A Comprehensive Analysis of Risk Factors Associated with Type 1 Diabetes Mellitus in Children and Adolescents at a Tertiary Healthcare Facility DOI Creative Commons
Aamir Naseem, Sommayya Aftab, Kashan Arshad

et al.

Pakistan Journal of Health Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 56 - 61

Published: Dec. 31, 2024

Type 1 Diabetes is an autoimmune condition affecting the pancreas. Objectives: To assess associations between genetic and environmental risk factors development of Mellitus in children adolescents. Methods: It was a case-control study conducted over 6 months at Department Pediatric Endocrinology Diabetes, Children’s Hospital Lahore. The population consisted two groups. Cases with while controls were without Diabetes. Data collected using pre-designed questionnaire by interview method from parents participating study. incidence various reported to be associated compared Results: 300 participated (n=150 cases n=150 control group). mean age participants 7.90 + 4.553 years. Pearson chi-square test revealed significant association like cow’s milk infancy, early weaning, vitamin D supplementation. Amongst factors, for history autoimmunity, family autoimmunity (p-value=<0.05). Conclusions: concluded that or self family, introduction supplementary foods are higher Meanwhile, no relationship established prior COVID-19 infection recurrent infections. Further studies needed establish cause effect relationship.

Language: Английский

Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality: An Umbrella Review of Meta‐Analyses DOI Creative Commons
Masoud Rahmati, Hyeri Lee, Hayeon Lee

et al.

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2025, Volume and Issue: 16(2)

Published: March 5, 2025

Numerous studies support the association of exercise training, physical activity (PA) and sedentary behaviour (SB) with both mortality morbidity outcomes. The results across have been inconsistent, no umbrella reviews yet conducted on this topic. We an review meta-analyses observational by screening articles in PubMed/MEDLINE, EMBASE Web Science databases from inception to 30 April 2024. Quality appraisal each included meta-analysis was done using AMSTAR 2 tool, evidence certainty evaluated based statistical significance, study size, heterogeneity, small-study effects, prediction intervals (PI) potential biases. Frothy-eight were (AMSTAR ratings: high 25, moderate 10, low critically 11). No highly suggestive or convincing. Suggestive linked any PA SB lower higher risks all-cause, cardiovascular cancer mortality. indicated a significant between self-reported device-measured total (equivalent odds ratio [eOR] 0.78 [0.70-0.86] eHR = 0.50 [0.38-0.65], respectively), leisure time (eHR 0.73 [0.66-0.80]), daily steps 0.44 [0.35-0.56]) aerobic plus resistance training 0.60 [0.56-0.64]) all-cause Weak supported links 1.3 [1.22-1.38] 2.16 [1.09-4.28], respectively). noted for 0.74 [0.69-0.80]) 0.82 [0.81-0.84]) also found 0.87 [0.83-0.91]) Associations running all causes, diseases (CVD) did not reach significance nor skeletal muscle mass Meta-regression analyses showed that reduces risk, age reducing protective effects against CVD combined (aerobic resistance) most effectively Converging supports are associated rates More high-quality prospective needed better understanding associations TV-viewing health-related

Language: Английский

Citations

2
Navigating the Post-COVID-19 Immunological Era: Understanding Long COVID-19 and Immune Response DOI Creative Commons

Aditi Mohan,

Venkatesh Anand Iyer,

Dharmender Kumar

et al.

Life, Journal Year: 2023, Volume and Issue: 13(11), P. 2121 - 2121

Published: Oct. 26, 2023

The COVID-19 pandemic has affected the world unprecedentedly, with both positive and negative impacts. significantly impacted immune system, understanding immunological consequences of is essential for developing effective treatment strategies. purpose this review to comprehensively explore provide insights into aspects long COVID-19, a phenomenon where individuals continue experience range symptoms complications, even after acute phase infection subsided. system responds initial by producing various cells molecules, including antibodies, T cells, cytokines. However, in some patients, response becomes dysregulated, leading chronic inflammation persistent symptoms. Long encompasses diverse affecting multiple organ systems, respiratory, cardiovascular, neurological, gastrointestinal systems. In post-COVID-19 era, its impact on have become significant concern. Post-COVID-19 pathology, autoimmunity immune-mediated disorders, also been reported patients. This provides an overview current relationship responses, pathology patient outcomes. Additionally, addresses potential treatments immunomodulatory therapies, rehabilitation programs, mental health support, all which aim improve quality life COVID-19. Understanding complex interplay between crucial targeted therapeutic strategies providing optimal care era.

Language: Английский

Citations

14
Covid 19 and diabetes in children: advances and strategies DOI Creative Commons
Zhaoyuan Wu, Jinling Wang, Rahim Ullah

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 29, 2024

Throughout the COVID-19 pandemic, there has been a notable increase in incidence of new-onset diabetes and diabetic ketoacidosis (DKA). Simultaneously, children diagnosed with type 1 (T1D) have encountered difficulties maintaining optimal blood glucose levels. The mechanisms underpinning these correlations still remain puzzle. We reviewed studies that examined changes during pandemic. These utilized various metrics for comparison, which encompassed timing data collection, diagnostic criteria, as well numbers rates DKA. found DKA was higher As to mechanisms, invivo invitro study revealed factors such direct viral damage, metabolic dysfunction, immune responses all attribute process T1D after suffering from COVID-19. Furthermore, we provide some useful strategies prevent treat Strong observed between Insights gleaned clinical descriptions basic research can offer valuable experience recommendations treatment prevention future pandemics.

