Unraveling the Link between Periodontitis and Inflammatory Bowel Disease: Challenges and Outlook.

Himanshi Tanwar,

Jeba Mercy Gnanasekaran,

Devon L. Allison

et al.

PubMed, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 19, 2023

Periodontitis and Inflammatory Bowel Disease (IBD) are chronic inflammatory conditions, characterized by microbial dysbiosis hyper-immunoinflammatory responses. Growing evidence suggest an interconnection between periodontitis IBD, implying a shift from the traditional concept of independent diseases to complex, reciprocal cycle. This review outlines supporting "Oral-Gut" axis, marked higher prevalence in IBD patients vice versa. The specific mechanisms linking remain be fully elucidated, but emerging points ectopic colonization gut oral bacteria, which promote intestinal inflammation activating host immune presents in-depth examination highlighting shared microbiological immunological pathways, proposing "multi-hit" hypothesis pathogenesis periodontitis-mediated inflammation. Furthermore, underscores critical need for collaborative approach dentists gastroenterologists provide holistic oral-systemic healthcare.

Language: Английский

Association between periodontitis and uric acid levels in blood and oral fluids: a systematic review and meta-analysis DOI Creative Commons

Lu-wen Ye,

Li Zhao,

Ze-song Mei

et al.

BMC Oral Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: March 27, 2023

Uric acid, a formerly-known antioxidant that has recently been linked to numerous inflammatory diseases as pro-inflammatory and -oxidative mediator in pathological conditions. It is imperative reassess the association between periodontitis uric acid locally systematically. The aim of this systematic review was systemically evaluate (UA) levels blood, saliva gingival crevicular fluid (GCF). Relevant clinical studies up January 28, 2023 were identified retrieved from electronic databases including PubMed, Scopus, EMBASE Web Science, with periodontitis, hyperuricemia gout keywords. weighted (WMD) or standardized mean difference (SMD) calculated using fixed- random-effect models. Methodological heterogeneity assessed. Sixteen eligible observational one RCT enrolled, which included 1354 patients 989 controls. Three sample types for UA detection involved, blood (n = 8), 9) GCF 1). Meta-analysis demonstrated an enhanced plasma concentration (WMD 1.00 mg/dL, 95% CI 0.63 1.37, P < 0.001) but decreased salivary level (SMD -0.95, -1.23 -0.68, versus control. Statistical among plasma- saliva-tested moderate (I2 58.3%, 0.066) low 33.8%, 0.196), respectively. Within limitations enrolled studies, it seems there increased UA. (Registration no. CRD42020172535 Prospero).

Language: Английский

Citations

10
Lower fecal microbiota transplantation ameliorates ulcerative colitis by eliminating oral-derived Fusobacterium nucleatum and virulence factor DOI Creative Commons
Yiyuan Li, Zongwei Li, Qi Sun

et al.

Gut Pathogens, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 8, 2024

Recently, the oral oncobacterium Fusobacterium nucleatum (F. nucleatum), has been linked with ulcerative colitis (UC). Here, we aim to investigate whether Fecal Microbiota Transplantation (FMT) can alleviate UC by restoring gut microbiota and eliminating oral-derived F. virulence factor fadA.

Language: Английский

Citations

3
Oral inoculation of fusobacterium nucleatum exacerbates ulcerative colitis via the secretion of virulence adhesin FadA DOI Creative Commons
Yiyuan Li, Zongwei Li, Lei Wang

et al.

Virulence, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 2, 2024

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Citations

3
Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches DOI Creative Commons
Jinting Ge, Xuanzhi Zhu,

Chengxin Weng

et al.

International Journal of Oral Science, Journal Year: 2024, Volume and Issue: 16(1)

Published: Oct. 15, 2024

Periodontitis is a chronic inflammatory disease initiated by biofilm microorganisms and mediated host immune imbalance. Uncontrolled periodontal infections are the leading cause of tooth loss in adults. Thrombotic diseases can lead to partial or complete obstruction blood flow circulatory system, manifesting as organ tissue ischemia necrosis patients with arterial thrombosis, local edema, pain instability venous which may mortality fatality severe case. Recent studies found that periodontitis might enhance thrombosis through bacterial transmission systemic inflammation affecting platelet-immune cell interactions, well coagulation, therapy could have prophylactic effect on thrombotic diseases. In this review, we summarized clinical findings association between discussed several novel prothrombotic periodontitis-related agents, presented perspective emphasize necessity oral health management for people at high risk thrombosis.

Language: Английский

Citations

3
Dress me an outfit: advanced probiotics hybrid systems for intelligent IBD therapy DOI
Yonglu Li, Yadi Wang,

Yapeng Li

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 24

Published: July 15, 2024

Inflammation bowel disease (IBD) has emerged as a public health challenge worldwide; with high incidence and rapid prevalence, it troubled billions of people further induced multitudinous systemic complications. Recent decade witnessed the vigorous application food-borne probiotics for IBD therapy; however, complicated changeable environments digestive tract have forced to face multiple

Language: Английский

Citations

2
Intestinal homeostasis disrupted by Periodontitis exacerbates Alzheimer’s Disease in APP/PS1 mice DOI Creative Commons

Xueshen Qian,

Xuxin Lin,

Weiqiang Hu

et al.

Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: Oct. 18, 2024

Periodontitis exacerbates Alzheimer's disease (AD) through multiple pathways. Both periodontitis and AD are intricately correlated to intestinal homeostasis, yet there is still a lack of direct evidence regarding whether can regulate the progression by modulating homeostasis. The current study induced experimental in mice bilaterally ligating maxillary second molars with silk administering Pg-LPS injections APPswe/PS1ΔE9 (APP/PS1) mice. Behavioral tests histological analyses brain tissue were conducted after 8 weeks. Gut microbiota was analyzed colon also evaluated. Then, fecal from transplanted into antibiotic-treated confirm effects on potential mechanism explored. results indicated exacerbated cognitive impairment anxious behaviour APP/PS1 mice, increased Aβ deposition, microglial overactivation neuroinflammation brain. Moreover, homeostasis altered periodontitis, including affecting gut composition, causing inflammation destroyed epithelial barrier. Furthermore, that underwent transplantation exhibited worsened disrupted It impaired barrier function, elevated peripheral inflammation, damaged blood-brain (BBB) caused synapses impairment. Taken together, demonstrated could disrupt exacerbate via microbial dysbiosis, induce damage BBB, ultimately leading synapse underscores importance maintaining both periodontal health reduce risk AD.

Language: Английский

Citations

2
Periodontal pathogen Fusobacterium nucleatum infection accelerates hepatic steatosis in high‐fat diet‐fed ApoE knockout mice by inhibiting Nrf2/Keap1 signaling DOI
Peiyao Wu, Mengyao Bie, Jieyu Zhou

et al.

Journal of Periodontal Research, Journal Year: 2024, Volume and Issue: 59(6), P. 1220 - 1233

Published: May 25, 2024

This study sought to explore the impact of Fusobacterium nucleatum on hepatic steatosis in apolipoprotein E (ApoE) knockout (KO) mice induced by a high-fat diet (HFD) and elucidate underlying mechanism.

Language: Английский

Citations

1
Relationship of Metabolic Dysfunction-associated Steatohepatitis-related Hepatocellular Carcinoma with Oral and Intestinal Microbiota: A Cross-Sectional Pilot Study DOI Open Access
Takaaki Matsui, Toshiya Morozumi, Yuko Yamamoto

et al.

Published: June 11, 2024

Background: The incidence of metabolic dysfunction-associated steatohepatitis (MASH)-related hepatocellular carcinoma (HCC) is increasing annually with a rise in the obesity and syndrome. Based on preliminary reports regarding potential association HCC periodontitis, this study aimed to analyze involvement periodontal bacteria as well oral intestinal bacterial flora MASH-related (MASH-HCC). Methods: Forty-one patients MASH 19 MASH-HCC who completed survey questionnaires, underwent examinations, subjected sample collection (saliva, mouth-rinsed water, feces, peripheral blood) participated study. Bayesian network analysis was used causation between various factors, including MASH-HCC, bacteria. Results: occupancy rate genus Fusobacterium significantly higher group than (p = 0.002), whereas that Butyricicoccus 0.022) Roseburia &amp;lt; 0.05) lower. revealed absence pathogenic enteric affecting HCC. However, directly affected species Porphyromonas gingivalis, Tannerella forsythia, nucleatum, Prevotella intermedia saliva, genera Lactobacillus, Roseburia, Fusobacterium, Prevotella, Clostridium, Ruminococcus, Trabulsiella, SMB53 intestine. Furthermore, P. gingivalis cavity Lactobacillus Streptococcus Conclusion: affects bacteria, may affect associated gastrointestinal cancer.

Language: Английский

Citations

1
Distinct characteristics of the gut virome in patients with osteoarthritis and gouty arthritis DOI Creative Commons
Changming Chen,

Qiulong Yan,

Ruochun Guo

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 13, 2024

Abstract Background/purpose(s) The gut microbiota and its metabolites play crucial roles in pathogenesis of arthritis, highlighting as a promising avenue for modulating autoimmunity. However, the characterization virome arthritis patients, including osteoarthritis (OA) gouty (GA), requires further investigation. Methods We employed virus-like particle (VLP)-based metagenomic sequencing to analyze viral community 20 OA 26 GA 31 healthy controls, encompassing total 77 fecal samples. Results Our analysis generated 6819 vOTUs, with considerable proportion genomes differing from existing catalogs. patients differed significantly showing variations diversity family abundances. identified 157 OA-associated 94 GA-associated achieving high accuracy patient-control discrimination random forest models. viruses were predicted infect pro-inflammatory bacteria or associated immunoglobulin A production, while linked Bacteroidaceae Lachnospiraceae phages. Furthermore, several functional orthologs displayed significant differences frequency between OA-enriched GA-enriched suggesting potential these viruses. Additionally, we trained classification models based on signatures effectively discriminate yielding AUC values up 0.97, indicating clinical utility diagnosing GA. Conclusion study highlights distinctive alterations taxonomy within offering insights into etiology treatment prevention strategies. Graphical

Language: Английский

Citations

1
Relationship of Metabolic Dysfunction-Associated Steatohepatitis-Related Hepatocellular Carcinoma with Oral and Intestinal Microbiota: A Cross-Sectional Pilot Study DOI Creative Commons
Takaaki Matsui, Toshiya Morozumi, Yuko Yamamoto

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(7), P. 1150 - 1150

Published: July 17, 2024

: The incidence of metabolic dysfunction-associated steatohepatitis (MASH)-related hepatocellular carcinoma (HCC) is increasing worldwide, alongside the epidemic obesity and syndrome. Based on preliminary reports regarding potential association HCC periodontitis, this study aimed to analyze involvement periodontal bacteria as well oral intestinal bacterial flora in MASH-related (MASH-HCC).

Language: Английский

Citations

1