratio (OR): 1.10, 95% confidence interval (CI): 1.00–1.21, p 0.048) hospitalized (OR: 1.34, CI: 1.07–1.67, 0.001). However, both not associated with risk of PTSD. Pathway revealed several immunity-related genes may link Conclusions: Our suggests was increased risks for susceptibility severity. Early diagnosis effective treatment individuals infected coronavirus improve management outcomes
Language: Английский
Citations
5
Schizophrenia, Journal Year: 2024, Volume and Issue: 10(1)
Published: Sept. 2, 2024
Growing evidence suggests a potential link between the gut microbiome and schizophrenia. However, it is unclear whether causally associated with We performed two-sample bidirectional Mendelian randomization to detect causal relationships Summary genome-wide association study (GWAS) datasets of from MiBioGen consortium (n = 18,340) schizophrenia 130,644) were utilized in our study. Then cohort sensitive analyses was followed validate robustness MR results. identified nine taxa that exerted positive effects on (OR: 1.08–1.16) six conferred negative 0.88–0.94). On other hand, reverse analysis showed may increase abundance 1.03–1.08) reduce two 0.94). Our unveiled mutual The findings provide for treatment microbiomes
Language: Английский
Citations
5
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 27, 2024
Introduction The complex and unresolved pathogenesis of schizophrenia has posed significant challenges to its diagnosis treatment. While recent research established a clear association between immune function schizophrenia, the causal relationship two remains elusive. Methods We employed bidirectional two-sample Mendelian randomization approach investigate 731 cell traits by utilizing public GWAS data. further validated six types white measures. Results found overall effects on were significantly higher than reverse ones (0.011 ± 0.049 vs 0.001 0.016, p < 0.001), implying that disease may lead an increase in cells itself. also identified four risk schizophrenia: CD11c+ monocyte %monocyte (odds ratio (OR): 1.06, 95% confidence interval (CI): 1.03~1.09, FDR = 0.027), CD62L- (OR:1.06, CI: CD25 IgD+ CD38- naive B (OR:1.03, CI:1.01~1.06, 0.042), CD86 (OR 1.04, 0.042). However, we did not detect any traits. Using blood data, increases lymphocyte counts 95%CI: 1.01-1.04, 0.007), total (OR:1.02, 0.021) 1.00-1.03, 0.034). nominally associated with (OR:1.08,95%CI:1.01-1.16, P=0.019). Discussion Our study system is complex, enhancing our understanding role regulation development this disorder. These findings offer new insights for exploring diagnostic therapeutic options schizophrenia.
Language: Английский
Citations
5
Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 359, P. 350 - 355
Published: May 25, 2024
Language: Английский
Citations
4
Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)
Published: Feb. 19, 2025
Posttraumatic stress disorder (PTSD) patients have a high comorbidity with type 2 diabetes (T2D). Whether PTSD influences the risk of is still not known. We used GWAS data from European ancestry (23,121 cases and 151,447 controls) T2D (80,154 853,816 to investigate bidirectional associations between by Mendelian randomization (MR) analysis. showed that was causally associated higher odds (OR = 1.04, 95% CI: 1.01–1.06, P 0.0086), but vice versa. Our study suggests may increase T2D. sufferers should be screened for its precursor known as metabolic syndrome.
Language: Английский
Citations
0
Human Genomics, Journal Year: 2025, Volume and Issue: 19(1)
Published: Feb. 25, 2025
Abstract Background The protective effects of higher educational attainment (EA) and intelligence on COVID-19 outcomes are not yet understood with regard to their dependency income. objective our study was examine the overall as well independent three psychosocial factors susceptibility severity COVID-19. To accomplish this, we utilized genetic correlation, Mendelian randomization (MR), multivariable MR (MVMR) analyses evaluate associations between EA, intelligence, household income, specific outcomes: SARS-CoV-2 infection, hospitalized COVID-19, critical Results correlation analysis revealed that were negatively correlated (r g : -0.19‒-0.36). indicated liability income exerted against infection (OR: 0.86‒0.92), 0.70‒0.80), 0.65‒0.85). MVMR elevated levels EA conferred 0.85), hospitalization due 0.79), 0.63). Furthermore, exhibited a negative association risk 0.91), whereas linked an 1.13). Conclusions Our findings could significantly reduce regardless However, impact or supported by research.
Language: Английский
Citations
0