Language: Английский

Citations

5
The relationship between SARS-CoV-2 infection and type 1 diabetes mellitus DOI
Cyril Debuysschere, Magloire Pandoua Nekoua, Enagnon Kazali Alidjinou

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(10), P. 588 - 599

Published: June 18, 2024

Language: Английский

Citations

5
Translating insights into therapies for Long Covid DOI Open Access
Annukka A.R. Antar, Andrea L. Cox

Science Translational Medicine, Journal Year: 2024, Volume and Issue: 16(773)

Published: Nov. 13, 2024

Long Covid is defined by a wide range of symptoms that persist after the acute phase severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported include fatigue, weakness, postexertional malaise, and cognitive dysfunction, with many other reported. Symptom range, duration, severity are highly variable partially overlap myalgic encephalomyelitis/chronic fatigue post-acute infectious syndromes, highlighting opportunities to define shared mechanisms pathogenesis. Potential diverse, including persistence viral reservoirs, dysregulated immune responses, direct damage tissues targeted SARS-CoV-2, inflammation driven reactivation latent infections, vascular endothelium activation or subsequent thromboinflammation, autoimmunity, metabolic derangements, microglial activation, microbiota dysbiosis. The heterogeneity baseline characteristics people Covid, as well varying states immunity therapies given at time infection, have made etiologies difficult determine. Here, we examine progress on preclinical models for review being in clinical trials, need large human studies further development better understand Covid. Such will inform trials treatments benefit those living this condition.

Language: Английский

Citations

4
Vision impairment and associated daily activity limitation: A systematic review and meta-analysis DOI Creative Commons
Masoud Rahmati, Lee Smith, Laurent Boyer

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317452 - e0317452

Published: Jan. 31, 2025

Vision impairment is a common disability that poses significant challenges to individuals' ability perform activities essential for independent living, including of daily living (ADL) and instrumental (IADL). Despite extensive research, the extent nature these associations remain unclear, particularly across varying levels types vision impairment. This meta-analysis aims estimate between difficulties with ADL IADL. We conducted systematic review relevant literature from inception databases February 2024, using electronic database searches, PubMed, MEDLINE (Ovid), EMBASE, Cochrane CENTRAL, CDSR. The articles were screened title abstract then full-text reports by two reviewers study quality was appraised. Meta-analyses performed random effects models calculate pooled effect size, expressed as odds ratio (OR) corresponding 95% confidence interval (CI) each outcome. Forty-six studies involving 210,960 participants included. A positive large correlation (Correlation coefficient [r] = 0.55, CI 0.37-0.68, p 0.001) IADL (r 0.60, 0.49-0.69, shown. also found associated in (OR 1.77, 1.56-2.01, < 0.0001) 1.96, 1.68-2.30, 0.0001). Subgroup analysis revealed moderate severe resulted 1.78, 1.43-2.21, 0.02) 1.86, 1.57-2.20, 0.0003). Further, there association mild 1.38, 1.23-1.55, Greater impact observed individuals near compared those distance Near significantly higher 1.57-2.01, 1.79, 1.32-2.42, In contrast, showed lower but still 1.19, 1.05-1.34, 0.005) nonsignificant 1.12, 0.90-1.40, 0.30). Meta-regression indicated every one-year increase age, performance decreased an average 0.0147 units (p 0.001), while declined at slower rate 0.0047 units/year 0.031). present several statistical methods indicates impairment, Thus, remains urgent increasingly important public health priority. These findings highlight need targeted measures raise awareness provide rehabilitation eye care examination strategies reduce risk developing disabilities adults elderly who have

Language: Английский

Citations

0
Potential hypothesis for the increased risk of Parkinson´s disease following COVID-19 DOI
Raffaella Mormile,

Cristina Mormile,

Carmine Picone

et al.

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Oct. 21, 2024

Language: Английский

Citations

2
Coverage and determinants of COVID-19 child vaccination in Munich, Germany in October 2022–January 2023: Results of the COVIP-Virenwächter study DOI
Sarah van de Berg, Liza Coyer, Ulrich von Both

et al.

European Journal of Pediatrics, Journal Year: 2024, Volume and Issue: 183(9), P. 3727 - 3738

Published: June 8, 2024

Language: Английский

Citations

2
Meta-analysis of the systemic immune-inflammatory index and in-hospital mortality of COVID-19 patients DOI Creative Commons
Yuan Hao, Jing Tian, Lu Wen

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 10(1), P. e23441 - e23441

Published: Dec. 8, 2023

The potential significance of immunoinflammatory factors in the prognosis individuals afflicted with coronavirus disease 2019 (COVID-19) is worthy examination. systemic immune-inflammatory index (SII), a recently developed metric based on enumeration neutrophils, platelets, and lymphocytes blood samples, holds promise for elucidating this relationship. Consequently, order to explore any possible correlation between SII levels at admission in-hospital mortality patients COVID-19, we undertook thorough systematic review meta-analysis.

Language: Английский

Citations

5
Routine pediatric vaccinations during the COVID-19 pandemic: A review of the global impact DOI Open Access
Jennifer A. Locke, Aleksandra Marinkovic,

Kareem A. Hamdy

et al.

World Journal of Virology, Journal Year: 2023, Volume and Issue: 12(5), P. 256 - 261

Published: Dec. 25, 2023

The coronavirus disease 2019 (COVID-19) pandemic has put standard, routine childhood vaccinations at risk worldwide. disruption in vaccine coverage resulted a negative impact on the health of children, with some races, ethnicities, age groups, areas settlement, and parts world affected more than others. This literature review studied examined COVID-19 infant, child, adolescent vaccinations. Retrospectively, analysis showed decline, delays, or interruptions vaccines during pan-demic decline countries' pre-pandemic post-pandemic eras. Necessary attempts efforts should be made for these delayed missed vaccinations, as failure to do so could children's risk. Thus, priority directed instituting catch-up programs support uptake decrease probability acquiring vaccine-preventable diseases.

Language: Английский

Citations

4